DT-Web: DB00834

Identification

Name

Mifepristone

Accession Number

DB00834 (APRD00432)

Type

small molecule

Description

A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome [PubChem]. The two marketed forms of mifepristone are Mifeprex(R) (mifepristone 200mg) and Korlym(TM) (mifepristone 300mg).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

429.5937

Groups

approved

Monoisotopic Weight

429.266779369

Pharmacology

Indication

For the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.

Mechanism of action

The anti-progestational activity of mifepristone results from competitive interaction with progesterone at progesterone-receptor sites. Based on studies with various oral doses in several animal species (mouse, rat, rabbit and monkey), the compound inhibits the activity of endogenous or exogenous progesterone. The termination of pregnancy results. In the treatment of Cushing's syndrome, Mifepristone blocks the binding of cortisol to its receptor. It does not decrease cortisol production but reduces the effects of excess cortisol, such as high blood sugar levels.

Absorption

The absolute bioavailability of a 20 mg oral dose is 69%

Protein binding

98% (bound to plasma proteins, albumin and a 1-acid glycoprotein)

Biotransformation

Hepatic. Hepatic, by Cytochrome P450 3A4 isoenzyme to the N-monodemethylated metabolite (RU 42 633); RU 42 698, which results from the loss of two methyl groups from position 11 beta; and RU 42 698, which results from terminal hydroxylation of the 17–propynyl chain.

Route of elimination

Fecal: 83%; Renal: 9%.

Toxicity

Nearly all of the women who receive mifepristone will report adverse reactions, and many can be expected to report more than one such reaction. About 90% of patients report adverse reactions following administration of misoprostol on day three of the treatment procedure. Side effects include more heavy bleeding than a heavy menstrual period, abdominal pain, uterine cramping, nausea, vomiting, and diarrhea.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Dabigatran etexilate	May lead to excessive post-abortion bleeding in patients on anticoagulant therapy. Concomitant therapy is contraindicated.
Degarelix	Enhance QTc-prolonging effect
Etravirine	Mifepristone, when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy.
Pasireotide	Avoid combination with mifepristone and other moderate to high risk QTc prolonging agents. The combinaton may enhance the QTc-prolonging effect of these drugs.
Tofacitinib	Mifepristone, when used in combination with tofacitinib, may increase tofacitinib concentrations. It is recommended to adjust therapy by using a minimized dose of tofacitinib, and monitoring for increased tofacitinib concentrations and signs of toxicity, during and 2 weeks after discontinuation of mifepristone therapy.

Food Interactions

Not Available

Progesterone receptor
Name	Progesterone receptor
Gene Name	PGR
Pharmacological action	yes
Actions	antagonist
References	Greb RR, Kiesel L, Selbmann AK, Wehrmann M, Hodgen GD, Goodman AL, Wallwiener D: Disparate actions of mifepristone (RU 486) on glands and stroma in the primate endometrium. Hum Reprod. 1999 Jan;14(1):198-206. - Pubmed Sun M, Zhu G, Zhou L: [Effect of mifepristone on the expression of progesterone receptor messenger RNA and protein in uterine leiomyomata] Zhonghua Fu Chan Ke Za Zhi. 1998 Apr;33(4):227-31. - Pubmed Hazra BG, Basu S, Pore VS, Joshi PL, Pal D, Chakrabarti P: Synthesis of 11beta-(4-dimethylaminophenyl)-17beta-hydroxy-17alpha- (3-methyl-1-butynyl)-4, 9-estradien-3-one and 11beta-(4-acetophenyl)- 17beta-hydroxy-17alpha-(3-methyl-1-butynyl)-4, 9-estradien-3-one: two new analogs of mifepristone (RU-486). Steroids. 2000 Mar;65(3):157-62. - Pubmed Gao Y, Cheng L, Liu Y: [Failure of mifepristone induced interruption of pregnancy: point mutation at genetic codon 722 in human progesterone receptor gene] Zhonghua Fu Chan Ke Za Zhi. 1998 Sep;33(9):549-52. - Pubmed Jiang J, Wu R, Wang Z: [Effects of mifepristone on expression of estrogen receptor and progesterone receptor in cultured human eutopic and ectopic endometria] Zhonghua Fu Chan Ke Za Zhi. 2001 Apr;36(4):218-21. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6162
Glucocorticoid receptor
Name	Glucocorticoid receptor
Gene Name	NR3C1
Pharmacological action	yes
Actions	antagonist
References	LeVan TD, Babin EA, Yamamura HI, Bloom JW: Pharmacological characterization of glucocorticoid receptors in primary human bronchial epithelial cells. Biochem Pharmacol. 1999 May 1;57(9):1003-9. - Pubmed Attardi BJ, Burgenson J, Hild SA, Reel JR: In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88. - Pubmed Aida K, Shi Q, Wang J, VandeBerg JL, McDonald T, Nathanielsz P, Wang XL: The effects of betamethasone (BM) on endothelial nitric oxide synthase (eNOS) expression in adult baboon femoral arterial endothelial cells. J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):219-24. - Pubmed Gu G, Hentunen TA, Nars M, Harkonen PL, Vaananen HK: Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis. Apoptosis. 2005 May;10(3):583-95. - Pubmed de Pablos RM, Villaran RF, Arguelles S, Herrera AJ, Venero JL, Ayala A, Cano J, Machado A: Stress increases vulnerability to inflammation in the rat prefrontal cortex. J Neurosci. 2006 May 24;26(21):5709-19. - Pubmed
DTHybrid score	0.8549

