DT-Web

DB00292 - Etomidate


Identification
Name Etomidate
Accession Number DB00292 (APRD00965)
Type small molecule
Description Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or the cardiovascular system. It has been proposed as an induction anesthetic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 244.289
Groups approved
Monoisotopic Weight 244.121177766
Pharmacology
Indication Used in the induction of general anesthesia.
Mechanism of action Etomidate binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Absorption Not Available
Protein binding 76%, primarily to serum albumin.
Biotransformation Hepatic. Metabolized rapidly by ester hydrolysis to inactive metabolites.
Route of elimination Approximately 75% of the administered dose is excreted in the urine during the first day after injection.
Toxicity Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Martin LJ, Oh GH, Orser BA: Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade. Anesthesiology. 2009 Nov;111(5):1025-35. - Pubmed
  • Desai R, Ruesch D, Forman SA: Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology. 2009 Oct;111(4):774-84. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2606
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action yes
Actions agonist
References
  • Creagh O, Torres H, Rodriguez N, Gatica SR: Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate. P R Health Sci J. 2010 Jun;29(2):91-5. - Pubmed
  • Paris A, Philipp M, Tonner PH, Steinfath M, Lohse M, Scholz J, Hein L: Activation of alpha 2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology. 2003 Oct;99(4):889-95. - Pubmed
DTHybrid score 0.2019

Enzymes


Cytochrome P450 11B1, mitochondrial
Name Cytochrome P450 11B1, mitochondrial
Gene Name CYP11B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3422
Cytochrome P450 11B2, mitochondrial
Name Cytochrome P450 11B2, mitochondrial
Gene Name CYP11B2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3512
Cytochrome P450 19A1
Name Cytochrome P450 19A1
Gene Name CYP19A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3963

