DT-Web: DB06204

Identification

Name

Tapentadol

Accession Number

DB06204

Type

small molecule

Description

Opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Analgesics, Opioid

Molecular Weight

221.3385

Groups

approved

Monoisotopic Weight

221.177964363

Pharmacology

Indication

The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy.

Mechanism of action

Tapendadol causes large increases in levels of extracellular norepinephrine (NE) due to a dual mechanism of action involving mu opioid receptor (MOR) agonism as well as noradrenaline reuptake inhibition.

Absorption

Bioavailability, immediate release (IR), 86 mg: 32%; Bioavailability, extended release (ER), 86 mg: 32%; Cmax, IR: 64.2 ng/mL; Cmax, ER: 22.5 ng/mL; T max, IR: 1.5 hours; T max, ER: 5.0 hours; Tapentadol accumulates following multiple repeat doses.

Protein binding

~20%

Biotransformation

97% of the dose is metabolized mostly via conjugation with glucuronic acid to produce glucuronides. Tapentadol is also metabolized into N-desmethyl tapentadol (13%) by CYP2C9 and CYP 2C19. CYP2D6 is involved in the formation of the metabolite, hydroxy tapentadol (2%). All metabolites are inactive.

Route of elimination

Tapentadol and its metabolites are excreted almost exclusively (99%) via the kidneys. Approximately 70% (55% O-glucuronide and 15% sulfate of tapentadol) is excreted in conjugated form. A total of 3% of drug was excreted in urine as unchanged drug.

Toxicity

Oral, rabbit: LD50 = 3200 mg/kg; Oral, mouse: LD50 = 300 mg/kg; Oral, rat: LD50: 980 mg/kg; The most common reasons for discontinuation due to adverse events were dizziness, nausea, vomiting, somnolence, and headache.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Alvimopan	Increases levels by receptor binding competition. Discontinue opioid administration at least 7 days prior to administrating Alvimopan.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Naproxen	Increases the AUC of tapentadol by 17%. These changes are not considered clinically relevant and no change in dose is required.
Probenecid	Increases the AUC of tapentadol by 57%. These changes are not considered clinically relevant and no change in dose is required.
Rasagiline	Increases the toxicity of tapentadol by unknown mechanism. Discontinue rasagiline at least 14 days prior to tapentadol administration.
Selegiline	Increases the toxicity of tapentadol by unknown mechanism. Discontinue selegiline at least 14 days prior to tapentadol administration.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and tapentadol, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.

Food Interactions

Food increases the AUC and Cmax of tapentadol. Despite this, tapentadol can be given without regards to food.

Mu-type opioid receptor
Name	Mu-type opioid receptor
Gene Name	OPRM1
Pharmacological action	yes
Actions	agonist
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.0114
Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Tzschentke TM, Christoph T, Kogel B, Schiene K, Hennies HH, Englberger W, Haurand M, Jahnel U, Cremers TI, Friderichs E, De Vry J: (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties. J Pharmacol Exp Ther. 2007 Oct;323(1):265-76. Epub 2007 Jul 26. - Pubmed
DTHybrid score	0.5038
Kappa-type opioid receptor
Name	Kappa-type opioid receptor
Gene Name	OPRK1
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.815
Delta-type opioid receptor
Name	Delta-type opioid receptor
Gene Name	OPRD1
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.8329
5-hydroxytryptamine 3 receptor
Name	5-hydroxytryptamine 3 receptor
Gene Name	HTR3A
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.2234
Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	unknown
Actions	inhibitor
References	Raffa RB, Buschmann H, Christoph T, Eichenbaum G, Englberger W, Flores CM, Hertrampf T, Kogel B, Schiene K, Strassburger W, Terlinden R, Tzschentke TM: Mechanistic and functional differentiation of tapentadol and tramadol. Expert Opin Pharmacother. 2012 Jul;13(10):1437-49. doi: 10.1517/14656566.2012.696097. Epub 2012 Jun 15. - Pubmed
DTHybrid score	0.3964

UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Kneip C, Terlinden R, Beier H, Chen G: Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. - Pubmed
DTHybrid score	0.2987
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	Kneip C, Terlinden R, Beier H, Chen G: Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. - Pubmed
DTHybrid score	0.2282
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Kneip C, Terlinden R, Beier H, Chen G: Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. - Pubmed
DTHybrid score	0.6148
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Kneip C, Terlinden R, Beier H, Chen G: Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. - Pubmed
DTHybrid score	0.486
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Kneip C, Terlinden R, Beier H, Chen G: Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. - Pubmed
DTHybrid score	0.3927

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.5029
1588	Multidrug resistance protein 1	ABCB1	0.2442
4200	Cytochrome P450 1A2	CYP1A2	0.2411
4924	Cytochrome P450 2C8	CYP2C8	0.2331
713	Sodium-dependent dopamine transporter	SLC6A3	0.2224
4118	Cytochrome P450 3A5	CYP3A5	0.197
6107	Cytochrome P450 3A7	CYP3A7	0.1725
6030	Cytochrome P450 2B6	CYP2B6	0.1707
20	Prostaglandin G/H synthase 1	PTGS1	0.1257
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1248
6013	Cytochrome P450 2E1	CYP2E1	0.1194
1716	Tripartite motif-containing protein 13	TRIM13	0.115
587	Serum albumin	ALB	0.1065
556	Alpha-1A adrenergic receptor	ADRA1A	0.103
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0944
492	Histamine H1 receptor	HRH1	0.0927
5718	Cytochrome P450 2A6	CYP2A6	0.0885
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0879
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0846
1262	Corticotropin-lipotropin	POMC	0.0841
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0748
6024	Cytochrome P450 1A1	CYP1A1	0.0744
290	Prostaglandin G/H synthase 2	PTGS2	0.072
318	Alpha-2A adrenergic receptor	ADRA2A	0.0694
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.068
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0643
3941	Amine oxidase [flavin-containing] A	MAOA	0.0633
6106	Cytochrome P450 2C18	CYP2C18	0.0628
6145	Solute carrier family 22 member 1	SLC22A1	0.0611
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0609
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0581
632	Alpha-1B adrenergic receptor	ADRA1B	0.0532
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0519
3939	Amine oxidase [flavin-containing] B	MAOB	0.0518
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0517
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0515
1729	Solute carrier family 22 member 6	SLC22A6	0.0506
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0504
831	D(2) dopamine receptor	DRD2	0.0492
131	Synaptic vesicular amine transporter	SLC18A2	0.0491
6144	Solute carrier family 22 member 2	SLC22A2	0.0481
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0471
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0461
766	Beta-2 adrenergic receptor	ADRB2	0.041
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0409
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0399
174	Sigma 1-type opioid receptor	SIGMAR1	0.0397
319	Opioid receptor, sigma 1	OPRS1	0.0397
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0392
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.039
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.039
4137	Nociceptin receptor	OPRL1	0.0389
23	D(1A) dopamine receptor	DRD1	0.0368
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0362
193	Beta-1 adrenergic receptor	ADRB1	0.036
862	Multidrug resistance-associated protein 1	ABCC1	0.036
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0356
629	Alpha-2B adrenergic receptor	ADRA2B	0.0353
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0336
2164	Multidrug resistance-associated protein 4	ABCC4	0.0327
789	Alpha-1D adrenergic receptor	ADRA1D	0.032
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0314
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0299
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0294
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0291
4604	Liver carboxylesterase 1	CES1	0.0289
378	Alpha-2C adrenergic receptor	ADRA2C	0.0288
3923	Cholinesterase	BCHE	0.0283
3810	Catechol O-methyltransferase	COMT	0.0277
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0276
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0274
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0274
