DT-Web

DB05109 - Trabectedin


Identification
Name Trabectedin
Accession Number DB05109
Type small molecule
Description Trabectedin, also referred as ET-743 during its development, is a marine derived antitumoral agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma refractory to or unsuitable to receive anthracycline or ifosfamide chemotherapy.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 761.837
Groups approved
Monoisotopic Weight 761.261829923
Pharmacology
Indication Indicated for treatment of advanced soft tissue sarcoma in patients refractory to or unsuitable to receive anthracycline or ifosfamide chemotherapy in Europe, Russia and South Korea. Approved for orphan drug status by the U.S. FDA for treatment of soft tissue sarcomas and ovarian cancer. Investigated for use/treatment in cancer/tumors (unspecified), gastric cancer, ovarian cancer, pediatric indications, sarcoma, and solid tumors.
Mechanism of action Trabectedin interacts with the minor groove of DNA and alkylates guanine at the N2 position, which bends towards the major groove. In this manner, it is thought that the drug affects various transcription factors involved in cell proliferation, particularly via the transcription-coupled nucleotide excision repair system. Trabectedin blocks the cell cycle at the G2 phase, while cells at the G1 phase are most sensitive to the drug. It also inhibits overexpression of the multidrug resistance-1 gene (MDR-1) coding for the P-glycoprotein that is a major factor responsible for cells developing resistance to cancer drugs. The agent is also thought to interfere with the nucleotide excision repair pathways of cancer cells, suggesting that it could be effective in the treatment of many cancer types including melanoma and sarcoma, as well as lung, breast, ovarian, endometrial and prostate cancers; clinical evaluations are underway in these indications.
Absorption Administered intravenously.
Protein binding 94 to 98%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions binder
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • D'Incalci M, Galmarini CM: A review of trabectedin (ET-743): a unique mechanism of action. Mol Cancer Ther. 2010 Aug;9(8):2157-63. Epub 2010 Jul 20. - Pubmed
  • Marco E, David-Cordonnier MH, Bailly C, Cuevas C, Gago F: Further insight into the DNA recognition mechanism of trabectedin from the differential affinity of its demethylated analogue ecteinascidin ET729 for the triplet DNA binding site CGA. J Med Chem. 2006 Nov 16;49(23):6925-9. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5518
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4621
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4285
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2772
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3868
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.453

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.2423
4924 Cytochrome P450 2C8 CYP2C8 0.2273
1588 Multidrug resistance protein 1 ABCB1 0.178
290 Prostaglandin G/H synthase 2 PTGS2 0.1769
4118 Cytochrome P450 3A5 CYP3A5 0.1616
6030 Cytochrome P450 2B6 CYP2B6 0.1529
6107 Cytochrome P450 3A7 CYP3A7 0.117
5718 Cytochrome P450 2A6 CYP2A6 0.1037
6024 Cytochrome P450 1A1 CYP1A1 0.096
587 Serum albumin ALB 0.0927
492 Histamine H1 receptor HRH1 0.0666
1729 Solute carrier family 22 member 6 SLC22A6 0.0619
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0592
824 Sodium-dependent serotonin transporter SLC6A4 0.0569
6106 Cytochrome P450 2C18 CYP2C18 0.052
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0474
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0457
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0457
502 5-hydroxytryptamine 2A receptor HTR2A 0.0422
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0417
556 Alpha-1A adrenergic receptor ADRA1A 0.0415
831 D(2) dopamine receptor DRD2 0.0415
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0409
3811 Cytochrome P450 19A1 CYP19A1 0.0395
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0392
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0385
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0362
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0352
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0349
862 Multidrug resistance-associated protein 1 ABCC1 0.0348
6145 Solute carrier family 22 member 1 SLC22A1 0.0341
766 Beta-2 adrenergic receptor ADRB2 0.0336
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0324
260 Cytochrome P450 51 ERG11 0.0315
761 Cytochrome P450 51 ERG11 0.0315
3163 Cytochrome P450 51 cyp51 0.0315
713 Sodium-dependent dopamine transporter SLC6A3 0.0311
1898 Cytochrome P450 1B1 CYP1B1 0.0304
6144 Solute carrier family 22 member 2 SLC22A2 0.0304
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0303
275 Arachidonate 5-lipoxygenase ALOX5 0.0301
320 5-hydroxytryptamine 1A receptor HTR1A 0.03
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0291
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.029
6142 Solute carrier family 22 member 8 SLC22A8 0.0279
2164 Multidrug resistance-associated protein 4 ABCC4 0.0273
590 5-hydroxytryptamine 2C receptor HTR2C 0.0272
23 D(1A) dopamine receptor DRD1 0.0272
847 Mu-type opioid receptor OPRM1 0.0272
318 Alpha-2A adrenergic receptor ADRA2A 0.0271
