DT-Web

DB00588 - Fluticasone Propionate


Identification
Name Fluticasone Propionate
Accession Number DB00588 (APRD00065)
Type small molecule
Description Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma. Fluticasone proprionate is marketed under several different brand names such as Flonase(R). Fluticasone propionate is also available as a combination product of azelastine hydrochloride and fluticasone propionate called Dymista(TM). Dymista(TM) is indicated in patients over 12 years old for symptomatic relief of seasonal allergic rhinitis.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 500.571
Groups approved
Monoisotopic Weight 500.184429407
Pharmacology
Indication Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
Mechanism of action Binds to the glucocorticoid receptor. Unbound corticosteroids cross the membranes of cells such as mast cells and eosinophils, binding with high affinity to glucocorticoid receptors (GR). The results include alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. In the management of asthma, the glucocorticoid receptor complexes down-regulates proinflammatory mediators such as interleukin-(IL)-1, 3, and 5, and up-regulates anti-inflammatory mediators such as IkappaB [inhibitory molecule for nuclear factor kappaB1], IL-10, and IL-12. The antiinflammatory actions of corticosteroids are also thought to involve inhibition of cytosolic phospholipase A2 (through activation of lipocortin-1 (annexin)) which controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Absorption The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Bioavailability, intranasal = <2%; Oral bioavailability is negligible and the major circulating entity is an inactive metabolite.
Protein binding 91%
Biotransformation Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4-mediated hydrolysis of the 5-fluoromethyl carbothioate grouping. This transformation occurs in 1 metabolic step to produce the inactive 17-(beta)-carboxylic acid metabolite, the only known metabolite detected in man.
Route of elimination Less than 5% of the oral dose was excreted in the urine as metabolites. The rest of the dose is excreted in the feces and parent drug and metabolites.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Conivaptan CYP3A4 Inhibitors (Strong) may increase the serum concentration of Fluticasone (Oral Inhalation). Concurrent use of orally inhaled fluticasone with strong CYP3A4 inhibitors is not recommended.
Crizotinib Concurrent use with crizotinib may prolong QTc interval. Consider alternative therapy.
Telithromycin Telithromycin may reduce clearance of Fluticasone. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Fluticasone if Telithromycin is initiated, discontinued or dose changed.
Tipranavir Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Fluticasone propionate. Concomitant therapy should be avoided if possible.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of fluticasone by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of fluticasone if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Glucocorticoid receptor
Name Glucocorticoid receptor
Gene Name NR3C1
Pharmacological action yes
Actions agonist
References
  • Andersson O, Cassel TN, Gronneberg R, Bronnegard M, Stierna P, Nord M: In vivo modulation of glucocorticoid receptor mRNA by inhaled fluticasone propionate in bronchial mucosa and blood lymphocytes in subjects with mild asthma. J Allergy Clin Immunol. 1999 Apr;103(4):595-600. - Pubmed
  • Lumry WR: A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis. J Allergy Clin Immunol. 1999 Oct;104(4 Pt 1):S150-8. - Pubmed
  • Zhang X, Moilanen E, Kankaanranta H: Beclomethasone, budesonide and fluticasone propionate inhibit human neutrophil apoptosis. Eur J Pharmacol. 2001 Nov 23;431(3):365-71. - Pubmed
  • Hogger P, Rohdewald P: Binding kinetics of fluticasone propionate to the human glucocorticoid receptor. Steroids. 1994 Oct;59(10):597-602. - Pubmed
  • Johnson M: Fluticasone propionate: safety profile. Cutis. 1996 Feb;57(2 Suppl):10-2. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.3094
Progesterone receptor
Name Progesterone receptor
Gene Name PGR
Pharmacological action unknown
Actions agonist
References
  • Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. - Pubmed
  • Austin RJ, Maschera B, Walker A, Fairbairn L, Meldrum E, Farrow SN, Uings IJ: Mometasone furoate is a less specific glucocorticoid than fluticasone propionate. Eur Respir J. 2002 Dec;20(6):1386-92. - Pubmed
DTHybrid score 0.6668
Cytosolic phospholipase A2
Name Cytosolic phospholipase A2
Gene Name PLA2G4A
Pharmacological action unknown
Actions inhibitor
References
  • Sano A, Munoz NM, Sano H, Choi J, Zhu X, Jacobs B, Leff AR: Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. Am J Respir Crit Care Med. 1999 Jun;159(6):1903-9. - Pubmed
  • Myo S, Zhu X, Myou S, Meliton AY, Liu J, Boetticher E, Lambertino AT, Xu C, Munoz NM, Leff AR: Additive blockade of beta 2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate. Eur Respir J. 2004 Apr;23(4):511-7. - Pubmed
DTHybrid score 0.4553
Mineralocorticoid receptor
Name Mineralocorticoid receptor
Gene Name NR3C2
Pharmacological action unknown
Actions antagonist
References
