DT-Web: DB00327

Identification

Name

Hydromorphone

Accession Number

DB00327 (APRD01021)

Type

small molecule

Description

An opioid analgesic derived from morphine and used mainly as an analgesic. It has a shorter duration of action and is more potent than morphine. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

285.3377

Groups

illicit

Monoisotopic Weight

285.136493479

Pharmacology

Indication

For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, or burns.

Mechanism of action

Hydromorphone is a narcotic analgesic; its principal therapeutic effect is relief of pain. Hydromorphone interacts predominantly with the opioid mu-receptors. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Hydromorphone also binds with kappa-receptors which are thought to mediate spinal analgesia, miosis and sedation.

Absorption

Better absorbed orally than morphine

Protein binding

20%

Biotransformation

Primarily hepatic. After absorption hydromorphone is metabolized by the liver to the glucuronide conjugate which is then excreted in the urine. Hydromorphone is metabolized to the major metabolites hydromorphone-3-glucuronide, hydromorphone-3-glucoside and dihydroisomorphine-6-glucuronide.

Route of elimination

Only a small amount of the hydromorphone dose is excreted unchanged in the urine. Most of the dose is excreted as hydromorphone-3-glucuronide along with minor amounts of 6-hydroxy reduction metabolites.

Toxicity

Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Alvimopan	Increases levels by receptor binding competition. Discontinue opioid administration at least 7 days prior to administrating Alvimopan.
Eltrombopag	Increases levels of Hydromorphone via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Triprolidine	The CNS depressants, Triprolidine and Hydromorphone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.

Food Interactions

Take without regard to meals. Avoid alcohol.

Mu-type opioid receptor
Name	Mu-type opioid receptor
Gene Name	OPRM1
Pharmacological action	yes
Actions	agonist
References	Quigley C: Hydromorphone for acute and chronic pain. Cochrane Database Syst Rev. 2002;(1):CD003447. - Pubmed Inturrisi CE: Clinical pharmacology of opioids for pain. Clin J Pain. 2002 Jul-Aug;18(4 Suppl):S3-13. - Pubmed Sarhill N, Walsh D, Nelson KA: Hydromorphone: pharmacology and clinical applications in cancer patients. Support Care Cancer. 2001 Mar;9(2):84-96. - Pubmed Kumar P, Sunkaraneni S, Sirohi S, Dighe SV, Walker EA, Yoburn BC: Hydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation. Eur J Pharmacol. 2008 Nov 12;597(1-3):39-45. Epub 2008 Aug 30. - Pubmed
DTHybrid score	0.9926
Delta-type opioid receptor
Name	Delta-type opioid receptor
Gene Name	OPRD1
Pharmacological action	yes
Actions	partial agonist
References	Fang X, Larson DL, Portoghese PS: 7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. J Med Chem. 1997 Sep 12;40(19):3064-70. - Pubmed Hennies HH, Friderichs E, Schneider J: Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Arzneimittelforschung. 1988 Jul;38(7):877-80. - Pubmed Jiang Q, Sebastian A, Archer S, Bidlack JM: 5 beta-Methyl-14 beta-(p-nitrocinnamoylamino)-7,8-dihydromorphinone and its corresponding N-cyclopropylmethyl analog, N-cyclopropylmethylnor-5 beta-methyl-14 beta-(p-nitrocinnamoylamino)- 7,8-dihydromorphinone: mu-selective irreversible opioid antagonists. J Pharmacol Exp Ther. 1994 Mar;268(3):1107-13. - Pubmed Guay DR: Use of oral oxymorphone in the elderly. Consult Pharm. 2007 May;22(5):417-30. - Pubmed Hartvig P, Neil A, Terenius L, Antoni G, Rimland A, Ulin J, Langstrom B: Brain and plasma kinetics of the opioid 11C-hydromorphone in two macaque species. Pharmacol Toxicol. 1989 Sep;65(3):214-6. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.8142
Kappa-type opioid receptor
Name	Kappa-type opioid receptor
Gene Name	OPRK1
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J: Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC Pharmacol. 2006 Jan 25;6:3. - Pubmed
DTHybrid score	0.7897

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5532
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4119
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4533
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4762
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.2708

