DT-Web

DB08607 - (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE


Identification
Name (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
Accession Number DB08607
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 441.54
Groups experimental
Monoisotopic Weight 441.160993669
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.1687

Carriers


Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.0866
4819 Hydrolase Not Available 0.073
5249 Hydrolase Not Available 0.073
5436 Hydrolase Not Available 0.073
3089 Lipase 1 LIP1 0.073
4512 Cytochrome P450 3A4 CYP3A4 0.067
6258 Protein S100-A7 S100A7 0.0549
2853 14 kDa fatty acid-binding protein Not Available 0.0487
6016 Cytochrome P450 2C19 CYP2C19 0.0478
4119 Cytochrome P450 2D6 CYP2D6 0.0427
1588 Multidrug resistance protein 1 ABCB1 0.0415
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0383
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0383
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0383
587 Serum albumin ALB 0.037
3617 Non-heme chloroperoxidase cpo 0.0365
5426 Non-heme chloroperoxidase cpo 0.0365
2211 Fatty acid-binding protein, heart FABP3 0.0337
4200 Cytochrome P450 1A2 CYP1A2 0.032
4037 Hypothetical protein GPX1 0.032
4297 Hypothetical protein SP_1951 0.032
4521 Hypothetical protein BC_2969 0.032
4540 Hypothetical protein TM_1070 0.032
4555 Hypothetical protein MT1739 0.032
4569 Hypothetical protein mshD 0.032
4578 Hypothetical protein PA3270 0.032
4747 Hypothetical protein PA3967 0.032
5177 Hypothetical protein TM_0096 0.032
5194 Hypothetical protein PA1204 0.032
5240 Hypothetical protein Rv2991 0.032
5370 Hypothetical protein TM_1158 0.032
5710 Hypothetical protein Tb927.5.1360 0.032
4532 Gephyrin GPHN 0.0317
6677 Myelin P2 protein PMP2 0.0316
4118 Cytochrome P450 3A5 CYP3A5 0.0315
20 Prostaglandin G/H synthase 1 PTGS1 0.0298
6030 Cytochrome P450 2B6 CYP2B6 0.0294
6085 Fatty acid-binding protein, intestinal FABP2 0.0289
373 Transthyretin TTR 0.0259
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0248
894 Alanine racemase alr 0.0241
2453 Alanine racemase alr 0.0241
6107 Cytochrome P450 3A7 CYP3A7 0.0231
6013 Cytochrome P450 2E1 CYP2E1 0.0228
6501 Fatty acid-binding protein, liver FABP1 0.0185
3382 Glycolipid transfer protein GLTP 0.017
4602 Osmotically inducible protein C tthHB8IM 0.0169
2664 S-ribosylhomocysteine lyase luxS 0.0169
2725 S-ribosylhomocysteine lyase luxS 0.0169
2670 Pyridoxamine kinase pdxY 0.0169
6024 Cytochrome P450 1A1 CYP1A1 0.0163
5718 Cytochrome P450 2A6 CYP2A6 0.0163
3616 Fatty acid-binding protein, epidermal FABP5 0.0159
5433 UPF0230 protein TM_1468 TM_1468 0.0158
5431 Lipid binding protein Not Available 0.0158
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0158
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0156
1992 Vitamin D-binding protein GC 0.0156
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0153
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0152
6106 Cytochrome P450 2C18 CYP2C18 0.0151
2688 Peptide deformylase def 0.0147
2708 Peptide deformylase def 0.0147
3004 Peptide deformylase def 0.0147
4337 Peptide deformylase def 0.0147
4338 Peptide deformylase def 0.0147
5368 Peptide deformylase def 0.0147
5371 Peptide deformylase def 0.0147
6375 Peptide deformylase def 0.0147
6378 Peptide deformylase def 0.0147
6379 Peptide deformylase def 0.0147
6776 Peptide deformylase def 0.0147
6900 Peptide deformylase def 0.0147
3599 Peroxiredoxin-2 PRDX2 0.0147
4601 HMG-CoA synthase mvaS 0.0147
2378 Carboxymethylenebutenolidase clcD 0.0147
2705 Dimethyl sulfoxide reductase dmsA 0.0147
3312 Fatty acid-binding protein, brain FABP7 0.0143
2714 Chorismate mutase aroH 0.0136
4611 Chorismate mutase aroG 0.0136
2603 Beta-lactamase II blm 0.0135
4600 Malonamidase E2 Not Available 0.0128
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0127
6459 Glycodelin PAEP 0.0127
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0118
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0116
283 SEC14-like protein 2 SEC14L2 0.0114
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0113
290 Prostaglandin G/H synthase 2 PTGS2 0.0105
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0095
714 Glutathione reductase, mitochondrial GSR 0.0089
1729 Solute carrier family 22 member 6 SLC22A6 0.0089
2207 Rhodopsin RHO 0.0089
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0082
1898 Cytochrome P450 1B1 CYP1B1 0.0079
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0079
862 Multidrug resistance-associated protein 1 ABCC1 0.0079
