DT-Web

DB00371 - Meprobamate


Identification
Name Meprobamate
Accession Number DB00371 (APRD01095)
Type small molecule
Description A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 218.2502
Groups illicit
Monoisotopic Weight 218.126657074
Pharmacology
Indication For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.
Mechanism of action Meprobamate's mechanism of action is not known. It has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system. Meprobamate binds to GABAA receptors which interrupt neuronal communication in the reticular formation and spinal cord, causing sedation and altered perception of pain.
Absorption Well absorbed from the gastrointestinal tract.
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include coma, drowsiness, loss of muscle control, severely impaired breathing, shock, sluggishness, and unresponsiveness. Death has been reported with ingestion of as little as 12 g meprobamate and survival with as much as 40 g.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take without regard to meals. Avoid alcohol.

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions agonist
References
  • Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. - Pubmed
  • Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. Epub 2009 Feb 24. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6184
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action yes
Actions agonist
References
  • Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. - Pubmed
  • Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. Epub 2009 Feb 24. - Pubmed
DTHybrid score 0.54
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action yes
Actions agonist
References
  • Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. - Pubmed
  • Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. Epub 2009 Feb 24. - Pubmed
DTHybrid score 0.5325
Gamma-aminobutyric-acid receptor subunit alpha-4
Name Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name GABRA4
Pharmacological action yes
Actions agonist
References
  • Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. - Pubmed
  • Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. Epub 2009 Feb 24. - Pubmed
DTHybrid score 0.467
Gamma-aminobutyric-acid receptor subunit alpha-5
Name Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name GABRA5
Pharmacological action yes
Actions agonist
References
  • Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. - Pubmed
  • Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. Epub 2009 Feb 24. - Pubmed
DTHybrid score 0.5418
Gamma-aminobutyric-acid receptor subunit alpha-6
Name Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name GABRA6
Pharmacological action yes
Actions agonist
References
  • Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. - Pubmed
  • Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. Epub 2009 Feb 24. - Pubmed
DTHybrid score 0.4641

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3217
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2873

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score 0.2891

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3264
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.2915
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.2913
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.2841
921 Glutamate receptor 2 GRIA2 0.2508
4757 Cytochrome P450 2C9 CYP2C9 0.2259
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.196
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.1891
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.1887
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.1854
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.1767
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.1755
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1753
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.1752
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.175
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1746
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.1743
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.1741
4200 Cytochrome P450 1A2 CYP1A2 0.1644
4119 Cytochrome P450 2D6 CYP2D6 0.1511
4924 Cytochrome P450 2C8 CYP2C8 0.145
6030 Cytochrome P450 2B6 CYP2B6 0.1329
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.129
4118 Cytochrome P450 3A5 CYP3A5 0.1166
811 Translocator protein TSPO 0.1089
6107 Cytochrome P450 3A7 CYP3A7 0.0925
5718 Cytochrome P450 2A6 CYP2A6 0.0879
20 Prostaglandin G/H synthase 1 PTGS1 0.0633
6024 Cytochrome P450 1A1 CYP1A1 0.0631
587 Serum albumin ALB 0.0551
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0493
6106 Cytochrome P450 2C18 CYP2C18 0.0459
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0364
862 Multidrug resistance-associated protein 1 ABCC1 0.0304
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0292
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0291
824 Sodium-dependent serotonin transporter SLC6A4 0.0284