94	5-hydroxytryptamine 4 receptor	HTR4	0.0262
3811	Cytochrome P450 19A1	CYP19A1	0.026
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.026
118	Organic cation/carnitine transporter 2	SLC22A5	0.0252
474	Acetylcholinesterase	ACHE	0.0233
6142	Solute carrier family 22 member 8	SLC22A8	0.0223
638	D(3) dopamine receptor	DRD3	0.0223
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0221
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0221
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.022
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0218
465	Calmodulin	CALM1	0.0215
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0213
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0207
6147	Solute carrier family 22 member 3	SLC22A3	0.0202
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0198
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0196
1898	Cytochrome P450 1B1	CYP1B1	0.0195
891	Dihydropteroate synthase	folP	0.0193
5359	Dihydropteroate synthase	folP	0.0193
7175	Dihydropteroate synthase	sulI	0.0193
6102	Arylamine N-acetyltransferase 2	NAT2	0.0192
3866	Serum amyloid A protein	SAA1	0.019
1200	AMBP protein	AMBP	0.019
1932	Apolipoprotein E	APOE	0.019
136	Estrogen receptor	ESR1	0.0184
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0184
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0179
432	D(4) dopamine receptor	DRD4	0.0177
5838	Transient receptor potential cation channel subfamily V member 3	TRPV3	0.0176
2162	Transient receptor potential cation channel subfamily M member 8	TRPM8	0.0176
1944	Transient receptor potential cation channel subfamily A member 1	TRPA1	0.0176
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0176
6143	Solute carrier family 22 member 7	SLC22A7	0.0175
731	HIV-1 protease	HIV-1 protease	0.0174
6182	Cytochrome P450 2J2	CYP2J2	0.0174
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0168
1656	CYP2B protein	CYP2B	0.0167
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0166
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0166
1291	cAMP response element-binding protein	CREB1	0.0166
1757	Myeloperoxidase	MPO	0.0165
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0164
817	DNA topoisomerase 2-alpha	TOP2A	0.0164
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0164
1024	Solute carrier family 22 member 11	SLC22A11	0.0157
776	Bile salt export pump	ABCB11	0.0157
723	Cytosolic phospholipase A2	PLA2G4A	0.0156
3233	Bile acid receptor	NR1H4	0.0156
716	5-hydroxytryptamine 7 receptor	HTR7	0.0154
1636	Trace amine-associated receptor 1	TAAR1	0.0152
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0152
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0151
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.015
4210	Toll-like receptor 4	TLR4	0.015
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0148
738	Monocarboxylate transporter 1	SLC16A1	0.0144
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0144
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0144
163	D(1B) dopamine receptor	DRD5	0.0142
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0141
6432	Transporter	snf	0.014
260	Cytochrome P450 51	ERG11	0.0139
761	Cytochrome P450 51	ERG11	0.0139
3163	Cytochrome P450 51	cyp51	0.0139
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0139
6031	Cytochrome P450 3A43	CYP3A43	0.0136
54	Prothrombin	F2	0.0135
833	Organic cation/carnitine transporter 1	SLC22A4	0.0134
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0131
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0129
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0127
70	Type-1 angiotensin II receptor	AGTR1	0.0126
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0125
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0124
1517	Beta-3 adrenergic receptor	ADRB3	0.0122
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0121
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0121
275	Arachidonate 5-lipoxygenase	ALOX5	0.0121
122	P2Y purinoceptor 12	P2RY12	0.012
2981	Phospholipase A2, membrane associated	PLA2G2A	0.012
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0118
459	Retinoic acid receptor RXR-alpha	RXRA	0.0117
1618	High affinity nerve growth factor receptor	NTRK1	0.0115
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0112
4120	NADPH--cytochrome P450 reductase	POR	0.0108
6141	Sodium/bile acid cotransporter	SLC10A1	0.0104
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0104
6138	Multidrug resistance protein 3	ABCB4	0.0103
124	Histamine H2 receptor	HRH2	0.0103
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0101
