Identification | |
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Name | Paromomycin |
Accession Number | DB01421 |
Type | small molecule |
Description | An oligosaccharide antibiotic produced by various streptomyces. [PubChem] |
Structure |
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Categories (*) | |
Molecular Weight | 615.6285 |
Groups | approved |
Monoisotopic Weight | 615.296301173 |
Pharmacology | |
Indication | For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy. |
Mechanism of action | Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death. |
Absorption | Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool. |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms |
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Interactions | |
Drug Interactions | Not Available |
Food Interactions |
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30S ribosomal protein S10 | |
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Name | 30S ribosomal protein S10 |
Gene Name | rpsJ |
Pharmacological action | yes |
Actions | inhibitor |
References |
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DTHybrid score | 0.8763 |
16S rRNA | |
Name | 16S rRNA |
Gene Name | Not Available |
Pharmacological action | yes |
Actions | inhibitor |
References |
|
DTHybrid score | Not Available |