DT-Web: DB00339

Identification

Name

Pyrazinamide

Accession Number

DB00339 (APRD01206)

Type

small molecule

Description

A pyrazine that is used therapeutically as an antitubercular agent.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antitubercular Agents

Molecular Weight

123.1127

Groups

approved

Monoisotopic Weight

123.043261797

Pharmacology

Indication

For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.

Mechanism of action

Pyrazinamide is an important sterilizing prodrug that shortens tuberculosis (TB) therapy. However, the mechanism of action of pyrazinamide is poorly understood because of its unusual properties. In literature it has been written that the pyrazinoic acid (POA), the active moiety of pyrazinamide, disrupted membrane energetics and inhibited membrane transport function at acid pH in Mycobacterium tuberculosis. The antimycobacterial activity appears to partly depend on conversion of the drug to POA. Susceptible strains of M. tuberculosis produce pyrazinamidase, an enzyme that deaminates pyrazinamide to POA, and the vitro susceptibility of a given strain of the organism appears to correspond to its pyrazinamidase activity. Experimental evidence suggests that pyrazinamide diffuses into M. tuberculosis in a passive manner, is converted into POA by pyrazinamidase, and because of an inefficient efflux system, accumulates in huge amounts in the bacterial cytoplasm. The accumulation of POA lowers the intracellular pH to a suboptimal level that is likely to inactivate a vital target enzyme such as fatty acid synthase. Recent studies (2007) demonstrated that pyrazinamide and its analogs inhibit the activity of purified FAS I.

Absorption

Rapidly and well absorbed from the gastrointestinal tract.

Protein binding

~10% (bound to plasma proteins)

Biotransformation

Hepatic.

Route of elimination

Approximately 70% of an oral dose is excreted in the urine, mainly by glomerular filtration within 24 hours

Toxicity

Side effects include liver injury, arthralgias, anorexia, nausea and vomiting, dysuria,malaise and fever, sideroblastic anemia, adverse effects on the blood clotting mechanism or vascular integrity, and hypersensitivity reactions such as urticaria, pruritis and skin rashes.

Affected organisms

Mycobacterium tuberculosis

Interactions

Drug Interactions

Drug	Mechanism of interaction
Cyclosporine	Pyrazinamide decreases the effect of cyclosporine

Food Interactions

Take without regard to meals.

PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)
Name	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)
Gene Name	fas
Pharmacological action	yes
Actions	inhibitor
References	Zimhony O, Cox JS, Welch JT, Vilcheze C, Jacobs WR Jr: Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat Med. 2000 Sep;6(9):1043-7. - Pubmed Ngo SC, Zimhony O, Chung WJ, Sayahi H, Jacobs WR Jr, Welch JT: Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs. Antimicrob Agents Chemother. 2007 Jul;51(7):2430-5. Epub 2007 May 7. - Pubmed Zimhony O, Vilcheze C, Arai M, Welch JT, Jacobs WR Jr: Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli. Antimicrob Agents Chemother. 2007 Feb;51(2):752-4. Epub 2006 Nov 13. - Pubmed Schroeder EK, de Souza N, Santos DS, Blanchard JS, Basso LA: Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis. Curr Pharm Biotechnol. 2002 Sep;3(3):197-225. - Pubmed
DTHybrid score	0.4511

Xanthine dehydrogenase/oxidase
Name	Xanthine dehydrogenase/oxidase
Gene Name	XDH
Actions	substrate
References	Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. - Pubmed
DTHybrid score	0.569
Aldehyde oxidase
Name	Aldehyde oxidase
Gene Name	AOX1
Actions	substrate
References	Moriwaki Y, Yamamoto T, Nasako Y, Takahashi S, Suda M, Hiroishi K, Hada T, Higashino K: In vitro oxidation of pyrazinamide and allopurinol by rat liver aldehyde oxidase. Biochem Pharmacol. 1993 Sep 14;46(6):975-81. - Pubmed
DTHybrid score	0.4011
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3428
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4116

