DT-Web

DB01416 - Cefpodoxime


Identification
Name Cefpodoxime
Accession Number DB01416
Type small molecule
Description Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 427.455
Groups approved
Monoisotopic Weight 427.062024681
Pharmacology
Indication For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.
Mechanism of action Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Cefpodoxime is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Cefpodoxime is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicillin binding protein 3, which inhibits production of peptidoglycan, the primary constituent of bacterial cell walls.
Absorption Cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically.
Protein binding 22 to 33% in serum and from 21 to 29% in plasma.
Biotransformation Not Available
Route of elimination Over the recommended dosing range (100 to 400 mg), approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours.
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions
  • Take on empty stomach: 1 hour before or 2 hours after meals.

Targets


Peptidoglycan synthetase ftsI
Name Peptidoglycan synthetase ftsI
Gene Name ftsI
Pharmacological action yes
Actions inhibitor
References
  • Boaretti M, Lleo MM, Canepari P: In vitro activity, beta-lactamase stability and PBP affinity of RU 51,746-2, the active metabolite of the new orally absorbed cephalosporin ester, RU 51807. J Chemother. 1991 Jan;3 Suppl 1:57-61. - Pubmed
DTHybrid score 0.019

Predictions


Id Partner name Gene Name Score
543 Penicillin-binding protein 1B mrcB 0.1242
6186 Penicillin-binding protein 1B ponB 0.1242
6822 Penicillin-binding protein 1b pbp1b 0.1242
6844 Penicillin-binding protein 1b pbp1b 0.1242
645 Penicillin-binding protein 1A mrcA 0.1222
5805 Penicillin-binding protein 1A ponA 0.1222
6185 Penicillin-binding protein 1A mrcA 0.1222
6799 Penicillin-binding protein 1A pbpA 0.1222
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0634
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0528
819 Penicillin-binding protein 4 dacB 0.05
633 Penicillin-binding proteins 1A/1B pbpA 0.0427
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0412
3760 Penicillin-binding protein 5 precursor dacA 0.0342
587 Serum albumin ALB 0.029
6067 Penicillin binding protein 2a mecA 0.0283
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0251
118 Organic cation/carnitine transporter 2 SLC22A5 0.0192
1 Peptidoglycan synthetase ftsI ftsI 0.019
115 Penicillin-binding protein 2 mrdA 0.0176
6069 Penicillin-binding protein 2 mrdA 0.0176
6118 Penicillin-binding protein 2 penA 0.0176
6187 Penicillin-binding protein 2 pbpA 0.0176
6686 Penicillin-binding protein 2 pbp2 0.0176
6939 Penicillin-binding protein 2 mrdA 0.0176
7163 Penicillin-binding protein 2 pbpA 0.0176
1198 Serum paraoxonase/arylesterase 1 PON1 0.0139
6223 Penicillin-binding protein 1C pbpC 0.0139
1729 Solute carrier family 22 member 6 SLC22A6 0.0139
332 Beta-lactamase blaZ 0.0116
2478 Beta-lactamase ampC 0.0116
2613 Beta-lactamase ampC 0.0116
2635 Beta-lactamase ampC 0.0116
2700 Beta-lactamase penP 0.0116
5445 Beta-lactamase blaB 0.0116
6019 Beta-lactamase SHV-7 0.0116
6701 Beta-lactamase cphA 0.0116
1024 Solute carrier family 22 member 11 SLC22A11 0.0107
6142 Solute carrier family 22 member 8 SLC22A8 0.0091
159 Penicillin-binding protein 2B penA 0.0089
6121 Penicillin-binding protein 2B penA 0.0089
1405 Thiopurine S-methyltransferase TPMT 0.0081
2164 Multidrug resistance-associated protein 4 ABCC4 0.0054
6143 Solute carrier family 22 member 7 SLC22A7 0.0048
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