DT-Web

DB04794 - Bifonazole


Identification
Name Bifonazole
Accession Number DB04794
Type small molecule
Description Bifonazole is an azole antifungal drug. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 310.3917
Groups approved
Monoisotopic Weight 310.146998586
Pharmacology
Indication Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).
Mechanism of action Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.
Absorption Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%).
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Fungi
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cytochrome P450 51
Name Cytochrome P450 51
Gene Name ERG11
Pharmacological action yes
Actions inhibitor
References
  • Carrillo-Munoz AJ, Giusiano G, Ezkurra PA, Quindos G: Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9. - Pubmed
  • Rossello A, Bertini S, Lapucci A, Macchia M, Martinelli A, Rapposelli S, Herreros E, Macchia B: Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. J Med Chem. 2002 Oct 24;45(22):4903-12. - Pubmed
  • Berg D, Plempel M: Bifonazole, a biochemist's view. Dermatologica. 1984;169 Suppl 1:3-9. - Pubmed
  • Berg D, Regel E, Harenberg HE, Plempel M: Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole. Arzneimittelforschung. 1984;34(2):139-46. - Pubmed
DTHybrid score 0.4484
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.2906

Enzymes


Cytochrome P450 19A1
Name Cytochrome P450 19A1
Gene Name CYP19A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3981
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3618
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2995
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.569

Predictions


Id Partner name Gene Name Score
761 Cytochrome P450 51 ERG11 0.4484
3163 Cytochrome P450 51 cyp51 0.4484
4757 Cytochrome P450 2C9 CYP2C9 0.2607
4200 Cytochrome P450 1A2 CYP1A2 0.2116
4119 Cytochrome P450 2D6 CYP2D6 0.2109
1588 Multidrug resistance protein 1 ABCB1 0.1829
4924 Cytochrome P450 2C8 CYP2C8 0.169
4118 Cytochrome P450 3A5 CYP3A5 0.1466
6107 Cytochrome P450 3A7 CYP3A7 0.1164
5718 Cytochrome P450 2A6 CYP2A6 0.1099
1010 Cytochrome P450 51A1 CYP51A1 0.0996
6024 Cytochrome P450 1A1 CYP1A1 0.0821
146 Androgen receptor AR 0.0728
587 Serum albumin ALB 0.0554
20 Prostaglandin G/H synthase 1 PTGS1 0.0538
136 Estrogen receptor ESR1 0.0525
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0494
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0485
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0463
6106 Cytochrome P450 2C18 CYP2C18 0.0422
492 Histamine H1 receptor HRH1 0.0402
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0382
824 Sodium-dependent serotonin transporter SLC6A4 0.0362
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0356
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0356
756 Sex hormone-binding globulin SHBG 0.0344
1898 Cytochrome P450 1B1 CYP1B1 0.0318
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0308
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0299
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0272
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0267
871 Glucocorticoid receptor NR3C1 0.0265
776 Bile salt export pump ABCB11 0.0264
862 Multidrug resistance-associated protein 1 ABCC1 0.0263
563 Thyroid peroxidase TPO 0.0263
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0255
556 Alpha-1A adrenergic receptor ADRA1A 0.0254
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0249
290 Prostaglandin G/H synthase 2 PTGS2 0.0246
4116 Dihydropteroate synthetase Not Available 0.0243
502 5-hydroxytryptamine 2A receptor HTR2A 0.024
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0237
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0236
3941 Amine oxidase [flavin-containing] A MAOA 0.0236
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0235
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0235
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0234
103 Muscarinic acetylcholine receptor M1 CHRM1 0.023
1729 Solute carrier family 22 member 6 SLC22A6 0.0229
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0226
6145 Solute carrier family 22 member 1 SLC22A1 0.0224
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0218
831 D(2) dopamine receptor DRD2 0.0217
731 HIV-1 protease HIV-1 protease 0.0216
6144 Solute carrier family 22 member 2 SLC22A2 0.0216
847 Mu-type opioid receptor OPRM1 0.0211
468 Cytochrome P450 4A11 CYP4A11 0.0211
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0208
713 Sodium-dependent dopamine transporter SLC6A3 0.0201
226 Gonadotropin-releasing hormone receptor GNRHR 0.02
3923 Cholinesterase BCHE 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
6142 Solute carrier family 22 member 8 SLC22A8 0.0197
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0194
3939 Amine oxidase [flavin-containing] B MAOB 0.0192
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0185
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0183
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0182