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7298
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4164
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.33
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4221

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor,inducer
References	Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem. 2001 May 4;276(18):14581-7. Epub 2001 Jan 31. - Pubmed Lecureur V, Fardel O, Guillouzo A: The antiprogestatin drug RU 486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P-glycoprotein function. FEBS Lett. 1994 Nov 28;355(2):187-91. - Pubmed
DTHybrid score	0.4748
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Payen L, Delugin L, Courtois A, Trinquart Y, Guillouzo A, Fardel O: Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486. Biochem Biophys Res Commun. 1999 May 19;258(3):513-8. - Pubmed
DTHybrid score	0.205

Id	Partner name	Gene Name	Score
232	Corticosteroid-binding globulin	SERPINA6	0.2664
4757	Cytochrome P450 2C9	CYP2C9	0.2167
6016	Cytochrome P450 2C19	CYP2C19	0.206
4924	Cytochrome P450 2C8	CYP2C8	0.1926
4200	Cytochrome P450 1A2	CYP1A2	0.1914
136	Estrogen receptor	ESR1	0.1593
6030	Cytochrome P450 2B6	CYP2B6	0.1243
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1131
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.106
6024	Cytochrome P450 1A1	CYP1A1	0.0961
6013	Cytochrome P450 2E1	CYP2E1	0.0956
587	Serum albumin	ALB	0.0812
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0769
146	Androgen receptor	AR	0.0747
737	Mineralocorticoid receptor	NR3C2	0.0679
5718	Cytochrome P450 2A6	CYP2A6	0.0673
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0626
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0609
492	Histamine H1 receptor	HRH1	0.0592
3811	Cytochrome P450 19A1	CYP19A1	0.0558
2202	Steryl-sulfatase	STS	0.0552
776	Bile salt export pump	ABCB11	0.0552
6145	Solute carrier family 22 member 1	SLC22A1	0.0538
824	Sodium-dependent serotonin transporter	SLC6A4	0.053
831	D(2) dopamine receptor	DRD2	0.0466
847	Mu-type opioid receptor	OPRM1	0.046
556	Alpha-1A adrenergic receptor	ADRA1A	0.0449
469	Annexin A1	ANXA1	0.0447
6144	Solute carrier family 22 member 2	SLC22A2	0.0447
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0446
1898	Cytochrome P450 1B1	CYP1B1	0.0443
1729	Solute carrier family 22 member 6	SLC22A6	0.0441
756	Sex hormone-binding globulin	SHBG	0.044
817	DNA topoisomerase 2-alpha	TOP2A	0.0439
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0425
723	Cytosolic phospholipase A2	PLA2G4A	0.0417
731	HIV-1 protease	HIV-1 protease	0.0406
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0384
6106	Cytochrome P450 2C18	CYP2C18	0.0383
20	Prostaglandin G/H synthase 1	PTGS1	0.0374
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0372
118	Organic cation/carnitine transporter 2	SLC22A5	0.0368
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0359
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0353
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0351
766	Beta-2 adrenergic receptor	ADRB2	0.0351
3923	Cholinesterase	BCHE	0.0345
6031	Cytochrome P450 3A43	CYP3A43	0.0341
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0336
467	Delta-type opioid receptor	OPRD1	0.0329
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0328
290	Prostaglandin G/H synthase 2	PTGS2	0.0326
193	Beta-1 adrenergic receptor	ADRB1	0.0323
6143	Solute carrier family 22 member 7	SLC22A7	0.0312
6148	Multidrug resistance-associated protein 7	ABCC10	0.0304
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0303
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0298
318	Alpha-2A adrenergic receptor	ADRA2A	0.0297
2164	Multidrug resistance-associated protein 4	ABCC4	0.0293
696	Kappa-type opioid receptor	OPRK1	0.0293
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0287
6147	Solute carrier family 22 member 3	SLC22A3	0.0283
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0279
6142	Solute carrier family 22 member 8	SLC22A8	0.0274
632	Alpha-1B adrenergic receptor	ADRA1B	0.0272
713	Sodium-dependent dopamine transporter	SLC6A3	0.027
23	D(1A) dopamine receptor	DRD1	0.0265
6137	Multidrug resistance-associated protein 6	ABCC6	0.0264
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0258
638	D(3) dopamine receptor	DRD3	0.0255
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0251
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0247
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0245
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.024
6241	Nuclear receptor coactivator 2	NCOA2	0.0236
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0225
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0224
4604	Liver carboxylesterase 1	CES1	0.0223
6182	Cytochrome P450 2J2	CYP2J2	0.0222