Carriers


Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1623
1588 Multidrug resistance protein 1 ABCB1 0.0889
378 Alpha-2C adrenergic receptor ADRA2C 0.0876
318 Alpha-2A adrenergic receptor ADRA2A 0.0862
380 Cytochrome P450 17A1 CYP17A1 0.0789
737 Mineralocorticoid receptor NR3C2 0.0768
6107 Cytochrome P450 3A7 CYP3A7 0.0741
4119 Cytochrome P450 2D6 CYP2D6 0.0738
146 Androgen receptor AR 0.071
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0694
4118 Cytochrome P450 3A5 CYP3A5 0.0693
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0689
756 Sex hormone-binding globulin SHBG 0.0671
4200 Cytochrome P450 1A2 CYP1A2 0.0663
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0644
6013 Cytochrome P450 2E1 CYP2E1 0.0631
831 D(2) dopamine receptor DRD2 0.0562
4757 Cytochrome P450 2C9 CYP2C9 0.055
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0537
6016 Cytochrome P450 2C19 CYP2C19 0.0535
5718 Cytochrome P450 2A6 CYP2A6 0.0533
4924 Cytochrome P450 2C8 CYP2C8 0.0497
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0481
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0477
260 Cytochrome P450 51 ERG11 0.0439
761 Cytochrome P450 51 ERG11 0.0439
3163 Cytochrome P450 51 cyp51 0.0439
23 D(1A) dopamine receptor DRD1 0.0397
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0393
94 5-hydroxytryptamine 4 receptor HTR4 0.0382
6030 Cytochrome P450 2B6 CYP2B6 0.0376
556 Alpha-1A adrenergic receptor ADRA1A 0.0366
269 Adrenodoxin, mitochondrial FDX1 0.0358
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0344
118 Organic cation/carnitine transporter 2 SLC22A5 0.0338
163 D(1B) dopamine receptor DRD5 0.0337
638 D(3) dopamine receptor DRD3 0.033
502 5-hydroxytryptamine 2A receptor HTR2A 0.0327
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0324
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0323
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0323
632 Alpha-1B adrenergic receptor ADRA1B 0.032
136 Estrogen receptor ESR1 0.0319
2298 Cytochrome P450-cam camC 0.0318
320 5-hydroxytryptamine 1A receptor HTR1A 0.0316
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0316
432 D(4) dopamine receptor DRD4 0.0311
921 Glutamate receptor 2 GRIA2 0.031
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0301
725 5-hydroxytryptamine 1D receptor HTR1D 0.0299
590 5-hydroxytryptamine 2C receptor HTR2C 0.0294
469 Annexin A1 ANXA1 0.0279
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0275
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0272
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0269
885 5-hydroxytryptamine 1B receptor HTR1B 0.0269
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.026
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0259
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0258
789 Alpha-1D adrenergic receptor ADRA1D 0.0251
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0246
6024 Cytochrome P450 1A1 CYP1A1 0.0243
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0237
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0237
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0236
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0236
871 Glucocorticoid receptor NR3C1 0.0234
563 Thyroid peroxidase TPO 0.0207
4116 Dihydropteroate synthetase Not Available 0.0199
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0195
226 Gonadotropin-releasing hormone receptor GNRHR 0.0193
540 Sodium-dependent noradrenaline transporter SLC6A2 0.019
811 Translocator protein TSPO 0.019
232 Corticosteroid-binding globulin SERPINA6 0.0188
436 5-hydroxytryptamine 2B receptor HTR2B 0.0185
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0181
6020 Aldehyde oxidase AOX1 0.0179
587 Serum albumin ALB 0.0176
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.0175
482 Glycine receptor subunit alpha-1 GLRA1 0.0172
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0161
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0161
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
6145 Solute carrier family 22 member 1 SLC22A1 0.015
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0149
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0147
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0146
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0144
6147 Solute carrier family 22 member 3 SLC22A3 0.0142
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0138
766 Beta-2 adrenergic receptor ADRB2 0.0137
3941 Amine oxidase [flavin-containing] A MAOA 0.0135
537 ATP synthase delta chain, mitochondrial ATP5D 0.0132
705 Glutamate receptor 1 GRIA1 0.0127
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0127
492 Histamine H1 receptor HRH1 0.0127
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0125
6144 Solute carrier family 22 member 2 SLC22A2 0.0125
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0125
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0124
3939 Amine oxidase [flavin-containing] B MAOB 0.0124
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0124
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0123
716 5-hydroxytryptamine 7 receptor HTR7 0.0123
193 Beta-1 adrenergic receptor ADRB1 0.0122
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0121
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.012
6044 Serum paraoxonase/lactonase 3 PON3 0.0118
6070 Nischarin NISCH 0.0118
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0116
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0113
1898 Cytochrome P450 1B1 CYP1B1 0.0111
776 Bile salt export pump ABCB11 0.0111
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0105
824 Sodium-dependent serotonin transporter SLC6A4 0.01
1517 Beta-3 adrenergic receptor ADRB3 0.0098
5934 Cytochrome P450 26A1 CYP26A1 0.0096
1010 Cytochrome P450 51A1 CYP51A1 0.0096
614 Progesterone receptor PGR 0.0096
6106 Cytochrome P450 2C18 CYP2C18 0.0095
828 Phenylalanine-4-hydroxylase PAH 0.009
3109 Phenylalanine-4-hydroxylase phhA 0.009
1256 5-hydroxytryptamine 6 receptor HTR6 0.0087
3426 Glutamine synthetase glnA 0.0084
3987 Glutamine synthetase GLUL 0.0084
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0084
6142 Solute carrier family 22 member 8 SLC22A8 0.0084
20 Prostaglandin G/H synthase 1 PTGS1 0.0083
274 Muscarinic acetylcholine receptor M5 CHRM5 0.008
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.008
869 Estrogen receptor beta ESR2 0.0079
3957 Adenosine deaminase ADA 0.0079
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0078
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0078
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0076
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0076
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0076
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0076
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0076
