DT-Web

DB00534 - Chlormerodrin


Identification
Name Chlormerodrin
Accession Number DB00534 (APRD00864)
Type small molecule
Description Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 367.2
Groups approved
Monoisotopic Weight 368.021530917
Pharmacology
Indication Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.
Mechanism of action Chlormerodrin most likely acts by a direct renal action. Mercurial diuresis is presumed to occur through inhibition of reabsorption of water and electrolytes in the convoluted tubules, although the problem of whether the locus of action is primarily on the proximal or distal portion has not yet been settled. There is also evidence that mercurials interfere with the permeability of the membrane of tubular cells by increasing passive influx of Na+ ion, Cl- ion and water into the cells, without interfering with the active extrusion of Na+ ion. Lastly, there is some evidence that chlormerodrin inhibits succinic dehydrogenase, but the clinical significance of this binding is not known.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity As chlormerodrin has been shown to increase the levels of mercury in the kidney to toxic levels, any symptoms of overdose will most likely correspond to symptoms experienced in exposure to mercury.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Solute carrier family 12 member 1
Name Solute carrier family 12 member 1
Gene Name SLC12A1
Pharmacological action yes
Actions inducer
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Tabern DL, Kearney J, Sohn H: The quantitative measurement of tubular chlormerodrin binding as an index of renal function: a study of 400 cases. Can Med Assoc J. 1970 Sep 26;103(6):601-7. - Pubmed
  • Mannuzzu LM, Moronne MM, Macey RI: Estimate of the number of urea transport sites in erythrocyte ghosts using a hydrophobic mercurial. J Membr Biol. 1993 Apr;133(1):85-97. - Pubmed
DTHybrid score 0.604
Succinate semialdehyde dehydrogenase, mitochondrial
Name Succinate semialdehyde dehydrogenase, mitochondrial
Gene Name ALDH5A1
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Oda Y: [Experimental study on renal succinic dehydrogenase. 2. Age differences in renal succinic dehydrogenase in rats administered diuretics] Nippon Shonika Gakkai Zasshi. 1968 Apr 1;72(4):370-80. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2747