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0276
556 Alpha-1A adrenergic receptor ADRA1A 0.026
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0259
6145 Solute carrier family 22 member 1 SLC22A1 0.0259
3811 Cytochrome P450 19A1 CYP19A1 0.0258
6144 Solute carrier family 22 member 2 SLC22A2 0.0258
492 Histamine H1 receptor HRH1 0.0252
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0251
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0249
482 Glycine receptor subunit alpha-1 GLRA1 0.0243
1898 Cytochrome P450 1B1 CYP1B1 0.0239
220 Sodium channel protein type 5 subunit alpha SCN5A 0.023
776 Bile salt export pump ABCB11 0.0227
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0225
260 Cytochrome P450 51 ERG11 0.0223
761 Cytochrome P450 51 ERG11 0.0223
3163 Cytochrome P450 51 cyp51 0.0223
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0211
1729 Solute carrier family 22 member 6 SLC22A6 0.021
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0206
468 Cytochrome P450 4A11 CYP4A11 0.0203
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0203
831 D(2) dopamine receptor DRD2 0.0201
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0201
3937 Fatty-acid amide hydrolase FAAH 0.02
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
502 5-hydroxytryptamine 2A receptor HTR2A 0.0197
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0192
537 ATP synthase delta chain, mitochondrial ATP5D 0.0191
705 Glutamate receptor 1 GRIA1 0.0183
23 D(1A) dopamine receptor DRD1 0.0181
6031 Cytochrome P450 3A43 CYP3A43 0.0181
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.018
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0173
290 Prostaglandin G/H synthase 2 PTGS2 0.0171
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0163
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0158
172 Potassium channel subfamily K member 1 KCNK1 0.0155
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
318 Alpha-2A adrenergic receptor ADRA2A 0.015
6102 Arylamine N-acetyltransferase 2 NAT2 0.0144
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0143
766 Beta-2 adrenergic receptor ADRB2 0.014
193 Beta-1 adrenergic receptor ADRB1 0.014
51 Muscarinic acetylcholine receptor M3 CHRM3 0.014
3941 Amine oxidase [flavin-containing] A MAOA 0.014
617 Muscarinic acetylcholine receptor M2 CHRM2 0.014
465 Calmodulin CALM1 0.0139
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0138
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0134
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0131
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0129
632 Alpha-1B adrenergic receptor ADRA1B 0.0129
136 Estrogen receptor ESR1 0.0128
731 HIV-1 protease HIV-1 protease 0.0128
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0126
6142 Solute carrier family 22 member 8 SLC22A8 0.012
320 5-hydroxytryptamine 1A receptor HTR1A 0.0119
817 DNA topoisomerase 2-alpha TOP2A 0.0117
3923 Cholinesterase BCHE 0.0117
871 Glucocorticoid receptor NR3C1 0.0115
3939 Amine oxidase [flavin-containing] B MAOB 0.0115
6143 Solute carrier family 22 member 7 SLC22A7 0.0113
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0113
2164 Multidrug resistance-associated protein 4 ABCC4 0.0112
789 Alpha-1D adrenergic receptor ADRA1D 0.0105
713 Sodium-dependent dopamine transporter SLC6A3 0.0105
118 Organic cation/carnitine transporter 2 SLC22A5 0.0104
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0104
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0102
590 5-hydroxytryptamine 2C receptor HTR2C 0.0101
6147 Solute carrier family 22 member 3 SLC22A3 0.0098
3426 Glutamine synthetase glnA 0.0097
3987 Glutamine synthetase GLUL 0.0097
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0096
777 Tumor necrosis factor TNF 0.0094
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0094
4604 Liver carboxylesterase 1 CES1 0.0093
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.009
124 Histamine H2 receptor HRH2 0.009
122 P2Y purinoceptor 12 P2RY12 0.0089
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0089
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0089
885 5-hydroxytryptamine 1B receptor HTR1B 0.0089
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0088
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0086
6182 Cytochrome P450 2J2 CYP2J2 0.0084
629 Alpha-2B adrenergic receptor ADRA2B 0.0083
820 Glycine receptor subunit alpha-2 GLRA2 0.0082
833 Organic cation/carnitine transporter 1 SLC22A4 0.0081
638 D(3) dopamine receptor DRD3 0.0079
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0078
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0078
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0077
6141 Sodium/bile acid cotransporter SLC10A1 0.0077
1192 Sulfotransferase 1A1 SULT1A1 0.0077
341 5-hydroxytryptamine 3 receptor HTR3A 0.0076
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0076
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0075
