DT-Web

DB00513 - Aminocaproic Acid


Identification
Name Aminocaproic Acid
Accession Number DB00513 (APRD00791, EXPT00408)
Type small molecule
Description An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 131.1729
Groups approved
Monoisotopic Weight 131.094628665
Pharmacology
Indication For use in the treatment of excessive postoperative bleeding.
Mechanism of action Aminocaproic acid binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. With NO activation of plasmin, there is a reduction in fibrinolysis. This consequently will reduce the amount of bleeding post surgery. Elevated plasma levels of lipoprotein(a) have been shown to increase the risk of vascular disease. Lipoprotein 9a)a has two components, apolipoprotein B-100, linked to apolipoprotein (a). Aminocaproic acid may change the conformation of apoliprotein (a), changing its binding properties and potentially preventing the formation of lipoprotein (a).
Absorption Absorbed rapidly following oral administration. In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1).
Protein binding Not Available
Biotransformation Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid.
Route of elimination Renal excretion is the primary route of elimination, whether aminocaproic acid is administered orally or intravenously.
Toxicity A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD50 were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take without regard to meals.

Targets


Plasminogen
Name Plasminogen
Gene Name PLG
Pharmacological action yes
Actions inhibitor
References
  • Mochalkin I, Cheng B, Klezovitch O, Scanu AM, Tulinsky A: Recombinant kringle IV-10 modules of human apolipoprotein(a): structure, ligand binding modes, and biological relevance. Biochemistry. 1999 Feb 16;38(7):1990-8. - Pubmed
  • Prandota J, Pankow-Prandota L, Kotecki L: Impaired activation of the fibrinolytic system in children with Henoch-Schonlein purpura: beneficial effect of hydrocortisone plus Sigma-aminocaproic acid therapy on disappearance rate of cutaneous vasculitis and fibrinolysis. Am J Ther. 2001 Jan-Feb;8(1):11-9. - Pubmed
  • Lee KN, Jackson KW, McKee PA: Effect of a synthetic carboxy-terminal peptide of alpha(2)-antiplasmin on urokinase-induced fibrinolysis. Thromb Res. 2002 Feb 1;105(3):263-70. - Pubmed
  • Sun Z, Chen YH, Wang P, Zhang J, Gurewich V, Zhang P, Liu JN: The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation. Biochim Biophys Acta. 2002 Apr 29;1596(2):182-92. - Pubmed
  • Kanalas JJ: Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330. Arch Biochem Biophys. 1992 Dec;299(2):255-60. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8889
Tissue-type plasminogen activator
Name Tissue-type plasminogen activator
Gene Name PLAT
Pharmacological action yes
Actions antagonist
References
  • Husain SS, Hasan AA, Budzynski AZ: Differences between binding of one-chain and two-chain tissue plasminogen activators to non-cross-linked and cross-linked fibrin clots. Blood. 1989 Aug 15;74(3):999-1006. - Pubmed
  • Urano T, Sator de Serrano V, Gaffney PJ, Castellino FJ: Effectors of the activation of human [Glu1]plasminogen by human tissue plasminogen activator. Biochemistry. 1988 Aug 23;27(17):6522-8. - Pubmed
  • Tran-Thang C, Vouillamoz D, Kruithof EK, Sordat B: Human Co115 colon carcinoma cells potentiate the degradation of laminin mediated by tissue-type plasminogen activator. J Cell Physiol. 1994 Nov;161(2):285-92. - Pubmed
  • Krishnamurti C, Vukelja SJ, Alving BM: Inhibitory effects of lysine analogues on t-PA induced whole blood clot lysis. Thromb Res. 1994 Mar 15;73(6):419-30. - Pubmed
DTHybrid score 1.0453
Apolipoprotein(a)
Name Apolipoprotein(a)
Gene Name LPA
Pharmacological action unknown
Actions other
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Becker L, Cook PM, Koschinsky ML: Identification of sequences in apolipoprotein(a) that maintain its closed conformation: a novel role for apo(a) isoform size in determining the efficiency of covalent Lp(a) formation. Biochemistry. 2004 Aug 10;43(31):9978-88. - Pubmed
DTHybrid score 0.682

Enzymes


Aldehyde oxidase
Name Aldehyde oxidase
Gene Name AOX1
Actions substrate
References
  • Subramanyam B, Callery PS, Geelhaar LA, Egorin MJ: A cyclic imine intermediate in the in vitro metabolic conversion of 1,6-diaminohexane to 6-aminohexanoic acid and caprolactam. Xenobiotica. 1989 Jan;19(1):33-42. - Pubmed
DTHybrid score 0.4651