318 Alpha-2A adrenergic receptor ADRA2A 0.0178
465 Calmodulin CALM1 0.0178
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0176
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.0175
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0173
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0173
614 Progesterone receptor PGR 0.0172
6031 Cytochrome P450 3A43 CYP3A43 0.017
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0168
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0163
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0162
590 5-hydroxytryptamine 2C receptor HTR2C 0.0157
23 D(1A) dopamine receptor DRD1 0.0154
122 P2Y purinoceptor 12 P2RY12 0.0148
320 5-hydroxytryptamine 1A receptor HTR1A 0.0148
632 Alpha-1B adrenergic receptor ADRA1B 0.0147
341 5-hydroxytryptamine 3 receptor HTR3A 0.0147
869 Estrogen receptor beta ESR2 0.0145
1656 CYP2B protein CYP2B 0.0142
467 Delta-type opioid receptor OPRD1 0.0142
2164 Multidrug resistance-associated protein 4 ABCC4 0.0138
482 Glycine receptor subunit alpha-1 GLRA1 0.0134
6147 Solute carrier family 22 member 3 SLC22A3 0.0132
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0131
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0129
6044 Serum paraoxonase/lactonase 3 PON3 0.0128
118 Organic cation/carnitine transporter 2 SLC22A5 0.0127
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0126
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0126
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0126
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0125
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0125
6143 Solute carrier family 22 member 7 SLC22A7 0.0124
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0123
766 Beta-2 adrenergic receptor ADRB2 0.0122
5934 Cytochrome P450 26A1 CYP26A1 0.0122
705 Glutamate receptor 1 GRIA1 0.012
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0119
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0119
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0118
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0118
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0118
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0118
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0118
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0118
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0118
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0118
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0117
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0117
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0117
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0117
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0116
789 Alpha-1D adrenergic receptor ADRA1D 0.0115
629 Alpha-2B adrenergic receptor ADRA2B 0.0115
380 Cytochrome P450 17A1 CYP17A1 0.0115
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0115
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0114
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0114
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0114
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0114
3947 Xanthine dehydrogenase/oxidase XDH 0.0114
833 Organic cation/carnitine transporter 1 SLC22A4 0.0114
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0114
696 Kappa-type opioid receptor OPRK1 0.0113
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0113
537 ATP synthase delta chain, mitochondrial ATP5D 0.0112
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0111
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0111
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.011
6020 Aldehyde oxidase AOX1 0.0109
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0109
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0108
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0107
1178 Adenosine A2a receptor ADORA2A 0.0105
818 50S ribosomal protein L10 rplJ 0.0104
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0103
4604 Liver carboxylesterase 1 CES1 0.0103
638 D(3) dopamine receptor DRD3 0.0101
6220 Aryl hydrocarbon receptor AHR 0.01
811 Translocator protein TSPO 0.0099
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0098
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0098
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0098
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0096
817 DNA topoisomerase 2-alpha TOP2A 0.0094
885 5-hydroxytryptamine 1B receptor HTR1B 0.0093
174 Sigma 1-type opioid receptor SIGMAR1 0.0093
6014 Cytochrome P450 2A13 CYP2A13 0.0092
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0092
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0092
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.009
777 Tumor necrosis factor TNF 0.009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.009
6136 Multidrug resistance-associated protein 5 ABCC5 0.0089
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0088
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0088
