DT-Web

DB00267 - Cefmenoxime


Identification
Name Cefmenoxime
Accession Number DB00267 (APRD00851)
Type small molecule
Description Cefmenoxime is a third-generation cephalosporin antibiotic. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 511.558
Groups approved
Monoisotopic Weight 511.051476769
Pharmacology
Indication Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria.
Mechanism of action The bactericidal activity of cefmenoxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefmenoxime is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.
Absorption Bioavailability is approximately 100% following intramuscular injection.
Protein binding 50-70%
Biotransformation Not appreciably metabolized.
Route of elimination Not Available
Toxicity Information on cefmenoxime overdosage in humans is not available. However, with other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Penicillin-binding proteins 1A/1B
Name Penicillin-binding proteins 1A/1B
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Tsuchiya K, Kondo M, Kida M, Nakao M, Iwahi T, Nishi T, Noji Y, Takeuchi M, Nozaki Y: Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother. 1981 Jan;19(1):56-65. - Pubmed
DTHybrid score 0.7833
Peptidoglycan synthetase ftsI
Name Peptidoglycan synthetase ftsI
Gene Name ftsI
Pharmacological action yes
Actions inhibitor
References
  • Tsuchiya K, Kondo M, Kida M, Nakao M, Iwahi T, Nishi T, Noji Y, Takeuchi M, Nozaki Y: Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother. 1981 Jan;19(1):56-65. - Pubmed
DTHybrid score 0.019

Predictions


Id Partner name Gene Name Score
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1326
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.1253
543 Penicillin-binding protein 1B mrcB 0.1242
6186 Penicillin-binding protein 1B ponB 0.1242
6822 Penicillin-binding protein 1b pbp1b 0.1242
6844 Penicillin-binding protein 1b pbp1b 0.1242
645 Penicillin-binding protein 1A mrcA 0.1222
5805 Penicillin-binding protein 1A ponA 0.1222
6185 Penicillin-binding protein 1A mrcA 0.1222
6799 Penicillin-binding protein 1A pbpA 0.1222
819 Penicillin-binding protein 4 dacB 0.0648
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0634
1729 Solute carrier family 22 member 6 SLC22A6 0.0553
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0433
6067 Penicillin binding protein 2a mecA 0.0426
118 Organic cation/carnitine transporter 2 SLC22A5 0.0378
587 Serum albumin ALB 0.0363
3760 Penicillin-binding protein 5 precursor dacA 0.0342
1024 Solute carrier family 22 member 11 SLC22A11 0.0224
6142 Solute carrier family 22 member 8 SLC22A8 0.0192
1 Peptidoglycan synthetase ftsI ftsI 0.019
115 Penicillin-binding protein 2 mrdA 0.0176
6069 Penicillin-binding protein 2 mrdA 0.0176
6118 Penicillin-binding protein 2 penA 0.0176
6187 Penicillin-binding protein 2 pbpA 0.0176
6686 Penicillin-binding protein 2 pbp2 0.0176
6939 Penicillin-binding protein 2 mrdA 0.0176
7163 Penicillin-binding protein 2 pbpA 0.0176
2385 Penicillin acylase Not Available 0.0166
4512 Cytochrome P450 3A4 CYP3A4 0.014
1757 Myeloperoxidase MPO 0.0139
1198 Serum paraoxonase/arylesterase 1 PON1 0.0139
6223 Penicillin-binding protein 1C pbpC 0.0139
332 Beta-lactamase blaZ 0.0133
2478 Beta-lactamase ampC 0.0133
2613 Beta-lactamase ampC 0.0133
2635 Beta-lactamase ampC 0.0133
2700 Beta-lactamase penP 0.0133
5445 Beta-lactamase blaB 0.0133
6019 Beta-lactamase SHV-7 0.0133
6701 Beta-lactamase cphA 0.0133
159 Penicillin-binding protein 2B penA 0.0126
6121 Penicillin-binding protein 2B penA 0.0126
4252 Penicillin-binding protein 5 dacA 0.0117
6143 Solute carrier family 22 member 7 SLC22A7 0.0082
1405 Thiopurine S-methyltransferase TPMT 0.0081
6016 Cytochrome P450 2C19 CYP2C19 0.0067
2164 Multidrug resistance-associated protein 4 ABCC4 0.0054
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0045
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0045
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