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0101
6136	Multidrug resistance-associated protein 5	ABCC5	0.0098
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0097
146	Androgen receptor	AR	0.0096
504	Mast/stem cell growth factor receptor	KIT	0.0095
468	Cytochrome P450 4A11	CYP4A11	0.0093
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0093
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0093
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0093
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0091
26	Vascular endothelial growth factor receptor 3	FLT4	0.0089
6103	Arylamine N-acetyltransferase 1	NAT1	0.0088
6137	Multidrug resistance-associated protein 6	ABCC6	0.0087
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0087
407	Vascular endothelial growth factor receptor 2	KDR	0.0087
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0086
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0086
32	Vascular endothelial growth factor receptor 1	FLT1	0.0085
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0085
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0084
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0083
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0083
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0083
228	Beta platelet-derived growth factor receptor	PDGFRB	0.008
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.008
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.008
6220	Aryl hydrocarbon receptor	AHR	0.0079
482	Glycine receptor subunit alpha-1	GLRA1	0.0079
2021	Thrombomodulin	THBD	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0078
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0077
6085	Fatty acid-binding protein, intestinal	FABP2	0.0077
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0075
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0075
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0075
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0075
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0075
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0074
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0074
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0074
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0074
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0074
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0073
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0073
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0072
267	Plasminogen activator inhibitor 1	SERPINE1	0.0072
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0071
811	Translocator protein	TSPO	0.0071
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.007
1275	Estrogen sulfotransferase	SULT1E1	0.007
49	Endothelin B receptor	EDNRB	0.007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0069
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0068
489	Monocarboxylate transporter 2	SLC16A7	0.0068
380	Cytochrome P450 17A1	CYP17A1	0.0067
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0066
6221	Steroid hormone receptor ERR1	ESRRA	0.0066
578	Endothelin-1 receptor	EDNRA	0.0066
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0065
1039	Histone deacetylase 9	HDAC9	0.0065
592	Carbonic anhydrase 4	CA4	0.0065
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0063
6500	Phospholipase A2	PLA2G1B	0.0063
1630	Integrin beta-2	ITGB2	0.0063
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0063
133	Dihydropterate synthase	sulI	0.0063
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0062
4116	Dihydropteroate synthetase	Not Available	0.0062
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0062
365	Dihydrofolate reductase	DHFR	0.0061
2381	Dihydrofolate reductase	DFR1	0.0061
2833	Dihydrofolate reductase	Not Available	0.0061
2931	Dihydrofolate reductase	folA	0.0061
3544	Dihydrofolate reductase	folA	0.0061
3682	Dihydrofolate reductase	folA	0.0061
6642	Dihydrofolate reductase	folA	0.0061
6756	Dihydrofolate reductase	dfrA	0.0061
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0061
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.006
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.006
3809	Estrogen-related receptor gamma	ESRRG	0.0059
362	Melatonin receptor type 1B	MTNR1B	0.0058
571	Melatonin receptor type 1A	MTNR1A	0.0058
6042	Prostaglandin reductase 2	PTGR2	0.0058
273	Apoptosis regulator Bcl-2	BCL2	0.0057
823	Fibroblast growth factor receptor 2	FGFR2	0.0056
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0056