380	Cytochrome P450 17A1	CYP17A1	0.0221
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.022
833	Organic cation/carnitine transporter 1	SLC22A4	0.0215
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0215
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0212
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0212
260	Cytochrome P450 51	ERG11	0.0204
761	Cytochrome P450 51	ERG11	0.0204
3163	Cytochrome P450 51	cyp51	0.0204
6141	Sodium/bile acid cotransporter	SLC10A1	0.0196
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0194
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0193
161	Tubulin beta chain	TUBB	0.0193
312	Tubulin beta chain	TUB2	0.0193
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0192
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0191
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0187
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
844	Epidermal growth factor receptor	EGFR	0.0178
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0177
629	Alpha-2B adrenergic receptor	ADRA2B	0.0177
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0177
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0177
465	Calmodulin	CALM1	0.0177
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0176
29	Tubulin beta-1 chain	TUBB1	0.0175
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0174
378	Alpha-2C adrenergic receptor	ADRA2C	0.0174
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0169
952	Dipeptidyl peptidase 4	DPP4	0.0168
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0167
477	DNA topoisomerase 4 subunit A	parC	0.0166
886	DNA topoisomerase 4 subunit A	parC	0.0166
6226	DNA topoisomerase 4 subunit A	parC	0.0166
468	Cytochrome P450 4A11	CYP4A11	0.0165
404	DNA gyrase subunit A	gyrA	0.0164
6224	DNA gyrase subunit A	gyrA	0.0164
789	Alpha-1D adrenergic receptor	ADRA1D	0.0164
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0164
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0163
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0163
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0161
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0159
432	D(4) dopamine receptor	DRD4	0.0157
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0154
3941	Amine oxidase [flavin-containing] A	MAOA	0.0144
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0144
1024	Solute carrier family 22 member 11	SLC22A11	0.0143
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0143
6136	Multidrug resistance-associated protein 5	ABCC5	0.0143
381	Prolactin receptor	PRLR	0.0142
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0141
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0136
504	Mast/stem cell growth factor receptor	KIT	0.0135
1649	Small inducible cytokine A2	CCL2	0.0134
4120	NADPH--cytochrome P450 reductase	POR	0.0134
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.013
3307	Acriflavine resistance protein B	acrB	0.013
4237	50S ribosomal protein L22	rplV	0.013
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0128
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0126
474	Acetylcholinesterase	ACHE	0.0126
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0123
738	Monocarboxylate transporter 1	SLC16A1	0.0122
818	50S ribosomal protein L10	rplJ	0.0122
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0122
4238	50S ribosomal protein L4	rplD	0.012
5578	50S ribosomal protein L4	rplD	0.012
6173	50S ribosomal protein L4	rplD	0.012
6219	50S ribosomal protein L4	rplD	0.012
716	5-hydroxytryptamine 7 receptor	HTR7	0.012
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0119
1852	Microtubule-associated protein 2	MAP2	0.0119
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0117
811	Translocator protein	TSPO	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
124	Histamine H2 receptor	HRH2	0.0113
3939	Amine oxidase [flavin-containing] B	MAOB	0.0111
226	Gonadotropin-releasing hormone receptor	GNRHR	0.011
26	Vascular endothelial growth factor receptor 3	FLT4	0.0108
273	Apoptosis regulator Bcl-2	BCL2	0.0107
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0107
407	Vascular endothelial growth factor receptor 2	KDR	0.0106
869	Estrogen receptor beta	ESR2	0.0105
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0105
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0105
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0104
32	Vascular endothelial growth factor receptor 1	FLT1	0.0103
5923	Microtubule-associated protein tau	MAPT	0.0102
5924	Microtubule-associated protein 4	MAP4	0.0102
2539	Tubulin alpha-1 chain	TUBA4A	0.0102
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0101
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0101
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0101