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.2205
4924	Cytochrome P450 2C8	CYP2C8	0.2084
290	Prostaglandin G/H synthase 2	PTGS2	0.1898
1588	Multidrug resistance protein 1	ABCB1	0.1896
4200	Cytochrome P450 1A2	CYP1A2	0.178
4118	Cytochrome P450 3A5	CYP3A5	0.1691
6107	Cytochrome P450 3A7	CYP3A7	0.1507
6030	Cytochrome P450 2B6	CYP2B6	0.1248
1716	Tripartite motif-containing protein 13	TRIM13	0.115
587	Serum albumin	ALB	0.1035
6013	Cytochrome P450 2E1	CYP2E1	0.0917
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0884
1262	Corticotropin-lipotropin	POMC	0.0846
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0842
5718	Cytochrome P450 2A6	CYP2A6	0.0734
6024	Cytochrome P450 1A1	CYP1A1	0.0624
824	Sodium-dependent serotonin transporter	SLC6A4	0.0615
1729	Solute carrier family 22 member 6	SLC22A6	0.061
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0574
492	Histamine H1 receptor	HRH1	0.0539
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0517
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0514
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0508
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0483
6106	Cytochrome P450 2C18	CYP2C18	0.0483
4137	Nociceptin receptor	OPRL1	0.0389
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0387
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0384
275	Arachidonate 5-lipoxygenase	ALOX5	0.0369
174	Sigma 1-type opioid receptor	SIGMAR1	0.0367
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0366
319	Opioid receptor, sigma 1	OPRS1	0.0361
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0342
831	D(2) dopamine receptor	DRD2	0.0337
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0334
6145	Solute carrier family 22 member 1	SLC22A1	0.0323
556	Alpha-1A adrenergic receptor	ADRA1A	0.0323
3811	Cytochrome P450 19A1	CYP19A1	0.032
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0315
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0314
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0306
2164	Multidrug resistance-associated protein 4	ABCC4	0.0301
862	Multidrug resistance-associated protein 1	ABCC1	0.0294
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0285
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0278
3810	Catechol O-methyltransferase	COMT	0.0277
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0274
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0266
766	Beta-2 adrenergic receptor	ADRB2	0.0266
136	Estrogen receptor	ESR1	0.0261
318	Alpha-2A adrenergic receptor	ADRA2A	0.026
6142	Solute carrier family 22 member 8	SLC22A8	0.0255
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0252
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0247
6102	Arylamine N-acetyltransferase 2	NAT2	0.0237
713	Sodium-dependent dopamine transporter	SLC6A3	0.023
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0225
193	Beta-1 adrenergic receptor	ADRB1	0.0221
1757	Myeloperoxidase	MPO	0.0217
465	Calmodulin	CALM1	0.0213
891	Dihydropteroate synthase	folP	0.0208
5359	Dihydropteroate synthase	folP	0.0208
7175	Dihydropteroate synthase	sulI	0.0208
23	D(1A) dopamine receptor	DRD1	0.0206
1898	Cytochrome P450 1B1	CYP1B1	0.0204
118	Organic cation/carnitine transporter 2	SLC22A5	0.0203
4604	Liver carboxylesterase 1	CES1	0.0203
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0199
6144	Solute carrier family 22 member 2	SLC22A2	0.0192
731	HIV-1 protease	HIV-1 protease	0.0191
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0191
3866	Serum amyloid A protein	SAA1	0.019
1200	AMBP protein	AMBP	0.019
1932	Apolipoprotein E	APOE	0.019
871	Glucocorticoid receptor	NR3C1	0.0184
632	Alpha-1B adrenergic receptor	ADRA1B	0.0182
738	Monocarboxylate transporter 1	SLC16A1	0.0177
5838	Transient receptor potential cation channel subfamily V member 3	TRPV3	0.0176
2162	Transient receptor potential cation channel subfamily M member 8	TRPM8	0.0176
1944	Transient receptor potential cation channel subfamily A member 1	TRPA1	0.0176
1024	Solute carrier family 22 member 11	SLC22A11	0.0173
1291	cAMP response element-binding protein	CREB1	0.0172
3923	Cholinesterase	BCHE	0.0172
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0171
6143	Solute carrier family 22 member 7	SLC22A7	0.017
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0167
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0167
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0166
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0163
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0162
776	Bile salt export pump	ABCB11	0.0156
4210	Toll-like receptor 4	TLR4	0.0155
638	D(3) dopamine receptor	DRD3	0.0154
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0153
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0153
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0149
70	Type-1 angiotensin II receptor	AGTR1	0.0145
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0144
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0143
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0143
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0143
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0142
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0142
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0142
789	Alpha-1D adrenergic receptor	ADRA1D	0.0139
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0138
260	Cytochrome P450 51	ERG11	0.0135
761	Cytochrome P450 51	ERG11	0.0135
