DT-Web: DB00349

Identification

Name

Clobazam

Accession Number

DB00349 (APRD00307)

Type

small molecule

Description

Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

300.74

Groups

illicit

Monoisotopic Weight

300.066555377

Pharmacology

Indication

For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.

Mechanism of action

Clobazam binds at distinct binding sites associated with the chloride ionopore at the post-synaptic GABA receptor. These GABA receptors are in various locations in the CNS (limbic, reticular formation) and clobazam increases the duration of time for which the chloride ionopore is open. As a result, hyper polarization and stabilization of the membrane occur as the post-synaptic inhibitory effect of GABA is enhanced.

Absorption

After oral administration of clobazam, it is almost completely absorbed (87% of dose). Bioavailability relative to solution was almost at 100%. Food does not affect absorption. Tmax = 1-3 hours.

Protein binding

Clobazam is the primary circulating entity in the serum and is highly protein-bound (80-90%).

Biotransformation

Clobazam is extensively metabolized in the liver via N-demethylation and hydroxylation. Clobazam has two major metabolites: N-desmethylclobazam (norclobazam) and 4'-hydroxyclobazam, the former of which is active. Norclobazam is one-fourth the potency of clobazam. The main enzyme that facilitates the process of N-demethylation is CYP3A4, and to a lesser extent by CYP2C19 and CYP2B6. Norclobazam itself is also metabolized via hydroxylation, primarily by CYP2C19. The formation of 4'-hydroxyclobazam is facilitated by CYP2C18 and CYP2C19. A factor in determining extent of metabolism is the genetic profile of the individual patient as CYP2C19 is a polymorphic enzyme.

Route of elimination

Clobazam is eliminated via the urine (~94%) as metabolites.

Toxicity

The most common adverse effects include somnolence, pyrexia, upper respiratory tract infection, and lethargy.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Axitinib	Clobazam decreases levels by affecting CYP3A4 metabolism. Consider alternate therapy.
Clozapine	Increased risk of toxicity
Kava	Kava may increase the effect of the benzodiazepine, clobazam.
Ketoconazole	Clobazam may increase levels by affecting CYP2C19 metabolism. Interaction is significant so monitor closely. Dose adjustment may be necessary.
Midazolam	Clobazam decrease the Cmax and AUC of midazolam by approximately 25% of both and increases the Cmax and AUC of its metabolite. Dose adjustment is not necessary.
Rotigotine	Concomitant therapy may potentiate adverse CNS effects such as increased sedation or respiratory depression. Monitor therapy closely.
Telithromycin	Telithromycin may reduce clearance of Clobazam. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Clobazam if Telithromycin is initiated, discontinued or dose changed.
Ticlopidine	Ticlopidine may decrease the metabolism and clearance of Clobazam. Consider alternate therapy or monitor for adverse/toxic effects of Clobazam if Ticlopidine is initiated, discontinued or dose changed.
Tipranavir	Tipranavir may decrease the metabolism and clearance of Clobazam. Consider alternate therapy or monitor for Clobazam toxic effects if Tipranavir is initiated or dose increased.
Triprolidine	The CNS depressants, Triprolidine and Clobazam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole	Voriconazole may increase the serum concentration of clobazam by decreasing its metabolism. Monitor for clobazam toxicity if voriconazole is initiated or dose increased.

Food Interactions

Take without regard to meals.
Alcohol increases clobazam absorption by 50%.