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0075
2164 Multidrug resistance-associated protein 4 ABCC4 0.0072
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0067
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0064
3811 Cytochrome P450 19A1 CYP19A1 0.0064
776 Bile salt export pump ABCB11 0.006
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0057
136 Estrogen receptor ESR1 0.0057
6142 Solute carrier family 22 member 8 SLC22A8 0.0057
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0053
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0051
696 Kappa-type opioid receptor OPRK1 0.005
871 Glucocorticoid receptor NR3C1 0.005
6143 Solute carrier family 22 member 7 SLC22A7 0.0049
492 Histamine H1 receptor HRH1 0.0048
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0048
467 Delta-type opioid receptor OPRD1 0.0048
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0048
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0047
6182 Cytochrome P450 2J2 CYP2J2 0.0047
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0045
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0044
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0044
847 Mu-type opioid receptor OPRM1 0.0043
6031 Cytochrome P450 3A43 CYP3A43 0.0043
1024 Solute carrier family 22 member 11 SLC22A11 0.0042
6141 Sodium/bile acid cotransporter SLC10A1 0.0042
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0042
824 Sodium-dependent serotonin transporter SLC6A4 0.0041
146 Androgen receptor AR 0.0041
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.004
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0039
6102 Arylamine N-acetyltransferase 2 NAT2 0.0038
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
468 Cytochrome P450 4A11 CYP4A11 0.0037
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0037
70 Type-1 angiotensin II receptor AGTR1 0.0037
502 5-hydroxytryptamine 2A receptor HTR2A 0.0036
380 Cytochrome P450 17A1 CYP17A1 0.0035
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0035
1541 Metalloproteinase mmp20 0.0035
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0034
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0034
504 Mast/stem cell growth factor receptor KIT 0.0034
365 Dihydrofolate reductase DHFR 0.0034
2381 Dihydrofolate reductase DFR1 0.0034
2833 Dihydrofolate reductase Not Available 0.0034
2931 Dihydrofolate reductase folA 0.0034
3544 Dihydrofolate reductase folA 0.0034
3682 Dihydrofolate reductase folA 0.0034
6642 Dihydrofolate reductase folA 0.0034
6756 Dihydrofolate reductase dfrA 0.0034
811 Translocator protein TSPO 0.0034
5880 Thrombopoietin receptor MPL 0.0033
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0033
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0033
844 Epidermal growth factor receptor EGFR 0.0032
6144 Solute carrier family 22 member 2 SLC22A2 0.0031
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0031
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0031
831 D(2) dopamine receptor DRD2 0.0031
6136 Multidrug resistance-associated protein 5 ABCC5 0.003
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.003
891 Dihydropteroate synthase folP 0.003
5359 Dihydropteroate synthase folP 0.003
7175 Dihydropteroate synthase sulI 0.003
465 Calmodulin CALM1 0.003
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.003
6145 Solute carrier family 22 member 1 SLC22A1 0.003
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.003
29 Tubulin beta-1 chain TUBB1 0.003
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.003
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0029
3941 Amine oxidase [flavin-containing] A MAOA 0.0029
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0028
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0028
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0028
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0027
869 Estrogen receptor beta ESR2 0.0027
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0027
88 Retinoic acid receptor RXR-beta RXRB 0.0027
162 Retinoic acid receptor gamma-1 RARG 0.0026
118 Organic cation/carnitine transporter 2 SLC22A5 0.0026
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0026
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0025
737 Mineralocorticoid receptor NR3C2 0.0025
6147 Solute carrier family 22 member 3 SLC22A3 0.0025
4116 Dihydropteroate synthetase Not Available 0.0025
952 Dipeptidyl peptidase 4 DPP4 0.0025
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0024
5300 Antigen peptide transporter 1 TAP1 0.0024
229 Retinoic acid receptor beta RARB 0.0024