3163	Cytochrome P450 51	cyp51	0.0135
3941	Amine oxidase [flavin-containing] A	MAOA	0.0131
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0127
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0126
6103	Arylamine N-acetyltransferase 1	NAT1	0.0124
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0123
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0123
6031	Cytochrome P450 3A43	CYP3A43	0.0121
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.012
629	Alpha-2B adrenergic receptor	ADRA2B	0.0118
122	P2Y purinoceptor 12	P2RY12	0.0117
6147	Solute carrier family 22 member 3	SLC22A3	0.0117
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0115
1507	Cytochrome c	CYCS	0.0114
504	Mast/stem cell growth factor receptor	KIT	0.0112
723	Cytosolic phospholipase A2	PLA2G4A	0.0111
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0111
373	Transthyretin	TTR	0.0109
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0108
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0108
4120	NADPH--cytochrome P450 reductase	POR	0.0108
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0107
811	Translocator protein	TSPO	0.0107
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0106
3939	Amine oxidase [flavin-containing] B	MAOB	0.0105
817	DNA topoisomerase 2-alpha	TOP2A	0.0104
432	D(4) dopamine receptor	DRD4	0.0103
146	Androgen receptor	AR	0.0102
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0102
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0101
378	Alpha-2C adrenergic receptor	ADRA2C	0.0101
833	Organic cation/carnitine transporter 1	SLC22A4	0.0101
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.01
725	5-hydroxytryptamine 1D receptor	HTR1D	0.01
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.01
94	5-hydroxytryptamine 4 receptor	HTR4	0.01
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.01
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0099
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0099
459	Retinoic acid receptor RXR-alpha	RXRA	0.0098
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0098
474	Acetylcholinesterase	ACHE	0.0098
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0096
407	Vascular endothelial growth factor receptor 2	KDR	0.0095
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0093
1618	High affinity nerve growth factor receptor	NTRK1	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
54	Prothrombin	F2	0.0092
6182	Cytochrome P450 2J2	CYP2J2	0.0092
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0092
6085	Fatty acid-binding protein, intestinal	FABP2	0.0091
6500	Phospholipase A2	PLA2G1B	0.009
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.009
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.009
489	Monocarboxylate transporter 2	SLC16A7	0.0089
6043	Putative G-protein coupled receptor 44	GPR44	0.0088
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0087
6137	Multidrug resistance-associated protein 6	ABCC6	0.0087
614	Progesterone receptor	PGR	0.0087
3312	Fatty acid-binding protein, brain	FABP7	0.0086
26	Vascular endothelial growth factor receptor 3	FLT4	0.0085
1275	Estrogen sulfotransferase	SULT1E1	0.0084
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0084
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0084
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0083
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0083
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0083
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0082
185	Vasopressin V1a receptor	AVPR1A	0.0082
32	Vascular endothelial growth factor receptor 1	FLT1	0.0081
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0081
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0081
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.008
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.008
716	5-hydroxytryptamine 7 receptor	HTR7	0.008
322	Vasopressin V2 receptor	AVPR2	0.008
468	Cytochrome P450 4A11	CYP4A11	0.008
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.008
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0079
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0078
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0078
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0078
1050	Bile salt sulfotransferase	SULT2A1	0.0076
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0076
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0076
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0074
163	D(1B) dopamine receptor	DRD5	0.0074
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0073
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0073
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0073
592	Carbonic anhydrase 4	CA4	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
4116	Dihydropteroate synthetase	Not Available	0.0072
295	Carbonic anhydrase 1	CA1	0.0072
130	Prostacyclin synthase	PTGIS	0.0072
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0071
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0071
5251	Carbonyl reductase [NADPH] 1	CBR1	0.007
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.007
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.007
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.007
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.007
777	Tumor necrosis factor	TNF	0.007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0069
49	Endothelin B receptor	EDNRB	0.0069