1050	Bile salt sulfotransferase	SULT2A1	0.0101
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0101
6220	Aryl hydrocarbon receptor	AHR	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0099
163	D(1B) dopamine receptor	DRD5	0.0099
1353	DNA topoisomerase 1	TOP1	0.0099
3552	DNA topoisomerase 1	topA	0.0099
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0098
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0098
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0098
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0097
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0096
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0094
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0093
4615	Chain A, Red Copper Protein Nitrosocyanin	NE0143	0.0093
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0093
1656	CYP2B protein	CYP2B	0.0092
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
122	P2Y purinoceptor 12	P2RY12	0.0092
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0091
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0091
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0091
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0091
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0091
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.009
94	5-hydroxytryptamine 4 receptor	HTR4	0.0089
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0089
3947	Xanthine dehydrogenase/oxidase	XDH	0.0088
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0088
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0087
777	Tumor necrosis factor	TNF	0.0087
131	Synaptic vesicular amine transporter	SLC18A2	0.0086
6020	Aldehyde oxidase	AOX1	0.0086
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0086
2449	Tubulin alpha-3 chain	TUBA1A	0.0085
1010	Cytochrome P450 51A1	CYP51A1	0.0085
373	Transthyretin	TTR	0.0085
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0084
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0083
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0082
1192	Sulfotransferase 1A1	SULT1A1	0.0082
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.008
2112	Toll-like receptor 9	TLR9	0.008
6138	Multidrug resistance protein 3	ABCB4	0.008
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0079
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0077
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0077
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0077
244	Angiotensin-converting enzyme	ACE	0.0076
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0076
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0076
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0076
165	FL cytokine receptor	FLT3	0.0075
6085	Fatty acid-binding protein, intestinal	FABP2	0.0074
427	Substance-P receptor	TACR1	0.0074
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0074
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
705	Glutamate receptor 1	GRIA1	0.0072
4773	Deoxycytidine kinase	DCK	0.0072
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0071
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0071
6500	Phospholipase A2	PLA2G1B	0.0071
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.007
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.007
5251	Carbonyl reductase [NADPH] 1	CBR1	0.007
1629	Transcription factor AP-1	JUN	0.0069
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0069
2300	Lysozyme	E	0.0068
3633	Lysozyme	R	0.0068
5597	Lysozyme	17	0.0068
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0068
1758	GTPase HRas	HRAS	0.0068
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0068
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0068
5787	Angiopoietin-1 receptor	TEK	0.0068
84	Nuclear receptor 0B1	NR0B1	0.0067
814	Ryanodine receptor 1	RYR1	0.0067
4192	DNA topoisomerase 2-beta	TOP2B	0.0067
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0067
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0067
70	Type-1 angiotensin II receptor	AGTR1	0.0066
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0066
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0066
461	Glycine receptor subunit alpha-3	GLRA3	0.0065
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0064
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0062
1178	Adenosine A2a receptor	ADORA2A	0.0062
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0062
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0061
319	Opioid receptor, sigma 1	OPRS1	0.006
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0059
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0058
239	Coagulation factor X	F10	0.0058
1517	Beta-3 adrenergic receptor	ADRB3	0.0058
33	Cystine/glutamate transporter	SLC7A11	0.0057
