DT-Web

DB01413 - Cefepime


Identification
Name Cefepime
Accession Number DB01413
Type small molecule
Description Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. Cefepime is usually reserved to treat severe nosocomial pneumonia, infections caused by multi-resistant microorganisms (e.g. Pseudomonas aeruginosa) and empirical treatment of febrile neutropenia.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 480.561
Groups approved
Monoisotopic Weight 480.124959288
Pharmacology
Indication For the treatment of pneumonia (moderate to severe) caused by Streptococcus pneumoniae, including cases associated with concurrent bacteremia, Pseudomonas aeruginosa, Klebsiella pneumoniae, or Enterobacter species. Also for empiric treatment of febrile neutropenic patients and uncomplicated and complicated urinary tract infections (including pyelonephritis) caused by Escherichia coli or Klebsiella pneumoniae, when the infection is severe, or caused by Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis, when the infection is mild to moderate, including cases associated with concurrent bacteremia with these microorganisms. Also for the treatment of uncomplicated skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible strains only) or Streptococcus pyogenes and complicated intra-abdominal infections (used in combination with metronidazole) caused by Escherichia coli, viridans group streptococci, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter species, or Bacteroides fragilis.
Mechanism of action Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs).
Absorption The absolute bioavailability of cefepime after an IM dose of 50 mg/kg was 82.3 (±15)% in eight patients.
Protein binding The serum protein binding of cefepime is approximately 20% and is independent of its concentration in serum.
Biotransformation Hepatic. Cefepime is metabolized to N-methylpyrrolidine (NMP) which is rapidly converted to the N-oxide (NMP-N-oxide).
Route of elimination Elimination of cefepime is principally via renal excretion with an average (?SD) half-life of 2 (?0.3) hours and total body clearance of 120 (?8) mL/min in healthy volunteers. Cefepime is excreted in human milk.
Toxicity Symptoms of overdose include seizures, encephalopathy, and neuromuscular excitability.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Probenecid Probenecid may increase the serum level of cefepime.
Food Interactions Not Available

Targets


Penicillin-binding protein 2
Name Penicillin-binding protein 2
Gene Name mrdA
Pharmacological action yes
Actions inhibitor
References
  • Grassi GG, Grassi C: Cefepime: overview of activity in vitro and in vivo. J Antimicrob Chemother. 1993 Nov;32 Suppl B:87-94. - Pubmed
DTHybrid score 0.0748
Peptidoglycan synthetase ftsI
Name Peptidoglycan synthetase ftsI
Gene Name ftsI
Pharmacological action yes
Actions inhibitor
References
  • Grassi GG, Grassi C: Cefepime: overview of activity in vitro and in vivo. J Antimicrob Chemother. 1993 Nov;32 Suppl B:87-94. - Pubmed
DTHybrid score 0.045
Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbpB
Pharmacological action yes
Actions inhibitor
References
  • Grassi GG, Grassi C: Cefepime: overview of activity in vitro and in vivo. J Antimicrob Chemother. 1993 Nov;32 Suppl B:87-94. - Pubmed
DTHybrid score 0.0405
Penicillin-binding protein 2
Name Penicillin-binding protein 2
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Grassi GG, Grassi C: Cefepime: overview of activity in vitro and in vivo. J Antimicrob Chemother. 1993 Nov;32 Suppl B:87-94. - Pubmed
DTHybrid score 0.0748

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
DTHybrid score 0.3063
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.6166
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.5973