Predictions


Id Partner name Gene Name Score
791 Urokinase plasminogen activator surface receptor PLAUR 0.2135
267 Plasminogen activator inhibitor 1 SERPINE1 0.1953
595 Fibrinogen alpha chain FGA 0.1553
1193 Proteinase-activated receptor 1 F2R 0.0899
723 Cytosolic phospholipase A2 PLA2G4A 0.0803
1349 Plasminogen activator inhibitor 2 SERPINB2 0.0802
2876 Membrane-bound lytic murein transglycosylase B mltB 0.0726
3133 UDP-galactopyranose mutase glf 0.0725
5099 UDP-galactopyranose mutase glf 0.0725
1812 Kallikrein-1 KLK1 0.0676
3834 Nidogen-1 NID1 0.0675
3833 Plasma serine protease inhibitor SERPINA5 0.0588
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0573
3011 Suppressor of tumorigenicity protein 14 ST14 0.0549
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.048
3947 Xanthine dehydrogenase/oxidase XDH 0.0474
6011 Chymotrypsinogen B CTRB1 0.0359
4512 Cytochrome P450 3A4 CYP3A4 0.0311
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.029
1074 Urokinase-type plasminogen activator PLAU 0.0289
6142 Solute carrier family 22 member 8 SLC22A8 0.0279
1757 Myeloperoxidase MPO 0.0258
3176 Trypsin-1 PRSS1 0.0248
338 DNA polymerase UL30 0.0246
379 DNA polymerase UL54 0.0246
697 DNA polymerase ORF28 0.0246
2482 DNA polymerase 43 0.0246
4104 DNA polymerase BALF5 0.0246
3825 Tetranectin CLEC3B 0.0245
2111 Annexin A2 ANXA2 0.0245
3826 Keratin, type II cytoskeletal 8 KRT8 0.0245
527 Prostacyclin receptor PTGIR 0.0222
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0219
1516 Calnexin CANX 0.0213
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.021
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0208
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0203
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.0197
6143 Solute carrier family 22 member 7 SLC22A7 0.0189
3830 Calreticulin CALR 0.0189
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0184
378 Alpha-2C adrenergic receptor ADRA2C 0.0176
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0174
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0173
629 Alpha-2B adrenergic receptor ADRA2B 0.0173
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0159
318 Alpha-2A adrenergic receptor ADRA2A 0.0154
2164 Multidrug resistance-associated protein 4 ABCC4 0.0151
811 Translocator protein TSPO 0.0137
2021 Thrombomodulin THBD 0.0125
4200 Cytochrome P450 1A2 CYP1A2 0.0117
4924 Cytochrome P450 2C8 CYP2C8 0.0111
1405 Thiopurine S-methyltransferase TPMT 0.0108
6171 Solute carrier family 28 member 3 SLC28A3 0.0107
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0105
869 Estrogen receptor beta ESR2 0.0103
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0098
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0097
3811 Cytochrome P450 19A1 CYP19A1 0.0095
6136 Multidrug resistance-associated protein 5 ABCC5 0.0089
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0088
6085 Fatty acid-binding protein, intestinal FABP2 0.0088
136 Estrogen receptor ESR1 0.0088
6107 Cytochrome P450 3A7 CYP3A7 0.0088
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0087
273 Apoptosis regulator Bcl-2 BCL2 0.0087
4118 Cytochrome P450 3A5 CYP3A5 0.0083
400 Coagulation factor IX F9 0.0079
5461 Coagulation factor IX F9 0.0079
1024 Solute carrier family 22 member 11 SLC22A11 0.0079
3917 Methylenetetrahydrofolate reductase MTHFR 0.0075
6030 Cytochrome P450 2B6 CYP2B6 0.0075
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0073
604 Vitamin K-dependent protein Z PROZ 0.0073
862 Multidrug resistance-associated protein 1 ABCC1 0.0072
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0071
422 Vitamin K-dependent protein C PROC 0.0066
1245 Vitamin K-dependent protein S PROS1 0.0066
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0063
1729 Solute carrier family 22 member 6 SLC22A6 0.0063
587 Serum albumin ALB 0.0062
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0061
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0061
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0059
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0059
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0057
6016 Cytochrome P450 2C19 CYP2C19 0.0054
798 Osteocalcin BGLAP 0.0053
1588 Multidrug resistance protein 1 ABCB1 0.0052
290 Prostaglandin G/H synthase 2 PTGS2 0.0051
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0049
5818 Folate receptor alpha FOLR1 0.0049
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0048
369 Coagulation factor VII F7 0.0048
20 Prostaglandin G/H synthase 1 PTGS1 0.0048
6128 Carbonic anhydrase-related protein 10 CA10 0.0044
6133 Sodium channel subunit beta-2 SCN2B 0.0044
6134 Sodium channel subunit beta-3 SCN3B 0.0044
6132 Sodium channel subunit beta-1 SCN1B 0.0044
6135 Sodium channel subunit beta-4 SCN4B 0.0044
6129 Carbonic anhydrase-related protein 11 CA11 0.0044
6127 Carbonic anhydrase-related protein CA8 0.0044
293 Gamma-glutamyl hydrolase GGH 0.0043
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0038
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0038
6130 Carbonic anhydrase 13 CA13 0.0038
4757 Cytochrome P450 2C9 CYP2C9 0.0037
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0037
1650 Heme carrier protein 1 SLC46A1 0.0037
6131 Carbonic anhydrase 14 CA14 0.0037
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0036
239 Coagulation factor X F10 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
6122 Carbonic anhydrase 3 CA3 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0032
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0032
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0031
3007 Carbonic anhydrase 12 CA12 0.0031
4205 Carbonic anhydrase 9 CA9 0.0031