  • Austin RJ, Maschera B, Walker A, Fairbairn L, Meldrum E, Farrow SN, Uings IJ: Mometasone furoate is a less specific glucocorticoid than fluticasone propionate. Eur Respir J. 2002 Dec;20(6):1386-92. - Pubmed
  • Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. - Pubmed
DTHybrid score 0.477

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Pearce RE, Leeder JS, Kearns GL: Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos. 2006 Jun;34(6):1035-40. Epub 2006 Mar 24. - Pubmed
  • Murai T, Reilly CA, Ward RM, Yost GS: The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme. Chem Res Toxicol. 2010 Aug 16;23(8):1356-64. - Pubmed
DTHybrid score 0.6546
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate,inhibitor
References
  • Pearce RE, Leeder JS, Kearns GL: Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos. 2006 Jun;34(6):1035-40. Epub 2006 Mar 24. - Pubmed
  • Murai T, Reilly CA, Ward RM, Yost GS: The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme. Chem Res Toxicol. 2010 Aug 16;23(8):1356-64. - Pubmed
DTHybrid score 0.391
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
  • Pearce RE, Leeder JS, Kearns GL: Biotransformation of fluticasone: in vitro characterization. Drug Metab Dispos. 2006 Jun;34(6):1035-40. Epub 2006 Mar 24. - Pubmed
DTHybrid score 0.3057

Carriers


Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.2278
4119 Cytochrome P450 2D6 CYP2D6 0.1651
136 Estrogen receptor ESR1 0.1515
4924 Cytochrome P450 2C8 CYP2C8 0.1306
146 Androgen receptor AR 0.1294
4757 Cytochrome P450 2C9 CYP2C9 0.1269
6016 Cytochrome P450 2C19 CYP2C19 0.1247
4200 Cytochrome P450 1A2 CYP1A2 0.1092
1193 Proteinase-activated receptor 1 F2R 0.0777
6030 Cytochrome P450 2B6 CYP2B6 0.0691
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0668
290 Prostaglandin G/H synthase 2 PTGS2 0.0635
6013 Cytochrome P450 2E1 CYP2E1 0.0609
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0604
756 Sex hormone-binding globulin SHBG 0.0598
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0591
6024 Cytochrome P450 1A1 CYP1A1 0.0588
862 Multidrug resistance-associated protein 1 ABCC1 0.0586
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0559
2202 Steryl-sulfatase STS 0.0552
5718 Cytochrome P450 2A6 CYP2A6 0.0508
1729 Solute carrier family 22 member 6 SLC22A6 0.0481
3811 Cytochrome P450 19A1 CYP19A1 0.0464
234 Plasminogen PLG 0.0448
3923 Cholinesterase BCHE 0.0439
469 Annexin A1 ANXA1 0.0433
587 Serum albumin ALB 0.043
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0415
6020 Aldehyde oxidase AOX1 0.0394
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0381
380 Cytochrome P450 17A1 CYP17A1 0.0331
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.033
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0327
1757 Myeloperoxidase MPO 0.0323
6144 Solute carrier family 22 member 2 SLC22A2 0.0314
6116 Gastric triacylglycerol lipase LIPF 0.0314
6228 Nuclear receptor coactivator 1 NCOA1 0.0313
20 Prostaglandin G/H synthase 1 PTGS1 0.0302
847 Mu-type opioid receptor OPRM1 0.0299
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0298
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0295
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0293
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0293
1295 Fatty acid synthase FASN 0.0291
6031 Cytochrome P450 3A43 CYP3A43 0.0288
817 DNA topoisomerase 2-alpha TOP2A 0.0285
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0281
754 Pancreatic triacylglycerol lipase PNLIP 0.028
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0279
6145 Solute carrier family 22 member 1 SLC22A1 0.0277
776 Bile salt export pump ABCB11 0.0275
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0274
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0274
3823 Cytokine receptor common gamma chain IL2RG 0.0266
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0265
1898 Cytochrome P450 1B1 CYP1B1 0.0263
269 Adrenodoxin, mitochondrial FDX1 0.0258
492 Histamine H1 receptor HRH1 0.025
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0245
6106 Cytochrome P450 2C18 CYP2C18 0.0244
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.024
4604 Liver carboxylesterase 1 CES1 0.024
1770 Phospholipase C PLCL1 0.0238
2841 Phospholipase C plc 0.0238
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0238
724 Interleukin-2 receptor alpha chain IL2RA 0.0232
717 Interleukin-2 receptor subunit beta IL2RB 0.0231
4132 Chloride channel protein ClC-Ka CLCNKA 0.0225
320 5-hydroxytryptamine 1A receptor HTR1A 0.0215
118 Organic cation/carnitine transporter 2 SLC22A5 0.0208
6241 Nuclear receptor coactivator 2 NCOA2 0.0206
824 Sodium-dependent serotonin transporter SLC6A4 0.0204
6500 Phospholipase A2 PLA2G1B 0.0201
814 Ryanodine receptor 1 RYR1 0.0201
467 Delta-type opioid receptor OPRD1 0.0198
4165 P2Y purinoceptor 2 P2RY2 0.0198
831 D(2) dopamine receptor DRD2 0.0189
502 5-hydroxytryptamine 2A receptor HTR2A 0.0187
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0181
430 Follicle-stimulating hormone receptor FSHR 0.0179
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0177
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0172
556 Alpha-1A adrenergic receptor ADRA1A 0.0172
696 Kappa-type opioid receptor OPRK1 0.017
4203 Histamine N-methyltransferase HNMT 0.0169