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.1137
4757	Cytochrome P450 2C9	CYP2C9	0.0952
1588	Multidrug resistance protein 1	ABCB1	0.0904
6016	Cytochrome P450 2C19	CYP2C19	0.0865
4118	Cytochrome P450 3A5	CYP3A5	0.0833
4924	Cytochrome P450 2C8	CYP2C8	0.0679
6013	Cytochrome P450 2E1	CYP2E1	0.0661
6030	Cytochrome P450 2B6	CYP2B6	0.0652
6024	Cytochrome P450 1A1	CYP1A1	0.0626
6107	Cytochrome P450 3A7	CYP3A7	0.0589
6142	Solute carrier family 22 member 8	SLC22A8	0.0474
1898	Cytochrome P450 1B1	CYP1B1	0.0414
723	Cytosolic phospholipase A2	PLA2G4A	0.0406
1757	Myeloperoxidase	MPO	0.0395
3811	Cytochrome P450 19A1	CYP19A1	0.0383
6143	Solute carrier family 22 member 7	SLC22A7	0.0373
5718	Cytochrome P450 2A6	CYP2A6	0.0369
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0363
318	Alpha-2A adrenergic receptor	ADRA2A	0.035
2353	Apolipoprotein(a)	LPA	0.0343
587	Serum albumin	ALB	0.0308
234	Plasminogen	PLG	0.0306
290	Prostaglandin G/H synthase 2	PTGS2	0.0283
629	Alpha-2B adrenergic receptor	ADRA2B	0.0281
1405	Thiopurine S-methyltransferase	TPMT	0.028
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0277
1792	Tissue-type plasminogen activator	PLAT	0.0268
378	Alpha-2C adrenergic receptor	ADRA2C	0.0268
20	Prostaglandin G/H synthase 1	PTGS1	0.026
36	Insulin receptor	INSR	0.0258
338	DNA polymerase	UL30	0.0258
379	DNA polymerase	UL54	0.0258
697	DNA polymerase	ORF28	0.0258
2482	DNA polymerase	43	0.0258
4104	DNA polymerase	BALF5	0.0258
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0246
556	Alpha-1A adrenergic receptor	ADRA1A	0.024
136	Estrogen receptor	ESR1	0.0239
492	Histamine H1 receptor	HRH1	0.0231
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0214
831	D(2) dopamine receptor	DRD2	0.0214
2164	Multidrug resistance-associated protein 4	ABCC4	0.021
862	Multidrug resistance-associated protein 1	ABCC1	0.0203
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0196
6145	Solute carrier family 22 member 1	SLC22A1	0.0193
6136	Multidrug resistance-associated protein 5	ABCC5	0.0192
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0189
871	Glucocorticoid receptor	NR3C1	0.0184
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0181
817	DNA topoisomerase 2-alpha	TOP2A	0.018
811	Translocator protein	TSPO	0.0179
3923	Cholinesterase	BCHE	0.0179
6171	Solute carrier family 28 member 3	SLC28A3	0.0176
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0175
896	Glutathione S-transferase Mu 1	GSTM1	0.0175
1729	Solute carrier family 22 member 6	SLC22A6	0.0173
824	Sodium-dependent serotonin transporter	SLC6A4	0.017
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0169
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0168
63	Malate dehydrogenase	mdh	0.0165
2329	Malate dehydrogenase	mdh	0.0165
3445	Malate dehydrogenase	mdh	0.0165
4420	Malate dehydrogenase	mdh	0.0165
4438	Malate dehydrogenase	mdh	0.0165
3823	Cytokine receptor common gamma chain	IL2RG	0.0163
833	Organic cation/carnitine transporter 1	SLC22A4	0.0159
6144	Solute carrier family 22 member 2	SLC22A2	0.0158
327	Glutathione reductase	gor	0.0156
5110	Glutathione reductase	GR2	0.0156
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0152
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0149
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0149
3941	Amine oxidase [flavin-containing] A	MAOA	0.0149
6106	Cytochrome P450 2C18	CYP2C18	0.0147
869	Estrogen receptor beta	ESR2	0.0146
1656	CYP2B protein	CYP2B	0.0146
477	DNA topoisomerase 4 subunit A	parC	0.0146
886	DNA topoisomerase 4 subunit A	parC	0.0146
6226	DNA topoisomerase 4 subunit A	parC	0.0146
23	D(1A) dopamine receptor	DRD1	0.0146
404	DNA gyrase subunit A	gyrA	0.0144
6224	DNA gyrase subunit A	gyrA	0.0144
118	Organic cation/carnitine transporter 2	SLC22A5	0.0142
724	Interleukin-2 receptor alpha chain	IL2RA	0.0142
717	Interleukin-2 receptor subunit beta	IL2RB	0.0142
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0139
400	Coagulation factor IX	F9	0.0137
5461	Coagulation factor IX	F9	0.0137
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0136
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0132
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0132
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0131
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0128
776	Bile salt export pump	ABCB11	0.0128
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0126
604	Vitamin K-dependent protein Z	PROZ	0.0125
6148	Multidrug resistance-associated protein 7	ABCC10	0.0125
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0124
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0123
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0122
193	Beta-1 adrenergic receptor	ADRB1	0.0121
3932	Glutathione S-transferase A2	GSTA2	0.012
632	Alpha-1B adrenergic receptor	ADRA1B	0.0119
766	Beta-2 adrenergic receptor	ADRB2	0.0118
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0117
422	Vitamin K-dependent protein C	PROC	0.0115
1245	Vitamin K-dependent protein S	PROS1	0.0115
465	Calmodulin	CALM1	0.0115
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0113
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0112
303	Diamine acetyltransferase 2	SAT2	0.0109
623	Spermine oxidase	SMOX	0.0109
1317	Spermine synthase	SMS	0.0109
6137	Multidrug resistance-associated protein 6	ABCC6	0.0108
3939	Amine oxidase [flavin-containing] B	MAOB	0.0108
731	HIV-1 protease	HIV-1 protease	0.0108
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0108
4031	Glutathione S-transferase A1	GSTA1	0.0108
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0108
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0108
6859	Protein S100-A4	S100A4	0.0105
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0102
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.01
123	Diamine acetyltransferase 1	SAT1	0.01
