Identification | |
---|---|
Name | Framycetin |
Accession Number | DB00452 (APRD00618) |
Type | small molecule |
Description | A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) |
Structure |
|
Categories (*) | |
Molecular Weight | 614.6437 |
Groups | approved |
Monoisotopic Weight | 614.312285588 |
Pharmacology | |
Indication | For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal |
Mechanism of action | Framycetin binds to specific 30S-subunit proteins and 16S rRNA, four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms |
|
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
16S rRNA | |
---|---|
Name | 16S rRNA |
Gene Name | Not Available |
Pharmacological action | yes |
Actions | inhibitor |
References |
|
DTHybrid score | Not Available |
30S ribosomal protein S12 | |
Name | 30S ribosomal protein S12 |
Gene Name | rpsL |
Pharmacological action | yes |
Actions | inhibitor |
References |
|
DTHybrid score | 1.2739 |
C-X-C chemokine receptor type 4 | |
Name | C-X-C chemokine receptor type 4 |
Gene Name | CXCR4 |
Pharmacological action | unknown |
Actions | antagonist |
References |
|
DTHybrid score | 1.3066 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
6704 | 30S ribosomal protein S12 | rpsL | 1.2739 |
4388 | Aminoglycoside 2'-N-acetyltransferase | aac | 0.1234 |
1244 | Low-density lipoprotein receptor-related protein 2 | LRP2 | 0.0525 |
6028 | Kanamycin nucleotidyltransferase | knt | 0.0448 |
3390 | Aminoglycoside 3'-phosphotransferase | aphA | 0.0448 |
6029 | Aminoglycoside 3'-phosphotransferase | aphA1 | 0.0448 |
4240 | Protein disulfide-isomerase | P4HB | 0.0444 |
1729 | Solute carrier family 22 member 6 | SLC22A6 | 0.044 |
4565 | Aminoglycoside 6'-N-acetyltransferase | aac(6')-Iy | 0.0363 |
6208 | 30S ribosomal protein S13 | rpsM | 0.0281 |
6706 | 30S ribosomal protein S13 | rpsM | 0.0281 |
6209 | 30S ribosomal protein S19 | rpsS | 0.0245 |
6712 | 30S ribosomal protein S19 | rpsS | 0.0245 |
6726 | 30S ribosomal protein S19 | rpsS | 0.0245 |
6207 | 30S ribosomal protein S14 | rpsN | 0.0245 |
140 | 30S ribosomal protein S9 | rpsI | 0.0185 |
6719 | 30S ribosomal protein S9 | rpsI | 0.0185 |
6725 | 30S ribosomal protein S9 | rpsI | 0.0185 |