DT-Web

DB04827 - Ethyl carbamate


Identification
Name Ethyl carbamate
Accession Number DB04827
Type small molecule
Description Ethyl carbamate (also known as urethan and urethane), formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 89.0932
Groups withdrawn
Monoisotopic Weight 89.047678473
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Enzymes


Cytosolic phospholipase A2
Name Cytosolic phospholipase A2
Gene Name PLA2G4A
Actions substrate
References
  • Dinnes DL, Santerre JP, Labow RS: Phospholipase A2 pathway association with macrophage-mediated polycarbonate-urethane biodegradation. Biomaterials. 2005 Jun;26(18):3881-9. - Pubmed
  • Labow RS, Santerre JP, Waghray G: The effect of phospholipids on the biodegradation of polyurethanes by lysosomal enzymes. J Biomater Sci Polym Ed. 1997;8(10):779-95. - Pubmed
DTHybrid score 0.4243
Myeloperoxidase
Name Myeloperoxidase
Gene Name MPO
Actions inducer
References
  • Kotanidou A, Choi AM, Winchurch RA, Otterbein L, Fessler HE: Urethan anesthesia protects rats against lethal endotoxemia and reduces TNF-alpha release. J Appl Physiol. 1996 Nov;81(5):2305-11. - Pubmed
DTHybrid score 0.3582
Aldehyde oxidase
Name Aldehyde oxidase
Gene Name AOX1
Actions substrate
References
  • Sugihara K, Kitamura S, Tatsumi K: Involvement of liver aldehyde oxidase in conversion of N-hydroxyurethane to urethane. J Pharmacobiodyn. 1983 Sep;6(9):677-83. - Pubmed
  • Sugihara K, Kitamura S, Tatsumi K: Involvement of liver aldehyde oxidase in conversion of N-hydroxyurethane to urethane. J Pharmacobiodyn. 1983 Sep;6(9):677-83. - Pubmed
DTHybrid score 0.2774

