DT-Web

DB01581 - Sulfamerazine


Identification
Name Sulfamerazine
Accession Number DB01581
Type small molecule
Description A sulfanilamide that is used as an antibacterial agent. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 264.304
Groups approved
Monoisotopic Weight 264.068096338
Pharmacology
Indication A sulfanilamide that is used as an antibacterial agent. It can be used to treat bronchitis, prostatitis and urinary tract infections.
Mechanism of action Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA.
Absorption Rapidly absorbed following oral administration.
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Sulfamerazine may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Chlorpropamide Sulfonamide/sulfonylurea: possible hypoglycemia
Methotrexate The sulfamide increases the toxicity of methotrexate
Food Interactions
  • Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.

Targets


Dihydropteroate synthase
Name Dihydropteroate synthase
Gene Name folP
Pharmacological action yes
Actions inhibitor
References
  • Hong YL, Hossler PA, Calhoun DH, Meshnick SR: Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63. - Pubmed
  • Friaza V, Morilla R, Respaldiza N, de la Horra C, Calderon EJ: Pneumocystis jiroveci dihydropteroate synthase gene mutations among colonized individuals and Pneumocystis pneumonia patients from Spain. Postgrad Med. 2010 Nov;122(6):24-8. - Pubmed
  • Thijssen HH: A simplified radioassay method of dihydropteroate synthetase activity in Escherichia coli and its application for an inhibition study of p-aminobenzoi acid derivatives. Anal Biochem. 1973 Jun;53(2):579-85. - Pubmed
DTHybrid score 0.8363