Gamma-aminobutyric-acid receptor subunit alpha-1
Name	Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name	GABRA1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.2582
Gamma-aminobutyric-acid receptor subunit alpha-2
Name	Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name	GABRA2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.1955
Gamma-aminobutyric-acid receptor subunit alpha-3
Name	Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name	GABRA3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.1926
Gamma-aminobutyric-acid receptor subunit alpha-4
Name	Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name	GABRA4
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.8571
Gamma-aminobutyric-acid receptor subunit alpha-5
Name	Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name	GABRA5
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.2179
Gamma-aminobutyric-acid receptor subunit alpha-6
Name	Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name	GABRA6
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.8263
Gamma-aminobutyric-acid receptor subunit beta-1
Name	Gamma-aminobutyric-acid receptor subunit beta-1
Gene Name	GABRB1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0728
Gamma-aminobutyric-acid receptor subunit beta-2
Name	Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name	GABRB2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0631
Gamma-aminobutyric-acid receptor subunit beta-3
Name	Gamma-aminobutyric-acid receptor subunit beta-3
Gene Name	GABRB3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0792
Gamma-aminobutyric acid receptor subunit gamma-1
Name	Gamma-aminobutyric acid receptor subunit gamma-1
Gene Name	GABRG1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.061
Gamma-aminobutyric acid receptor subunit gamma-2
Name	Gamma-aminobutyric acid receptor subunit gamma-2
Gene Name	GABRG2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0935
Gamma-aminobutyric acid receptor subunit gamma-3
Name	Gamma-aminobutyric acid receptor subunit gamma-3
Gene Name	GABRG3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0427
Gamma-aminobutyric acid receptor subunit delta
Name	Gamma-aminobutyric acid receptor subunit delta
Gene Name	GABRD
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0496
Gamma-aminobutyric acid receptor subunit epsilon
Name	Gamma-aminobutyric acid receptor subunit epsilon
Gene Name	GABRE
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0477
Gamma-aminobutyric acid receptor subunit pi
Name	Gamma-aminobutyric acid receptor subunit pi
Gene Name	GABRP
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0334
Gamma-aminobutyric-acid receptor subunit rho-1
Name	Gamma-aminobutyric-acid receptor subunit rho-1
Gene Name	GABRR1
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0387
Gamma-aminobutyric acid receptor subunit rho-2
Name	Gamma-aminobutyric acid receptor subunit rho-2
Gene Name	GABRR2
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0443
Gamma-aminobutyric acid receptor subunit rho-3
Name	Gamma-aminobutyric acid receptor subunit rho-3
Gene Name	GABRR3
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	1.0413
Gamma-aminobutyric acid receptor subunit theta
Name	Gamma-aminobutyric acid receptor subunit theta
Gene Name	GABRQ
Pharmacological action	yes
Actions	potentiator
References	Mohler H, Fritschy JM, Rudolph U: A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan;300(1):2-8. - Pubmed Riss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. Epub 2008 Mar 31. - Pubmed
DTHybrid score	0.6892

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed FDA label -
DTHybrid score	0.9657
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5494
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.296
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4319

Sodium- and chloride-dependent GABA transporter 1
Name	Sodium- and chloride-dependent GABA transporter 1
Gene Name	SLC6A1
Actions	Other
References	Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. - Pubmed
DTHybrid score	0.8533
Sodium- and chloride-dependent GABA transporter 3
Name	Sodium- and chloride-dependent GABA transporter 3
Gene Name	Not Available
Actions	Other
References	Giarratano M, Standley K, Benbadis SR: Clobazam for treatment of epilepsy. Expert Opin Pharmacother. 2012 Feb;13(2):227-33. doi: 10.1517/14656566.2012.647686. Epub 2012 Jan 13. - Pubmed
DTHybrid score	Not Available
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	FDA label -
DTHybrid score	0.4654