122 P2Y purinoceptor 12 P2RY12 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0023
731 HIV-1 protease HIV-1 protease 0.0023
260 Cytochrome P450 51 ERG11 0.0023
761 Cytochrome P450 51 ERG11 0.0023
3163 Cytochrome P450 51 cyp51 0.0023
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0023
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0023
1050 Bile salt sulfotransferase SULT2A1 0.0022
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0022
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0022
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0022
94 5-hydroxytryptamine 4 receptor HTR4 0.0022
3086 Plasmepsin-2 Not Available 0.0022
1648 Elastin ELN 0.0022
24 Thymidylate synthase TMP1 0.0022
359 Thymidylate synthase TYMS 0.0022
2626 Thymidylate synthase thyA 0.0022
2729 Thymidylate synthase thyA 0.0022
5352 Thymidylate synthase THYA 0.0022
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0021
4120 NADPH--cytochrome P450 reductase POR 0.0021
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0021
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
208 DNA-directed RNA polymerase beta' chain rpoC 0.0021
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0021
833 Organic cation/carnitine transporter 1 SLC22A4 0.0021
6148 Multidrug resistance-associated protein 7 ABCC10 0.002
1010 Cytochrome P450 51A1 CYP51A1 0.002
407 Vascular endothelial growth factor receptor 2 KDR 0.002
614 Progesterone receptor PGR 0.002
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.002
4203 Histamine N-methyltransferase HNMT 0.002
950 Alpha platelet-derived growth factor receptor PDGFRA 0.002
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.002
26 Vascular endothelial growth factor receptor 3 FLT4 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0019
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0019
32 Vascular endothelial growth factor receptor 1 FLT1 0.0019
4604 Liver carboxylesterase 1 CES1 0.0019
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0019
590 5-hydroxytryptamine 2C receptor HTR2C 0.0019
6137 Multidrug resistance-associated protein 6 ABCC6 0.0018
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0018
341 5-hydroxytryptamine 3 receptor HTR3A 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
3856 Fibroblast growth factor receptor 3 FGFR3 0.0018
275 Arachidonate 5-lipoxygenase ALOX5 0.0018
228 Beta platelet-derived growth factor receptor PDGFRB 0.0018
6103 Arylamine N-acetyltransferase 1 NAT1 0.0018
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0017
2112 Toll-like receptor 9 TLR9 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0017
738 Monocarboxylate transporter 1 SLC16A1 0.0017
3939 Amine oxidase [flavin-containing] B MAOB 0.0017
766 Beta-2 adrenergic receptor ADRB2 0.0016
518 Peroxidase/catalase T katG 0.0016
469 Annexin A1 ANXA1 0.0016
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0016
756 Sex hormone-binding globulin SHBG 0.0016
23 D(1A) dopamine receptor DRD1 0.0016
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0016
427 Substance-P receptor TACR1 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0015
758 Thyroid hormone receptor alpha THRA 0.0015
1757 Myeloperoxidase MPO 0.0015
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0015
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0015
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0015
6174 50S ribosomal protein L32 rpmF 0.0015
1629 Transcription factor AP-1 JUN 0.0015
4238 50S ribosomal protein L4 rplD 0.0015
5578 50S ribosomal protein L4 rplD 0.0015
6173 50S ribosomal protein L4 rplD 0.0015
6219 50S ribosomal protein L4 rplD 0.0015
1196 Complement decay-accelerating factor CD55 0.0015
3809 Estrogen-related receptor gamma ESRRG 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0015
6020 Aldehyde oxidase AOX1 0.0015
921 Glutamate receptor 2 GRIA2 0.0015
199 Monocarboxylate transporter 8 SLC16A2 0.0014
777 Tumor necrosis factor TNF 0.0014
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0014
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0014
2539 Tubulin alpha-1 chain TUBA4A 0.0014
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0014
6138 Multidrug resistance protein 3 ABCB4 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
16 Adenosine A1 receptor ADORA1 0.0014
1178 Adenosine A2a receptor ADORA2A 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0013
634 Squalene monooxygenase SQLE 0.0013
7196 Squalene monooxygenase ERG1 0.0013
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0013