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0099
468	Cytochrome P450 4A11	CYP4A11	0.0099
713	Sodium-dependent dopamine transporter	SLC6A3	0.0098
789	Alpha-1D adrenergic receptor	ADRA1D	0.0098
847	Mu-type opioid receptor	OPRM1	0.0098
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
6146	High affinity copper uptake protein 1	SLC31A1	0.0096
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0095
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0095
798	Osteocalcin	BGLAP	0.0093
638	D(3) dopamine receptor	DRD3	0.0093
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0091
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0091
260	Cytochrome P450 51	ERG11	0.009
761	Cytochrome P450 51	ERG11	0.009
3163	Cytochrome P450 51	cyp51	0.009
6163	Copper-transporting ATPase 2	ATP7B	0.0089
6165	Copper-transporting ATPase 1	ATP7A	0.0089
818	50S ribosomal protein L10	rplJ	0.0089
908	Glutathione S-transferase theta-1	GSTT1	0.0088
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0088
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0087
6168	Solute carrier family 22 member 16	SLC22A16	0.0087
904	Glutathione S-transferase P	GSTP1	0.0086
4120	NADPH--cytochrome P450 reductase	POR	0.0084
369	Coagulation factor VII	F7	0.0084
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0083
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0082
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0082
239	Coagulation factor X	F10	0.0081
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0081
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
467	Delta-type opioid receptor	OPRD1	0.008
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0079
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0079
449	Ornithine decarboxylase	ODC1	0.0078
16	Adenosine A1 receptor	ADORA1	0.0078
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0078
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0077
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0076
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0076
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0076
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0075
432	D(4) dopamine receptor	DRD4	0.0071
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.007
4604	Liver carboxylesterase 1	CES1	0.007
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0069
696	Kappa-type opioid receptor	OPRK1	0.0068
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0067
6220	Aryl hydrocarbon receptor	AHR	0.0067
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0067
777	Tumor necrosis factor	TNF	0.0066
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0066
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0066
614	Progesterone receptor	PGR	0.0065
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0065
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0065
1178	Adenosine A2a receptor	ADORA2A	0.0064
571	Melatonin receptor type 1A	MTNR1A	0.0064
362	Melatonin receptor type 1B	MTNR1B	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
1374	Natriuretic peptides B	NPPB	0.0062
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0062
1827	Gap junction alpha-1 protein	GJA1	0.0062
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0062
1908	Vascular cell adhesion protein 1	VCAM1	0.0062
54	Prothrombin	F2	0.0062
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0062
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0062
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.006
6147	Solute carrier family 22 member 3	SLC22A3	0.006
714	Glutathione reductase, mitochondrial	GSR	0.0059
1024	Solute carrier family 22 member 11	SLC22A11	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
6031	Cytochrome P450 3A43	CYP3A43	0.0057
4192	DNA topoisomerase 2-beta	TOP2B	0.0056
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0056
592	Carbonic anhydrase 4	CA4	0.0055
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0055
6014	Cytochrome P450 2A13	CYP2A13	0.0054
551	Carnitine O-acetyltransferase	CRAT	0.0054
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0054
122	P2Y purinoceptor 12	P2RY12	0.0054
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0054
183	Vascular endothelial growth factor A	VEGFA	0.0053
365	Dihydrofolate reductase	DHFR	0.0053
2381	Dihydrofolate reductase	DFR1	0.0053
2833	Dihydrofolate reductase	Not Available	0.0053
2931	Dihydrofolate reductase	folA	0.0053
3544	Dihydrofolate reductase	folA	0.0053
3682	Dihydrofolate reductase	folA	0.0053
6642	Dihydrofolate reductase	folA	0.0053
6756	Dihydrofolate reductase	dfrA	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0053
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0053
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0053
295	Carbonic anhydrase 1	CA1	0.0053
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0052
565	Extracellular calcium-sensing receptor	CASR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
613	Atrial natriuretic peptide receptor A	NPR1	0.005
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0049
163	D(1B) dopamine receptor	DRD5	0.0049
474	Acetylcholinesterase	ACHE	0.0049
5818	Folate receptor alpha	FOLR1	0.0049
716	5-hydroxytryptamine 7 receptor	HTR7	0.0049
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0049
284	DNA-directed RNA polymerase beta chain	rpoB	0.0048
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0048
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0048
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0047
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0046
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0046
6134	Sodium channel subunit beta-3	SCN3B	0.0046
6128	Carbonic anhydrase-related protein 10	CA10	0.0046
6132	Sodium channel subunit beta-1	SCN1B	0.0046
6135	Sodium channel subunit beta-4	SCN4B	0.0046