29 Tubulin beta-1 chain TUBB1 0.0088
3957 Adenosine deaminase ADA 0.0088
4120 NADPH--cytochrome P450 reductase POR 0.0087
1757 Myeloperoxidase MPO 0.0087
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0086
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0086
193 Beta-1 adrenergic receptor ADRB1 0.0085
7 Nitric oxide synthase, inducible NOS2 0.0085
844 Epidermal growth factor receptor EGFR 0.0084
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0084
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0084
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0084
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0083
161 Tubulin beta chain TUBB 0.0083
312 Tubulin beta chain TUB2 0.0083
16 Adenosine A1 receptor ADORA1 0.0082
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
6148 Multidrug resistance-associated protein 7 ABCC10 0.0082
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0082
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
6182 Cytochrome P450 2J2 CYP2J2 0.008
891 Dihydropteroate synthase folP 0.008
5359 Dihydropteroate synthase folP 0.008
7175 Dihydropteroate synthase sulI 0.008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
373 Transthyretin TTR 0.0079
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0079
3809 Estrogen-related receptor gamma ESRRG 0.0079
124 Histamine H2 receptor HRH2 0.0078
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0078
6102 Arylamine N-acetyltransferase 2 NAT2 0.0077
725 5-hydroxytryptamine 1D receptor HTR1D 0.0076
592 Carbonic anhydrase 4 CA4 0.0075
921 Glutamate receptor 2 GRIA2 0.0075
1024 Solute carrier family 22 member 11 SLC22A11 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
6137 Multidrug resistance-associated protein 6 ABCC6 0.0073
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0072
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
1649 Small inducible cytokine A2 CCL2 0.007
716 5-hydroxytryptamine 7 receptor HTR7 0.0069
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0069
634 Squalene monooxygenase SQLE 0.0069
7196 Squalene monooxygenase ERG1 0.0069
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0067
378 Alpha-2C adrenergic receptor ADRA2C 0.0067
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0067
474 Acetylcholinesterase ACHE 0.0066
6141 Sodium/bile acid cotransporter SLC10A1 0.0066
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0066
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0065
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0065
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0064
251 Alcohol dehydrogenase 1A ADH1A 0.0064
444 Alcohol dehydrogenase 1B ADH1B 0.0064
780 Retinoic acid receptor RXR-gamma RXRG 0.0063
504 Mast/stem cell growth factor receptor KIT 0.0063
432 D(4) dopamine receptor DRD4 0.0063
3810 Catechol O-methyltransferase COMT 0.0063
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0062
295 Carbonic anhydrase 1 CA1 0.0062
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0062
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0062
94 5-hydroxytryptamine 4 receptor HTR4 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0059
291 Nitric-oxide synthase, endothelial NOS3 0.0059
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0058
3932 Glutathione S-transferase A2 GSTA2 0.0058
88 Retinoic acid receptor RXR-beta RXRB 0.0058
436 5-hydroxytryptamine 2B receptor HTR2B 0.0056
357 Carbonic anhydrase 2 CA2 0.0056
144 Hemoglobin subunit alpha HBA1 0.0056
26 Vascular endothelial growth factor receptor 3 FLT4 0.0055
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0055
427 Substance-P receptor TACR1 0.0054
407 Vascular endothelial growth factor receptor 2 KDR 0.0054
84 Nuclear receptor 0B1 NR0B1 0.0053
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0053
6138 Multidrug resistance protein 3 ABCB4 0.0053
32 Vascular endothelial growth factor receptor 1 FLT1 0.0053
856 Vitamin D3 receptor VDR 0.0053
49 Endothelin B receptor EDNRB 0.0052
1192 Sulfotransferase 1A1 SULT1A1 0.0052
4122 Histone deacetylase 2 HDAC2 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.005
6126 Carbonic anhydrase 7 CA7 0.005
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
517 Alcohol dehydrogenase 1C ADH1C 0.0049
459 Retinoic acid receptor RXR-alpha RXRA 0.0049
952 Dipeptidyl peptidase 4 DPP4 0.0048
6432 Transporter snf 0.0048
68 Cannabinoid receptor 1 CNR1 0.0048
162 Retinoic acid receptor gamma-1 RARG 0.0048
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
1483 Membrane copper amine oxidase AOC3 0.0046
1253 Interferon gamma IFNG 0.0046
284 DNA-directed RNA polymerase beta chain rpoB 0.0046
5773 DNA-directed RNA polymerase beta chain rpoB 0.0046
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0046
2230 Catalase CAT 0.0045
3249 Catalase katA 0.0045
3625 Catalase katA 0.0045
4539 Catalase katA 0.0045
4941 Catalase katB 0.0045
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0045
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0045
814 Ryanodine receptor 1 RYR1 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0045