Carriers


Predictions


Id Partner name Gene Name Score
5359 Dihydropteroate synthase folP 0.8363
7175 Dihydropteroate synthase sulI 0.8363
4757 Cytochrome P450 2C9 CYP2C9 0.1106
4512 Cytochrome P450 3A4 CYP3A4 0.0519
4924 Cytochrome P450 2C8 CYP2C8 0.0395
4119 Cytochrome P450 2D6 CYP2D6 0.0345
6016 Cytochrome P450 2C19 CYP2C19 0.0329
20 Prostaglandin G/H synthase 1 PTGS1 0.0283
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0283
6103 Arylamine N-acetyltransferase 1 NAT1 0.027
1588 Multidrug resistance protein 1 ABCB1 0.0267
1729 Solute carrier family 22 member 6 SLC22A6 0.0239
6030 Cytochrome P450 2B6 CYP2B6 0.0232
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0196
6013 Cytochrome P450 2E1 CYP2E1 0.0194
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0187
4200 Cytochrome P450 1A2 CYP1A2 0.0184
290 Prostaglandin G/H synthase 2 PTGS2 0.018
5718 Cytochrome P450 2A6 CYP2A6 0.0171
6102 Arylamine N-acetyltransferase 2 NAT2 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
6541 Peptostreptococcal albumin-binding protein pab 0.0142
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.014
6142 Solute carrier family 22 member 8 SLC22A8 0.0139
4118 Cytochrome P450 3A5 CYP3A5 0.0132
1024 Solute carrier family 22 member 11 SLC22A11 0.0121
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0109
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0107
2211 Fatty acid-binding protein, heart FABP3 0.0098
566 Serotransferrin TF 0.0094
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0087
6143 Solute carrier family 22 member 7 SLC22A7 0.0086
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0083
6145 Solute carrier family 22 member 1 SLC22A1 0.0083
2164 Multidrug resistance-associated protein 4 ABCC4 0.0083
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0077
862 Multidrug resistance-associated protein 1 ABCC1 0.0075
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0074
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0074
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
645 Penicillin-binding protein 1A mrcA 0.0071
5805 Penicillin-binding protein 1A ponA 0.0071
6185 Penicillin-binding protein 1A mrcA 0.0071
6799 Penicillin-binding protein 1A pbpA 0.0071
502 5-hydroxytryptamine 2A receptor HTR2A 0.0071
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0071
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
36 Insulin receptor INSR 0.0066
6107 Cytochrome P450 3A7 CYP3A7 0.0065
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0065
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0063
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0063
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
705 Glutamate receptor 1 GRIA1 0.0061
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0061
482 Glycine receptor subunit alpha-1 GLRA1 0.006
756 Sex hormone-binding globulin SHBG 0.006
23 D(1A) dopamine receptor DRD1 0.006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0059
831 D(2) dopamine receptor DRD2 0.0056
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0054
320 5-hydroxytryptamine 1A receptor HTR1A 0.0054
2853 14 kDa fatty acid-binding protein Not Available 0.0053
6024 Cytochrome P450 1A1 CYP1A1 0.0052
183 Vascular endothelial growth factor A VEGFA 0.0052
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.005
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6085 Fatty acid-binding protein, intestinal FABP2 0.0049
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
3382 Glycolipid transfer protein GLTP 0.0046
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0045
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0045
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0045
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0044
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0044
373 Transthyretin TTR 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
556 Alpha-1A adrenergic receptor ADRA1A 0.0043
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0042
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0042
844 Epidermal growth factor receptor EGFR 0.0041
118 Organic cation/carnitine transporter 2 SLC22A5 0.0041
632 Alpha-1B adrenergic receptor ADRA1B 0.0041
738 Monocarboxylate transporter 1 SLC16A1 0.0041
404 DNA gyrase subunit A gyrA 0.004
6224 DNA gyrase subunit A gyrA 0.004
477 DNA topoisomerase 4 subunit A parC 0.004
886 DNA topoisomerase 4 subunit A parC 0.004
6226 DNA topoisomerase 4 subunit A parC 0.004
558 Solute carrier family 12 member 1 SLC12A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
4604 Liver carboxylesterase 1 CES1 0.0039
6141 Sodium/bile acid cotransporter SLC10A1 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
70 Type-1 angiotensin II receptor AGTR1 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0034
6106 Cytochrome P450 2C18 CYP2C18 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0033
594 Thyroxine-binding globulin SERPINA7 0.0032
6677 Myelin P2 protein PMP2 0.0032
136 Estrogen receptor ESR1 0.0032
595 Fibrinogen alpha chain FGA 0.0032
3760 Penicillin-binding protein 5 precursor dacA 0.0031
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.003
758 Thyroid hormone receptor alpha THRA 0.003
459 Retinoic acid receptor RXR-alpha RXRA 0.003
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3932 Glutathione S-transferase A2 GSTA2 0.0029
146 Androgen receptor AR 0.0029
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
1898 Cytochrome P450 1B1 CYP1B1 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
122 P2Y purinoceptor 12 P2RY12 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
4252 Penicillin-binding protein 5 dacA 0.0025
6043 Putative G-protein coupled receptor 44 GPR44 0.0025
824 Sodium-dependent serotonin transporter SLC6A4 0.0025
847 Mu-type opioid receptor OPRM1 0.0025
811 Translocator protein TSPO 0.0024
1867 Major prion protein PRNP 0.0024
3923 Cholinesterase BCHE 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6231 Pepsin A PGA3 0.0024
633 Penicillin-binding proteins 1A/1B pbpA 0.0024
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
696 Kappa-type opioid receptor OPRK1 0.0023
1525 Heparin-binding growth factor 2 FGF2 0.0022
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
707 72 kDa type IV collagenase MMP2 0.0021
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
6209 30S ribosomal protein S19 rpsS 0.0021
6712 30S ribosomal protein S19 rpsS 0.0021
6726 30S ribosomal protein S19 rpsS 0.0021
6207 30S ribosomal protein S14 rpsN 0.0021
1050 Bile salt sulfotransferase SULT2A1 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.002
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
1992 Vitamin D-binding protein GC 0.002
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
869 Estrogen receptor beta ESR2 0.0019
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0019
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0019
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0019
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
776 Bile salt export pump ABCB11 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
380 Cytochrome P450 17A1 CYP17A1 0.0018
6033 High affinity interleukin-8 receptor A CXCR1 0.0018