731 HIV-1 protease HIV-1 protease 0.027
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0269
193 Beta-1 adrenergic receptor ADRB1 0.0268
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0268
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.026
341 5-hydroxytryptamine 3 receptor HTR3A 0.0257
632 Alpha-1B adrenergic receptor ADRA1B 0.0253
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0251
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0245
118 Organic cation/carnitine transporter 2 SLC22A5 0.0239
3941 Amine oxidase [flavin-containing] A MAOA 0.0237
136 Estrogen receptor ESR1 0.0235
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0233
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0229
467 Delta-type opioid receptor OPRD1 0.0228
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0227
776 Bile salt export pump ABCB11 0.0226
696 Kappa-type opioid receptor OPRK1 0.0213
871 Glucocorticoid receptor NR3C1 0.0201
891 Dihydropteroate synthase folP 0.0201
5359 Dihydropteroate synthase folP 0.0201
7175 Dihydropteroate synthase sulI 0.0201
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
6143 Solute carrier family 22 member 7 SLC22A7 0.0197
1757 Myeloperoxidase MPO 0.0193
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0191
465 Calmodulin CALM1 0.0189
3939 Amine oxidase [flavin-containing] B MAOB 0.0188
6031 Cytochrome P450 3A43 CYP3A43 0.0187
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0185
3923 Cholinesterase BCHE 0.0182
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0182
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0182
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.018
1024 Solute carrier family 22 member 11 SLC22A11 0.0179
468 Cytochrome P450 4A11 CYP4A11 0.0178
638 D(3) dopamine receptor DRD3 0.0178
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0178
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0177
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0177
885 5-hydroxytryptamine 1B receptor HTR1B 0.0175
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0171
789 Alpha-1D adrenergic receptor ADRA1D 0.0171
122 P2Y purinoceptor 12 P2RY12 0.017
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.017
70 Type-1 angiotensin II receptor AGTR1 0.0166
6102 Arylamine N-acetyltransferase 2 NAT2 0.016
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0158
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0157
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0157
817 DNA topoisomerase 2-alpha TOP2A 0.0156
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0154
6147 Solute carrier family 22 member 3 SLC22A3 0.0153
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0153
811 Translocator protein TSPO 0.0153
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0151
146 Androgen receptor AR 0.015
833 Organic cation/carnitine transporter 1 SLC22A4 0.015
373 Transthyretin TTR 0.0143
629 Alpha-2B adrenergic receptor ADRA2B 0.014
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.014
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0137
777 Tumor necrosis factor TNF 0.0137
725 5-hydroxytryptamine 1D receptor HTR1D 0.0136
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0136
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0136
436 5-hydroxytryptamine 2B receptor HTR2B 0.0136
432 D(4) dopamine receptor DRD4 0.0134
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0127
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0127
378 Alpha-2C adrenergic receptor ADRA2C 0.0126
6182 Cytochrome P450 2J2 CYP2J2 0.0123
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0121
592 Carbonic anhydrase 4 CA4 0.0116
482 Glycine receptor subunit alpha-1 GLRA1 0.0115
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0114
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0114
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0114
1507 Cytochrome c CYCS 0.0114
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0112
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0112
4604 Liver carboxylesterase 1 CES1 0.0111
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0111
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0111
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0111
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0111
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.011
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0109
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0109
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0108
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0108
6014 Cytochrome P450 2A13 CYP2A13 0.0108
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0106
716 5-hydroxytryptamine 7 receptor HTR7 0.0106
4116 Dihydropteroate synthetase Not Available 0.0106
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0105
124 Histamine H2 receptor HRH2 0.0104
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0104
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0104
94 5-hydroxytryptamine 4 receptor HTR4 0.0104
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0104
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0103
6220 Aryl hydrocarbon receptor AHR 0.0103
295 Carbonic anhydrase 1 CA1 0.0101
16 Adenosine A1 receptor ADORA1 0.0101