365 Dihydrofolate reductase DHFR 0.003
2381 Dihydrofolate reductase DFR1 0.003
2833 Dihydrofolate reductase Not Available 0.003
2931 Dihydrofolate reductase folA 0.003
3544 Dihydrofolate reductase folA 0.003
3682 Dihydrofolate reductase folA 0.003
6642 Dihydrofolate reductase folA 0.003
6756 Dihydrofolate reductase dfrA 0.003
6126 Carbonic anhydrase 7 CA7 0.0029
5718 Cytochrome P450 2A6 CYP2A6 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
54 Prothrombin F2 0.0029
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0029
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0029
6024 Cytochrome P450 1A1 CYP1A1 0.0028
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0028
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0027
6148 Multidrug resistance-associated protein 7 ABCC10 0.0027
6013 Cytochrome P450 2E1 CYP2E1 0.0027
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0026
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0026
24 Thymidylate synthase TMP1 0.0026
359 Thymidylate synthase TYMS 0.0026
2626 Thymidylate synthase thyA 0.0026
2729 Thymidylate synthase thyA 0.0026
5352 Thymidylate synthase THYA 0.0026
738 Monocarboxylate transporter 1 SLC16A1 0.0025
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0024
592 Carbonic anhydrase 4 CA4 0.0024
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0023
295 Carbonic anhydrase 1 CA1 0.0022
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0021
3941 Amine oxidase [flavin-containing] A MAOA 0.0021
3939 Amine oxidase [flavin-containing] B MAOB 0.0021
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.002
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0019
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0019
357 Carbonic anhydrase 2 CA2 0.0017
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
816 Biliverdin reductase A BLVRA 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.001
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.001
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.001
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.001
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.001
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.001
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.001
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.001
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.001
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.001
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.001
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.001
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.001
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.001
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.001
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.001
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.001
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.001
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.001
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.001
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.001
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.001
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.0009
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0009
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0009
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0009
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0009
328 Sorbitol dehydrogenase SORD 0.0009
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0009
597 Dihydropteridine reductase QDPR 0.0009
396 Alcohol dehydrogenase 4 ADH4 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0009
666 NADP-dependent malic enzyme ME1 0.0009
6026 Alcohol dehydrogenase 6 ADH6 0.0008
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0008
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0008
857 Malate dehydrogenase, mitochondrial MDH2 0.0008
77 L-lactate dehydrogenase B chain LDHB 0.0008
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0008
12 Alcohol dehydrogenase class 3 ADH5 0.0008
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0008
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0008
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0008
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0008
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0008
626 Cysteine dioxygenase type 1 CDO1 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0008
627 11-cis retinol dehydrogenase RDH5 0.0008
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0008
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0008
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0008
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0008
13 Aminomethyltransferase, mitochondrial AMT 0.0008
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0007
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0007
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0007
279 Tyrosinase TYR 0.0007
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
654 Flavin reductase BLVRB 0.0007
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
380 Cytochrome P450 17A1 CYP17A1 0.0006
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0006
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0006
714 Glutathione reductase, mitochondrial GSR 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
468 Cytochrome P450 4A11 CYP4A11 0.0006
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0006
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0005
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0005
822 Aldose reductase AKR1B1 0.0005
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