904	Glutathione S-transferase P	GSTP1	0.0056
295	Carbonic anhydrase 1	CA1	0.0056
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0056
373	Transthyretin	TTR	0.0055
777	Tumor necrosis factor	TNF	0.0054
844	Epidermal growth factor receptor	EGFR	0.0054
1792	Tissue-type plasminogen activator	PLAT	0.0054
1760	Aminopeptidase N	ANPEP	0.0054
6843	Aminopeptidase N	pepN	0.0054
4217	Telomerase reverse transcriptase	TERT	0.0054
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0054
1192	Sulfotransferase 1A1	SULT1A1	0.0054
6043	Putative G-protein coupled receptor 44	GPR44	0.0054
4122	Histone deacetylase 2	HDAC2	0.0053
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0053
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0053
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0053
117	Sterol O-acyltransferase 1	SOAT1	0.0053
183	Vascular endothelial growth factor A	VEGFA	0.0052
161	Tubulin beta chain	TUBB	0.0052
312	Tubulin beta chain	TUB2	0.0052
6044	Serum paraoxonase/lactonase 3	PON3	0.0052
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0051
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0051
6148	Multidrug resistance-associated protein 7	ABCC10	0.005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.005
164	Histamine H4 receptor	HRH4	0.0049
828	Phenylalanine-4-hydroxylase	PAH	0.0049
3109	Phenylalanine-4-hydroxylase	phhA	0.0049
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0049
1050	Bile salt sulfotransferase	SULT2A1	0.0048
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0048
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0048
572	Integrin alpha-L	ITGAL	0.0048
357	Carbonic anhydrase 2	CA2	0.0048
6126	Carbonic anhydrase 7	CA7	0.0047
6014	Cytochrome P450 2A13	CYP2A13	0.0046
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0045
5798	Mitogen-activated protein kinase 11	MAPK11	0.0045
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0045
1313	Lactoylglutathione lyase	GLO1	0.0045
1010	Cytochrome P450 51A1	CYP51A1	0.0045
2112	Toll-like receptor 9	TLR9	0.0044
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0044
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0043
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0043
427	Substance-P receptor	TACR1	0.0043
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0042
2320	Thymidine kinase, cytosolic	TK1	0.0042
952	Dipeptidyl peptidase 4	DPP4	0.0042
165	FL cytokine receptor	FLT3	0.0042
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0041
4203	Histamine N-methyltransferase	HNMT	0.004
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0039
3937	Fatty-acid amide hydrolase	FAAH	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
614	Progesterone receptor	PGR	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
5787	Angiopoietin-1 receptor	TEK	0.0038
921	Glutamate receptor 2	GRIA2	0.0038
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0038
130	Prostacyclin synthase	PTGIS	0.0037
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0037
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0036
518	Peroxidase/catalase T	katG	0.0034
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0034
936	Ephrin type-A receptor 2	EPHA2	0.0034
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0033
871	Glucocorticoid receptor	NR3C1	0.0033
558	Solute carrier family 12 member 1	SLC12A1	0.0033
6506	Stathmin-4	STMN4	0.0033
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0033
173	Toll-like receptor 7	TLR7	0.0033
756	Sex hormone-binding globulin	SHBG	0.0032
1353	DNA topoisomerase 1	TOP1	0.0032
3552	DNA topoisomerase 1	topA	0.0032
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0032
563	Thyroid peroxidase	TPO	0.0032
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0031
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0031
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0031
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0031
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0031
153	Dopamine beta-hydroxylase	DBH	0.003
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.003
634	Squalene monooxygenase	SQLE	0.003
7196	Squalene monooxygenase	ERG1	0.003
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.003
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0029
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
565	Extracellular calcium-sensing receptor	CASR	0.0028
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0028
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0028
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0028