Predictions


Id Partner name Gene Name Score
645 Penicillin-binding protein 1A mrcA 0.2874
5805 Penicillin-binding protein 1A ponA 0.2874
6185 Penicillin-binding protein 1A mrcA 0.2874
6799 Penicillin-binding protein 1A pbpA 0.2874
543 Penicillin-binding protein 1B mrcB 0.2764
6186 Penicillin-binding protein 1B ponB 0.2764
6822 Penicillin-binding protein 1b pbp1b 0.2764
6844 Penicillin-binding protein 1b pbp1b 0.2764
633 Penicillin-binding proteins 1A/1B pbpA 0.2104
244 Angiotensin-converting enzyme ACE 0.1747
1729 Solute carrier family 22 member 6 SLC22A6 0.1281
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.1026
819 Penicillin-binding protein 4 dacB 0.102
587 Serum albumin ALB 0.0902
6142 Solute carrier family 22 member 8 SLC22A8 0.0803
115 Penicillin-binding protein 2 mrdA 0.0748
6118 Penicillin-binding protein 2 penA 0.0748
6187 Penicillin-binding protein 2 pbpA 0.0748
6686 Penicillin-binding protein 2 pbp2 0.0748
6939 Penicillin-binding protein 2 mrdA 0.0748
1024 Solute carrier family 22 member 11 SLC22A11 0.0575
6067 Penicillin binding protein 2a mecA 0.0574
3760 Penicillin-binding protein 5 precursor dacA 0.0546
833 Organic cation/carnitine transporter 1 SLC22A4 0.0479
1 Peptidoglycan synthetase ftsI ftsI 0.045
1588 Multidrug resistance protein 1 ABCB1 0.0433
867 Penicillin-binding protein 3 pbpC 0.0405
6119 Penicillin-binding protein 3 pbp3 0.0405
7154 Penicillin-binding protein 3 pbp3 0.0405
7157 Penicillin-binding protein 3 LMHCC_2184 0.0405
7172 Penicillin-binding protein 3 pbp3 0.0405
4119 Cytochrome P450 2D6 CYP2D6 0.0401
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.036
332 Beta-lactamase blaZ 0.036
2478 Beta-lactamase ampC 0.036
2613 Beta-lactamase ampC 0.036
2635 Beta-lactamase ampC 0.036
2700 Beta-lactamase penP 0.036
5445 Beta-lactamase blaB 0.036
6019 Beta-lactamase SHV-7 0.036
6701 Beta-lactamase cphA 0.036
1385 Angiotensin-converting enzyme 2 ACE2 0.035
4512 Cytochrome P450 3A4 CYP3A4 0.035
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0333
1198 Serum paraoxonase/arylesterase 1 PON1 0.0322
6223 Penicillin-binding protein 1C pbpC 0.0322
6145 Solute carrier family 22 member 1 SLC22A1 0.0307
1757 Myeloperoxidase MPO 0.0303
6143 Solute carrier family 22 member 7 SLC22A7 0.0302
6144 Solute carrier family 22 member 2 SLC22A2 0.0269
234 Plasminogen PLG 0.0246
6016 Cytochrome P450 2C19 CYP2C19 0.0236
3923 Cholinesterase BCHE 0.0234
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0228
6147 Solute carrier family 22 member 3 SLC22A3 0.022
4757 Cytochrome P450 2C9 CYP2C9 0.0211
2164 Multidrug resistance-associated protein 4 ABCC4 0.0203
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0203
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
738 Monocarboxylate transporter 1 SLC16A1 0.0197
4604 Liver carboxylesterase 1 CES1 0.0192
1405 Thiopurine S-methyltransferase TPMT 0.0189
4200 Cytochrome P450 1A2 CYP1A2 0.0186
477 DNA topoisomerase 4 subunit A parC 0.0178
886 DNA topoisomerase 4 subunit A parC 0.0178
6226 DNA topoisomerase 4 subunit A parC 0.0178
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0176
404 DNA gyrase subunit A gyrA 0.0175
6224 DNA gyrase subunit A gyrA 0.0175
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0173
3917 Methylenetetrahydrofolate reductase MTHFR 0.0164
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
817 DNA topoisomerase 2-alpha TOP2A 0.0131
862 Multidrug resistance-associated protein 1 ABCC1 0.0129
318 Alpha-2A adrenergic receptor ADRA2A 0.0129
159 Penicillin-binding protein 2B penA 0.0123
6121 Penicillin-binding protein 2B penA 0.0123
4252 Penicillin-binding protein 5 dacA 0.0117
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0114
6106 Cytochrome P450 2C18 CYP2C18 0.0108
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0106
3810 Catechol O-methyltransferase COMT 0.0106
20 Prostaglandin G/H synthase 1 PTGS1 0.0102
509 Thymidine kinase TK 0.0101
570 Thymidine kinase TK 0.0101
2559 Thymidine kinase TK 0.0101
3430 Thymidine kinase tdk 0.0101
3518 Thymidine kinase TK 0.0101
5301 Thymidine kinase tdk 0.0101
5771 Thymidine kinase ORF36 0.0101
7009 Thymidine kinase ORF36 0.0101
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0098
4924 Cytochrome P450 2C8 CYP2C8 0.0097
4118 Cytochrome P450 3A5 CYP3A5 0.0097
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
3426 Glutamine synthetase glnA 0.0089
3987 Glutamine synthetase GLUL 0.0089
492 Histamine H1 receptor HRH1 0.0088
338 DNA polymerase UL30 0.0087
379 DNA polymerase UL54 0.0087
697 DNA polymerase ORF28 0.0087
2482 DNA polymerase 43 0.0087
4104 DNA polymerase BALF5 0.0087
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0085
