DT-Web

DB00751 - Epinastine


Identification
Name Epinastine
Accession Number DB00751 (APRD00043)
Type small molecule
Description Epinastine is used for the prevention of itching associated with allergic conjunctivitis. It has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and H2-receptors to stop itching and provide lasting protection, and 3. prevents the release of proinflammatory chemical mediators from the blood vessel to halt progression of the allergic response.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 249.3104
Groups approved
Monoisotopic Weight 249.126597495
Pharmacology
Indication For the prevention of itching associated with allergic conjunctivitis.
Mechanism of action Epinastine has a multiaction effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and H2-receptors to stop itching and provide lasting protection, and 3. prevents the release of proinflammatory chemical mediators from the blood vessel to halt progression of the allergic response.
Absorption The absolute bioavailability of epinastine is about 40%.
Protein binding 64%
Biotransformation Mainly excreted unchanged, less than 10% metabolized.
Route of elimination Epinastine is mainly excreted unchanged. The renal elimination is mainly via active tubular secretion.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions antagonist
References
  • Tsujii T, Yamamoto E, Ohira T, Saito N, Watanabe S: Effects of sedative and non-sedative H1 antagonists on cognitive tasks: behavioral and near-infrared spectroscopy (NIRS) examinations. Psychopharmacology (Berl). 2007 Sep;194(1):83-91. Epub 2007 May 30. - Pubmed
  • Walther G, Daniel H, Bechtel WD, Brandt K: New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine. Arzneimittelforschung. 1990 Apr;40(4):440-6. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6389
Histamine H2 receptor
Name Histamine H2 receptor
Gene Name HRH2
Pharmacological action yes
Actions antagonist
References
  • Bielory L, Ghafoor S: Histamine receptors and the conjunctiva. Curr Opin Allergy Clin Immunol. 2005 Oct;5(5):437-40. - Pubmed
DTHybrid score 0.5922
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions unknown
References
  • Dupont LJ, Meade CJ, Demedts MG, Verleden GM: Epinastine (WAL 801CL) modulates the noncholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1-like receptor. Eur Respir J. 1996 Jul;9(7):1433-8. - Pubmed
DTHybrid score 0.4942
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions unknown
References
  • Dupont LJ, Meade CJ, Demedts MG, Verleden GM: Epinastine (WAL 801CL) modulates the noncholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1-like receptor. Eur Respir J. 1996 Jul;9(7):1433-8. - Pubmed
DTHybrid score 0.4412
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action unknown
Actions antagonist
References
  • Dupont LJ, Pype JL, Meade CJ, DeLeyn P, Deneffe G, Demedts MG, Verleden GM: Epinastine (WAL 801CL) inhibits the electrical field stimulation-induced cholinergic contraction in guinea pig and human airways in vitro. Eur Respir J. 1999 Nov;14(5):1068-75. - Pubmed
  • Dupont LJ, Meade CJ, Demedts MG, Verleden GM: Epinastine (WAL 801CL) modulates the noncholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1-like receptor. Eur Respir J. 1996 Jul;9(7):1433-8. - Pubmed
DTHybrid score 0.3639
5-hydroxytryptamine 7 receptor
Name 5-hydroxytryptamine 7 receptor
Gene Name HTR7
Pharmacological action unknown
Actions antagonist
References
  • Dupont LJ, Pype JL, Meade CJ, DeLeyn P, Deneffe G, Demedts MG, Verleden GM: Epinastine (WAL 801CL) inhibits the electrical field stimulation-induced cholinergic contraction in guinea pig and human airways in vitro. Eur Respir J. 1999 Nov;14(5):1068-75. - Pubmed
DTHybrid score 0.1972

Enzymes


Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.287
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.56
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6289

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Ishiguro N, Nozawa T, Tsujihata A, Saito A, Kishimoto W, Yokoyama K, Yotsumoto T, Sakai K, Igarashi T, Tamai I: Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier. Drug Metab Dispos. 2004 May;32(5):519-24. - Pubmed
DTHybrid score 0.429

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.2647
831 D(2) dopamine receptor DRD2 0.2414
6016 Cytochrome P450 2C19 CYP2C19 0.2316
4757 Cytochrome P450 2C9 CYP2C9 0.2274
320 5-hydroxytryptamine 1A receptor HTR1A 0.1871
4118 Cytochrome P450 3A5 CYP3A5 0.1862
632 Alpha-1B adrenergic receptor ADRA1B 0.177
23 D(1A) dopamine receptor DRD1 0.1745
590 5-hydroxytryptamine 2C receptor HTR2C 0.1722
378 Alpha-2C adrenergic receptor ADRA2C 0.1613
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1568
4924 Cytochrome P450 2C8 CYP2C8 0.1525
629 Alpha-2B adrenergic receptor ADRA2B 0.1479
6107 Cytochrome P450 3A7 CYP3A7 0.1348
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1318
638 D(3) dopamine receptor DRD3 0.1304
6013 Cytochrome P450 2E1 CYP2E1 0.1245
824 Sodium-dependent serotonin transporter SLC6A4 0.1175
789 Alpha-1D adrenergic receptor ADRA1D 0.1068
432 D(4) dopamine receptor DRD4 0.1039
436 5-hydroxytryptamine 2B receptor HTR2B 0.1002
885 5-hydroxytryptamine 1B receptor HTR1B 0.0914
725 5-hydroxytryptamine 1D receptor HTR1D 0.0897
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0894
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0884
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0842