65 Matrix metalloproteinase-9 Not Available 0.0018
6136 Multidrug resistance-associated protein 5 ABCC5 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
3811 Cytochrome P450 19A1 CYP19A1 0.0017
1714 Mitogen-activated protein kinase 3 MAPK3 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0016
6144 Solute carrier family 22 member 2 SLC22A2 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0016
2207 Rhodopsin RHO 0.0016
244 Angiotensin-converting enzyme ACE 0.0016
492 Histamine H1 receptor HRH1 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
162 Retinoic acid receptor gamma-1 RARG 0.0015
614 Progesterone receptor PGR 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0015
6147 Solute carrier family 22 member 3 SLC22A3 0.0015
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0015
871 Glucocorticoid receptor NR3C1 0.0014
789 Alpha-1D adrenergic receptor ADRA1D 0.0014
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0014
465 Calmodulin CALM1 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
467 Delta-type opioid receptor OPRD1 0.0013
1656 CYP2B protein CYP2B 0.0013
6151 Monocarboxylate transporter 10 SLC16A10 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0013
6459 Glycodelin PAEP 0.0013
6432 Transporter snf 0.0013
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
822 Aldose reductase AKR1B1 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
3917 Methylenetetrahydrofolate reductase MTHFR 0.0012
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0012
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
4225 Uridine phosphorylase 1 UPP1 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
2981 Phospholipase A2, membrane associated PLA2G2A 0.0011
318 Alpha-2A adrenergic receptor ADRA2A 0.001
51 Muscarinic acetylcholine receptor M3 CHRM3 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
413 Amidophosphoribosyltransferase PPAT 0.001
2515 Amidophosphoribosyltransferase purF 0.001
3714 Amidophosphoribosyltransferase purF 0.001
617 Muscarinic acetylcholine receptor M2 CHRM2 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
6137 Multidrug resistance-associated protein 6 ABCC6 0.001
2021 Thrombomodulin THBD 0.001
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.001
103 Muscarinic acetylcholine receptor M1 CHRM1 0.001
357 Carbonic anhydrase 2 CA2 0.001
904 Glutathione S-transferase P GSTP1 0.001
2320 Thymidine kinase, cytosolic TK1 0.0009
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0009
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
436 5-hydroxytryptamine 2B receptor HTR2B 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1864 RET proto-oncogene RET 0.0009
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0009
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0009
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0009
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0009
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
468 Cytochrome P450 4A11 CYP4A11 0.0008
378 Alpha-2C adrenergic receptor ADRA2C 0.0008
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0008
3639 Thymidine phosphorylase deoA 0.0008
3936 Thymidine phosphorylase TYMP 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
6148 Multidrug resistance-associated protein 7 ABCC10 0.0008
629 Alpha-2B adrenergic receptor ADRA2B 0.0008
6218 Pannexin-1 PANX1 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
3937 Fatty-acid amide hydrolase FAAH 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0008
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0008
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
6042 Prostaglandin reductase 2 PTGR2 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0007
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0007
5818 Folate receptor alpha FOLR1 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
1792 Tissue-type plasminogen activator PLAT 0.0007
228 Beta platelet-derived growth factor receptor PDGFRB 0.0007
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
273 Apoptosis regulator Bcl-2 BCL2 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
6014 Cytochrome P450 2A13 CYP2A13 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
504 Mast/stem cell growth factor receptor KIT 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0006
275 Arachidonate 5-lipoxygenase ALOX5 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
1650 Heme carrier protein 1 SLC46A1 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
6031 Cytochrome P450 3A43 CYP3A43 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0005
193 Beta-1 adrenergic receptor ADRB1 0.0005
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0005
5961 Insulin INS 0.0005
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
528 5-hydroxytryptamine 1E receptor HTR1E 0.0004
833 Organic cation/carnitine transporter 1 SLC22A4 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
6020 Aldehyde oxidase AOX1 0.0004
3941 Amine oxidase [flavin-containing] A MAOA 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
365 Dihydrofolate reductase DHFR 0.0004
2381 Dihydrofolate reductase DFR1 0.0004
2833 Dihydrofolate reductase Not Available 0.0004
2931 Dihydrofolate reductase folA 0.0004
3544 Dihydrofolate reductase folA 0.0004
3682 Dihydrofolate reductase folA 0.0004
6642 Dihydrofolate reductase folA 0.0004
6756 Dihydrofolate reductase dfrA 0.0004
716 5-hydroxytryptamine 7 receptor HTR7 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
163 D(1B) dopamine receptor DRD5 0.0004
341 5-hydroxytryptamine 3 receptor HTR3A 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
432 D(4) dopamine receptor DRD4 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
725 5-hydroxytryptamine 1D receptor HTR1D 0.0003
638 D(3) dopamine receptor DRD3 0.0003
885 5-hydroxytryptamine 1B receptor HTR1B 0.0003
4943 Cytochrome c6 petJ 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4942 Diheme cytochrome c napB napB 0.0003
5000 HemO hemO 0.0003
4916 Cyanoglobin glbN 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4984 Neuroglobin NGB 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4961 Hemophore HasA hasA 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4952 Catalase/peroxidase katA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
4920 Peroxidase/catalase katG 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
4990 PpcA ppcA 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
518 Peroxidase/catalase T katG 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
605 Fumarate reductase flavoprotein subunit frdA 0.0002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0002
3673 Fumarate reductase flavoprotein subunit fccA 0.0002
4912 Fumarate reductase flavoprotein subunit ifcA 0.0002
6549 Fumarate reductase flavoprotein subunit frdA 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
260 Cytochrome P450 51 ERG11 0.0002
761 Cytochrome P450 51 ERG11 0.0002
3163 Cytochrome P450 51 cyp51 0.0002
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
7 Nitric oxide synthase, inducible NOS2 0.0001
291 Nitric-oxide synthase, endothelial NOS3 0.0001
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