16 Adenosine A1 receptor ADORA1 0.0075
725 5-hydroxytryptamine 1D receptor HTR1D 0.0074
161 Tubulin beta chain TUBB 0.0073
312 Tubulin beta chain TUB2 0.0073
6148 Multidrug resistance-associated protein 7 ABCC10 0.0073
592 Carbonic anhydrase 4 CA4 0.0073
844 Epidermal growth factor receptor EGFR 0.0073
847 Mu-type opioid receptor OPRM1 0.0073
146 Androgen receptor AR 0.0073
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0073
6137 Multidrug resistance-associated protein 6 ABCC6 0.0072
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0071
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0071
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.007
444 Alcohol dehydrogenase 1B ADH1B 0.007
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
436 5-hydroxytryptamine 2B receptor HTR2B 0.0069
251 Alcohol dehydrogenase 1A ADH1A 0.0067
1010 Cytochrome P450 51A1 CYP51A1 0.0067
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0066
467 Delta-type opioid receptor OPRD1 0.0066
1024 Solute carrier family 22 member 11 SLC22A11 0.0066
6136 Multidrug resistance-associated protein 5 ABCC5 0.0064
696 Kappa-type opioid receptor OPRK1 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1178 Adenosine A2a receptor ADORA2A 0.0063
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
869 Estrogen receptor beta ESR2 0.0062
4120 NADPH--cytochrome P450 reductase POR 0.0062
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0061
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.006
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0058
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0058
461 Glycine receptor subunit alpha-3 GLRA3 0.0057
373 Transthyretin TTR 0.0057
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0056
613 Atrial natriuretic peptide receptor A NPR1 0.0056
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0056
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0056
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0056
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0055
614 Progesterone receptor PGR 0.0055
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0054
357 Carbonic anhydrase 2 CA2 0.0053
517 Alcohol dehydrogenase 1C ADH1C 0.0053
380 Cytochrome P450 17A1 CYP17A1 0.0053
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0052
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0052
26 Vascular endothelial growth factor receptor 3 FLT4 0.0051
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0051
70 Type-1 angiotensin II receptor AGTR1 0.005
2981 Phospholipase A2, membrane associated PLA2G2A 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
32 Vascular endothelial growth factor receptor 1 FLT1 0.0049
6220 Aryl hydrocarbon receptor AHR 0.0049
504 Mast/stem cell growth factor receptor KIT 0.0049
6020 Aldehyde oxidase AOX1 0.0049
1757 Myeloperoxidase MPO 0.0048
756 Sex hormone-binding globulin SHBG 0.0048
6766 O-GlcNAcase BT_4395 BT_4395 0.0048
716 5-hydroxytryptamine 7 receptor HTR7 0.0047
3947 Xanthine dehydrogenase/oxidase XDH 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
319 Opioid receptor, sigma 1 OPRS1 0.0047
6138 Multidrug resistance protein 3 ABCB4 0.0046
1253 Interferon gamma IFNG 0.0046
378 Alpha-2C adrenergic receptor ADRA2C 0.0046
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0045
6014 Cytochrome P450 2A13 CYP2A13 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0044
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0044
432 D(4) dopamine receptor DRD4 0.0044
4122 Histone deacetylase 2 HDAC2 0.0044
407 Vascular endothelial growth factor receptor 2 KDR 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0042
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0042
891 Dihydropteroate synthase folP 0.0042
5359 Dihydropteroate synthase folP 0.0042
7175 Dihydropteroate synthase sulI 0.0042
6432 Transporter snf 0.0041
823 Fibroblast growth factor receptor 2 FGFR2 0.004
3810 Catechol O-methyltransferase COMT 0.004
904 Glutathione S-transferase P GSTP1 0.004
952 Dipeptidyl peptidase 4 DPP4 0.004
228 Beta platelet-derived growth factor receptor PDGFRB 0.004
29 Tubulin beta-1 chain TUBB1 0.004
474 Acetylcholinesterase ACHE 0.004
818 50S ribosomal protein L10 rplJ 0.0039
94 5-hydroxytryptamine 4 receptor HTR4 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0039
1656 CYP2B protein CYP2B 0.0039
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0038
2539 Tubulin alpha-1 chain TUBA4A 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
365 Dihydrofolate reductase DHFR 0.0038
2381 Dihydrofolate reductase DFR1 0.0038
2833 Dihydrofolate reductase Not Available 0.0038
2931 Dihydrofolate reductase folA 0.0038
3544 Dihydrofolate reductase folA 0.0038
3682 Dihydrofolate reductase folA 0.0038
6642 Dihydrofolate reductase folA 0.0038
6756 Dihydrofolate reductase dfrA 0.0038
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0038
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0037