6133	Sodium channel subunit beta-2	SCN2B	0.0046
6129	Carbonic anhydrase-related protein 11	CA11	0.0046
6127	Carbonic anhydrase-related protein	CA8	0.0046
4122	Histone deacetylase 2	HDAC2	0.0046
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0046
6131	Carbonic anhydrase 14	CA14	0.0046
173	Toll-like receptor 7	TLR7	0.0046
4237	50S ribosomal protein L22	rplV	0.0046
6182	Cytochrome P450 2J2	CYP2J2	0.0045
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0045
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0045
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0045
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0044
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0044
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0043
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0043
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0043
6122	Carbonic anhydrase 3	CA3	0.0043
293	Gamma-glutamyl hydrolase	GGH	0.0043
407	Vascular endothelial growth factor receptor 2	KDR	0.0042
6126	Carbonic anhydrase 7	CA7	0.0042
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0042
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0042
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0042
756	Sex hormone-binding globulin	SHBG	0.0041
357	Carbonic anhydrase 2	CA2	0.0041
6043	Putative G-protein coupled receptor 44	GPR44	0.0041
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
273	Apoptosis regulator Bcl-2	BCL2	0.004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.004
29	Tubulin beta-1 chain	TUBB1	0.004
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.004
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.004
504	Mast/stem cell growth factor receptor	KIT	0.004
952	Dipeptidyl peptidase 4	DPP4	0.004
814	Ryanodine receptor 1	RYR1	0.004
26	Vascular endothelial growth factor receptor 3	FLT4	0.004
6130	Carbonic anhydrase 13	CA13	0.004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.004
146	Androgen receptor	AR	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0038
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0038
32	Vascular endothelial growth factor receptor 1	FLT1	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0038
380	Cytochrome P450 17A1	CYP17A1	0.0038
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0038
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0038
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0038
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0038
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0038
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0038
70	Type-1 angiotensin II receptor	AGTR1	0.0037
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0037
24	Thymidylate synthase	TMP1	0.0037
359	Thymidylate synthase	TYMS	0.0037
2626	Thymidylate synthase	thyA	0.0037
2729	Thymidylate synthase	thyA	0.0037
5352	Thymidylate synthase	THYA	0.0037
124	Histamine H2 receptor	HRH2	0.0037
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0037
1650	Heme carrier protein 1	SLC46A1	0.0037
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0037
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0036
844	Epidermal growth factor receptor	EGFR	0.0036
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0036
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0036
856	Vitamin D3 receptor	VDR	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
373	Transthyretin	TTR	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
738	Monocarboxylate transporter 1	SLC16A1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0034
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
1517	Beta-3 adrenergic receptor	ADRB3	0.0034
94	5-hydroxytryptamine 4 receptor	HTR4	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
3007	Carbonic anhydrase 12	CA12	0.0032
4205	Carbonic anhydrase 9	CA9	0.0032
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0032
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0032
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0032
6102	Arylamine N-acetyltransferase 2	NAT2	0.0032
275	Arachidonate 5-lipoxygenase	ALOX5	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0031
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0031
6044	Serum paraoxonase/lactonase 3	PON3	0.0031
705	Glutamate receptor 1	GRIA1	0.0031
427	Substance-P receptor	TACR1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
543	Penicillin-binding protein 1B	mrcB	0.003
6186	Penicillin-binding protein 1B	ponB	0.003
6822	Penicillin-binding protein 1b	pbp1b	0.003
6844	Penicillin-binding protein 1b	pbp1b	0.003
4228	Keratin, type II cytoskeletal 7	KRT7	0.003
1010	Cytochrome P450 51A1	CYP51A1	0.003
159	Penicillin-binding protein 2B	penA	0.0029
6121	Penicillin-binding protein 2B	penA	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0029
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0028
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0028
76	Nitric-oxide synthase, brain	NOS1	0.0028
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0027
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0027
921	Glutamate receptor 2	GRIA2	0.0027
1629	Transcription factor AP-1	JUN	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
737	Mineralocorticoid receptor	NR3C2	0.0026
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0026
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0026
1648	Elastin	ELN	0.0026
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0026
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
3957	Adenosine deaminase	ADA	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0025
7	Nitric oxide synthase, inducible	NOS2	0.0025
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0023
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
482	Glycine receptor subunit alpha-1	GLRA1	0.0023
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0023