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0101
614 Progesterone receptor PGR 0.0101
161 Tubulin beta chain TUBB 0.01
312 Tubulin beta chain TUB2 0.01
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.01
6137 Multidrug resistance-associated protein 6 ABCC6 0.0098
474 Acetylcholinesterase ACHE 0.0098
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0096
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0096
49 Endothelin B receptor EDNRB 0.0096
1010 Cytochrome P450 51A1 CYP51A1 0.0094
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0094
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0094
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0093
6148 Multidrug resistance-associated protein 7 ABCC10 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0092
705 Glutamate receptor 1 GRIA1 0.0092
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0092
738 Monocarboxylate transporter 1 SLC16A1 0.0091
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0091
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0091
578 Endothelin-1 receptor EDNRA 0.009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.009
163 D(1B) dopamine receptor DRD5 0.0089
365 Dihydrofolate reductase DHFR 0.0088
2381 Dihydrofolate reductase DFR1 0.0088
2833 Dihydrofolate reductase Not Available 0.0088
2931 Dihydrofolate reductase folA 0.0088
3544 Dihydrofolate reductase folA 0.0088
3682 Dihydrofolate reductase folA 0.0088
6642 Dihydrofolate reductase folA 0.0088
6756 Dihydrofolate reductase dfrA 0.0088
380 Cytochrome P450 17A1 CYP17A1 0.0087
1178 Adenosine A2a receptor ADORA2A 0.0087
357 Carbonic anhydrase 2 CA2 0.0087
3810 Catechol O-methyltransferase COMT 0.0086
3312 Fatty acid-binding protein, brain FABP7 0.0086
537 ATP synthase delta chain, mitochondrial ATP5D 0.0086
6136 Multidrug resistance-associated protein 5 ABCC5 0.0085
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0085
3947 Xanthine dehydrogenase/oxidase XDH 0.0084
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0084
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0084
6126 Carbonic anhydrase 7 CA7 0.0084
427 Substance-P receptor TACR1 0.0083
504 Mast/stem cell growth factor receptor KIT 0.0083
183 Vascular endothelial growth factor A VEGFA 0.0083
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0083
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0083
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0082
185 Vasopressin V1a receptor AVPR1A 0.0082
68 Cannabinoid receptor 1 CNR1 0.0081
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0081
322 Vasopressin V2 receptor AVPR2 0.008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0079
6141 Sodium/bile acid cotransporter SLC10A1 0.0079
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0079
844 Epidermal growth factor receptor EGFR 0.0077
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0077
921 Glutamate receptor 2 GRIA2 0.0077
6085 Fatty acid-binding protein, intestinal FABP2 0.0077
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0077
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0076
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0075
1656 CYP2B protein CYP2B 0.0075
528 5-hydroxytryptamine 1E receptor HTR1E 0.0075
823 Fibroblast growth factor receptor 2 FGFR2 0.0075
407 Vascular endothelial growth factor receptor 2 KDR 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0072
130 Prostacyclin synthase PTGIS 0.0072
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0072
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0072
818 50S ribosomal protein L10 rplJ 0.0071
4122 Histone deacetylase 2 HDAC2 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
6043 Putative G-protein coupled receptor 44 GPR44 0.007
1256 5-hydroxytryptamine 6 receptor HTR6 0.007
723 Cytosolic phospholipase A2 PLA2G4A 0.0069
7 Nitric oxide synthase, inducible NOS2 0.0069
952 Dipeptidyl peptidase 4 DPP4 0.0069
153 Dopamine beta-hydroxylase DBH 0.0067
558 Solute carrier family 12 member 1 SLC12A1 0.0067
4120 NADPH--cytochrome P450 reductase POR 0.0066
29 Tubulin beta-1 chain TUBB1 0.0066
634 Squalene monooxygenase SQLE 0.0066
7196 Squalene monooxygenase ERG1 0.0066
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0065
1629 Transcription factor AP-1 JUN 0.0065
518 Peroxidase/catalase T katG 0.0064
869 Estrogen receptor beta ESR2 0.0063
1275 Estrogen sulfotransferase SULT1E1 0.0063
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0063
133 Dihydropterate synthase sulI 0.0063
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0061
756 Sex hormone-binding globulin SHBG 0.0061
228 Beta platelet-derived growth factor receptor PDGFRB 0.0061
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.006
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0059
1648 Elastin ELN 0.0059
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0059
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0059
444 Alcohol dehydrogenase 1B ADH1B 0.0059
251 Alcohol dehydrogenase 1A ADH1A 0.0058
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0058
3808 Dihydropteroate synthase 2 folP2 0.0058
3601 Dihydropteroate synthase 1 folP1 0.0058
3807 Dihydropteroate synthase 1 folP1 0.0058
814 Ryanodine receptor 1 RYR1 0.0058
26 Vascular endothelial growth factor receptor 3 FLT4 0.0057