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.4091
811	Translocator protein	TSPO	0.3936
6013	Cytochrome P450 2E1	CYP2E1	0.3028
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.2945
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.2943
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.2867
4924	Cytochrome P450 2C8	CYP2C8	0.2811
4118	Cytochrome P450 3A5	CYP3A5	0.2771
4119	Cytochrome P450 2D6	CYP2D6	0.2742
4200	Cytochrome P450 1A2	CYP1A2	0.2602
921	Glutamate receptor 2	GRIA2	0.2532
6107	Cytochrome P450 3A7	CYP3A7	0.2401
587	Serum albumin	ALB	0.1507
5718	Cytochrome P450 2A6	CYP2A6	0.1458
20	Prostaglandin G/H synthase 1	PTGS1	0.1013
6024	Cytochrome P450 1A1	CYP1A1	0.0918
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0759
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0652
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0648
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0609
6144	Solute carrier family 22 member 2	SLC22A2	0.0586
6145	Solute carrier family 22 member 1	SLC22A1	0.0565
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0565
6102	Arylamine N-acetyltransferase 2	NAT2	0.0543
6031	Cytochrome P450 3A43	CYP3A43	0.0537
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0527
824	Sodium-dependent serotonin transporter	SLC6A4	0.0508
482	Glycine receptor subunit alpha-1	GLRA1	0.0492
862	Multidrug resistance-associated protein 1	ABCC1	0.0488
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.047
492	Histamine H1 receptor	HRH1	0.0454
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0441
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0434
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0426
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0414
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.04
3811	Cytochrome P450 19A1	CYP19A1	0.0395
1898	Cytochrome P450 1B1	CYP1B1	0.0394
468	Cytochrome P450 4A11	CYP4A11	0.0378
556	Alpha-1A adrenergic receptor	ADRA1A	0.0367
461	Glycine receptor subunit alpha-3	GLRA3	0.0364
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.035
1729	Solute carrier family 22 member 6	SLC22A6	0.0349
820	Glycine receptor subunit alpha-2	GLRA2	0.0305
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0302
831	D(2) dopamine receptor	DRD2	0.0299
776	Bile salt export pump	ABCB11	0.0298
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.029
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0283
871	Glucocorticoid receptor	NR3C1	0.0279
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0276
3937	Fatty-acid amide hydrolase	FAAH	0.0272
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.027
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0267
3426	Glutamine synthetase	glnA	0.0261
3987	Glutamine synthetase	GLUL	0.0261
731	HIV-1 protease	HIV-1 protease	0.0258
260	Cytochrome P450 51	ERG11	0.0248
761	Cytochrome P450 51	ERG11	0.0248
3163	Cytochrome P450 51	cyp51	0.0248
136	Estrogen receptor	ESR1	0.0247
290	Prostaglandin G/H synthase 2	PTGS2	0.0242
118	Organic cation/carnitine transporter 2	SLC22A5	0.0242
847	Mu-type opioid receptor	OPRM1	0.0237
318	Alpha-2A adrenergic receptor	ADRA2A	0.0237
3923	Cholinesterase	BCHE	0.0237
23	D(1A) dopamine receptor	DRD1	0.0233
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0233
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0227
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0221
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0218
465	Calmodulin	CALM1	0.021
467	Delta-type opioid receptor	OPRD1	0.021
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.021
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0207
6142	Solute carrier family 22 member 8	SLC22A8	0.0207
713	Sodium-dependent dopamine transporter	SLC6A3	0.0205
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0204
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0203
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0199
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0197
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0195
766	Beta-2 adrenergic receptor	ADRB2	0.0194
705	Glutamate receptor 1	GRIA1	0.0191
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0185
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0183
193	Beta-1 adrenergic receptor	ADRB1	0.018
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0178
632	Alpha-1B adrenergic receptor	ADRA1B	0.0177
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0174
696	Kappa-type opioid receptor	OPRK1	0.0172
122	P2Y purinoceptor 12	P2RY12	0.0169
6143	Solute carrier family 22 member 7	SLC22A7	0.016
738	Monocarboxylate transporter 1	SLC16A1	0.0159
2164	Multidrug resistance-associated protein 4	ABCC4	0.0158
172	Potassium channel subfamily K member 1	KCNK1	0.0158
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0157