731 HIV-1 protease HIV-1 protease 0.0168
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0164
6220 Aryl hydrocarbon receptor AHR 0.0164
6147 Solute carrier family 22 member 3 SLC22A3 0.0163
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0161
2654 Complement control protein C3L 0.0161
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0157
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0154
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0151
260 Cytochrome P450 51 ERG11 0.0151
761 Cytochrome P450 51 ERG11 0.0151
3163 Cytochrome P450 51 cyp51 0.0151
318 Alpha-2A adrenergic receptor ADRA2A 0.015
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0148
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0148
5455 Arylsulfatase A ARSA 0.0146
638 D(3) dopamine receptor DRD3 0.0146
4148 Serine/threonine-protein kinase mTOR MTOR 0.0145
6143 Solute carrier family 22 member 7 SLC22A7 0.0145
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0143
738 Monocarboxylate transporter 1 SLC16A1 0.0142
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0142
381 Prolactin receptor PRLR 0.0142
3947 Xanthine dehydrogenase/oxidase XDH 0.0141
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0139
489 Monocarboxylate transporter 2 SLC16A7 0.0138
6182 Cytochrome P450 2J2 CYP2J2 0.0136
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0136
1649 Small inducible cytokine A2 CCL2 0.0134
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0134
341 5-hydroxytryptamine 3 receptor HTR3A 0.0133
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0132
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0131
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0126
6148 Multidrug resistance-associated protein 7 ABCC10 0.0126
2981 Phospholipase A2, membrane associated PLA2G2A 0.0121
632 Alpha-1B adrenergic receptor ADRA1B 0.0121
6141 Sodium/bile acid cotransporter SLC10A1 0.012
590 5-hydroxytryptamine 2C receptor HTR2C 0.012
54 Prothrombin F2 0.0117
23 D(1A) dopamine receptor DRD1 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0112
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0111
226 Gonadotropin-releasing hormone receptor GNRHR 0.011
468 Cytochrome P450 4A11 CYP4A11 0.0108
465 Calmodulin CALM1 0.0108
713 Sodium-dependent dopamine transporter SLC6A3 0.0108
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0107
811 Translocator protein TSPO 0.0106
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0103
2164 Multidrug resistance-associated protein 4 ABCC4 0.0102
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0102
6048 Troponin C, skeletal muscle TNNC2 0.0102
766 Beta-2 adrenergic receptor ADRB2 0.0101
6142 Solute carrier family 22 member 8 SLC22A8 0.01
378 Alpha-2C adrenergic receptor ADRA2C 0.01
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0097
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0097
885 5-hydroxytryptamine 1B receptor HTR1B 0.0097
818 50S ribosomal protein L10 rplJ 0.0095
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0095
4615 Chain A, Red Copper Protein Nitrosocyanin NE0143 0.0093
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0093
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0092
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0091
629 Alpha-2B adrenergic receptor ADRA2B 0.009
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.009
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0088
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0088
29 Tubulin beta-1 chain TUBB1 0.0086
432 D(4) dopamine receptor DRD4 0.0084
768 FK506-binding protein 1A FKBP1A 0.0083
833 Organic cation/carnitine transporter 1 SLC22A4 0.008
725 5-hydroxytryptamine 1D receptor HTR1D 0.008
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.008
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.008
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0079
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0079
844 Epidermal growth factor receptor EGFR 0.0078
504 Mast/stem cell growth factor receptor KIT 0.0077
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0077
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0077
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0076
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0076
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0076
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0076
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0076
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0076
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0075
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0075
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0075
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0075
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0074
477 DNA topoisomerase 4 subunit A parC 0.0074
886 DNA topoisomerase 4 subunit A parC 0.0074
6226 DNA topoisomerase 4 subunit A parC 0.0074
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0074
404 DNA gyrase subunit A gyrA 0.0073
6224 DNA gyrase subunit A gyrA 0.0073
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0071
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0071
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0071