Predictions


Id Partner name Gene Name Score
1193 Proteinase-activated receptor 1 F2R 0.0777
234 Plasminogen PLG 0.0754
3947 Xanthine dehydrogenase/oxidase XDH 0.0683
4512 Cytochrome P450 3A4 CYP3A4 0.0623
290 Prostaglandin G/H synthase 2 PTGS2 0.0568
232 Corticosteroid-binding globulin SERPINA6 0.0432
1729 Solute carrier family 22 member 6 SLC22A6 0.0407
871 Glucocorticoid receptor NR3C1 0.0368
20 Prostaglandin G/H synthase 1 PTGS1 0.035
2353 Apolipoprotein(a) LPA 0.0343
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.033
54 Prothrombin F2 0.0317
1736 Somatostatin SST 0.0311
4186 Neuropeptide Y receptor type 2 NPY2R 0.0311
6116 Gastric triacylglycerol lipase LIPF 0.0301
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.029
6142 Solute carrier family 22 member 8 SLC22A8 0.0281
1295 Fatty acid synthase FASN 0.028
1792 Tissue-type plasminogen activator PLAT 0.0268
754 Pancreatic triacylglycerol lipase PNLIP 0.0268
4200 Cytochrome P450 1A2 CYP1A2 0.0263
3823 Cytokine receptor common gamma chain IL2RG 0.0254
4118 Cytochrome P450 3A5 CYP3A5 0.0252
309 Antithrombin-III SERPINC1 0.0251
338 DNA polymerase UL30 0.0246
379 DNA polymerase UL54 0.0246
697 DNA polymerase ORF28 0.0246
2482 DNA polymerase 43 0.0246
4104 DNA polymerase BALF5 0.0246
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0239
563 Thyroid peroxidase TPO 0.0238
153 Dopamine beta-hydroxylase DBH 0.0238
4132 Chloride channel protein ClC-Ka CLCNKA 0.0225
724 Interleukin-2 receptor alpha chain IL2RA 0.0221
717 Interleukin-2 receptor subunit beta IL2RB 0.0221
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0219
275 Arachidonate 5-lipoxygenase ALOX5 0.0215
503 Somatostatin receptor type 1 SSTR1 0.0214
3866 Serum amyloid A protein SAA1 0.0209
1932 Apolipoprotein E APOE 0.0208
1200 AMBP protein AMBP 0.0208
1770 Phospholipase C PLCL1 0.0206
2841 Phospholipase C plc 0.0206
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0206
239 Coagulation factor X F10 0.0202
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
3872 Somatostatin receptor type 5 SSTR5 0.02
6008 Somatostatin receptor type 2 SSTR2 0.02
4165 P2Y purinoceptor 2 P2RY2 0.0198
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.019
6143 Solute carrier family 22 member 7 SLC22A7 0.0189
6107 Cytochrome P450 3A7 CYP3A7 0.0189
856 Vitamin D3 receptor VDR 0.0189
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0189
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0183
6013 Cytochrome P450 2E1 CYP2E1 0.0182
430 Follicle-stimulating hormone receptor FSHR 0.0179
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0179
378 Alpha-2C adrenergic receptor ADRA2C 0.0176
629 Alpha-2B adrenergic receptor ADRA2B 0.0173
817 DNA topoisomerase 2-alpha TOP2A 0.0173
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0171
862 Multidrug resistance-associated protein 1 ABCC1 0.0168
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0165
2654 Complement control protein C3L 0.0161
115 Penicillin-binding protein 2 mrdA 0.016
6069 Penicillin-binding protein 2 mrdA 0.016
6118 Penicillin-binding protein 2 penA 0.016
6187 Penicillin-binding protein 2 pbpA 0.016
6686 Penicillin-binding protein 2 pbp2 0.016
6939 Penicillin-binding protein 2 mrdA 0.016
7163 Penicillin-binding protein 2 pbpA 0.016
867 Penicillin-binding protein 3 pbpC 0.016
6119 Penicillin-binding protein 3 pbp3 0.016
7154 Penicillin-binding protein 3 pbp3 0.016
7157 Penicillin-binding protein 3 LMHCC_2184 0.016
7162 Penicillin-binding protein 3 pbpB 0.016
7172 Penicillin-binding protein 3 pbp3 0.016
6012 Tryptophan 2,3-dioxygenase TDO2 0.0155
318 Alpha-2A adrenergic receptor ADRA2A 0.0154
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0154
5455 Arylsulfatase A ARSA 0.0146
814 Ryanodine receptor 1 RYR1 0.0146
4203 Histamine N-methyltransferase HNMT 0.0143
6500 Phospholipase A2 PLA2G1B 0.0141
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0139
811 Translocator protein TSPO 0.0137
738 Monocarboxylate transporter 1 SLC16A1 0.0137
489 Monocarboxylate transporter 2 SLC16A7 0.0137
4757 Cytochrome P450 2C9 CYP2C9 0.0132
6165 Copper-transporting ATPase 1 ATP7A 0.0132
6163 Copper-transporting ATPase 2 ATP7B 0.0132
6144 Solute carrier family 22 member 2 SLC22A2 0.0132
633 Penicillin-binding proteins 1A/1B pbpA 0.0132
737 Mineralocorticoid receptor NR3C2 0.013
6146 High affinity copper uptake protein 1 SLC31A1 0.0125
6030 Cytochrome P450 2B6 CYP2B6 0.0125
4924 Cytochrome P450 2C8 CYP2C8 0.0123
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0121
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0121
3811 Cytochrome P450 19A1 CYP19A1 0.012
908 Glutathione S-transferase theta-1 GSTT1 0.0119
2981 Phospholipase A2, membrane associated PLA2G2A 0.0119
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0119
614 Progesterone receptor PGR 0.0117
6136 Multidrug resistance-associated protein 5 ABCC5 0.0112
136 Estrogen receptor ESR1 0.0112
1405 Thiopurine S-methyltransferase TPMT 0.0108
6171 Solute carrier family 28 member 3 SLC28A3 0.0107
6024 Cytochrome P450 1A1 CYP1A1 0.0107
896 Glutathione S-transferase Mu 1 GSTM1 0.0105
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0105
118 Organic cation/carnitine transporter 2 SLC22A5 0.0103
869 Estrogen receptor beta ESR2 0.0103
3941 Amine oxidase [flavin-containing] A MAOA 0.0101
3939 Amine oxidase [flavin-containing] B MAOB 0.0101
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0098
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0098
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0097
2164 Multidrug resistance-associated protein 4 ABCC4 0.0096
904 Glutathione S-transferase P GSTP1 0.0094
1588 Multidrug resistance protein 1 ABCB1 0.0094
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.009
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0088
6016 Cytochrome P450 2C19 CYP2C19 0.0085
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0083
713 Sodium-dependent dopamine transporter SLC6A3 0.008
238 Peroxisome proliferator-activated receptor gamma PPARG 0.008
400 Coagulation factor IX F9 0.0079
5461 Coagulation factor IX F9 0.0079
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0076
3917 Methylenetetrahydrofolate reductase MTHFR 0.0075
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0075
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0073
604 Vitamin K-dependent protein Z PROZ 0.0073
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0067
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0067
422 Vitamin K-dependent protein C PROC 0.0066
1245 Vitamin K-dependent protein S PROS1 0.0066
3601 Dihydropteroate synthase 1 folP1 0.0065
3807 Dihydropteroate synthase 1 folP1 0.0065
3808 Dihydropteroate synthase 2 folP2 0.0065
122 P2Y purinoceptor 12 P2RY12 0.0062
6036 Eosinophil peroxidase EPX 0.0059
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0059
6168 Solute carrier family 22 member 16 SLC22A16 0.0058
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0058
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0058
3830 Calreticulin CALR 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
551 Carnitine O-acetyltransferase CRAT 0.0057
6034 Hydroxyindole O-methyltransferase ASMT 0.0055
6035 Nuclear receptor ROR-beta RORB 0.0055
1898 Cytochrome P450 1B1 CYP1B1 0.0053