5300 Antigen peptide transporter 1 TAP1 0.0037
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0035
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0035
153 Dopamine beta-hydroxylase DBH 0.0034
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0034
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
528 5-hydroxytryptamine 1E receptor HTR1E 0.0034
4116 Dihydropteroate synthetase Not Available 0.0033
518 Peroxidase/catalase T katG 0.0033
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0033
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0033
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0033
239 Coagulation factor X F10 0.0032
295 Carbonic anhydrase 1 CA1 0.0032
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0032
362 Melatonin receptor type 1B MTNR1B 0.0032
571 Melatonin receptor type 1A MTNR1A 0.0032
4103 Proteasome subunit beta type 2 PSMB2 0.0032
4102 Proteasome subunit beta type 5 PSMB5 0.0032
4101 Proteasome subunit beta type 1 PSMB1 0.0032
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0032
737 Mineralocorticoid receptor NR3C2 0.0031
563 Thyroid peroxidase TPO 0.0031
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0031
1618 High affinity nerve growth factor receptor NTRK1 0.003
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.003
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.003
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
723 Cytosolic phospholipase A2 PLA2G4A 0.0029
683 Potassium transporter GK0582 0.0029
738 Monocarboxylate transporter 1 SLC16A1 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0028
427 Substance-P receptor TACR1 0.0028
1256 5-hydroxytryptamine 6 receptor HTR6 0.0028
976 Platelet glycoprotein IX GP9 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
390 Adenosine A3 receptor ADORA3 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0028
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
3404 Exotoxin A eta 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
6085 Fatty acid-binding protein, intestinal FABP2 0.0027
49 Endothelin B receptor EDNRB 0.0027
3809 Estrogen-related receptor gamma ESRRG 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
3601 Dihydropteroate synthase 1 folP1 0.0026
3807 Dihydropteroate synthase 1 folP1 0.0026
3808 Dihydropteroate synthase 2 folP2 0.0026
4311 tRNA TRDMT1 0.0026
4325 tRNA trmD 0.0026
4328 tRNA trmD 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0026
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
85 Growth hormone receptor GHR 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
578 Endothelin-1 receptor EDNRA 0.0025
908 Glutathione S-transferase theta-1 GSTT1 0.0025
174 Sigma 1-type opioid receptor SIGMAR1 0.0025
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0025
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
185 Vasopressin V1a receptor AVPR1A 0.0024
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0024
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0024
1268 Neuropeptide S receptor NPSR1 0.0024
3913 Glutamic acid decarboxylase GAD65 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
106 Cannabinoid receptor 2 CNR2 0.0023
511 5-hydroxytryptamine 1F receptor HTR1F 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6174 50S ribosomal protein L32 rpmF 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
163 D(1B) dopamine receptor DRD5 0.0023
358 Cystathionine beta-synthase CBS 0.0023
1483 Membrane copper amine oxidase AOC3 0.0022
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0022
469 Annexin A1 ANXA1 0.0022
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0022
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
3917 Methylenetetrahydrofolate reductase MTHFR 0.0022
68 Cannabinoid receptor 1 CNR1 0.0022
1517 Beta-3 adrenergic receptor ADRB3 0.0022
7 Nitric oxide synthase, inducible NOS2 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
6073 Potassium channel subfamily K member 9 KCNK9 0.0022
6072 Potassium channel subfamily K member 3 KCNK3 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0021
2207 Rhodopsin RHO 0.0021
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0021
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0021
6146 High affinity copper uptake protein 1 SLC31A1 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
634 Squalene monooxygenase SQLE 0.002
7196 Squalene monooxygenase ERG1 0.002
735 Alanine aminotransferase 1 GPT 0.002
3904 Alanine aminotransferase 2 GPT2 0.002
2298 Cytochrome P450-cam camC 0.002
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.002
165 FL cytokine receptor FLT3 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0019
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0019
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0019
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0019
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0019
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0019