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0023
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0023
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0023
291	Nitric-oxide synthase, endothelial	NOS3	0.0023
6432	Transporter	snf	0.0022
251	Alcohol dehydrogenase 1A	ADH1A	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
1050	Bile salt sulfotransferase	SULT2A1	0.0022
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0022
780	Retinoic acid receptor RXR-gamma	RXRG	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
33	Cystine/glutamate transporter	SLC7A11	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
6141	Sodium/bile acid cotransporter	SLC10A1	0.002
473	L-lactate dehydrogenase A chain	LDHA	0.002
2268	Cholesterol oxidase	choB	0.002
2822	Cholesterol oxidase	choA	0.002
1820	Beta-nerve growth factor	NGF	0.002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.002
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
444	Alcohol dehydrogenase 1B	ADH1B	0.002
528	5-hydroxytryptamine 1E receptor	HTR1E	0.002
88	Retinoic acid receptor RXR-beta	RXRB	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0019
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0019
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0019
4311	tRNA	TRDMT1	0.0019
4325	tRNA	trmD	0.0019
4328	tRNA	trmD	0.0019
518	Peroxidase/catalase T	katG	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0018
683	Potassium transporter	GK0582	0.0018
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0018
459	Retinoic acid receptor RXR-alpha	RXRA	0.0018
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0017
816	Biliverdin reductase A	BLVRA	0.0017
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0017
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0017
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0017
517	Alcohol dehydrogenase 1C	ADH1C	0.0017
563	Thyroid peroxidase	TPO	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0017
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0017
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0016
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0016
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0016
569	Retinal dehydrogenase 2	ALDH1A2	0.0016
1243	Cathepsin D	CTSD	0.0016
634	Squalene monooxygenase	SQLE	0.0016
7196	Squalene monooxygenase	ERG1	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0016
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0016
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0016
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0016
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0016
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0016
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0016
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0016
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0016
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0016
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0016
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0016
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0016
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0016
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0016
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0016
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0016
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0016
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0016
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0016
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0016
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0016
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0016
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0016
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0016
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0016
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0016
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0016
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0016
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0016
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0016
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0016
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0016
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0016
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0016
644	Heme oxygenase 2	HMOX2	0.0016
4982	Heme oxygenase 2	pbsA2	0.0016
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0016
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0016
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0016
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0016
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0016
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0016
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0016
729	GDP-L-fucose synthetase	TSTA3	0.0016
3463	GDP-L-fucose synthetase	fcl	0.0016
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0016
167	L-lactate dehydrogenase C chain	LDHC	0.0016
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0016
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0016
206	3-keto-steroid reductase	HSD17B7	0.0016
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0016
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0016
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0016
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0016
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0016
107	C-4 methylsterol oxidase	SC4MOL	0.0016
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0016
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0016
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0016
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0016