556 Alpha-1A adrenergic receptor ADRA1A 0.0013
713 Sodium-dependent dopamine transporter SLC6A3 0.0013
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
2808 Chloramphenicol acetyltransferase 3 cat3 0.0013
3932 Glutathione S-transferase A2 GSTA2 0.0013
1262 Corticotropin-lipotropin POMC 0.0013
84 Nuclear receptor 0B1 NR0B1 0.0013
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
1192 Sulfotransferase 1A1 SULT1A1 0.0013
632 Alpha-1B adrenergic receptor ADRA1B 0.0012
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0012
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0012
165 FL cytokine receptor FLT3 0.0012
5787 Angiopoietin-1 receptor TEK 0.0012
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0012
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0012
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0012
823 Fibroblast growth factor receptor 2 FGFR2 0.0012
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0012
273 Apoptosis regulator Bcl-2 BCL2 0.0012
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0012
3808 Dihydropteroate synthase 2 folP2 0.0012
3601 Dihydropteroate synthase 1 folP1 0.0012
3807 Dihydropteroate synthase 1 folP1 0.0012
2417 Chloramphenicol acetyltransferase cat 0.0012
3278 Chloramphenicol acetyltransferase cat 0.0012
2810 Dr hemagglutinin structural subunit draA 0.0012
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0012
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0012
725 5-hydroxytryptamine 1D receptor HTR1D 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0011
318 Alpha-2A adrenergic receptor ADRA2A 0.0011
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0011
885 5-hydroxytryptamine 1B receptor HTR1B 0.0011
638 D(3) dopamine receptor DRD3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0011
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0011
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0011
581 Cytochrome P450 2R1 CYP2R1 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
161 Tubulin beta chain TUBB 0.0011
312 Tubulin beta chain TUB2 0.0011
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0011
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0011
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0011
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0011
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0011
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.001
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.001
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.001
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.001
319 Opioid receptor, sigma 1 OPRS1 0.001
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.001
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.001
1483 Membrane copper amine oxidase AOC3 0.001
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.001
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
215 Sodium channel protein type 11 subunit alpha SCN11A 0.001
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.001
1618 High affinity nerve growth factor receptor NTRK1 0.001
6014 Cytochrome P450 2A13 CYP2A13 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
1630 Integrin beta-2 ITGB2 0.001
976 Platelet glycoprotein IX GP9 0.001
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
4103 Proteasome subunit beta type 2 PSMB2 0.001
4102 Proteasome subunit beta type 5 PSMB5 0.001
4101 Proteasome subunit beta type 1 PSMB1 0.001
436 5-hydroxytryptamine 2B receptor HTR2B 0.001
4226 Uridine phosphorylase 2 UPP2 0.0009
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0009
2216 Fibroblast growth factor receptor 4 FGFR4 0.0009
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0009
4217 Telomerase reverse transcriptase TERT 0.0009
814 Ryanodine receptor 1 RYR1 0.0009
735 Alanine aminotransferase 1 GPT 0.0009
3904 Alanine aminotransferase 2 GPT2 0.0009
239 Coagulation factor X F10 0.0009
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
6048 Troponin C, skeletal muscle TNNC2 0.0008
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0008
719 Retinoic acid receptor responder protein 1 RARRES1 0.0008
770 Retinoic acid-induced protein 3 GPRC5A 0.0008
268 Adenosine A2b receptor ADORA2B 0.0008
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
6044 Serum paraoxonase/lactonase 3 PON3 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
2021 Thrombomodulin THBD 0.0008
856 Vitamin D3 receptor VDR 0.0008
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0008
572 Integrin alpha-L ITGAL 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0007