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0028
1178	Adenosine A2a receptor	ADORA2A	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
24	Thymidylate synthase	TMP1	0.0027
359	Thymidylate synthase	TYMS	0.0027
2626	Thymidylate synthase	thyA	0.0027
2729	Thymidylate synthase	thyA	0.0027
5352	Thymidylate synthase	THYA	0.0027
1629	Transcription factor AP-1	JUN	0.0026
869	Estrogen receptor beta	ESR2	0.0026
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0026
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0026
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0026
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0026
85	Growth hormone receptor	GHR	0.0025
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0025
1541	Metalloproteinase	mmp20	0.0025
581	Cytochrome P450 2R1	CYP2R1	0.0025
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
106	Cannabinoid receptor 2	CNR2	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
6146	High affinity copper uptake protein 1	SLC31A1	0.0024
4311	tRNA	TRDMT1	0.0024
4325	tRNA	trmD	0.0024
4328	tRNA	trmD	0.0024
6174	50S ribosomal protein L32	rpmF	0.0024
4238	50S ribosomal protein L4	rplD	0.0024
5578	50S ribosomal protein L4	rplD	0.0024
6173	50S ribosomal protein L4	rplD	0.0024
6219	50S ribosomal protein L4	rplD	0.0024
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0024
1196	Complement decay-accelerating factor	CD55	0.0023
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0023
1992	Vitamin D-binding protein	GC	0.0023
65	Matrix metalloproteinase-9	Not Available	0.0023
6151	Monocarboxylate transporter 10	SLC16A10	0.0023
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0023
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0023
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0023
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0023
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0022
68	Cannabinoid receptor 1	CNR1	0.0022
3947	Xanthine dehydrogenase/oxidase	XDH	0.0022
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
2539	Tubulin alpha-1 chain	TUBA4A	0.0022
976	Platelet glycoprotein IX	GP9	0.0022
4103	Proteasome subunit beta type 2	PSMB2	0.0022
4102	Proteasome subunit beta type 5	PSMB5	0.0022
4101	Proteasome subunit beta type 1	PSMB1	0.0022
780	Retinoic acid receptor RXR-gamma	RXRG	0.0021
5300	Antigen peptide transporter 1	TAP1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
3090	Chitosanase	csn	0.002
511	5-hydroxytryptamine 1F receptor	HTR1F	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
2808	Chloramphenicol acetyltransferase 3	cat3	0.002
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.002
88	Retinoic acid receptor RXR-beta	RXRB	0.0019
3639	Thymidine phosphorylase	deoA	0.0019
3936	Thymidine phosphorylase	TYMP	0.0019
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0019
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0019
3808	Dihydropteroate synthase 2	folP2	0.0019
3601	Dihydropteroate synthase 1	folP1	0.0019
3807	Dihydropteroate synthase 1	folP1	0.0019
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0019
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0019
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0019
16	Adenosine A1 receptor	ADORA1	0.0019
2417	Chloramphenicol acetyltransferase	cat	0.0018
3278	Chloramphenicol acetyltransferase	cat	0.0018
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
2810	Dr hemagglutinin structural subunit	draA	0.0018
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0018
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
7	Nitric oxide synthase, inducible	NOS2	0.0018
737	Mineralocorticoid receptor	NR3C2	0.0018
1341	Histamine H3 receptor	HRH3	0.0018
84	Nuclear receptor 0B1	NR0B1	0.0017
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0017
856	Vitamin D3 receptor	VDR	0.0017
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0017
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0017
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
3830	Calreticulin	CALR	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0016
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0016
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0016
633	Penicillin-binding proteins 1A/1B	pbpA	0.0016
4228	Keratin, type II cytoskeletal 7	KRT7	0.0016
6149	Solute carrier family 22 member 10	SLC22A10	0.0016
1864	RET proto-oncogene	RET	0.0016
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0016
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0016
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0016