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0057
563 Thyroid peroxidase TPO 0.0056
703 NADPH azoreductase azr 0.0056
1192 Sulfotransferase 1A1 SULT1A1 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0056
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0055
32 Vascular endothelial growth factor receptor 1 FLT1 0.0055
6506 Stathmin-4 STMN4 0.0055
106 Cannabinoid receptor 2 CNR2 0.0054
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0054
1618 High affinity nerve growth factor receptor NTRK1 0.0054
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0054
904 Glutathione S-transferase P GSTP1 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0053
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0053
856 Vitamin D3 receptor VDR 0.0053
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
6146 High affinity copper uptake protein 1 SLC31A1 0.0051
2112 Toll-like receptor 9 TLR9 0.0051
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
459 Retinoic acid receptor RXR-alpha RXRA 0.005
3404 Exotoxin A eta 0.0049
174 Sigma 1-type opioid receptor SIGMAR1 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6432 Transporter snf 0.0048
6103 Arylamine N-acetyltransferase 1 NAT1 0.0048
2230 Catalase CAT 0.0047
3249 Catalase katA 0.0047
3625 Catalase katA 0.0047
4539 Catalase katA 0.0047
4941 Catalase katB 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
3932 Glutathione S-transferase A2 GSTA2 0.0047
1483 Membrane copper amine oxidase AOC3 0.0046
1253 Interferon gamma IFNG 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
1374 Natriuretic peptides B NPPB 0.0045
1827 Gap junction alpha-1 protein GJA1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
1908 Vascular cell adhesion protein 1 VCAM1 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
517 Alcohol dehydrogenase 1C ADH1C 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0044
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0044
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0044
6138 Multidrug resistance protein 3 ABCB4 0.0044
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0044
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0044
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
284 DNA-directed RNA polymerase beta chain rpoB 0.0043
5773 DNA-directed RNA polymerase beta chain rpoB 0.0043
6020 Aldehyde oxidase AOX1 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0042
4103 Proteasome subunit beta type 2 PSMB2 0.0042
54 Prothrombin F2 0.0042
4102 Proteasome subunit beta type 5 PSMB5 0.0042
4101 Proteasome subunit beta type 1 PSMB1 0.0042
6131 Carbonic anhydrase 14 CA14 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0041
319 Opioid receptor, sigma 1 OPRS1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
3937 Fatty-acid amide hydrolase FAAH 0.004
737 Mineralocorticoid receptor NR3C2 0.004
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
581 Cytochrome P450 2R1 CYP2R1 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0039
1541 Metalloproteinase mmp20 0.0039
4132 Chloride channel protein ClC-Ka CLCNKA 0.0039
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
976 Platelet glycoprotein IX GP9 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
511 5-hydroxytryptamine 1F receptor HTR1F 0.0039
4311 tRNA TRDMT1 0.0039
4325 tRNA trmD 0.0039
4328 tRNA trmD 0.0039
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0038
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0038
6149 Solute carrier family 22 member 10 SLC22A10 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0038
85 Growth hormone receptor GHR 0.0038
164 Histamine H4 receptor HRH4 0.0037
208 DNA-directed RNA polymerase beta' chain rpoC 0.0037
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0037
2183 Fatty acid-binding protein, adipocyte FABP4 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0036
4237 50S ribosomal protein L22 rplV 0.0035
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0035
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
1650 Heme carrier protein 1 SLC46A1 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
3809 Estrogen-related receptor gamma ESRRG 0.0034
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
908 Glutathione S-transferase theta-1 GSTT1 0.0033
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
33 Cystine/glutamate transporter SLC7A11 0.0033
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0033
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0032
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0032
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
239 Coagulation factor X F10 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
489 Monocarboxylate transporter 2 SLC16A7 0.0031
2207 Rhodopsin RHO 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
1517 Beta-3 adrenergic receptor ADRB3 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
88 Retinoic acid receptor RXR-beta RXRB 0.003
1864 RET proto-oncogene RET 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.003
84 Nuclear receptor 0B1 NR0B1 0.003
6174 50S ribosomal protein L32 rpmF 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0029
1196 Complement decay-accelerating factor CD55 0.0029
2236 Casein kinase II subunit alpha CSNK2A1 0.0029
2298 Cytochrome P450-cam camC 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1992 Vitamin D-binding protein GC 0.0028