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0016
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0016
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0016
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0016
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0016
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0016
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0016
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0016
34	7-dehydrocholesterol reductase	DHCR7	0.0016
711	UDP-glucose 6-dehydrogenase	UGDH	0.0016
3672	UDP-glucose 6-dehydrogenase	hasB	0.0016
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0016
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0016
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0016
643	Peroxisomal bifunctional enzyme	EHHADH	0.0016
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0016
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0016
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0016
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0015
3233	Bile acid receptor	NR1H4	0.0015
822	Aldose reductase	AKR1B1	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0015
3856	Fibroblast growth factor receptor 3	FGFR3	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
1192	Sulfotransferase 1A1	SULT1A1	0.0015
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0015
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0015
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0015
611	Retinal dehydrogenase 1	ALDH1A1	0.0015
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0015
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0015
328	Sorbitol dehydrogenase	SORD	0.0015
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0015
1714	Mitogen-activated protein kinase 3	MAPK3	0.0015
597	Dihydropteridine reductase	QDPR	0.0015
396	Alcohol dehydrogenase 4	ADH4	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0015
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
823	Fibroblast growth factor receptor 2	FGFR2	0.0015
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0015
1618	High affinity nerve growth factor receptor	NTRK1	0.0015
1541	Metalloproteinase	mmp20	0.0014
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0014
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0014
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0014
666	NADP-dependent malic enzyme	ME1	0.0014
153	Dopamine beta-hydroxylase	DBH	0.0014
6167	Organic solute transporter subunit beta	OSTB	0.0014
6166	Organic solute transporter subunit alpha	OSTA	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0014
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0014
857	Malate dehydrogenase, mitochondrial	MDH2	0.0014
6026	Alcohol dehydrogenase 6	ADH6	0.0014
77	L-lactate dehydrogenase B chain	LDHB	0.0014
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0014
12	Alcohol dehydrogenase class 3	ADH5	0.0014
165	FL cytokine receptor	FLT3	0.0013
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0013
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0013
626	Cysteine dioxygenase type 1	CDO1	0.0013
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
627	11-cis retinol dehydrogenase	RDH5	0.0013
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0013
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0013
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0013
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0013
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0013
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0013
4486	Phenol 2-hydroxylase component B	pheA2	0.0013
4439	Ferredoxin reductase	bphA4	0.0013
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0013
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0013
5117	Dihydrolipoyl dehydrogenase	lpd	0.0013
13	Aminomethyltransferase, mitochondrial	AMT	0.0013
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0013
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0013
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0012
3810	Catechol O-methyltransferase	COMT	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
5078	Amine oxidase, flavin-containing	PSPTO1126	0.0012
5122	Mersacidin decarboxylase	mrsD	0.0012
526	Thioredoxin reductase	trxB	0.0012
3767	Thioredoxin reductase	trxB	0.0012
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.0012
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0012
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0012
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0012
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.0012
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.0012
5115	FkbI	fkbI	0.0012
3133	UDP-galactopyranose mutase	glf	0.0012
5099	UDP-galactopyranose mutase	glf	0.0012
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.0012
5095	Putidaredoxin reductase	camA	0.0012
5083	Cryptochrome DASH	cry	0.0012
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.0012
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.0012
5081	L-aspartate oxidase	nadB	0.0012
5111	Phenylacetone monooxygenase	pamO	0.0012
1410	Oxidoreductase	HSD17B6	0.0012
4725	Oxidoreductase	Not Available	0.0012
5124	Oxidoreductase	Not Available	0.0012
5109	Outer membrane protein p64k or PM-6	m-6	0.0012
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0012
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0012
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0012
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0012
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0012
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0012
1295	Fatty acid synthase	FASN	0.0012
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0012
936	Ephrin type-A receptor 2	EPHA2	0.0012
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0012