85	Growth hormone receptor	GHR	0.0156
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0156
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0154
789	Alpha-1D adrenergic receptor	ADRA1D	0.0154
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0153
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0153
6147	Solute carrier family 22 member 3	SLC22A3	0.0152
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0151
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0145
833	Organic cation/carnitine transporter 1	SLC22A4	0.0141
3941	Amine oxidase [flavin-containing] A	MAOA	0.0141
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.014
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.014
844	Epidermal growth factor receptor	EGFR	0.0138
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0135
817	DNA topoisomerase 2-alpha	TOP2A	0.0135
146	Androgen receptor	AR	0.0134
489	Monocarboxylate transporter 2	SLC16A7	0.0133
6182	Cytochrome P450 2J2	CYP2J2	0.0132
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0132
62	Glycine receptor subunit beta	GLRB	0.0132
4120	NADPH--cytochrome P450 reductase	POR	0.013
818	50S ribosomal protein L10	rplJ	0.013
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0122
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0121
629	Alpha-2B adrenergic receptor	ADRA2B	0.012
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0119
3939	Amine oxidase [flavin-containing] B	MAOB	0.0119
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0118
500	Monocarboxylate transporter 4	SLC16A3	0.0118
4604	Liver carboxylesterase 1	CES1	0.0118
614	Progesterone receptor	PGR	0.0117
124	Histamine H2 receptor	HRH2	0.0117
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0115
380	Cytochrome P450 17A1	CYP17A1	0.0115
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0115
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0115
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0112
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.011
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.011
6137	Multidrug resistance-associated protein 6	ABCC6	0.011
161	Tubulin beta chain	TUBB	0.0107
312	Tubulin beta chain	TUB2	0.0107
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0106
638	D(3) dopamine receptor	DRD3	0.0106
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0105
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0102
6148	Multidrug resistance-associated protein 7	ABCC10	0.0102
756	Sex hormone-binding globulin	SHBG	0.01
504	Mast/stem cell growth factor receptor	KIT	0.01
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0099
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0098
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0097
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0096
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0096
6020	Aldehyde oxidase	AOX1	0.0095
1656	CYP2B protein	CYP2B	0.0094
869	Estrogen receptor beta	ESR2	0.0093
6174	50S ribosomal protein L32	rpmF	0.0093
1024	Solute carrier family 22 member 11	SLC22A11	0.0092
232	Corticosteroid-binding globulin	SERPINA6	0.0091
6136	Multidrug resistance-associated protein 5	ABCC5	0.0091
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0089
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0088
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0087
174	Sigma 1-type opioid receptor	SIGMAR1	0.0087
6432	Transporter	snf	0.0086
592	Carbonic anhydrase 4	CA4	0.0085
26	Vascular endothelial growth factor receptor 3	FLT4	0.0085
952	Dipeptidyl peptidase 4	DPP4	0.0085
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0083
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0083
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0082
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0081
32	Vascular endothelial growth factor receptor 1	FLT1	0.0081
407	Vascular endothelial growth factor receptor 2	KDR	0.008
29	Tubulin beta-1 chain	TUBB1	0.008
373	Transthyretin	TTR	0.008
6141	Sodium/bile acid cotransporter	SLC10A1	0.0079
716	5-hydroxytryptamine 7 receptor	HTR7	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
6220	Aryl hydrocarbon receptor	AHR	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
777	Tumor necrosis factor	TNF	0.0076
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0076
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0076
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0075
70	Type-1 angiotensin II receptor	AGTR1	0.0073
474	Acetylcholinesterase	ACHE	0.0073
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0073
1353	DNA topoisomerase 1	TOP1	0.0072
3552	DNA topoisomerase 1	topA	0.0072
378	Alpha-2C adrenergic receptor	ADRA2C	0.0072
1192	Sulfotransferase 1A1	SULT1A1	0.0072
1757	Myeloperoxidase	MPO	0.0072
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0071