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0069
68	Cannabinoid receptor 1	CNR1	0.0069
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0068
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0067
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0067
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0067
823	Fibroblast growth factor receptor 2	FGFR2	0.0067
6014	Cytochrome P450 2A13	CYP2A13	0.0066
1192	Sulfotransferase 1A1	SULT1A1	0.0066
427	Substance-P receptor	TACR1	0.0066
161	Tubulin beta chain	TUBB	0.0066
312	Tubulin beta chain	TUB2	0.0066
952	Dipeptidyl peptidase 4	DPP4	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
1629	Transcription factor AP-1	JUN	0.0065
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0065
380	Cytochrome P450 17A1	CYP17A1	0.0063
365	Dihydrofolate reductase	DHFR	0.0063
2381	Dihydrofolate reductase	DFR1	0.0063
2833	Dihydrofolate reductase	Not Available	0.0063
2931	Dihydrofolate reductase	folA	0.0063
3544	Dihydrofolate reductase	folA	0.0063
3682	Dihydrofolate reductase	folA	0.0063
6642	Dihydrofolate reductase	folA	0.0063
6756	Dihydrofolate reductase	dfrA	0.0063
133	Dihydropterate synthase	sulI	0.0063
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0062
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0062
6148	Multidrug resistance-associated protein 7	ABCC10	0.0061
6141	Sodium/bile acid cotransporter	SLC10A1	0.0061
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.006
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0059
1648	Elastin	ELN	0.0059
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0059
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0059
124	Histamine H2 receptor	HRH2	0.0059
818	50S ribosomal protein L10	rplJ	0.0058
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0058
6220	Aryl hydrocarbon receptor	AHR	0.0058
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0057
703	NADPH azoreductase	azr	0.0056
1656	CYP2B protein	CYP2B	0.0056
3947	Xanthine dehydrogenase/oxidase	XDH	0.0056
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0055
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0055
6506	Stathmin-4	STMN4	0.0055
357	Carbonic anhydrase 2	CA2	0.0055
7	Nitric oxide synthase, inducible	NOS2	0.0054
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0054
844	Epidermal growth factor receptor	EGFR	0.0054
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0054
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0054
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0054
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0054
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0053
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0053
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0053
29	Tubulin beta-1 chain	TUBB1	0.0052
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0051
2021	Thrombomodulin	THBD	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0051
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
6136	Multidrug resistance-associated protein 5	ABCC5	0.005
183	Vascular endothelial growth factor A	VEGFA	0.005
2981	Phospholipase A2, membrane associated	PLA2G2A	0.005
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0049
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0049
558	Solute carrier family 12 member 1	SLC12A1	0.0049
173	Toll-like receptor 7	TLR7	0.0049
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0048
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
565	Extracellular calcium-sensing receptor	CASR	0.0046
856	Vitamin D3 receptor	VDR	0.0046
6126	Carbonic anhydrase 7	CA7	0.0046
165	FL cytokine receptor	FLT3	0.0046
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0046
634	Squalene monooxygenase	SQLE	0.0045
7196	Squalene monooxygenase	ERG1	0.0045
273	Apoptosis regulator Bcl-2	BCL2	0.0045
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
814	Ryanodine receptor 1	RYR1	0.0045
1353	DNA topoisomerase 1	TOP1	0.0045
3552	DNA topoisomerase 1	topA	0.0045
1039	Histone deacetylase 9	HDAC9	0.0045
5787	Angiopoietin-1 receptor	TEK	0.0044
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0044
482	Glycine receptor subunit alpha-1	GLRA1	0.0044
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0043
756	Sex hormone-binding globulin	SHBG	0.0043
869	Estrogen receptor beta	ESR2	0.0043
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0043
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0043
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0043
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0042
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0042
5798	Mitogen-activated protein kinase 11	MAPK11	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
106	Cannabinoid receptor 2	CNR2	0.0041
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0041
3937	Fatty-acid amide hydrolase	FAAH	0.0041
1010	Cytochrome P450 51A1	CYP51A1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3809	Estrogen-related receptor gamma	ESRRG	0.0039
1541	Metalloproteinase	mmp20	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
1178	Adenosine A2a receptor	ADORA2A	0.0039
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0039
6042	Prostaglandin reductase 2	PTGR2	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0038
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0038
267	Plasminogen activator inhibitor 1	SERPINE1	0.0038
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0038