1374 Natriuretic peptides B NPPB 0.0019
1827 Gap junction alpha-1 protein GJA1 0.0019
1908 Vascular cell adhesion protein 1 VCAM1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
6459 Glycodelin PAEP 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
814 Ryanodine receptor 1 RYR1 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0018
4192 DNA topoisomerase 2-beta TOP2B 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
1650 Heme carrier protein 1 SLC46A1 0.0018
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0018
1360 Sphingomyelin phosphodiesterase SMPD1 0.0018
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0018
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0017
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
3957 Adenosine deaminase ADA 0.0017
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0016
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
84 Nuclear receptor 0B1 NR0B1 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
6755 Poliovirus receptor PVR 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
702 UMP-CMP kinase CMPK1 0.0015
1630 Integrin beta-2 ITGB2 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0015
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0015
4217 Telomerase reverse transcriptase TERT 0.0014
284 DNA-directed RNA polymerase beta chain rpoB 0.0014
5773 DNA-directed RNA polymerase beta chain rpoB 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
6131 Carbonic anhydrase 14 CA14 0.0014
1629 Transcription factor AP-1 JUN 0.0014
1275 Estrogen sulfotransferase SULT1E1 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0014
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
54 Prothrombin F2 0.0014
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
1050 Bile salt sulfotransferase SULT2A1 0.0013
3221 Cytochrome c4 cc4 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
5787 Angiopoietin-1 receptor TEK 0.0013
6122 Carbonic anhydrase 3 CA3 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
1196 Complement decay-accelerating factor CD55 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0013
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
4773 Deoxycytidine kinase DCK 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
6044 Serum paraoxonase/lactonase 3 PON3 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2021 Thrombomodulin THBD 0.0012
3007 Carbonic anhydrase 12 CA12 0.0012
4205 Carbonic anhydrase 9 CA9 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
6859 Protein S100-A4 S100A4 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
572 Integrin alpha-L ITGAL 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
5798 Mitogen-activated protein kinase 11 MAPK11 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2320 Thymidine kinase, cytosolic TK1 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
2808 Chloramphenicol acetyltransferase 3 cat3 0.0011
1864 RET proto-oncogene RET 0.0011
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0011
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0011
268 Adenosine A2b receptor ADORA2B 0.0011
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0011
164 Histamine H4 receptor HRH4 0.0011
275 Arachidonate 5-lipoxygenase ALOX5 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
2802 Endoglucanase G celCCG 0.0011
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0011
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0011
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
2417 Chloramphenicol acetyltransferase cat 0.001
3278 Chloramphenicol acetyltransferase cat 0.001
4203 Histamine N-methyltransferase HNMT 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2810 Dr hemagglutinin structural subunit draA 0.001
6218 Pannexin-1 PANX1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.001
5934 Cytochrome P450 26A1 CYP26A1 0.001
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
581 Cytochrome P450 2R1 CYP2R1 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
997 Protein kinase C beta type PRKCB 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
3830 Calreticulin CALR 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1992 Vitamin D-binding protein GC 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
798 Osteocalcin BGLAP 0.0009
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0009
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6043 Putative G-protein coupled receptor 44 GPR44 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
369 Coagulation factor VII F7 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
856 Vitamin D3 receptor VDR 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
267 Plasminogen activator inhibitor 1 SERPINE1 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
6221 Steroid hormone receptor ERR1 ESRRA 0.0006
1039 Histone deacetylase 9 HDAC9 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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