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0016
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
1648	Elastin	ELN	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0015
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0015
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0015
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0015
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0015
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0015
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0015
3611	Cytidine deaminase	cdd	0.0014
3707	Cytidine deaminase	cdd	0.0014
4211	Cytidine deaminase	CDA	0.0014
5934	Cytochrome P450 26A1	CYP26A1	0.0014
4773	Deoxycytidine kinase	DCK	0.0014
3086	Plasmepsin-2	Not Available	0.0014
239	Coagulation factor X	F10	0.0014
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0014
251	Alcohol dehydrogenase 1A	ADH1A	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
2232	Interleukin-5	IL5	0.0014
1593	Mucin-2	MUC2	0.0014
3404	Exotoxin A	eta	0.0013
1374	Natriuretic peptides B	NPPB	0.0013
818	50S ribosomal protein L10	rplJ	0.0013
1827	Gap junction alpha-1 protein	GJA1	0.0013
1908	Vascular cell adhesion protein 1	VCAM1	0.0013
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0013
820	Glycine receptor subunit alpha-2	GLRA2	0.0013
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0013
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0013
3426	Glutamine synthetase	glnA	0.0013
3987	Glutamine synthetase	GLUL	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
814	Ryanodine receptor 1	RYR1	0.0013
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0012
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0012
33	Cystine/glutamate transporter	SLC7A11	0.0012
444	Alcohol dehydrogenase 1B	ADH1B	0.0012
232	Corticosteroid-binding globulin	SERPINA6	0.0012
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0012
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0012
3856	Fibroblast growth factor receptor 3	FGFR3	0.0012
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0012
29	Tubulin beta-1 chain	TUBB1	0.0012
705	Glutamate receptor 1	GRIA1	0.0012
473	L-lactate dehydrogenase A chain	LDHA	0.0011
6048	Troponin C, skeletal muscle	TNNC2	0.0011
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0011
469	Annexin A1	ANXA1	0.0011
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
268	Adenosine A2b receptor	ADORA2B	0.0011
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
2290	ADP-ribosyl cyclase 2	BST1	0.001
517	Alcohol dehydrogenase 1C	ADH1C	0.001
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
6218	Pannexin-1	PANX1	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
144	Hemoglobin subunit alpha	HBA1	0.001
291	Nitric-oxide synthase, endothelial	NOS3	0.001
3913	Glutamic acid decarboxylase	GAD65	0.001
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0009
1268	Neuropeptide S receptor	NPSR1	0.0009
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0009
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
1483	Membrane copper amine oxidase	AOC3	0.0009
751	Potassium channel subfamily K member 6	KCNK6	0.0009
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0008
3932	Glutathione S-transferase A2	GSTA2	0.0008
6073	Potassium channel subfamily K member 9	KCNK9	0.0008
6072	Potassium channel subfamily K member 3	KCNK3	0.0008
735	Alanine aminotransferase 1	GPT	0.0008
3904	Alanine aminotransferase 2	GPT2	0.0008
244	Angiotensin-converting enzyme	ACE	0.0008
172	Potassium channel subfamily K member 1	KCNK1	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
284	DNA-directed RNA polymerase beta chain	rpoB	0.0008
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
3957	Adenosine deaminase	ADA	0.0007
4948	Cytochrome c-553	Not Available	0.0007
4923	Cytochrome c3	DvMF_2499	0.0007
4945	Cytochrome c3	Not Available	0.0007
4949	Cytochrome c3	DVU_3171	0.0007
4968	Cytochrome c3	cytc3	0.0007
4997	Cytochrome c3	SO_2727	0.0007
5219	Cytochrome c3	cyd	0.0007
4902	Nine-heme cytochrome c	Ddes_2038	0.0007
3189	High-molecular-weight cytochrome c	hmcA	0.0007
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
2207	Rhodopsin	RHO	0.0006
4386	Hemoglobin-like protein HbN	glbN	0.0006
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
4225	Uridine phosphorylase 1	UPP1	0.0006
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0006
719	Retinoic acid receptor responder protein 1	RARRES1	0.0006
770	Retinoic acid-induced protein 3	GPRC5A	0.0006
2449	Tubulin alpha-3 chain	TUBA1A	0.0006
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