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0037
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0037
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0036
705	Glutamate receptor 1	GRIA1	0.0036
6221	Steroid hormone receptor ERR1	ESRRA	0.0036
737	Mineralocorticoid receptor	NR3C2	0.0036
1792	Tissue-type plasminogen activator	PLAT	0.0036
4237	50S ribosomal protein L22	rplV	0.0035
936	Ephrin type-A receptor 2	EPHA2	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6033	High affinity interleukin-8 receptor A	CXCR1	0.0034
6146	High affinity copper uptake protein 1	SLC31A1	0.0034
921	Glutamate receptor 2	GRIA2	0.0034
24	Thymidylate synthase	TMP1	0.0034
359	Thymidylate synthase	TYMS	0.0034
2626	Thymidylate synthase	thyA	0.0034
2729	Thymidylate synthase	thyA	0.0034
5352	Thymidylate synthase	THYA	0.0034
6149	Solute carrier family 22 member 10	SLC22A10	0.0034
6020	Aldehyde oxidase	AOX1	0.0033
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0033
780	Retinoic acid receptor RXR-gamma	RXRG	0.0033
4103	Proteasome subunit beta type 2	PSMB2	0.0033
4102	Proteasome subunit beta type 5	PSMB5	0.0033
4101	Proteasome subunit beta type 1	PSMB1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0033
153	Dopamine beta-hydroxylase	DBH	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
1374	Natriuretic peptides B	NPPB	0.0033
1827	Gap junction alpha-1 protein	GJA1	0.0032
1908	Vascular cell adhesion protein 1	VCAM1	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
284	DNA-directed RNA polymerase beta chain	rpoB	0.0032
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0032
3808	Dihydropteroate synthase 2	folP2	0.0032
3601	Dihydropteroate synthase 1	folP1	0.0032
3807	Dihydropteroate synthase 1	folP1	0.0032
4122	Histone deacetylase 2	HDAC2	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
16	Adenosine A1 receptor	ADORA1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0031
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
518	Peroxidase/catalase T	katG	0.003
88	Retinoic acid receptor RXR-beta	RXRB	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
1313	Lactoylglutathione lyase	GLO1	0.003
581	Cytochrome P450 2R1	CYP2R1	0.003
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.003
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0029
164	Histamine H4 receptor	HRH4	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
904	Glutathione S-transferase P	GSTP1	0.0028
3932	Glutathione S-transferase A2	GSTA2	0.0028
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0028
6131	Carbonic anhydrase 14	CA14	0.0027
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0027
1714	Mitogen-activated protein kinase 3	MAPK3	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
33	Cystine/glutamate transporter	SLC7A11	0.0026
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0025
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0025
6138	Multidrug resistance protein 3	ABCB4	0.0025
563	Thyroid peroxidase	TPO	0.0025
2207	Rhodopsin	RHO	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0024
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0024
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0024
1864	RET proto-oncogene	RET	0.0024
759	Free fatty acid receptor 1	FFAR1	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0024
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0024
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0024
1517	Beta-3 adrenergic receptor	ADRB3	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4773	Deoxycytidine kinase	DCK	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
2236	Casein kinase II subunit alpha	CSNK2A1	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
3404	Exotoxin A	eta	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
1053	BC269730_2	FADS1	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
1852	Microtubule-associated protein 2	MAP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.002
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.002
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.002
6432	Transporter	snf	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.002
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.002
1650	Heme carrier protein 1	SLC46A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0019
3639	Thymidine phosphorylase	deoA	0.0019
3936	Thymidine phosphorylase	TYMP	0.0019
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
1992	Vitamin D-binding protein	GC	0.0019
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0018
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
84	Nuclear receptor 0B1	NR0B1	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
239	Coagulation factor X	F10	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
976	Platelet glycoprotein IX	GP9	0.0017
1630	Integrin beta-2	ITGB2	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
4311	tRNA	TRDMT1	0.0017
4325	tRNA	trmD	0.0017
4328	tRNA	trmD	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
6174	50S ribosomal protein L32	rpmF	0.0017
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0017
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0017
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0017
1196	Complement decay-accelerating factor	CD55	0.0017
4192	DNA topoisomerase 2-beta	TOP2B	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
908	Glutathione S-transferase theta-1	GSTT1	0.0016