713 Sodium-dependent dopamine transporter SLC6A3 0.0823
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0819
6145 Solute carrier family 22 member 1 SLC22A1 0.0803
6024 Cytochrome P450 1A1 CYP1A1 0.0789
5718 Cytochrome P450 2A6 CYP2A6 0.0769
766 Beta-2 adrenergic receptor ADRB2 0.0767
163 D(1B) dopamine receptor DRD5 0.0765
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0763
587 Serum albumin ALB 0.0753
193 Beta-1 adrenergic receptor ADRB1 0.0721
1256 5-hydroxytryptamine 6 receptor HTR6 0.0706
6144 Solute carrier family 22 member 2 SLC22A2 0.0691
3923 Cholinesterase BCHE 0.0588
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0588
131 Synaptic vesicular amine transporter SLC18A2 0.0523
341 5-hydroxytryptamine 3 receptor HTR3A 0.0478
118 Organic cation/carnitine transporter 2 SLC22A5 0.0465
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0461
528 5-hydroxytryptamine 1E receptor HTR1E 0.0426
3941 Amine oxidase [flavin-containing] A MAOA 0.0423
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0405
6142 Solute carrier family 22 member 8 SLC22A8 0.0404
6147 Solute carrier family 22 member 3 SLC22A3 0.0397
20 Prostaglandin G/H synthase 1 PTGS1 0.0392
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0384
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.038
6106 Cytochrome P450 2C18 CYP2C18 0.0374
862 Multidrug resistance-associated protein 1 ABCC1 0.0368
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0332
465 Calmodulin CALM1 0.0325
1341 Histamine H3 receptor HRH3 0.031
3811 Cytochrome P450 19A1 CYP19A1 0.0299
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0292
847 Mu-type opioid receptor OPRM1 0.0291
696 Kappa-type opioid receptor OPRK1 0.0288
871 Glucocorticoid receptor NR3C1 0.0285
776 Bile salt export pump ABCB11 0.0282
1729 Solute carrier family 22 member 6 SLC22A6 0.0277
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0273
833 Organic cation/carnitine transporter 1 SLC22A4 0.0271
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0262
1898 Cytochrome P450 1B1 CYP1B1 0.0255
467 Delta-type opioid receptor OPRD1 0.0255
174 Sigma 1-type opioid receptor SIGMAR1 0.0246
731 HIV-1 protease HIV-1 protease 0.024
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0237
1656 CYP2B protein CYP2B 0.0235
3939 Amine oxidase [flavin-containing] B MAOB 0.0231
136 Estrogen receptor ESR1 0.0226
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0223
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0218
164 Histamine H4 receptor HRH4 0.0215
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0214
474 Acetylcholinesterase ACHE 0.0212
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0209
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0207
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0204
94 5-hydroxytryptamine 4 receptor HTR4 0.0199
4120 NADPH--cytochrome P450 reductase POR 0.0193
6182 Cytochrome P450 2J2 CYP2J2 0.0184
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0179
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0177
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0174
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0173
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0171
516 Neurotensin receptor type 2 NTSR2 0.0168
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0167
260 Cytochrome P450 51 ERG11 0.0166
761 Cytochrome P450 51 ERG11 0.0166
3163 Cytochrome P450 51 cyp51 0.0166
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0154
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0153
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.015
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0149
6143 Solute carrier family 22 member 7 SLC22A7 0.0149
4203 Histamine N-methyltransferase HNMT 0.0148
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0148
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0147
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0147
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.014
290 Prostaglandin G/H synthase 2 PTGS2 0.014
817 DNA topoisomerase 2-alpha TOP2A 0.0139
122 P2Y purinoceptor 12 P2RY12 0.0139
468 Cytochrome P450 4A11 CYP4A11 0.0136
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0135
1517 Beta-3 adrenergic receptor ADRB3 0.0134
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0134
3426 Glutamine synthetase glnA 0.0133
3987 Glutamine synthetase GLUL 0.0133
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0128
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0128
2164 Multidrug resistance-associated protein 4 ABCC4 0.0124
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0123
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0122
6432 Transporter snf 0.0122
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0122
4604 Liver carboxylesterase 1 CES1 0.0118
818 50S ribosomal protein L10 rplJ 0.0117
6020 Aldehyde oxidase AOX1 0.0117
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0115
614 Progesterone receptor PGR 0.0113
161 Tubulin beta chain TUBB 0.0112
312 Tubulin beta chain TUB2 0.0112
504 Mast/stem cell growth factor receptor KIT 0.0109
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0108
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0107
828 Phenylalanine-4-hydroxylase PAH 0.0107
3109 Phenylalanine-4-hydroxylase phhA 0.0107
6138 Multidrug resistance protein 3 ABCB4 0.0105
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0103