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.007
1010	Cytochrome P450 51A1	CYP51A1	0.007
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0069
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0069
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0068
244	Angiotensin-converting enzyme	ACE	0.0068
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0068
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0066
3808	Dihydropteroate synthase 2	folP2	0.0065
3601	Dihydropteroate synthase 1	folP1	0.0065
3807	Dihydropteroate synthase 1	folP1	0.0065
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0065
427	Substance-P receptor	TACR1	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0063
357	Carbonic anhydrase 2	CA2	0.0063
4237	50S ribosomal protein L22	rplV	0.0062
6138	Multidrug resistance protein 3	ABCB4	0.0062
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0061
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0061
84	Nuclear receptor 0B1	NR0B1	0.0061
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
2539	Tubulin alpha-1 chain	TUBA4A	0.0059
432	D(4) dopamine receptor	DRD4	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
68	Cannabinoid receptor 1	CNR1	0.0058
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
6014	Cytochrome P450 2A13	CYP2A13	0.0056
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0055
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0055
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0055
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0055
891	Dihydropteroate synthase	folP	0.0054
5359	Dihydropteroate synthase	folP	0.0054
7175	Dihydropteroate synthase	sulI	0.0054
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0054
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
737	Mineralocorticoid receptor	NR3C2	0.0054
3947	Xanthine dehydrogenase/oxidase	XDH	0.0054
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0054
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0054
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0054
780	Retinoic acid receptor RXR-gamma	RXRG	0.0053
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0053
856	Vitamin D3 receptor	VDR	0.0053
49	Endothelin B receptor	EDNRB	0.0052
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0052
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0052
319	Opioid receptor, sigma 1	OPRS1	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.005
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
719	Retinoic acid receptor responder protein 1	RARRES1	0.0049
770	Retinoic acid-induced protein 3	GPRC5A	0.0049
88	Retinoic acid receptor RXR-beta	RXRB	0.0048
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0048
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0048
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0047
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0047
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
3932	Glutathione S-transferase A2	GSTA2	0.0047
275	Arachidonate 5-lipoxygenase	ALOX5	0.0047
5300	Antigen peptide transporter 1	TAP1	0.0047
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
295	Carbonic anhydrase 1	CA1	0.0047
683	Potassium transporter	GK0582	0.0047
6085	Fatty acid-binding protein, intestinal	FABP2	0.0047
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0046
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0046
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0045
1618	High affinity nerve growth factor receptor	NTRK1	0.0045
571	Melatonin receptor type 1A	MTNR1A	0.0044
362	Melatonin receptor type 1B	MTNR1B	0.0044
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0044
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0044
1039	Histone deacetylase 9	HDAC9	0.0044
284	DNA-directed RNA polymerase beta chain	rpoB	0.0043
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0043
569	Retinal dehydrogenase 2	ALDH1A2	0.0043
251	Alcohol dehydrogenase 1A	ADH1A	0.0042
768	FK506-binding protein 1A	FKBP1A	0.0042
1852	Microtubule-associated protein 2	MAP2	0.0042
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0041
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0041
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
444	Alcohol dehydrogenase 1B	ADH1B	0.004
611	Retinal dehydrogenase 1	ALDH1A1	0.004
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.004
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.004
581	Cytochrome P450 2R1	CYP2R1	0.0039
814	Ryanodine receptor 1	RYR1	0.0039
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0039
131	Synaptic vesicular amine transporter	SLC18A2	0.0039
162	Retinoic acid receptor gamma-1	RARG	0.0039
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0039
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0038
904	Glutathione S-transferase P	GSTP1	0.0038