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0076
713 Sodium-dependent dopamine transporter SLC6A3 0.0075
3923 Cholinesterase BCHE 0.0072
528 5-hydroxytryptamine 1E receptor HTR1E 0.0072
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0072
465 Calmodulin CALM1 0.0071
51 Muscarinic acetylcholine receptor M3 CHRM3 0.007
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0068
1656 CYP2B protein CYP2B 0.0068
131 Synaptic vesicular amine transporter SLC18A2 0.0068
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0067
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0065
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0065
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0064
124 Histamine H2 receptor HRH2 0.0064
833 Organic cation/carnitine transporter 1 SLC22A4 0.0064
820 Glycine receptor subunit alpha-2 GLRA2 0.0063
1649 Small inducible cytokine A2 CCL2 0.0062
172 Potassium channel subfamily K member 1 KCNK1 0.0061
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.006
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0057
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0057
341 5-hydroxytryptamine 3 receptor HTR3A 0.0057
847 Mu-type opioid receptor OPRM1 0.0056
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0055
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0054
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0052
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0052
3947 Xanthine dehydrogenase/oxidase XDH 0.005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.005
144 Hemoglobin subunit alpha HBA1 0.0049
3809 Estrogen-related receptor gamma ESRRG 0.0048
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0047
7 Nitric oxide synthase, inducible NOS2 0.0047
6143 Solute carrier family 22 member 7 SLC22A7 0.0047
461 Glycine receptor subunit alpha-3 GLRA3 0.0045
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0045
1178 Adenosine A2a receptor ADORA2A 0.0045
780 Retinoic acid receptor RXR-gamma RXRG 0.0043
229 Retinoic acid receptor beta RARB 0.0043
634 Squalene monooxygenase SQLE 0.0043
7196 Squalene monooxygenase ERG1 0.0043
730 Retinoic acid receptor alpha RARA 0.0042
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0042
290 Prostaglandin G/H synthase 2 PTGS2 0.0041
1636 Trace amine-associated receptor 1 TAAR1 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.004
88 Retinoic acid receptor RXR-beta RXRB 0.0039
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0039
162 Retinoic acid receptor gamma-1 RARG 0.0039
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0038
468 Cytochrome P450 4A11 CYP4A11 0.0037
1024 Solute carrier family 22 member 11 SLC22A11 0.0037
2782 Complement C1s subcomponent C1S 0.0037
6031 Cytochrome P450 3A43 CYP3A43 0.0037
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0036
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0036
291 Nitric-oxide synthase, endothelial NOS3 0.0035
3815 Complement C1q subcomponent subunit A C1QA 0.0034
3816 Complement C1q subcomponent subunit B C1QB 0.0034
3817 Complement C1q subcomponent subunit C C1QC 0.0034
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0034
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0034
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0034
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0034
3814 Complement C1r subcomponent C1R 0.0034
3830 Calreticulin CALR 0.0034
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0034
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0034
474 Acetylcholinesterase ACHE 0.0033
2981 Phospholipase A2, membrane associated PLA2G2A 0.0033
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0032
6035 Nuclear receptor ROR-beta RORB 0.0032
6034 Hydroxyindole O-methyltransferase ASMT 0.0032
6036 Eosinophil peroxidase EPX 0.0032
592 Carbonic anhydrase 4 CA4 0.003
1729 Solute carrier family 22 member 6 SLC22A6 0.0029
844 Epidermal growth factor receptor EGFR 0.0028
765 Indoleamine 2,3-dioxygenase IDO1 0.0027
233 Potassium channel subfamily K member 2 KCNK2 0.0027
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
3810 Catechol O-methyltransferase COMT 0.0025
6151 Monocarboxylate transporter 10 SLC16A10 0.0024
5923 Microtubule-associated protein tau MAPT 0.0024
5924 Microtubule-associated protein 4 MAP4 0.0024
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0023
267 Plasminogen activator inhibitor 1 SERPINE1 0.0023
1852 Microtubule-associated protein 2 MAP2 0.0023
357 Carbonic anhydrase 2 CA2 0.0021
273 Apoptosis regulator Bcl-2 BCL2 0.0021
373 Transthyretin TTR 0.0021
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0021
6221 Steroid hormone receptor ERR1 ESRRA 0.0021
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0021
3937 Fatty-acid amide hydrolase FAAH 0.002
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.002
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.002
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.002
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0019
29 Tubulin beta-1 chain TUBB1 0.0019
84 Nuclear receptor 0B1 NR0B1 0.0019
251 Alcohol dehydrogenase 1A ADH1A 0.0019
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0018
862 Multidrug resistance-associated protein 1 ABCC1 0.0018
6167 Organic solute transporter subunit beta OSTB 0.0018
6166 Organic solute transporter subunit alpha OSTA 0.0018
467 Delta-type opioid receptor OPRD1 0.0018
1192 Sulfotransferase 1A1 SULT1A1 0.0018
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0018
1757 Myeloperoxidase MPO 0.0017
6014 Cytochrome P450 2A13 CYP2A13 0.0017
444 Alcohol dehydrogenase 1B ADH1B 0.0016
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0016
6148 Multidrug resistance-associated protein 7 ABCC10 0.0016
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0016
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0015
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0015
1268 Neuropeptide S receptor NPSR1 0.0015
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0015
164 Histamine H4 receptor HRH4 0.0015
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0014
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
6073 Potassium channel subfamily K member 9 KCNK9 0.0014
6072 Potassium channel subfamily K member 3 KCNK3 0.0014
6136 Multidrug resistance-associated protein 5 ABCC5 0.0013
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0013
6141 Sodium/bile acid cotransporter SLC10A1 0.0013
4604 Liver carboxylesterase 1 CES1 0.0012
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0012
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0012
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0012
2164 Multidrug resistance-associated protein 4 ABCC4 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.001
2207 Rhodopsin RHO 0.001
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