632 Alpha-1B adrenergic receptor ADRA1B 0.0084
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0084
556 Alpha-1A adrenergic receptor ADRA1A 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
6107 Cytochrome P450 3A7 CYP3A7 0.0079
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
5718 Cytochrome P450 2A6 CYP2A6 0.0075
1636 Trace amine-associated receptor 1 TAAR1 0.0073
6030 Cytochrome P450 2B6 CYP2B6 0.0068
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0067
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0067
6024 Cytochrome P450 1A1 CYP1A1 0.0066
6137 Multidrug resistance-associated protein 6 ABCC6 0.0066
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0065
629 Alpha-2B adrenergic receptor ADRA2B 0.0065
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
474 Acetylcholinesterase ACHE 0.0063
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0062
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.006
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
131 Synaptic vesicular amine transporter SLC18A2 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
788 Creatine kinase M-type CKM 0.0057
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0056
5482 Sialidase-2 NEU2 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
378 Alpha-2C adrenergic receptor ADRA2C 0.0049
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0048
707 72 kDa type IV collagenase MMP2 0.0048
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0046
776 Bile salt export pump ABCB11 0.0045
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
380 Cytochrome P450 17A1 CYP17A1 0.0042
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0042
6151 Monocarboxylate transporter 10 SLC16A10 0.004
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
65 Matrix metalloproteinase-9 Not Available 0.0039
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0038
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0038
3941 Amine oxidase [flavin-containing] A MAOA 0.0038
163 D(1B) dopamine receptor DRD5 0.0038
3939 Amine oxidase [flavin-containing] B MAOB 0.0037
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
193 Beta-1 adrenergic receptor ADRB1 0.0036
6013 Cytochrome P450 2E1 CYP2E1 0.0036
5126 Arginase rocF 0.0036
432 D(4) dopamine receptor DRD4 0.0036
766 Beta-2 adrenergic receptor ADRB2 0.0035
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0035
638 D(3) dopamine receptor DRD3 0.0034
1341 Histamine H3 receptor HRH3 0.0034
124 Histamine H2 receptor HRH2 0.0034
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0034
499 Arginine decarboxylase ADC 0.0033
164 Histamine H4 receptor HRH4 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0031
789 Alpha-1D adrenergic receptor ADRA1D 0.0031
23 D(1A) dopamine receptor DRD1 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
824 Sodium-dependent serotonin transporter SLC6A4 0.003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0029
831 D(2) dopamine receptor DRD2 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0027
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
4203 Histamine N-methyltransferase HNMT 0.0026
976 Platelet glycoprotein IX GP9 0.0025
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0025
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0025
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0023
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
5682 Ribonuclease pancreatic RNASE1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
844 Epidermal growth factor receptor EGFR 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
7 Nitric oxide synthase, inducible NOS2 0.0019
357 Carbonic anhydrase 2 CA2 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0017
6218 Pannexin-1 PANX1 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0017
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0017
751 Potassium channel subfamily K member 6 KCNK6 0.0017
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0012
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0012
6014 Cytochrome P450 2A13 CYP2A13 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
6432 Transporter snf 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.001
6141 Sodium/bile acid cotransporter SLC10A1 0.001
6136 Multidrug resistance-associated protein 5 ABCC5 0.0009
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0008
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0007
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0007
502 5-hydroxytryptamine 2A receptor HTR2A 0.0007
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0007
6148 Multidrug resistance-associated protein 7 ABCC10 0.0007
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