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0103
232 Corticosteroid-binding globulin SERPINA6 0.0103
146 Androgen receptor AR 0.0102
952 Dipeptidyl peptidase 4 DPP4 0.0102
6031 Cytochrome P450 3A43 CYP3A43 0.0102
844 Epidermal growth factor receptor EGFR 0.0101
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0101
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0101
3810 Catechol O-methyltransferase COMT 0.01
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0099
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0098
1275 Estrogen sulfotransferase SULT1E1 0.0098
3947 Xanthine dehydrogenase/oxidase XDH 0.0097
1636 Trace amine-associated receptor 1 TAAR1 0.0097
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
6137 Multidrug resistance-associated protein 6 ABCC6 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
511 5-hydroxytryptamine 1F receptor HTR1F 0.0097
1024 Solute carrier family 22 member 11 SLC22A11 0.0093
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0093
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0092
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0092
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0091
869 Estrogen receptor beta ESR2 0.009
6148 Multidrug resistance-associated protein 7 ABCC10 0.0087
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0085
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0085
380 Cytochrome P450 17A1 CYP17A1 0.0083
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0083
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0083
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0083
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0083
756 Sex hormone-binding globulin SHBG 0.0082
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0082
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0082
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0081
921 Glutamate receptor 2 GRIA2 0.008
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.008
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.008
29 Tubulin beta-1 chain TUBB1 0.008
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
6136 Multidrug resistance-associated protein 5 ABCC5 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
1192 Sulfotransferase 1A1 SULT1A1 0.0076
923 Glutamate receptor 3 GRIA3 0.0075
6070 Nischarin NISCH 0.0075
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0075
6220 Aryl hydrocarbon receptor AHR 0.0075
1618 High affinity nerve growth factor receptor NTRK1 0.0074
407 Vascular endothelial growth factor receptor 2 KDR 0.0074
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0073
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0073
1353 DNA topoisomerase 1 TOP1 0.0072
3552 DNA topoisomerase 1 topA 0.0072
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0072
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0072
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0072
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0072
26 Vascular endothelial growth factor receptor 3 FLT4 0.0072
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0071
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0071
482 Glycine receptor subunit alpha-1 GLRA1 0.0071
705 Glutamate receptor 1 GRIA1 0.007
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
32 Vascular endothelial growth factor receptor 1 FLT1 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0068
228 Beta platelet-derived growth factor receptor PDGFRB 0.0068
6141 Sodium/bile acid cotransporter SLC10A1 0.0068
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0065
1010 Cytochrome P450 51A1 CYP51A1 0.0065
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0064
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0063
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0063
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0063
811 Translocator protein TSPO 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0063
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0063
891 Dihydropteroate synthase folP 0.0062
5359 Dihydropteroate synthase folP 0.0062
7175 Dihydropteroate synthase sulI 0.0062
4237 50S ribosomal protein L22 rplV 0.0062
2449 Tubulin alpha-3 chain TUBA1A 0.0062
2112 Toll-like receptor 9 TLR9 0.0062
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0062
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0062
537 ATP synthase delta chain, mitochondrial ATP5D 0.0061
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0061
373 Transthyretin TTR 0.006
6097 Protein S100-A2 S100A2 0.006
1810 Protein S100-A1 S100A1 0.006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.006
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
233 Potassium channel subfamily K member 2 KCNK2 0.0059
777 Tumor necrosis factor TNF 0.0059
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0059
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0059
70 Type-1 angiotensin II receptor AGTR1 0.0059
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0058
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0058
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0058
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0058
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0058
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0057
1360 Sphingomyelin phosphodiesterase SMPD1 0.0057
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0056
737 Mineralocorticoid receptor NR3C2 0.0056