3221	Cytochrome c4	cc4	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
543	Penicillin-binding protein 1B	mrcB	0.0005
6186	Penicillin-binding protein 1B	ponB	0.0005
6822	Penicillin-binding protein 1b	pbp1b	0.0005
6844	Penicillin-binding protein 1b	pbp1b	0.0005
645	Penicillin-binding protein 1A	mrcA	0.0005
5805	Penicillin-binding protein 1A	ponA	0.0005
6185	Penicillin-binding protein 1A	mrcA	0.0005
6799	Penicillin-binding protein 1A	pbpA	0.0005
159	Penicillin-binding protein 2B	penA	0.0005
6121	Penicillin-binding protein 2B	penA	0.0005
5924	Microtubule-associated protein 4	MAP4	0.0005
5923	Microtubule-associated protein tau	MAPT	0.0005
569	Retinal dehydrogenase 2	ALDH1A2	0.0005
1852	Microtubule-associated protein 2	MAP2	0.0005
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0005
611	Retinal dehydrogenase 1	ALDH1A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1507	Cytochrome c	CYCS	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0005
6824	Tyrosine-protein kinase Lyn	LYN	0.0005
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0004
760	Fibroblast growth factor 1	FGF1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
6131	Carbonic anhydrase 14	CA14	0.0004
162	Retinoic acid receptor gamma-1	RARG	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
6122	Carbonic anhydrase 3	CA3	0.0004
908	Glutathione S-transferase theta-1	GSTT1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0003
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0003
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0003
3007	Carbonic anhydrase 12	CA12	0.0003
4205	Carbonic anhydrase 9	CA9	0.0003
896	Glutathione S-transferase Mu 1	GSTM1	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0003
6020	Aldehyde oxidase	AOX1	0.0003
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0003
4954	Soluble cytochrome b558	Not Available	0.0002
4916	Cyanoglobin	glbN	0.0002
4934	Cytochrome c-551	nirM	0.0002
5218	Cytochrome c-551	nirM	0.0002
4947	Bacterial hemoglobin	vhb	0.0002
4915	Cytochrome c-550	psbV	0.0002
4959	Cytochrome c-550	psbV	0.0002
5216	Cytochrome c-550	psbV	0.0002
4925	Cytochrome c-type protein SHP	shp	0.0002
4998	Hemoglobin-like protein yjbI	yjbI	0.0002
4905	Cytochrome c2	Not Available	0.0002
4939	Cytochrome c2	cycA	0.0002
4964	Cytochrome c2	cycA	0.0002
4979	Cytochrome c2	cycA	0.0002
6673	Cytochrome c2	cycA	0.0002
5000	HemO	hemO	0.0002
4975	Cytochrome c-556	RPA3973	0.0002
4984	Neuroglobin	NGB	0.0002
4943	Cytochrome c6	petJ	0.0002
4910	Cytoglobin	CYGB	0.0002
4907	Cytochrome c-L	moxG	0.0002
6865	Cytochrome c-L	moxG	0.0002
4981	Iron-starvation protein PigA	pigA	0.0002
4971	Nonaheme cytochrome c	hmcA	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0002
4909	CooA protein	cooA	0.0002
4994	Hemoglobin-like protein HbO	glbO	0.0002
4935	Cytochrome c-554	cycA1	0.0002
644	Heme oxygenase 2	HMOX2	0.0002
4982	Heme oxygenase 2	pbsA2	0.0002
4942	Diheme cytochrome c napB	napB	0.0002
3116	Bacterioferritin	bfr	0.0002
4906	Bacterioferritin	bfr	0.0002
4965	Bacterioferritin	bfr	0.0002
4922	Cytochrome c, putative	SO_4144	0.0002
4764	Cytochrome P450 165C4	CYP165C4	0.0002
4937	Cytochrome oxidase subunit II	rcoxA	0.0002
4989	Cytochrome c551 peroxidase	ccp	0.0002
5222	Cytochrome c551 peroxidase	ccpA	0.0002
4961	Hemophore HasA	hasA	0.0002
4976	Apocytochrome f	petA	0.0002
6407	Apocytochrome f	petA	0.0002
4904	Cytochrome c family protein	GSU1996	0.0002
4903	Methyl-accepting chemotaxis protein	Tar4	0.0002
4999	Cytochrome P450 165B3	CYP165B3	0.0002
4960	Putative cytochrome P450-family protein	SCO7417	0.0002
4931	Cytochrome P450 167A1	CYP167A1	0.0002
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0002
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0002
4993	Hydroxylamine oxidoreductase	hao1	0.0002
4972	P450cin	cinA	0.0002
3093	Catalase HPII	katE	0.0002
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0002
4952	Catalase/peroxidase	katA	0.0002
4920	Peroxidase/catalase	katG	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
4990	PpcA	ppcA	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
605	Fumarate reductase flavoprotein subunit	frdA	0.0001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0001
3673	Fumarate reductase flavoprotein subunit	fccA	0.0001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0001
6549	Fumarate reductase flavoprotein subunit	frdA	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001
2298	Cytochrome P450-cam	camC	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB06204 - Tapentadol

Targets

Enzymes

Predictions