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0038
6043	Putative G-protein coupled receptor 44	GPR44	0.0038
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0038
239	Coagulation factor X	F10	0.0038
163	D(1B) dopamine receptor	DRD5	0.0038
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0038
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
563	Thyroid peroxidase	TPO	0.0037
183	Vascular endothelial growth factor A	VEGFA	0.0037
165	FL cytokine receptor	FLT3	0.0036
823	Fibroblast growth factor receptor 2	FGFR2	0.0036
4103	Proteasome subunit beta type 2	PSMB2	0.0036
4102	Proteasome subunit beta type 5	PSMB5	0.0036
4101	Proteasome subunit beta type 1	PSMB1	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
7	Nitric oxide synthase, inducible	NOS2	0.0035
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0034
365	Dihydrofolate reductase	DHFR	0.0034
2381	Dihydrofolate reductase	DFR1	0.0034
2833	Dihydrofolate reductase	Not Available	0.0034
2931	Dihydrofolate reductase	folA	0.0034
3544	Dihydrofolate reductase	folA	0.0034
3682	Dihydrofolate reductase	folA	0.0034
6642	Dihydrofolate reductase	folA	0.0034
6756	Dihydrofolate reductase	dfrA	0.0034
517	Alcohol dehydrogenase 1C	ADH1C	0.0034
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0033
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0032
1630	Integrin beta-2	ITGB2	0.0032
5787	Angiopoietin-1 receptor	TEK	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
605	Fumarate reductase flavoprotein subunit	frdA	0.0031
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0031
3673	Fumarate reductase flavoprotein subunit	fccA	0.0031
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0031
6549	Fumarate reductase flavoprotein subunit	frdA	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1517	Beta-3 adrenergic receptor	ADRB3	0.0031
1262	Corticotropin-lipotropin	POMC	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
106	Cannabinoid receptor 2	CNR2	0.003
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0029
469	Annexin A1	ANXA1	0.0029
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0029
1629	Transcription factor AP-1	JUN	0.0029
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
94	5-hydroxytryptamine 4 receptor	HTR4	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0028
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0028
936	Ephrin type-A receptor 2	EPHA2	0.0028
518	Peroxidase/catalase T	katG	0.0028
1992	Vitamin D-binding protein	GC	0.0028
24	Thymidylate synthase	TMP1	0.0027
359	Thymidylate synthase	TYMS	0.0027
2626	Thymidylate synthase	thyA	0.0027
2729	Thymidylate synthase	thyA	0.0027
5352	Thymidylate synthase	THYA	0.0027
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0027
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0027
1268	Neuropeptide S receptor	NPSR1	0.0027
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0027
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3809	Estrogen-related receptor gamma	ESRRG	0.0027
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0026
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0026
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0026
6824	Tyrosine-protein kinase Lyn	LYN	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
6126	Carbonic anhydrase 7	CA7	0.0026
1178	Adenosine A2a receptor	ADORA2A	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0026
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0025
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0025
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0025
5798	Mitogen-activated protein kinase 11	MAPK11	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
6073	Potassium channel subfamily K member 9	KCNK9	0.0024
6072	Potassium channel subfamily K member 3	KCNK3	0.0024
4311	tRNA	TRDMT1	0.0024
4325	tRNA	trmD	0.0024
4328	tRNA	trmD	0.0024
273	Apoptosis regulator Bcl-2	BCL2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4122	Histone deacetylase 2	HDAC2	0.0024
6149	Solute carrier family 22 member 10	SLC22A10	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
65	Matrix metalloproteinase-9	Not Available	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0023
5816	Cadherin-5	CDH5	0.0023
291	Nitric-oxide synthase, endothelial	NOS3	0.0023
2207	Rhodopsin	RHO	0.0023
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0023
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0023
6146	High affinity copper uptake protein 1	SLC31A1	0.0022
2599	Tyrosine-protein kinase HCK	HCK	0.0022
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0022
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0022
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0022
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0022
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0022
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0022