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0056
3932 Glutathione S-transferase A2 GSTA2 0.0055
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0055
6506 Stathmin-4 STMN4 0.0055
477 DNA topoisomerase 4 subunit A parC 0.0054
886 DNA topoisomerase 4 subunit A parC 0.0054
6226 DNA topoisomerase 4 subunit A parC 0.0054
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0054
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0053
404 DNA gyrase subunit A gyrA 0.0053
6224 DNA gyrase subunit A gyrA 0.0053
904 Glutathione S-transferase P GSTP1 0.0053
1048 Protein S100-A13 S100A13 0.0052
2226 Protein S100-A12 S100A12 0.0052
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0052
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0051
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0051
856 Vitamin D3 receptor VDR 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.005
80 Peroxisome proliferator-activated receptor alpha PPARA 0.005
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.005
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0049
319 Opioid receptor, sigma 1 OPRS1 0.0049
2132 Protein S100-B S100B 0.0049
173 Toll-like receptor 7 TLR7 0.0049
738 Monocarboxylate transporter 1 SLC16A1 0.0048
6014 Cytochrome P450 2A13 CYP2A13 0.0048
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0048
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
427 Substance-P receptor TACR1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
6859 Protein S100-A4 S100A4 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
68 Cannabinoid receptor 1 CNR1 0.0045
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0045
295 Carbonic anhydrase 1 CA1 0.0045
814 Ryanodine receptor 1 RYR1 0.0045
1629 Transcription factor AP-1 JUN 0.0045
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0044
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0044
1178 Adenosine A2a receptor ADORA2A 0.0044
365 Dihydrofolate reductase DHFR 0.0044
2381 Dihydrofolate reductase DFR1 0.0044
2833 Dihydrofolate reductase Not Available 0.0044
2931 Dihydrofolate reductase folA 0.0044
3544 Dihydrofolate reductase folA 0.0044
3682 Dihydrofolate reductase folA 0.0044
6642 Dihydrofolate reductase folA 0.0044
6756 Dihydrofolate reductase dfrA 0.0044
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
768 FK506-binding protein 1A FKBP1A 0.0042
1852 Microtubule-associated protein 2 MAP2 0.0042
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0042
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0041
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.004
6151 Monocarboxylate transporter 10 SLC16A10 0.004
1262 Corticotropin-lipotropin POMC 0.004
165 FL cytokine receptor FLT3 0.0039
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0039
6085 Fatty acid-binding protein, intestinal FABP2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
284 DNA-directed RNA polymerase beta chain rpoB 0.0039
5773 DNA-directed RNA polymerase beta chain rpoB 0.0039
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0038
592 Carbonic anhydrase 4 CA4 0.0038
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0037
2539 Tubulin alpha-1 chain TUBA4A 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
581 Cytochrome P450 2R1 CYP2R1 0.0037
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0036
1050 Bile salt sulfotransferase SULT2A1 0.0036
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0036
1374 Natriuretic peptides B NPPB 0.0036
1827 Gap junction alpha-1 protein GJA1 0.0036
1908 Vascular cell adhesion protein 1 VCAM1 0.0036
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0034
6102 Arylamine N-acetyltransferase 2 NAT2 0.0034
563 Thyroid peroxidase TPO 0.0034
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0034
4103 Proteasome subunit beta type 2 PSMB2 0.0034
4102 Proteasome subunit beta type 5 PSMB5 0.0034
4101 Proteasome subunit beta type 1 PSMB1 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
183 Vascular endothelial growth factor A VEGFA 0.0033
7 Nitric oxide synthase, inducible NOS2 0.0033
1757 Myeloperoxidase MPO 0.0032
3856 Fibroblast growth factor receptor 3 FGFR3 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
5787 Angiopoietin-1 receptor TEK 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
6824 Tyrosine-protein kinase Lyn LYN 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1630 Integrin beta-2 ITGB2 0.003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.003
239 Coagulation factor X F10 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.003
84 Nuclear receptor 0B1 NR0B1 0.003
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
4773 Deoxycytidine kinase DCK 0.0029
780 Retinoic acid receptor RXR-gamma RXRG 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
469 Annexin A1 ANXA1 0.0028
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0028
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0027
4122 Histone deacetylase 2 HDAC2 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
16 Adenosine A1 receptor ADORA1 0.0026
605 Fumarate reductase flavoprotein subunit frdA 0.0026
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0026
3673 Fumarate reductase flavoprotein subunit fccA 0.0026
4912 Fumarate reductase flavoprotein subunit ifcA 0.0026
6549 Fumarate reductase flavoprotein subunit frdA 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
88 Retinoic acid receptor RXR-beta RXRB 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0026