976	Platelet glycoprotein IX	GP9	0.0012
3102	Flavohemoprotein	hmp	0.0012
4969	Flavohemoprotein	hmp	0.0012
279	Tyrosinase	TYR	0.0012
4103	Proteasome subunit beta type 2	PSMB2	0.0012
4101	Proteasome subunit beta type 1	PSMB1	0.0012
4102	Proteasome subunit beta type 5	PSMB5	0.0012
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0011
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0011
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0011
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0011
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4440	NADH peroxidase	npr	0.0011
3937	Fatty-acid amide hydrolase	FAAH	0.0011
810	Heme oxygenase 1	HMOX1	0.0011
3391	Heme oxygenase 1	pbsA1	0.0011
654	Flavin reductase	BLVRB	0.0011
5787	Angiopoietin-1 receptor	TEK	0.0011
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0011
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0011
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0011
5072	N,N-dimethylglycine oxidase	dmg	0.0011
5073	Ferredoxin--NADP reductase	petH	0.0011
5076	Ferredoxin--NADP reductase	fpr	0.0011
5119	Ferredoxin--NADP reductase	petH	0.0011
5121	Ferredoxin--NADP reductase	fpr	0.0011
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0011
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0011
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0011
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0011
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0011
2526	NADPH-ferredoxin reductase fprA	fprA	0.0011
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0011
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0011
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0011
2470	Pyruvate oxidase	pox5	0.0011
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0011
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0011
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0011
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0011
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.001
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.001
162	Retinoic acid receptor gamma-1	RARG	0.001
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
126	D-lactate dehydrogenase	dld	0.001
3545	D-lactate dehydrogenase	Not Available	0.001
4510	D-lactate dehydrogenase	ldhA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.001
820	Glycine receptor subunit alpha-2	GLRA2	0.001
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.001
268	Adenosine A2b receptor	ADORA2B	0.001
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.001
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.001
164	Histamine H4 receptor	HRH4	0.001
2893	Glycine oxidase	thiO	0.001
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0009
2567	Thymidylate synthase thyX	thyX	0.0009
484	Tyrosine-protein kinase ABL2	ABL2	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6085	Fatty acid-binding protein, intestinal	FABP2	0.0009
3086	Plasmepsin-2	Not Available	0.0009
2823	Trypanothione reductase	TPR	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0009
6149	Solute carrier family 22 member 10	SLC22A10	0.0009
2769	P-hydroxybenzoate hydroxylase	pobA	0.0009
2809	P-hydroxybenzoate hydroxylase	pobA	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
1864	RET proto-oncogene	RET	0.0009
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0009
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0008
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
2380	Monomeric sarcosine oxidase	soxA	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3830	Calreticulin	CALR	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
6645	D-amino-acid oxidase	DAO	0.0008
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0008
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0008
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0008
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0008
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0008
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0008
760	Fibroblast growth factor 1	FGF1	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
5934	Cytochrome P450 26A1	CYP26A1	0.0008
751	Potassium channel subfamily K member 6	KCNK6	0.0008
1025	Aquaporin-1	AQP1	0.0008
1039	Histone deacetylase 9	HDAC9	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
172	Potassium channel subfamily K member 1	KCNK1	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
469	Annexin A1	ANXA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
2298	Cytochrome P450-cam	camC	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
125	DNA polymerase beta	POLB	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0007
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
3809	Estrogen-related receptor gamma	ESRRG	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0006
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
84	Nuclear receptor 0B1	NR0B1	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
1992	Vitamin D-binding protein	GC	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
319	Opioid receptor, sigma 1	OPRS1	0.0004
1630	Integrin beta-2	ITGB2	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
4217	Telomerase reverse transcriptase	TERT	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
174	Sigma 1-type opioid receptor	SIGMAR1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
572	Integrin alpha-L	ITGAL	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0003
2320	Thymidine kinase, cytosolic	TK1	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0002
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0002
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0002
2207	Rhodopsin	RHO	0.0002
489	Monocarboxylate transporter 2	SLC16A7	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00339 - Pyrazinamide

Targets

Enzymes

Predictions