798 Osteocalcin BGLAP 0.0053
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0051
5818 Folate receptor alpha FOLR1 0.0049
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0048
369 Coagulation factor VII F7 0.0048
765 Indoleamine 2,3-dioxygenase IDO1 0.0047
6102 Arylamine N-acetyltransferase 2 NAT2 0.0045
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0045
362 Melatonin receptor type 1B MTNR1B 0.0045
571 Melatonin receptor type 1A MTNR1A 0.0045
6128 Carbonic anhydrase-related protein 10 CA10 0.0044
6133 Sodium channel subunit beta-2 SCN2B 0.0044
6134 Sodium channel subunit beta-3 SCN3B 0.0044
6132 Sodium channel subunit beta-1 SCN1B 0.0044
6135 Sodium channel subunit beta-4 SCN4B 0.0044
6129 Carbonic anhydrase-related protein 11 CA11 0.0044
6127 Carbonic anhydrase-related protein CA8 0.0044
293 Gamma-glutamyl hydrolase GGH 0.0043
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0041
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0038
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0038
6130 Carbonic anhydrase 13 CA13 0.0038
4604 Liver carboxylesterase 1 CES1 0.0037
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0037
1650 Heme carrier protein 1 SLC46A1 0.0037
6131 Carbonic anhydrase 14 CA14 0.0037
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0036
833 Organic cation/carnitine transporter 1 SLC22A4 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
6122 Carbonic anhydrase 3 CA3 0.0034
6106 Cytochrome P450 2C18 CYP2C18 0.0033
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0032
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0032
468 Cytochrome P450 4A11 CYP4A11 0.0032
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0031
3007 Carbonic anhydrase 12 CA12 0.0031
4205 Carbonic anhydrase 9 CA9 0.0031
365 Dihydrofolate reductase DHFR 0.003
2381 Dihydrofolate reductase DFR1 0.003
2833 Dihydrofolate reductase Not Available 0.003
2931 Dihydrofolate reductase folA 0.003
3544 Dihydrofolate reductase folA 0.003
3682 Dihydrofolate reductase folA 0.003
6642 Dihydrofolate reductase folA 0.003
6756 Dihydrofolate reductase dfrA 0.003
6126 Carbonic anhydrase 7 CA7 0.0029
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0029
5718 Cytochrome P450 2A6 CYP2A6 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
465 Calmodulin CALM1 0.0029
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0029
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0029
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0028
4119 Cytochrome P450 2D6 CYP2D6 0.0028
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0027
6147 Solute carrier family 22 member 3 SLC22A3 0.0027
6148 Multidrug resistance-associated protein 7 ABCC10 0.0027
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0026
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0026
24 Thymidylate synthase TMP1 0.0026
359 Thymidylate synthase TYMS 0.0026
2626 Thymidylate synthase thyA 0.0026
2729 Thymidylate synthase thyA 0.0026
5352 Thymidylate synthase THYA 0.0026
6137 Multidrug resistance-associated protein 6 ABCC6 0.0026
592 Carbonic anhydrase 4 CA4 0.0024
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0023
6145 Solute carrier family 22 member 1 SLC22A1 0.0023
1024 Solute carrier family 22 member 11 SLC22A11 0.0022
295 Carbonic anhydrase 1 CA1 0.0022
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0021
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.002
3923 Cholinesterase BCHE 0.0018
587 Serum albumin ALB 0.0017
357 Carbonic anhydrase 2 CA2 0.0017
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
816 Biliverdin reductase A BLVRA 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.001
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.001
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.001
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.001
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.001
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.001
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.001
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.001
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.001
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.001
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.001
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.001
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.001
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.001
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.001
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.001
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.001
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.001
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.001
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.001
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.001
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.001
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.0009
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0009
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0009
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0009
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0009
328 Sorbitol dehydrogenase SORD 0.0009
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0009
597 Dihydropteridine reductase QDPR 0.0009
396 Alcohol dehydrogenase 4 ADH4 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0009
666 NADP-dependent malic enzyme ME1 0.0009
6026 Alcohol dehydrogenase 6 ADH6 0.0008
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0008
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0008
857 Malate dehydrogenase, mitochondrial MDH2 0.0008
77 L-lactate dehydrogenase B chain LDHB 0.0008
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0008
12 Alcohol dehydrogenase class 3 ADH5 0.0008
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0008
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0008
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0008
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0008
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0008
626 Cysteine dioxygenase type 1 CDO1 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0008
627 11-cis retinol dehydrogenase RDH5 0.0008
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0008
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0008
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0008
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0008
13 Aminomethyltransferase, mitochondrial AMT 0.0008
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0007
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0007
279 Tyrosinase TYR 0.0007
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
654 Flavin reductase BLVRB 0.0007
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
380 Cytochrome P450 17A1 CYP17A1 0.0006
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0006
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0006
714 Glutathione reductase, mitochondrial GSR 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0006
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0005
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0005
822 Aldose reductase AKR1B1 0.0005
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