DT-Web

DB00276 - Amsacrine


Identification
Name Amsacrine
Accession Number DB00276 (APRD00064)
Type small molecule
Description Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 393.459
Groups approved
Monoisotopic Weight 393.114712179
Pharmacology
Indication For treatment of acute myeloid leukaemia.
Mechanism of action Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsacrine appears to cleave DNA by inducing double stranded breaks. Amsacrine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.
Absorption Poorly absorbed
Protein binding 96-98%
Biotransformation Extensive, primarily hepatic, converted to glutathione conjugate.
Route of elimination Not Available
Toxicity Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions intercalation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gabelica V, Rosu F, De Pauw E, Antoine R, Tabarin T, Broyer M, Dugourd P: Electron Photodetachment Dissociation of DNA Anions with Covalently or Noncovalently Bound Chromophores. J Am Soc Mass Spectrom. 2007 Aug 22;. - Pubmed
  • Capranico G, Guano F, Moro S, Zagotto G, Sissi C, Gatto B, Zunino F, Menta E, Palumbo M: Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners. J Biol Chem. 1998 May 22;273(21):12732-9. - Pubmed
DTHybrid score Not Available
DNA topoisomerase 2-alpha
Name DNA topoisomerase 2-alpha
Gene Name TOP2A
Pharmacological action yes
Actions inhibitor
References
  • Finlay GJ, Atwell GJ, Baguley BC: Inhibition of the action of the topoisomerase II poison amsacrine by simple aniline derivatives: evidence for drug-protein interactions. Oncol Res. 1999;11(6):249-54. - Pubmed
  • Ferlin MG, Marzano C, Chiarelotto G, Baccichetti F, Bordin F: Synthesis and antiproliferative activity of some variously substituted acridine and azacridine derivatives. Eur J Med Chem. 2000 Sep;35(9):827-37. - Pubmed
  • Matsumoto Y, Takano H, Kunishio K, Nagao S, Fojo T: Hypophosphorylation of topoisomerase IIalpha in etoposide (VP-16)-resistant human carcinoma cell lines associated with carboxy-terminal truncation. Jpn J Cancer Res. 2001 Jul;92(7):799-805. - Pubmed
  • Lee MS, Wang JC, Beran M: Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II. J Mol Biol. 1992 Feb 20;223(4):837-43. - Pubmed
  • Nitiss JL, Liu YX, Harbury P, Jannatipour M, Wasserman R, Wang JC: Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II. Cancer Res. 1992 Aug 15;52(16):4467-72. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Arimondo P, Boukarim C, Bailly C, Dauzonne D, Monneret C: Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity. Anticancer Drug Des. 2000 Dec;15(6):413-21. - Pubmed
DTHybrid score 0.3782
Potassium voltage-gated channel subfamily H member 2
Name Potassium voltage-gated channel subfamily H member 2
Gene Name KCNH2
Pharmacological action unknown
Actions inhibitor
References
  • Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathofer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J: Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94. Epub 2004 May 17. - Pubmed
DTHybrid score 0.1923