284	DNA-directed RNA polymerase beta chain	rpoB	0.0057
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
3932	Glutathione S-transferase A2	GSTA2	0.0056
4203	Histamine N-methyltransferase	HNMT	0.0055
904	Glutathione S-transferase P	GSTP1	0.0055
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0055
6506	Stathmin-4	STMN4	0.0055
6102	Arylamine N-acetyltransferase 2	NAT2	0.0054
183	Vascular endothelial growth factor A	VEGFA	0.0054
6212	Tubulin gamma-1 chain	TUBG1	0.0053
6210	Tubulin delta chain	TUBD1	0.0053
6211	Tubulin epsilon chain	TUBE1	0.0053
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0052
365	Dihydrofolate reductase	DHFR	0.0052
2381	Dihydrofolate reductase	DFR1	0.0052
2833	Dihydrofolate reductase	Not Available	0.0052
2931	Dihydrofolate reductase	folA	0.0052
3544	Dihydrofolate reductase	folA	0.0052
3682	Dihydrofolate reductase	folA	0.0052
6642	Dihydrofolate reductase	folA	0.0052
6756	Dihydrofolate reductase	dfrA	0.0052
5300	Antigen peptide transporter 1	TAP1	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
174	Sigma 1-type opioid receptor	SIGMAR1	0.005
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.005
3868	Calcineurin subunit B isoform 2	PPP3R2	0.005
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.005
295	Carbonic anhydrase 1	CA1	0.005
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0049
173	Toll-like receptor 7	TLR7	0.0049
1483	Membrane copper amine oxidase	AOC3	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0047
6014	Cytochrome P450 2A13	CYP2A13	0.0047
6149	Solute carrier family 22 member 10	SLC22A10	0.0047
6043	Putative G-protein coupled receptor 44	GPR44	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0046
3086	Plasmepsin-2	Not Available	0.0046
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
7	Nitric oxide synthase, inducible	NOS2	0.0045
68	Cannabinoid receptor 1	CNR1	0.0045
6167	Organic solute transporter subunit beta	OSTB	0.0045
6166	Organic solute transporter subunit alpha	OSTA	0.0045
54	Prothrombin	F2	0.0045
16	Adenosine A1 receptor	ADORA1	0.0044
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0044
4122	Histone deacetylase 2	HDAC2	0.0043
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0043
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0043
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0043
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0043
1618	High affinity nerve growth factor receptor	NTRK1	0.0043
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
992	Protein tyrosine kinase 2 beta	PTK2B	0.0042
2599	Tyrosine-protein kinase HCK	HCK	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1630	Integrin beta-2	ITGB2	0.0041
976	Platelet glycoprotein IX	GP9	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
856	Vitamin D3 receptor	VDR	0.004
908	Glutathione S-transferase theta-1	GSTT1	0.004
3856	Fibroblast growth factor receptor 3	FGFR3	0.004
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.004
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0039
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0039
6432	Transporter	snf	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0039
592	Carbonic anhydrase 4	CA4	0.0038
6824	Tyrosine-protein kinase Lyn	LYN	0.0038
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0037
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0037
4311	tRNA	TRDMT1	0.0037
4325	tRNA	trmD	0.0037
4328	tRNA	trmD	0.0037
275	Arachidonate 5-lipoxygenase	ALOX5	0.0037
823	Fibroblast growth factor receptor 2	FGFR2	0.0037
891	Dihydropteroate synthase	folP	0.0037
5359	Dihydropteroate synthase	folP	0.0037
7175	Dihydropteroate synthase	sulI	0.0037
3809	Estrogen-related receptor gamma	ESRRG	0.0037
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0036
2808	Chloramphenicol acetyltransferase 3	cat3	0.0036
702	UMP-CMP kinase	CMPK1	0.0036
24	Thymidylate synthase	TMP1	0.0036
359	Thymidylate synthase	TYMS	0.0036
2626	Thymidylate synthase	thyA	0.0036
2729	Thymidylate synthase	thyA	0.0036
5352	Thymidylate synthase	THYA	0.0036
153	Dopamine beta-hydroxylase	DBH	0.0036
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6048	Troponin C, skeletal muscle	TNNC2	0.0035
780	Retinoic acid receptor RXR-gamma	RXRG	0.0035
489	Monocarboxylate transporter 2	SLC16A7	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0034
4103	Proteasome subunit beta type 2	PSMB2	0.0034
4102	Proteasome subunit beta type 5	PSMB5	0.0034
4101	Proteasome subunit beta type 1	PSMB1	0.0034
6044	Serum paraoxonase/lactonase 3	PON3	0.0034
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0033
3587	Gastrotropin	FABP6	0.0033
3601	Dihydropteroate synthase 1	folP1	0.0033
3807	Dihydropteroate synthase 1	folP1	0.0033
3808	Dihydropteroate synthase 2	folP2	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0033