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0022
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0022
4773	Deoxycytidine kinase	DCK	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
1050	Bile salt sulfotransferase	SULT2A1	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
5934	Cytochrome P450 26A1	CYP26A1	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0021
4203	Histamine N-methyltransferase	HNMT	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
3856	Fibroblast growth factor receptor 3	FGFR3	0.002
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
976	Platelet glycoprotein IX	GP9	0.0019
54	Prothrombin	F2	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
1196	Complement decay-accelerating factor	CD55	0.0019
267	Plasminogen activator inhibitor 1	SERPINE1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
558	Solute carrier family 12 member 1	SLC12A1	0.0018
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0018
4217	Telomerase reverse transcriptase	TERT	0.0018
1253	Interferon gamma	IFNG	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0018
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0018
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0018
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
5923	Microtubule-associated protein tau	MAPT	0.0018
5924	Microtubule-associated protein 4	MAP4	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
3810	Catechol O-methyltransferase	COMT	0.0018
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
16	Adenosine A1 receptor	ADORA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
908	Glutathione S-transferase theta-1	GSTT1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
6221	Steroid hormone receptor ERR1	ESRRA	0.0017
634	Squalene monooxygenase	SQLE	0.0017
7196	Squalene monooxygenase	ERG1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
896	Glutathione S-transferase Mu 1	GSTM1	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0017
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
2808	Chloramphenicol acetyltransferase 3	cat3	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0016
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
6044	Serum paraoxonase/lactonase 3	PON3	0.0016
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0015
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0015
3233	Bile acid receptor	NR1H4	0.0015
4192	DNA topoisomerase 2-beta	TOP2B	0.0015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0015
751	Potassium channel subfamily K member 6	KCNK6	0.0015
6755	Poliovirus receptor	PVR	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0015
2417	Chloramphenicol acetyltransferase	cat	0.0015
3278	Chloramphenicol acetyltransferase	cat	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
2810	Dr hemagglutinin structural subunit	draA	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
153	Dopamine beta-hydroxylase	DBH	0.0015
1525	Heparin-binding growth factor 2	FGF2	0.0015
572	Integrin alpha-L	ITGAL	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0014
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0014
1541	Metalloproteinase	mmp20	0.0014
2320	Thymidine kinase, cytosolic	TK1	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1864	RET proto-oncogene	RET	0.0014
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0014
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0014
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
76	Nitric-oxide synthase, brain	NOS1	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
4954	Soluble cytochrome b558	Not Available	0.0014
4925	Cytochrome c-type protein SHP	shp	0.0014
4934	Cytochrome c-551	nirM	0.0014
5218	Cytochrome c-551	nirM	0.0014
4905	Cytochrome c2	Not Available	0.0014
4939	Cytochrome c2	cycA	0.0014
4964	Cytochrome c2	cycA	0.0014
4979	Cytochrome c2	cycA	0.0014
6673	Cytochrome c2	cycA	0.0014
4915	Cytochrome c-550	psbV	0.0014
4959	Cytochrome c-550	psbV	0.0014
5216	Cytochrome c-550	psbV	0.0014
4947	Bacterial hemoglobin	vhb	0.0014
4984	Neuroglobin	NGB	0.0014
4998	Hemoglobin-like protein yjbI	yjbI	0.0014
4975	Cytochrome c-556	RPA3973	0.0014
4943	Cytochrome c6	petJ	0.0014
4916	Cyanoglobin	glbN	0.0014
4994	Hemoglobin-like protein HbO	glbO	0.0014
4907	Cytochrome c-L	moxG	0.0014
6865	Cytochrome c-L	moxG	0.0014
4936	Cytochrome c2 iso-2	Not Available	0.0014
4909	CooA protein	cooA	0.0014
644	Heme oxygenase 2	HMOX2	0.0014
4982	Heme oxygenase 2	pbsA2	0.0014
4942	Diheme cytochrome c napB	napB	0.0014
4910	Cytoglobin	CYGB	0.0014
4981	Iron-starvation protein PigA	pigA	0.0014
4935	Cytochrome c-554	cycA1	0.0014
4971	Nonaheme cytochrome c	hmcA	0.0014
4961	Hemophore HasA	hasA	0.0014
4904	Cytochrome c family protein	GSU1996	0.0014
4976	Apocytochrome f	petA	0.0014
6407	Apocytochrome f	petA	0.0014
5000	HemO	hemO	0.0014
4989	Cytochrome c551 peroxidase	ccp	0.0014