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3119

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
DTHybrid score 0.3042

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2112
477 DNA topoisomerase 4 subunit A parC 0.1396
886 DNA topoisomerase 4 subunit A parC 0.1396
6226 DNA topoisomerase 4 subunit A parC 0.1396
404 DNA gyrase subunit A gyrA 0.1371
6224 DNA gyrase subunit A gyrA 0.1371
4200 Cytochrome P450 1A2 CYP1A2 0.1291
4757 Cytochrome P450 2C9 CYP2C9 0.1036
4118 Cytochrome P450 3A5 CYP3A5 0.1018
6016 Cytochrome P450 2C19 CYP2C19 0.0977
4924 Cytochrome P450 2C8 CYP2C8 0.0839
6107 Cytochrome P450 3A7 CYP3A7 0.0735
862 Multidrug resistance-associated protein 1 ABCC1 0.0601
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0589
6030 Cytochrome P450 2B6 CYP2B6 0.0526
556 Alpha-1A adrenergic receptor ADRA1A 0.0524
6013 Cytochrome P450 2E1 CYP2E1 0.0523
193 Beta-1 adrenergic receptor ADRB1 0.0499
6024 Cytochrome P450 1A1 CYP1A1 0.0484
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0477
4192 DNA topoisomerase 2-beta TOP2B 0.0449
492 Histamine H1 receptor HRH1 0.043
766 Beta-2 adrenergic receptor ADRB2 0.0429
632 Alpha-1B adrenergic receptor ADRA1B 0.0404
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0401
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0399
118 Organic cation/carnitine transporter 2 SLC22A5 0.0391
831 D(2) dopamine receptor DRD2 0.0388
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0358
502 5-hydroxytryptamine 2A receptor HTR2A 0.0345
824 Sodium-dependent serotonin transporter SLC6A4 0.0333
789 Alpha-1D adrenergic receptor ADRA1D 0.0332
5718 Cytochrome P450 2A6 CYP2A6 0.0327
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.0305
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0289
6144 Solute carrier family 22 member 2 SLC22A2 0.0282
6145 Solute carrier family 22 member 1 SLC22A1 0.0273
233 Potassium channel subfamily K member 2 KCNK2 0.027
587 Serum albumin ALB 0.027
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0253
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0252
1353 DNA topoisomerase 1 TOP1 0.0252
3552 DNA topoisomerase 1 topA 0.0252
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0247
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0231
6182 Cytochrome P450 2J2 CYP2J2 0.0228
1729 Solute carrier family 22 member 6 SLC22A6 0.0227
1898 Cytochrome P450 1B1 CYP1B1 0.0225
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0224
833 Organic cation/carnitine transporter 1 SLC22A4 0.0221
6137 Multidrug resistance-associated protein 6 ABCC6 0.0215
776 Bile salt export pump ABCB11 0.0196
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0192
23 D(1A) dopamine receptor DRD1 0.0187
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0187
590 5-hydroxytryptamine 2C receptor HTR2C 0.0186
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0182
161 Tubulin beta chain TUBB 0.0181
312 Tubulin beta chain TUB2 0.0181
320 5-hydroxytryptamine 1A receptor HTR1A 0.0169
318 Alpha-2A adrenergic receptor ADRA2A 0.0167
20 Prostaglandin G/H synthase 1 PTGS1 0.0165
713 Sodium-dependent dopamine transporter SLC6A3 0.0163
847 Mu-type opioid receptor OPRM1 0.0161
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0159
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0155
465 Calmodulin CALM1 0.0155
638 D(3) dopamine receptor DRD3 0.0151
6148 Multidrug resistance-associated protein 7 ABCC10 0.0143
2539 Tubulin alpha-1 chain TUBA4A 0.0142
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0135
3086 Plasmepsin-2 Not Available 0.0134
751 Potassium channel subfamily K member 6 KCNK6 0.0133
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0131
467 Delta-type opioid receptor OPRD1 0.013
6106 Cytochrome P450 2C18 CYP2C18 0.013
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0129
3923 Cholinesterase BCHE 0.0128
723 Cytosolic phospholipase A2 PLA2G4A 0.0124
696 Kappa-type opioid receptor OPRK1 0.0123
172 Potassium channel subfamily K member 1 KCNK1 0.0121
341 5-hydroxytryptamine 3 receptor HTR3A 0.012
6147 Solute carrier family 22 member 3 SLC22A3 0.0118
871 Glucocorticoid receptor NR3C1 0.0117
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0116
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0113
136 Estrogen receptor ESR1 0.0112
4120 NADPH--cytochrome P450 reductase POR 0.011
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0109
629 Alpha-2B adrenergic receptor ADRA2B 0.0109
3947 Xanthine dehydrogenase/oxidase XDH 0.0108
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0107
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0106
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0105
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0102
731 HIV-1 protease HIV-1 protease 0.0102
3811 Cytochrome P450 19A1 CYP19A1 0.0101
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0101
3941 Amine oxidase [flavin-containing] A MAOA 0.0101
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.01
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0097
1256 5-hydroxytryptamine 6 receptor HTR6 0.0097
378 Alpha-2C adrenergic receptor ADRA2C 0.0096
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0096
885 5-hydroxytryptamine 1B receptor HTR1B 0.0096
436 5-hydroxytryptamine 2B receptor HTR2B 0.0094
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0093
474 Acetylcholinesterase ACHE 0.0092
6142 Solute carrier family 22 member 8 SLC22A8 0.0092
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0089
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0088
869 Estrogen receptor beta ESR2 0.0085
94 5-hydroxytryptamine 4 receptor HTR4 0.0084