823 Fibroblast growth factor receptor 2 FGFR2 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
70 Type-1 angiotensin II receptor AGTR1 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0044
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0043
228 Beta platelet-derived growth factor receptor PDGFRB 0.0043
153 Dopamine beta-hydroxylase DBH 0.0043
904 Glutathione S-transferase P GSTP1 0.0043
3830 Calreticulin CALR 0.0043
229 Retinoic acid receptor beta RARB 0.0043
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0043
469 Annexin A1 ANXA1 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
730 Retinoic acid receptor alpha RARA 0.0042
183 Vascular endothelial growth factor A VEGFA 0.0042
267 Plasminogen activator inhibitor 1 SERPINE1 0.0042
518 Peroxidase/catalase T katG 0.0042
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0041
319 Opioid receptor, sigma 1 OPRS1 0.0041
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0041
3937 Fatty-acid amide hydrolase FAAH 0.004
6035 Nuclear receptor ROR-beta RORB 0.004
6034 Hydroxyindole O-methyltransferase ASMT 0.004
6036 Eosinophil peroxidase EPX 0.004
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.004
1618 High affinity nerve growth factor receptor NTRK1 0.004
581 Cytochrome P450 2R1 CYP2R1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1852 Microtubule-associated protein 2 MAP2 0.0039
1256 5-hydroxytryptamine 6 receptor HTR6 0.0038
6221 Steroid hormone receptor ERR1 ESRRA 0.0038
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0038
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0038
85 Growth hormone receptor GHR 0.0038
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
2782 Complement C1s subcomponent C1S 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
365 Dihydrofolate reductase DHFR 0.0037
2381 Dihydrofolate reductase DFR1 0.0037
2833 Dihydrofolate reductase Not Available 0.0037
2931 Dihydrofolate reductase folA 0.0037
3544 Dihydrofolate reductase folA 0.0037
3682 Dihydrofolate reductase folA 0.0037
6642 Dihydrofolate reductase folA 0.0037
6756 Dihydrofolate reductase dfrA 0.0037
163 D(1B) dopamine receptor DRD5 0.0037
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0036
3404 Exotoxin A eta 0.0036
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0036
65 Matrix metalloproteinase-9 Not Available 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0035
765 Indoleamine 2,3-dioxygenase IDO1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
3815 Complement C1q subcomponent subunit A C1QA 0.0034
3816 Complement C1q subcomponent subunit B C1QB 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
3817 Complement C1q subcomponent subunit C C1QC 0.0034
6043 Putative G-protein coupled receptor 44 GPR44 0.0034
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0034
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0034
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0034
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0034
3814 Complement C1r subcomponent C1R 0.0034
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0032
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0032
528 5-hydroxytryptamine 1E receptor HTR1E 0.0032
273 Apoptosis regulator Bcl-2 BCL2 0.0032
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0031
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0031
5923 Microtubule-associated protein tau MAPT 0.0031
5924 Microtubule-associated protein 4 MAP4 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
3601 Dihydropteroate synthase 1 folP1 0.0031
3807 Dihydropteroate synthase 1 folP1 0.0031
3808 Dihydropteroate synthase 2 folP2 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.003
275 Arachidonate 5-lipoxygenase ALOX5 0.003
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0029
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
2298 Cytochrome P450-cam camC 0.0028
4311 tRNA TRDMT1 0.0028
4325 tRNA trmD 0.0028
4328 tRNA trmD 0.0028
6146 High affinity copper uptake protein 1 SLC31A1 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0028
131 Synaptic vesicular amine transporter SLC18A2 0.0028
6085 Fatty acid-binding protein, intestinal FABP2 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0028
1992 Vitamin D-binding protein GC 0.0028
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
908 Glutathione S-transferase theta-1 GSTT1 0.0027
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0027
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
737 Mineralocorticoid receptor NR3C2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0026
1050 Bile salt sulfotransferase SULT2A1 0.0026
976 Platelet glycoprotein IX GP9 0.0026
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0026
1630 Integrin beta-2 ITGB2 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0025
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0025
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0025
239 Coagulation factor X F10 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