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.007
789 Alpha-1D adrenergic receptor ADRA1D 0.007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.007
228 Beta platelet-derived growth factor receptor PDGFRB 0.0069
26 Vascular endothelial growth factor receptor 3 FLT4 0.0069
407 Vascular endothelial growth factor receptor 2 KDR 0.0069
716 5-hydroxytryptamine 7 receptor HTR7 0.0069
1758 GTPase HRas HRAS 0.0068
4237 50S ribosomal protein L22 rplV 0.0068
705 Glutamate receptor 1 GRIA1 0.0067
32 Vascular endothelial growth factor receptor 1 FLT1 0.0066
427 Substance-P receptor TACR1 0.0064
952 Dipeptidyl peptidase 4 DPP4 0.0063
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
193 Beta-1 adrenergic receptor ADRB1 0.0062
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0062
1256 5-hydroxytryptamine 6 receptor HTR6 0.0061
208 DNA-directed RNA polymerase beta' chain rpoC 0.006
5774 DNA-directed RNA polymerase beta' chain rpoC 0.006
84 Nuclear receptor 0B1 NR0B1 0.006
1010 Cytochrome P450 51A1 CYP51A1 0.006
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
2539 Tubulin alpha-1 chain TUBA4A 0.0059
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0059
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0059
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0058
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0058
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0057
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0056
94 5-hydroxytryptamine 4 receptor HTR4 0.0056
161 Tubulin beta chain TUBB 0.0056
312 Tubulin beta chain TUB2 0.0056
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0055
1852 Microtubule-associated protein 2 MAP2 0.0054
4238 50S ribosomal protein L4 rplD 0.0054
5578 50S ribosomal protein L4 rplD 0.0054
6173 50S ribosomal protein L4 rplD 0.0054
6219 50S ribosomal protein L4 rplD 0.0054
1656 CYP2B protein CYP2B 0.0053
165 FL cytokine receptor FLT3 0.0052
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0051
777 Tumor necrosis factor TNF 0.005
6137 Multidrug resistance-associated protein 6 ABCC6 0.005
6136 Multidrug resistance-associated protein 5 ABCC5 0.005
4120 NADPH--cytochrome P450 reductase POR 0.0049
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0049
122 P2Y purinoceptor 12 P2RY12 0.0048
1483 Membrane copper amine oxidase AOC3 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0047
2300 Lysozyme E 0.0047
3633 Lysozyme R 0.0047
5597 Lysozyme 17 0.0047
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0047
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0046
163 D(1B) dopamine receptor DRD5 0.0044
1024 Solute carrier family 22 member 11 SLC22A11 0.0044
3941 Amine oxidase [flavin-containing] A MAOA 0.0043
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0043
273 Apoptosis regulator Bcl-2 BCL2 0.0042
1196 Complement decay-accelerating factor CD55 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0041
284 DNA-directed RNA polymerase beta chain rpoB 0.0041
5773 DNA-directed RNA polymerase beta chain rpoB 0.0041
1050 Bile salt sulfotransferase SULT2A1 0.0041
124 Histamine H2 receptor HRH2 0.0041
528 5-hydroxytryptamine 1E receptor HTR1E 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.004
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0039
239 Coagulation factor X F10 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
869 Estrogen receptor beta ESR2 0.0039
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0039
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0039
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
6102 Arylamine N-acetyltransferase 2 NAT2 0.0038
295 Carbonic anhydrase 1 CA1 0.0038
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0038
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
2808 Chloramphenicol acetyltransferase 3 cat3 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
856 Vitamin D3 receptor VDR 0.0035
4773 Deoxycytidine kinase DCK 0.0035
5300 Antigen peptide transporter 1 TAP1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0034
474 Acetylcholinesterase ACHE 0.0033
3601 Dihydropteroate synthase 1 folP1 0.0033
3807 Dihydropteroate synthase 1 folP1 0.0033
3808 Dihydropteroate synthase 2 folP2 0.0033
2417 Chloramphenicol acetyltransferase cat 0.0033
3278 Chloramphenicol acetyltransferase cat 0.0033
6014 Cytochrome P450 2A13 CYP2A13 0.0033
3932 Glutathione S-transferase A2 GSTA2 0.0033
2810 Dr hemagglutinin structural subunit draA 0.0032
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
3086 Plasmepsin-2 Not Available 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
153 Dopamine beta-hydroxylase DBH 0.0031
3913 Glutamic acid decarboxylase GAD65 0.0031
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
16 Adenosine A1 receptor ADORA1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
70 Type-1 angiotensin II receptor AGTR1 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.003
3939 Amine oxidase [flavin-containing] B MAOB 0.003
4122 Histone deacetylase 2 HDAC2 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
1178 Adenosine A2a receptor ADORA2A 0.003
319 Opioid receptor, sigma 1 OPRS1 0.003
1630 Integrin beta-2 ITGB2 0.0028
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0028
