DT-Web

DB01421 - Paromomycin


Identification
Name Paromomycin
Accession Number DB01421
Type small molecule
Description An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 615.6285
Groups approved
Monoisotopic Weight 615.296301173
Pharmacology
Indication For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy.
Mechanism of action Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death.
Absorption Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool.
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions
  • Take with food.

Targets


30S ribosomal protein S10
Name 30S ribosomal protein S10
Gene Name rpsJ
Pharmacological action yes
Actions inhibitor
References
  • Dlugosz M, Trylska J: Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30. - Pubmed
DTHybrid score 0.8763
16S rRNA
Name 16S rRNA
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Konno T, Kurita D, Takahashi T, Muto A, Himeno H: Initiation-shift of trans-translation by aminoglycosides. Nucleic Acids Symp Ser (Oxf). 2004;(48):299-300. - Pubmed
  • Chao PW, Chow CS: Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching. Bioorg Med Chem. 2007 Jun 1;15(11):3825-31. Epub 2007 Mar 13. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
176 30S ribosomal protein S10 rpsJ 0.8763
6713 30S ribosomal protein S20 rpsT 0.0298
6722 30S ribosomal protein S20 rpsT 0.0298
6720 30S ribosomal protein Thx rpsU 0.0298
6208 30S ribosomal protein S13 rpsM 0.0298
6706 30S ribosomal protein S13 rpsM 0.0298
6718 30S ribosomal protein S8 rpsH 0.0298
7169 30S ribosomal protein S8 rpsH 0.0298
6707 30S ribosomal protein S14 type Z rpsZ 0.0298
6709 30S ribosomal protein S16 rpsP 0.0298
6711 30S ribosomal protein S18 rpsR 0.0298
6708 30S ribosomal protein S15 rpsO 0.0298
6209 30S ribosomal protein S19 rpsS 0.0298
6712 30S ribosomal protein S19 rpsS 0.0298
6726 30S ribosomal protein S19 rpsS 0.0298
6716 30S ribosomal protein S6 rpsF 0.0298
6710 30S ribosomal protein S17 rpsQ 0.0298
6721 30S ribosomal protein S17 rpsQ 0.0298
140 30S ribosomal protein S9 rpsI 0.0297
6719 30S ribosomal protein S9 rpsI 0.0297
6725 30S ribosomal protein S9 rpsI 0.0297
6705 30S ribosomal protein S11 rpsK 0.0297
308 30S ribosomal protein S12 rpsL 0.0297
6704 30S ribosomal protein S12 rpsL 0.0297
6717 30S ribosomal protein S7 rpsG 0.0297
7170 30S ribosomal protein S7 rpsG 0.0297
6715 30S ribosomal protein S5 rpsE 0.0297
22 30S ribosomal protein S4 rpsD 0.0297
6714 30S ribosomal protein S4 rpsD 0.0297
6724 30S ribosomal protein S3 rpsC 0.0297
6728 30S ribosomal protein S3 rpsC 0.0297
7168 30S ribosomal protein S3 rpsC 0.0297
6723 30S ribosomal protein S2 rpsB 0.0297
6727 30S ribosomal protein S2 rpsB 0.0297
3396 Elongation factor Tu tufA 0.0259
5621 Elongation factor Tu tuf 0.0259
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