6837	Serine/threonine-protein kinase 17B	STK17B	0.0033
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0032
2810	Dr hemagglutinin structural subunit	draA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0032
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0032
88	Retinoic acid receptor RXR-beta	RXRB	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
572	Integrin alpha-L	ITGAL	0.0031
1757	Myeloperoxidase	MPO	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
6228	Nuclear receptor coactivator 1	NCOA1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
1864	RET proto-oncogene	RET	0.003
342	P protein [Includes: DNA-directed DNA polymerase	P	0.003
612	P protein [Includes: DNA-directed DNA polymerase	P	0.003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.003
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.003
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0029
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0029
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0029
357	Carbonic anhydrase 2	CA2	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0029
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0028
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0028
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0028
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0027
921	Glutamate receptor 2	GRIA2	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
3810	Catechol O-methyltransferase	COMT	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0027
1650	Heme carrier protein 1	SLC46A1	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0026
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0026
5626	Nucleoside diphosphate kinase B	NME2	0.0026
2216	Fibroblast growth factor receptor 4	FGFR4	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
49	Endothelin B receptor	EDNRB	0.0026
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0025
2021	Thrombomodulin	THBD	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0025
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0025
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0024
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0024
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0024
6218	Pannexin-1	PANX1	0.0024
6168	Solute carrier family 22 member 16	SLC22A16	0.0024
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0023
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0023
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0023
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0023
936	Ephrin type-A receptor 2	EPHA2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0023
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0023
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
1262	Corticotropin-lipotropin	POMC	0.0022
162	Retinoic acid receptor gamma-1	RARG	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
5294	Nucleoside diphosphate kinase A	NME1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
1313	Lactoylglutathione lyase	GLO1	0.0022
298	Renin	REN	0.0021
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
569	Retinal dehydrogenase 2	ALDH1A2	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
267	Plasminogen activator inhibitor 1	SERPINE1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
291	Nitric-oxide synthase, endothelial	NOS3	0.002
6126	Carbonic anhydrase 7	CA7	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
751	Potassium channel subfamily K member 6	KCNK6	0.002
164	Histamine H4 receptor	HRH4	0.002
482	Glycine receptor subunit alpha-1	GLRA1	0.002
611	Retinal dehydrogenase 1	ALDH1A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0019
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0019
65	Matrix metalloproteinase-9	Not Available	0.0019
6042	Prostaglandin reductase 2	PTGR2	0.0019
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
5818	Folate receptor alpha	FOLR1	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
6221	Steroid hormone receptor ERR1	ESRRA	0.0018
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
172	Potassium channel subfamily K member 1	KCNK1	0.0018
4041	Microsomal glutathione S-transferase 2	MGST2	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
2391	Ferrochelatase	hemH	0.0018
6502	Ferrochelatase	DKFZp686P18130	0.0018
1591	Ferrochelatase, mitochondrial	FECH	0.0018
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0018
1792	Tissue-type plasminogen activator	PLAT	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
896	Glutathione S-transferase Mu 1	GSTM1	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0017
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0017
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