822	Aldose reductase	AKR1B1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0015
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0015
2808	Chloramphenicol acetyltransferase 3	cat3	0.0014
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
6044	Serum paraoxonase/lactonase 3	PON3	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
469	Annexin A1	ANXA1	0.0014
572	Integrin alpha-L	ITGAL	0.0013
2417	Chloramphenicol acetyltransferase	cat	0.0013
3278	Chloramphenicol acetyltransferase	cat	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
2810	Dr hemagglutinin structural subunit	draA	0.0013
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0013
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0013
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
605	Fumarate reductase flavoprotein subunit	frdA	0.0013
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0013
3673	Fumarate reductase flavoprotein subunit	fccA	0.0013
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0013
6549	Fumarate reductase flavoprotein subunit	frdA	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0012
5934	Cytochrome P450 26A1	CYP26A1	0.0011
291	Nitric-oxide synthase, endothelial	NOS3	0.0011
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0011
751	Potassium channel subfamily K member 6	KCNK6	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
4948	Cytochrome c-553	Not Available	0.0011
4923	Cytochrome c3	DvMF_2499	0.0011
4945	Cytochrome c3	Not Available	0.0011
4949	Cytochrome c3	DVU_3171	0.0011
4968	Cytochrome c3	cytc3	0.0011
4997	Cytochrome c3	SO_2727	0.0011
5219	Cytochrome c3	cyd	0.0011
4902	Nine-heme cytochrome c	Ddes_2038	0.0011
3189	High-molecular-weight cytochrome c	hmcA	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
4217	Telomerase reverse transcriptase	TERT	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.001
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
172	Potassium channel subfamily K member 1	KCNK1	0.001
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.001
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
3957	Adenosine deaminase	ADA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
719	Retinoic acid receptor responder protein 1	RARRES1	0.0009
770	Retinoic acid-induced protein 3	GPRC5A	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
65	Matrix metalloproteinase-9	Not Available	0.0009
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
2298	Cytochrome P450-cam	camC	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
76	Nitric-oxide synthase, brain	NOS1	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
1184	Interferon beta	IFNB1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
3221	Cytochrome c4	cc4	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
569	Retinal dehydrogenase 2	ALDH1A2	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
611	Retinal dehydrogenase 1	ALDH1A1	0.0008
1025	Aquaporin-1	AQP1	0.0008
517	Alcohol dehydrogenase 1C	ADH1C	0.0008
3830	Calreticulin	CALR	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0007
6218	Pannexin-1	PANX1	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0006
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4916	Cyanoglobin	glbN	0.0006
4943	Cytochrome c6	petJ	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4984	Neuroglobin	NGB	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4909	CooA protein	cooA	0.0006
5000	HemO	hemO	0.0006
4961	Hemophore HasA	hasA	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4910	Cytoglobin	CYGB	0.0006
3116	Bacterioferritin	bfr	0.0006
4906	Bacterioferritin	bfr	0.0006
4965	Bacterioferritin	bfr	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4972	P450cin	cinA	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4952	Catalase/peroxidase	katA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
3093	Catalase HPII	katE	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
4225	Uridine phosphorylase 1	UPP1	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
162	Retinoic acid receptor gamma-1	RARG	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
4920	Peroxidase/catalase	katG	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
2119	Cytochrome b5	CYB5A	0.0005
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0005
4990	PpcA	ppcA	0.0005
4037	Hypothetical protein	GPX1	0.0005
4297	Hypothetical protein	SP_1951	0.0005
4521	Hypothetical protein	BC_2969	0.0005
4540	Hypothetical protein	TM_1070	0.0005
4555	Hypothetical protein	MT1739	0.0005
4569	Hypothetical protein	mshD	0.0005
4578	Hypothetical protein	PA3270	0.0005
4747	Hypothetical protein	PA3967	0.0005
5177	Hypothetical protein	TM_0096	0.0005
5194	Hypothetical protein	PA1204	0.0005
5240	Hypothetical protein	Rv2991	0.0005
5370	Hypothetical protein	TM_1158	0.0005
5710	Hypothetical protein	Tb927.5.1360	0.0005
4988	Sulfite oxidase, mitochondrial	SUOX	0.0005
3570	Cytochrome P450 152A1	cypC	0.0005
3375	Acidic cytochrome c3	Not Available	0.0005
2915	Sensor protein fixL	fixL	0.0005
4944	Sensor protein fixL	fixL	0.0005
4289	Cytochrome P450	TT_P0059	0.0005
6262	Cytochrome P450	staP	0.0005
4992	Cytochrome c peroxidase	Not Available	0.0005
4385	Cytochrome c'	Not Available	0.0005
4967	Cytochrome c'	cycA	0.0005
5038	Cytochrome c'	Not Available	0.0005
5223	Cytochrome c'	cycP	0.0005
4813	Heme oxygenase	hmuO	0.0005
5769	Heme oxygenase	Not Available	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00327 - Hydromorphone

Targets

Enzymes

Predictions