49 Endothelin B receptor EDNRB 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
1992 Vitamin D-binding protein GC 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
823 Fibroblast growth factor receptor 2 FGFR2 0.0025
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0024
275 Arachidonate 5-lipoxygenase ALOX5 0.0024
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0023
936 Ephrin type-A receptor 2 EPHA2 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
3809 Estrogen-related receptor gamma ESRRG 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0022
3404 Exotoxin A eta 0.0022
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0022
291 Nitric-oxide synthase, endothelial NOS3 0.0022
298 Renin REN 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
4311 tRNA TRDMT1 0.0021
4325 tRNA trmD 0.0021
4328 tRNA trmD 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0021
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0021
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0021
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0021
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0021
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0021
6146 High affinity copper uptake protein 1 SLC31A1 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
564 Cellular retinoic acid-binding protein 1 CRABP1 0.002
6126 Carbonic anhydrase 7 CA7 0.002
5934 Cytochrome P450 26A1 CYP26A1 0.002
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.002
273 Apoptosis regulator Bcl-2 BCL2 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
54 Prothrombin F2 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
518 Peroxidase/catalase T katG 0.0018
3937 Fatty-acid amide hydrolase FAAH 0.0018
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5798 Mitogen-activated protein kinase 11 MAPK11 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
5923 Microtubule-associated protein tau MAPT 0.0018
5924 Microtubule-associated protein 4 MAP4 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
908 Glutathione S-transferase theta-1 GSTT1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
444 Alcohol dehydrogenase 1B ADH1B 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
976 Platelet glycoprotein IX GP9 0.0017
896 Glutathione S-transferase Mu 1 GSTM1 0.0017
162 Retinoic acid receptor gamma-1 RARG 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
2216 Fibroblast growth factor receptor 4 FGFR4 0.0016
2207 Rhodopsin RHO 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
3233 Bile acid receptor NR1H4 0.0015
4192 DNA topoisomerase 2-beta TOP2B 0.0015
251 Alcohol dehydrogenase 1A ADH1A 0.0015
6755 Poliovirus receptor PVR 0.0015
3957 Adenosine deaminase ADA 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
1541 Metalloproteinase mmp20 0.0014
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
6044 Serum paraoxonase/lactonase 3 PON3 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
153 Dopamine beta-hydroxylase DBH 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
572 Integrin alpha-L ITGAL 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
267 Plasminogen activator inhibitor 1 SERPINE1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2981 Phospholipase A2, membrane associated PLA2G2A 0.0013
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
1864 RET proto-oncogene RET 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0012
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0012
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0012
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
1295 Fatty acid synthase FASN 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6221 Steroid hormone receptor ERR1 ESRRA 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0011
6165 Copper-transporting ATPase 1 ATP7A 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1039 Histone deacetylase 9 HDAC9 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6459 Glycodelin PAEP 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
4116 Dihydropteroate synthetase Not Available 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
4217 Telomerase reverse transcriptase TERT 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.001
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.001
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
1648 Elastin ELN 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0008
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
2298 Cytochrome P450-cam camC 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
6218 Pannexin-1 PANX1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
3221 Cytochrome c4 cc4 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
33 Cystine/glutamate transporter SLC7A11 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2021 Thrombomodulin THBD 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4943 Cytochrome c6 petJ 0.0004
4984 Neuroglobin NGB 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4909 CooA protein cooA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4972 P450cin cinA 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4961 Hemophore HasA hasA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4952 Catalase/peroxidase katA 0.0004
3093 Catalase HPII katE 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
4920 Peroxidase/catalase katG 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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