Predictions


Id Partner name Gene Name Score
295 Carbonic anhydrase 1 CA1 0.0632
310 Solute carrier family 12 member 2 SLC12A2 0.0618
357 Carbonic anhydrase 2 CA2 0.0545
592 Carbonic anhydrase 4 CA4 0.0493
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.044
53 Solute carrier family 12 member 5 SLC12A5 0.0343
663 Solute carrier family 12 member 4 SLC12A4 0.0343
1729 Solute carrier family 22 member 6 SLC22A6 0.0275
304 Solute carrier family 12 member 7 SLC12A7 0.0243
157 Solute carrier family 12 member 6 SLC12A6 0.0242
6142 Solute carrier family 22 member 8 SLC22A8 0.0226
466 Solute carrier family 12 member 3 SLC12A3 0.0222
3932 Glutathione S-transferase A2 GSTA2 0.0201
1405 Thiopurine S-methyltransferase TPMT 0.0178
20 Prostaglandin G/H synthase 1 PTGS1 0.0176
587 Serum albumin ALB 0.0171
1039 Histone deacetylase 9 HDAC9 0.0159
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0158
4924 Cytochrome P450 2C8 CYP2C8 0.0152
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0151
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0151
1410 Oxidoreductase HSD17B6 0.0151
4725 Oxidoreductase Not Available 0.0151
5124 Oxidoreductase Not Available 0.0151
4007 Succinate receptor 1 SUCNR1 0.0151
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0151
25 Solute carrier family 13 member 1 SLC13A1 0.0151
673 Solute carrier family 13 member 3 SLC13A3 0.0151
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0151
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0151
498 Solute carrier family 13 member 2 SLC13A2 0.0151
6016 Cytochrome P450 2C19 CYP2C19 0.0148
3007 Carbonic anhydrase 12 CA12 0.0147
4205 Carbonic anhydrase 9 CA9 0.0147
4757 Cytochrome P450 2C9 CYP2C9 0.0141
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0134
1024 Solute carrier family 22 member 11 SLC22A11 0.0133
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0131
118 Organic cation/carnitine transporter 2 SLC22A5 0.0127
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0127
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0125
6143 Solute carrier family 22 member 7 SLC22A7 0.0124
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0122
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0121
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0121
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.012
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.012
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0112
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0112
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0112
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0109
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0108
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0102
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.01
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0095
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0095
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0095
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0094
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0094
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0092
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0088
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0083
738 Monocarboxylate transporter 1 SLC16A1 0.0074
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0073
6141 Sodium/bile acid cotransporter SLC10A1 0.0071
6106 Cytochrome P450 2C18 CYP2C18 0.0069
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0068
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0068
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0062
5718 Cytochrome P450 2A6 CYP2A6 0.0056
290 Prostaglandin G/H synthase 2 PTGS2 0.0055
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0054
6030 Cytochrome P450 2B6 CYP2B6 0.005
4118 Cytochrome P450 3A5 CYP3A5 0.0048
4200 Cytochrome P450 1A2 CYP1A2 0.0044
4512 Cytochrome P450 3A4 CYP3A4 0.0037
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0028
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0028
816 Biliverdin reductase A BLVRA 0.0028
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0028
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0026
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0026
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0026
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0026
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0026
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0026
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0026
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0026
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0026
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0026
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0026
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0026
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0026
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0026
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0026
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0026
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0026
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0026
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0026
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0026
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0026
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0026
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0026
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0026
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0026
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0026
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0026
644 Heme oxygenase 2 HMOX2 0.0026
4982 Heme oxygenase 2 pbsA2 0.0026
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0026
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0026
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0026
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0026
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0026
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0026
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0026
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0026
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0026
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0026
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0026
107 C-4 methylsterol oxidase SC4MOL 0.0026
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0026
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0026
34 7-dehydrocholesterol reductase DHCR7 0.0026
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0026
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0026
729 GDP-L-fucose synthetase TSTA3 0.0026
3463 GDP-L-fucose synthetase fcl 0.0026
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0026
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0026
167 L-lactate dehydrogenase C chain LDHC 0.0026
206 3-keto-steroid reductase HSD17B7 0.0026
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0026
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0026
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0026
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0026
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0026
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0026
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0026
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0026
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0026
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0026
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0026
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0026
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0026
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0026
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0026
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0026
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0026
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0026
711 UDP-glucose 6-dehydrogenase UGDH 0.0026
3672 UDP-glucose 6-dehydrogenase hasB 0.0026
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0026
3726 D-3-phosphoglycerate dehydrogenase serA 0.0026
4291 D-3-phosphoglycerate dehydrogenase serA 0.0026
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0026
643 Peroxisomal bifunctional enzyme EHHADH 0.0026
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0026
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0026
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0024
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0024
646 Malate dehydrogenase, cytoplasmic MDH1 0.0024
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0024
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0024
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0024
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0024
597 Dihydropteridine reductase QDPR 0.0023
328 Sorbitol dehydrogenase SORD 0.0023
396 Alcohol dehydrogenase 4 ADH4 0.0023
626 Cysteine dioxygenase type 1 CDO1 0.0023
857 Malate dehydrogenase, mitochondrial MDH2 0.0023
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0023
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0023
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0022
666 NADP-dependent malic enzyme ME1 0.0022
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0022
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0022
6026 Alcohol dehydrogenase 6 ADH6 0.0022
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0022
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0021
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0021
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0021
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0021
77 L-lactate dehydrogenase B chain LDHB 0.0021
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0021
627 11-cis retinol dehydrogenase RDH5 0.0021
12 Alcohol dehydrogenase class 3 ADH5 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0021
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.002
11 NAD(P) transhydrogenase, mitochondrial NNT 0.002
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.002
13 Aminomethyltransferase, mitochondrial AMT 0.002
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.002
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.002
473 L-lactate dehydrogenase A chain LDHA 0.002
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.002
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0019
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0019
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0019
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0018
279 Tyrosinase TYR 0.0018
251 Alcohol dehydrogenase 1A ADH1A 0.0018
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0017
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0017
654 Flavin reductase BLVRB 0.0016
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0016
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0016
444 Alcohol dehydrogenase 1B ADH1B 0.0016
810 Heme oxygenase 1 HMOX1 0.0016
3391 Heme oxygenase 1 pbsA1 0.0016
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0016
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0016
380 Cytochrome P450 17A1 CYP17A1 0.0015
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0015
714 Glutathione reductase, mitochondrial GSR 0.0015
468 Cytochrome P450 4A11 CYP4A11 0.0015
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0015
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0015
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0014
6020 Aldehyde oxidase AOX1 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0013
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0013
3947 Xanthine dehydrogenase/oxidase XDH 0.0013
822 Aldose reductase AKR1B1 0.0012
365 Dihydrofolate reductase DHFR 0.0012
2381 Dihydrofolate reductase DFR1 0.0012
2833 Dihydrofolate reductase Not Available 0.0012
2931 Dihydrofolate reductase folA 0.0012
3544 Dihydrofolate reductase folA 0.0012
3682 Dihydrofolate reductase folA 0.0012
6642 Dihydrofolate reductase folA 0.0012
6756 Dihydrofolate reductase dfrA 0.0012
↑