1517 Beta-3 adrenergic receptor ADRB3 0.0028
976 Platelet glycoprotein IX GP9 0.0028
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0027
436 5-hydroxytryptamine 2B receptor HTR2B 0.0027
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
780 Retinoic acid receptor RXR-gamma RXRG 0.0027
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0027
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
735 Alanine aminotransferase 1 GPT 0.0026
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0026
49 Endothelin B receptor EDNRB 0.0026
1618 High affinity nerve growth factor receptor NTRK1 0.0025
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0025
275 Arachidonate 5-lipoxygenase ALOX5 0.0025
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0025
823 Fibroblast growth factor receptor 2 FGFR2 0.0025
2112 Toll-like receptor 9 TLR9 0.0025
174 Sigma 1-type opioid receptor SIGMAR1 0.0025
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0025
88 Retinoic acid receptor RXR-beta RXRB 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0024
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0023
7 Nitric oxide synthase, inducible NOS2 0.0023
131 Synaptic vesicular amine transporter SLC18A2 0.0023
6044 Serum paraoxonase/lactonase 3 PON3 0.0023
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0023
4311 tRNA TRDMT1 0.0023
4325 tRNA trmD 0.0023
4328 tRNA trmD 0.0023
33 Cystine/glutamate transporter SLC7A11 0.0023
6174 50S ribosomal protein L32 rpmF 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0021
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0021
572 Integrin alpha-L ITGAL 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
267 Plasminogen activator inhibitor 1 SERPINE1 0.0021
4192 DNA topoisomerase 2-beta TOP2B 0.0021
1864 RET proto-oncogene RET 0.002
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.002
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.002
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.002
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.002
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.002
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.002
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
373 Transthyretin TTR 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0019
5934 Cytochrome P450 26A1 CYP26A1 0.0019
3809 Estrogen-related receptor gamma ESRRG 0.0018
6221 Steroid hormone receptor ERR1 ESRRA 0.0018
1192 Sulfotransferase 1A1 SULT1A1 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0018
921 Glutamate receptor 2 GRIA2 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
5787 Angiopoietin-1 receptor TEK 0.0018
683 Potassium transporter GK0582 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
904 Glutathione S-transferase P GSTP1 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
3856 Fibroblast growth factor receptor 3 FGFR3 0.0016
6085 Fatty acid-binding protein, intestinal FABP2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3233 Bile acid receptor NR1H4 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
162 Retinoic acid receptor gamma-1 RARG 0.0015
1629 Transcription factor AP-1 JUN 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0015
1541 Metalloproteinase mmp20 0.0014
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
6432 Transporter snf 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
2216 Fibroblast growth factor receptor 4 FGFR4 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0011
365 Dihydrofolate reductase DHFR 0.0011
2381 Dihydrofolate reductase DFR1 0.0011
2833 Dihydrofolate reductase Not Available 0.0011
2931 Dihydrofolate reductase folA 0.0011
3544 Dihydrofolate reductase folA 0.0011
3682 Dihydrofolate reductase folA 0.0011
6642 Dihydrofolate reductase folA 0.0011
6756 Dihydrofolate reductase dfrA 0.0011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
908 Glutathione S-transferase theta-1 GSTT1 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
183 Vascular endothelial growth factor A VEGFA 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
1867 Major prion protein PRNP 0.0008
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
1830 5'-nucleotidase NT5E 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
164 Histamine H4 receptor HRH4 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3937 Fatty-acid amide hydrolase FAAH 0.0006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0006
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0006
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0006
563 Thyroid peroxidase TPO 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
634 Squalene monooxygenase SQLE 0.0006
7196 Squalene monooxygenase ERG1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3810 Catechol O-methyltransferase COMT 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1992 Vitamin D-binding protein GC 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
1275 Estrogen sulfotransferase SULT1E1 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
3957 Adenosine deaminase ADA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
2207 Rhodopsin RHO 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0001
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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