5222	Cytochrome c551 peroxidase	ccpA	0.0014
4960	Putative cytochrome P450-family protein	SCO7417	0.0014
4931	Cytochrome P450 167A1	CYP167A1	0.0014
4764	Cytochrome P450 165C4	CYP165C4	0.0014
4999	Cytochrome P450 165B3	CYP165B3	0.0014
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0014
4972	P450cin	cinA	0.0014
4903	Methyl-accepting chemotaxis protein	Tar4	0.0014
4993	Hydroxylamine oxidoreductase	hao1	0.0014
4937	Cytochrome oxidase subunit II	rcoxA	0.0014
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0014
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0014
3093	Catalase HPII	katE	0.0014
4922	Cytochrome c, putative	SO_4144	0.0014
4952	Catalase/peroxidase	katA	0.0014
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0013
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0013
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0013
6168	Solute carrier family 22 member 16	SLC22A16	0.0013
33	Cystine/glutamate transporter	SLC7A11	0.0013
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0013
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0013
6218	Pannexin-1	PANX1	0.0013
164	Histamine H4 receptor	HRH4	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3221	Cytochrome c4	cc4	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
2021	Thrombomodulin	THBD	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
2298	Cytochrome P450-cam	camC	0.0012
3957	Adenosine deaminase	ADA	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0012
6163	Copper-transporting ATPase 2	ATP7B	0.0011
6165	Copper-transporting ATPase 1	ATP7A	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0011
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.001
1063	Signal transducer and activator of transcription 5B	STAT5B	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4920	Peroxidase/catalase	katG	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
2119	Cytochrome b5	CYB5A	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.001
4990	PpcA	ppcA	0.001
3375	Acidic cytochrome c3	Not Available	0.001
4988	Sulfite oxidase, mitochondrial	SUOX	0.001
4385	Cytochrome c'	Not Available	0.001
4967	Cytochrome c'	cycA	0.001
5038	Cytochrome c'	Not Available	0.001
5223	Cytochrome c'	cycP	0.001
2915	Sensor protein fixL	fixL	0.001
4944	Sensor protein fixL	fixL	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
3570	Cytochrome P450 152A1	cypC	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
4992	Cytochrome c peroxidase	Not Available	0.001
4813	Heme oxygenase	hmuO	0.001
5769	Heme oxygenase	Not Available	0.001
4289	Cytochrome P450	TT_P0059	0.001
6262	Cytochrome P450	staP	0.001
2230	Catalase	CAT	0.001
3249	Catalase	katA	0.001
3625	Catalase	katA	0.001
4539	Catalase	katA	0.001
4941	Catalase	katB	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
3830	Calreticulin	CALR	0.0009
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
3670	Soluble cytochrome b562 precursor	cybC	0.0009
3411	Cytochrome P450 121	cyp121	0.0009
6034	Hydroxyindole O-methyltransferase	ASMT	0.0009
6035	Nuclear receptor ROR-beta	RORB	0.0009
6036	Eosinophil peroxidase	EPX	0.0009
2132	Protein S100-B	S100B	0.0009
3291	Cytochrome c-552	cycA	0.0009
4927	Cytochrome c-552	nrfA	0.0009
4938	Cytochrome c-552	cycA	0.0009
4953	Cytochrome c-552	nrfA	0.0009
5217	Cytochrome c-552	cycM	0.0009
2617	Nitric oxide synthase oxygenase	nos	0.0009
2701	Nitric oxide synthase oxygenase	nos	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
3404	Exotoxin A	eta	0.0008
3102	Flavohemoprotein	hmp	0.0008
4969	Flavohemoprotein	hmp	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
1792	Tissue-type plasminogen activator	PLAT	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0008
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
3127	Nitrite reductase	nirS	0.0008
3284	Nitrite reductase	nirS	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0008
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
4608	Putative cytochrome P450	SCO1207	0.0007
4963	Putative cytochrome P450	SCO2884	0.0007
6254	Putative cytochrome P450	SCO6998	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
358	Cystathionine beta-synthase	CBS	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6151	Monocarboxylate transporter 10	SLC16A10	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
1507	Cytochrome c	CYCS	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
693	Hemoglobin subunit beta	HBB	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6268	Hydroxyacid oxidase 1	HAO1	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
810	Heme oxygenase 1	HMOX1	0.0006
3391	Heme oxygenase 1	pbsA1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1650	Heme carrier protein 1	SLC46A1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00349 - Clobazam

Targets

Enzymes

Transporters

Predictions