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0007
5798 Mitogen-activated protein kinase 11 MAPK11 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
2320 Thymidine kinase, cytosolic TK1 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
267 Plasminogen activator inhibitor 1 SERPINE1 0.0007
569 Retinal dehydrogenase 2 ALDH1A2 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
1275 Estrogen sulfotransferase SULT1E1 0.0007
1852 Microtubule-associated protein 2 MAP2 0.0007
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
789 Alpha-1D adrenergic receptor ADRA1D 0.0007
4192 DNA topoisomerase 2-beta TOP2B 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
6218 Pannexin-1 PANX1 0.0006
5934 Cytochrome P450 26A1 CYP26A1 0.0006
751 Potassium channel subfamily K member 6 KCNK6 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
1039 Histone deacetylase 9 HDAC9 0.0006
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0006
908 Glutathione S-transferase theta-1 GSTT1 0.0006
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
3917 Methylenetetrahydrofolate reductase MTHFR 0.0006
193 Beta-1 adrenergic receptor ADRB1 0.0006
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0006
780 Retinoic acid receptor RXR-gamma RXRG 0.0006
3937 Fatty-acid amide hydrolase FAAH 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0006
172 Potassium channel subfamily K member 1 KCNK1 0.0006
6220 Aryl hydrocarbon receptor AHR 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0006
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0005
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0005
3957 Adenosine deaminase ADA 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0005
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0005
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0005
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0005
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0005
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0005
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
284 DNA-directed RNA polymerase beta chain rpoB 0.0005
5773 DNA-directed RNA polymerase beta chain rpoB 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
817 DNA topoisomerase 2-alpha TOP2A 0.0005
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0005
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0005
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0005
295 Carbonic anhydrase 1 CA1 0.0005
320 5-hydroxytryptamine 1A receptor HTR1A 0.0005
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0005
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
124 Histamine H2 receptor HRH2 0.0004
7 Nitric oxide synthase, inducible NOS2 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0004
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0004
2981 Phospholipase A2, membrane associated PLA2G2A 0.0004
164 Histamine H4 receptor HRH4 0.0004
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0004
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0003
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0003
528 5-hydroxytryptamine 1E receptor HTR1E 0.0003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0003
1256 5-hydroxytryptamine 6 receptor HTR6 0.0003
716 5-hydroxytryptamine 7 receptor HTR7 0.0003
432 D(4) dopamine receptor DRD4 0.0002
4954 Soluble cytochrome b558 Not Available 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4943 Cytochrome c6 petJ 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4961 Hemophore HasA hasA 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
5000 HemO hemO 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
4984 Neuroglobin NGB 0.0002
3116 Bacterioferritin bfr 0.0002
4906 Bacterioferritin bfr 0.0002
4965 Bacterioferritin bfr 0.0002
4935 Cytochrome c-554 cycA1 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4910 Cytoglobin CYGB 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
378 Alpha-2C adrenergic receptor ADRA2C 0.0002
629 Alpha-2B adrenergic receptor ADRA2B 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
3221 Cytochrome c4 cc4 0.0001
605 Fumarate reductase flavoprotein subunit frdA 0.0001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0001
3673 Fumarate reductase flavoprotein subunit fccA 0.0001
4912 Fumarate reductase flavoprotein subunit ifcA 0.0001
6549 Fumarate reductase flavoprotein subunit frdA 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
291 Nitric-oxide synthase, endothelial NOS3 0.0001
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