518	Peroxidase/catalase T	katG	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
76	Nitric-oxide synthase, brain	NOS1	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
293	Gamma-glutamyl hydrolase	GGH	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0016
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0016
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0016
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0015
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0015
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0015
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0015
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0015
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0015
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0015
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0015
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
3233	Bile acid receptor	NR1H4	0.0015
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0015
6558	Cytochrome c oxidase subunit 1	ctaD	0.0015
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0015
6755	Poliovirus receptor	PVR	0.0015
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0015
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0015
3957	Adenosine deaminase	ADA	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
563	Thyroid peroxidase	TPO	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
4031	Glutathione S-transferase A1	GSTA1	0.0014
1541	Metalloproteinase	mmp20	0.0014
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
2540	Choloylglycine hydrolase	cbh	0.0014
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
6501	Fatty acid-binding protein, liver	FABP1	0.0013
6146	High affinity copper uptake protein 1	SLC31A1	0.0013
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0013
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0013
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
517	Alcohol dehydrogenase 1C	ADH1C	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1275	Estrogen sulfotransferase	SULT1E1	0.0012
1295	Fatty acid synthase	FASN	0.0012
6151	Monocarboxylate transporter 10	SLC16A10	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
1992	Vitamin D-binding protein	GC	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0011
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6459	Glycodelin	PAEP	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3937	Fatty-acid amide hydrolase	FAAH	0.001
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4217	Telomerase reverse transcriptase	TERT	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
2207	Rhodopsin	RHO	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
1928	Leukotriene C4 synthase	LTC4S	0.001
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.001
4034	Glutaredoxin-1	GLRX	0.001
910	Epididymal secretory glutathione peroxidase	GPX5	0.001
4036	Glutathione peroxidase 6	GPX6	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
4029	Microsomal glutathione S-transferase 3	MGST3	0.001
900	Glutathione S-transferase A4	GSTA4	0.001
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.001
911	Glutathione peroxidase 3	GPX3	0.001
4040	Glutathione peroxidase 7	GPX7	0.001
907	Glutathione peroxidase 2	GPX2	0.001
4032	Microsomal glutathione S-transferase 1	MGST1	0.001
906	Glutathione peroxidase 1	GPX1	0.001
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.001
4035	Glutathione S-transferase Mu 5	GSTM5	0.001
903	Glutathione S-transferase A5	GSTA5	0.001
4042	Glutathione transferase omega-2	GSTO2	0.001
4033	S-formylglutathione hydrolase	ESD	0.001
4038	Glutathione peroxidase 4	GPX4	0.001
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.001
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.001
1039	Histone deacetylase 9	HDAC9	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
898	Glutathione S-transferase A3	GSTA3	0.0009
897	Glutathione S-transferase kappa 1	GSTK1	0.0009
909	Maleylacetoacetate isomerase	GSTZ1	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
899	Glutathione S-transferase Mu 3	GSTM3	0.0008
905	Glutathione transferase omega-1	GSTO1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
2165	Glutathione S-transferase Mu 2	GSTM2	0.0008
1593	Mucin-2	MUC2	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
207	Glutathione synthetase	GSS	0.0008
5269	Glutathione synthetase	gshB	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
901	Glutathione S-transferase Mu 4	GSTM4	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
1830	5'-nucleotidase	NT5E	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
714	Glutathione reductase, mitochondrial	GSR	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00834 - Mifepristone

Targets

Enzymes

Transporters

Predictions