358 Cystathionine beta-synthase CBS 0.0025
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0025
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0024
1360 Sphingomyelin phosphodiesterase SMPD1 0.0024
735 Alanine aminotransferase 1 GPT 0.0024
3904 Alanine aminotransferase 2 GPT2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
6167 Organic solute transporter subunit beta OSTB 0.0024
6166 Organic solute transporter subunit alpha OSTA 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
5787 Angiopoietin-1 receptor TEK 0.0023
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0023
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
1262 Corticotropin-lipotropin POMC 0.0023
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0022
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
165 FL cytokine receptor FLT3 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.002
3917 Methylenetetrahydrofolate reductase MTHFR 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.002
106 Cannabinoid receptor 2 CNR2 0.002
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0019
6174 50S ribosomal protein L32 rpmF 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
2981 Phospholipase A2, membrane associated PLA2G2A 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
1196 Complement decay-accelerating factor CD55 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0018
558 Solute carrier family 12 member 1 SLC12A1 0.0018
936 Ephrin type-A receptor 2 EPHA2 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0018
738 Monocarboxylate transporter 1 SLC16A1 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
683 Potassium transporter GK0582 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
6163 Copper-transporting ATPase 2 ATP7B 0.0017
6165 Copper-transporting ATPase 1 ATP7A 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0017
1374 Natriuretic peptides B NPPB 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
2808 Chloramphenicol acetyltransferase 3 cat3 0.0016
1517 Beta-3 adrenergic receptor ADRB3 0.0016
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0016
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0016
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3233 Bile acid receptor NR1H4 0.0015
54 Prothrombin F2 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0015
164 Histamine H4 receptor HRH4 0.0015
2417 Chloramphenicol acetyltransferase cat 0.0015
3278 Chloramphenicol acetyltransferase cat 0.0015
2810 Dr hemagglutinin structural subunit draA 0.0015
1629 Transcription factor AP-1 JUN 0.0015
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0015
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
4192 DNA topoisomerase 2-beta TOP2B 0.0015
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
1541 Metalloproteinase mmp20 0.0014
2207 Rhodopsin RHO 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4103 Proteasome subunit beta type 2 PSMB2 0.0012
4102 Proteasome subunit beta type 5 PSMB5 0.0012
4101 Proteasome subunit beta type 1 PSMB1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
1295 Fatty acid synthase FASN 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
511 5-hydroxytryptamine 1F receptor HTR1F 0.0012
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3221 Cytochrome c4 cc4 0.0011
2236 Casein kinase II subunit alpha CSNK2A1 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
215 Sodium channel protein type 11 subunit alpha SCN11A 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
572 Integrin alpha-L ITGAL 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0009
997 Protein kinase C beta type PRKCB 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
4773 Deoxycytidine kinase DCK 0.0009
2320 Thymidine kinase, cytosolic TK1 0.0009
1864 RET proto-oncogene RET 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
798 Osteocalcin BGLAP 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
6218 Pannexin-1 PANX1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
6459 Glycodelin PAEP 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
1025 Aquaporin-1 AQP1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0007
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
2802 Endoglucanase G celCCG 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2021 Thrombomodulin THBD 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
1830 5'-nucleotidase NT5E 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4943 Cytochrome c6 petJ 0.0004
4984 Neuroglobin NGB 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4909 CooA protein cooA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4972 P450cin cinA 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4961 Hemophore HasA hasA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4952 Catalase/peroxidase katA 0.0004
3093 Catalase HPII katE 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
4920 Peroxidase/catalase katG 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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