273 Apoptosis regulator Bcl-2 BCL2 0.0028
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0027
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0027
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0027
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0027
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0027
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0027
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0027
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
6500 Phospholipase A2 PLA2G1B 0.0026
1714 Mitogen-activated protein kinase 3 MAPK3 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0026
165 FL cytokine receptor FLT3 0.0026
358 Cystathionine beta-synthase CBS 0.0026
1630 Integrin beta-2 ITGB2 0.0026
2808 Chloramphenicol acetyltransferase 3 cat3 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
268 Adenosine A2b receptor ADORA2B 0.0025
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0025
4192 DNA topoisomerase 2-beta TOP2B 0.0025
469 Annexin A1 ANXA1 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
2021 Thrombomodulin THBD 0.0025
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0025
735 Alanine aminotransferase 1 GPT 0.0024
3904 Alanine aminotransferase 2 GPT2 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
5787 Angiopoietin-1 receptor TEK 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
3917 Methylenetetrahydrofolate reductase MTHFR 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
2417 Chloramphenicol acetyltransferase cat 0.0023
3278 Chloramphenicol acetyltransferase cat 0.0023
2810 Dr hemagglutinin structural subunit draA 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0023
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0023
1039 Histone deacetylase 9 HDAC9 0.0023
1341 Histamine H3 receptor HRH3 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
6044 Serum paraoxonase/lactonase 3 PON3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
1360 Sphingomyelin phosphodiesterase SMPD1 0.002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
572 Integrin alpha-L ITGAL 0.002
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
896 Glutathione S-transferase Mu 1 GSTM1 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6042 Prostaglandin reductase 2 PTGR2 0.0018
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0017
5934 Cytochrome P450 26A1 CYP26A1 0.0017
3221 Cytochrome c4 cc4 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
3957 Adenosine deaminase ADA 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
822 Aldose reductase AKR1B1 0.0016
3233 Bile acid receptor NR1H4 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
267 Plasminogen activator inhibitor 1 SERPINE1 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6163 Copper-transporting ATPase 2 ATP7B 0.0014
6165 Copper-transporting ATPase 1 ATP7A 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
6218 Pannexin-1 PANX1 0.0013
6221 Steroid hormone receptor ERR1 ESRRA 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0013
605 Fumarate reductase flavoprotein subunit frdA 0.0013
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0013
3673 Fumarate reductase flavoprotein subunit fccA 0.0013
4912 Fumarate reductase flavoprotein subunit ifcA 0.0013
6549 Fumarate reductase flavoprotein subunit frdA 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
1295 Fatty acid synthase FASN 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
4692 A/G-specific adenine glycosylase mutY 0.0011
4948 Cytochrome c-553 Not Available 0.0011
4923 Cytochrome c3 DvMF_2499 0.0011
4945 Cytochrome c3 Not Available 0.0011
4949 Cytochrome c3 DVU_3171 0.0011
4968 Cytochrome c3 cytc3 0.0011
4997 Cytochrome c3 SO_2727 0.0011
5219 Cytochrome c3 cyd 0.0011
4902 Nine-heme cytochrome c Ddes_2038 0.0011
3189 High-molecular-weight cytochrome c hmcA 0.0011
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
2802 Endoglucanase G celCCG 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
798 Osteocalcin BGLAP 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
1184 Interferon beta IFNB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6459 Glycodelin PAEP 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4916 Cyanoglobin glbN 0.0006
4943 Cytochrome c6 petJ 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4984 Neuroglobin NGB 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4909 CooA protein cooA 0.0006
5000 HemO hemO 0.0006
4961 Hemophore HasA hasA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4910 Cytoglobin CYGB 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4972 P450cin cinA 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4952 Catalase/peroxidase katA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
162 Retinoic acid receptor gamma-1 RARG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
4920 Peroxidase/catalase katG 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
4990 PpcA ppcA 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
1439 Lactotransferrin LTF 0.0003
309 Antithrombin-III SERPINC1 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
693 Hemoglobin subunit beta HBB 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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