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DB01003 - Cromoglicic acid


Identification
Name Cromoglicic acid
Accession Number DB01003 (APRD00336)
Type small molecule
Description A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 468.3665
Groups approved
Monoisotopic Weight 468.069261354
Pharmacology
Indication For the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
Mechanism of action Cromoglicate inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Cromoglicate also may reduce the release of inflammatory leukotrienes. Cromoglicate may act by inhibiting calcium influx.
Absorption 1%
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of overdose include cough, nasal congestion, nausea, sneezing and wheezing.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Calcium-activated potassium channel subunit alpha 1
Name Calcium-activated potassium channel subunit alpha 1
Gene Name KCNMA1
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5913
Protein S100-P
Name Protein S100-P
Gene Name S100P
Pharmacological action unknown
Actions antagonist
References
  • Arumugam T, Ramachandran V, Logsdon CD: Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models. J Natl Cancer Inst. 2006 Dec 20;98(24):1806-18. - Pubmed
DTHybrid score 1.0971

Predictions


Id Partner name Gene Name Score
466 Solute carrier family 12 member 3 SLC12A3 0.0594
295 Carbonic anhydrase 1 CA1 0.0587
592 Carbonic anhydrase 4 CA4 0.047
357 Carbonic anhydrase 2 CA2 0.0433
4205 Carbonic anhydrase 9 CA9 0.0368
3007 Carbonic anhydrase 12 CA12 0.0368
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0301
6013 Cytochrome P450 2E1 CYP2E1 0.0232
1405 Thiopurine S-methyltransferase TPMT 0.0224
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0197
537 ATP synthase delta chain, mitochondrial ATP5D 0.0188
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0182
3426 Glutamine synthetase glnA 0.0178
3987 Glutamine synthetase GLUL 0.0178
5718 Cytochrome P450 2A6 CYP2A6 0.0177
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0174
482 Glycine receptor subunit alpha-1 GLRA1 0.017
558 Solute carrier family 12 member 1 SLC12A1 0.0149
705 Glutamate receptor 1 GRIA1 0.0137
4119 Cytochrome P450 2D6 CYP2D6 0.0133
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0124
4512 Cytochrome P450 3A4 CYP3A4 0.0118
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0117
4200 Cytochrome P450 1A2 CYP1A2 0.0115
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0114
6024 Cytochrome P450 1A1 CYP1A1 0.0109
587 Serum albumin ALB 0.01
1729 Solute carrier family 22 member 6 SLC22A6 0.009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0082
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0082
1268 Neuropeptide S receptor NPSR1 0.0082
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0082
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0077
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0077
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0077
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0077
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0077
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0077
6072 Potassium channel subfamily K member 3 KCNK3 0.0069
6073 Potassium channel subfamily K member 9 KCNK9 0.0069
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0063
6030 Cytochrome P450 2B6 CYP2B6 0.0057
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0055
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0052
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0052
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0051
4757 Cytochrome P450 2C9 CYP2C9 0.0049
2207 Rhodopsin RHO 0.0047
260 Cytochrome P450 51 ERG11 0.0045
761 Cytochrome P450 51 ERG11 0.0045
3163 Cytochrome P450 51 cyp51 0.0045
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0043
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0042
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0039
7 Nitric oxide synthase, inducible NOS2 0.0035
3811 Cytochrome P450 19A1 CYP19A1 0.0034
291 Nitric-oxide synthase, endothelial NOS3 0.0034
6016 Cytochrome P450 2C19 CYP2C19 0.0025
1588 Multidrug resistance protein 1 ABCB1 0.0023
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