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0084
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0083
290 Prostaglandin G/H synthase 2 PTGS2 0.0082
3939 Amine oxidase [flavin-containing] B MAOB 0.0081
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0081
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.008
725 5-hydroxytryptamine 1D receptor HTR1D 0.0079
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0079
2164 Multidrug resistance-associated protein 4 ABCC4 0.0076
260 Cytochrome P450 51 ERG11 0.0075
761 Cytochrome P450 51 ERG11 0.0075
3163 Cytochrome P450 51 cyp51 0.0075
373 Transthyretin TTR 0.0075
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0074
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0074
992 Protein tyrosine kinase 2 beta PTK2B 0.0073
124 Histamine H2 receptor HRH2 0.0073
6143 Solute carrier family 22 member 7 SLC22A7 0.0072
432 D(4) dopamine receptor DRD4 0.0072
244 Angiotensin-converting enzyme ACE 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
1374 Natriuretic peptides B NPPB 0.0068
1827 Gap junction alpha-1 protein GJA1 0.0068
1908 Vascular cell adhesion protein 1 VCAM1 0.0068
844 Epidermal growth factor receptor EGFR 0.0068
4604 Liver carboxylesterase 1 CES1 0.0068
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0066
1192 Sulfotransferase 1A1 SULT1A1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
131 Synaptic vesicular amine transporter SLC18A2 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
380 Cytochrome P450 17A1 CYP17A1 0.0063
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0059
504 Mast/stem cell growth factor receptor KIT 0.0058
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0057
952 Dipeptidyl peptidase 4 DPP4 0.0057
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0057
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0057
2112 Toll-like receptor 9 TLR9 0.0055
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0055
163 D(1B) dopamine receptor DRD5 0.0054
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0054
614 Progesterone receptor PGR 0.0051
183 Vascular endothelial growth factor A VEGFA 0.0051
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0051
716 5-hydroxytryptamine 7 receptor HTR7 0.0051
6228 Nuclear receptor coactivator 1 NCOA1 0.005
6241 Nuclear receptor coactivator 2 NCOA2 0.0049
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0049
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0049
6141 Sodium/bile acid cotransporter SLC10A1 0.0049
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
7 Nitric oxide synthase, inducible NOS2 0.0048
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0047
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0047
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0047
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0047
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0047
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0045
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0045
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0044
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0044
904 Glutathione S-transferase P GSTP1 0.0044
122 P2Y purinoceptor 12 P2RY12 0.0043
6031 Cytochrome P450 3A43 CYP3A43 0.0043
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0042
291 Nitric-oxide synthase, endothelial NOS3 0.0042
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0042
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0041
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0041
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0041
146 Androgen receptor AR 0.0041
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.004
908 Glutathione S-transferase theta-1 GSTT1 0.004
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.004
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.004
1656 CYP2B protein CYP2B 0.0039
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0039
26 Vascular endothelial growth factor receptor 3 FLT4 0.0039
228 Beta platelet-derived growth factor receptor PDGFRB 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
468 Cytochrome P450 4A11 CYP4A11 0.0037
32 Vascular endothelial growth factor receptor 1 FLT1 0.0037
407 Vascular endothelial growth factor receptor 2 KDR 0.0037
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0037
777 Tumor necrosis factor TNF 0.0037
6136 Multidrug resistance-associated protein 5 ABCC5 0.0037
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0036
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0036
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0036
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0036
70 Type-1 angiotensin II receptor AGTR1 0.0036
738 Monocarboxylate transporter 1 SLC16A1 0.0036
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0036
1024 Solute carrier family 22 member 11 SLC22A11 0.0036
6168 Solute carrier family 22 member 16 SLC22A16 0.0036
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
737 Mineralocorticoid receptor NR3C2 0.0034
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0033
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0033
6506 Stathmin-4 STMN4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
1178 Adenosine A2a receptor ADORA2A 0.0032
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0032
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0031
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
319 Opioid receptor, sigma 1 OPRS1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
528 5-hydroxytryptamine 1E receptor HTR1E 0.0031
756 Sex hormone-binding globulin SHBG 0.003
1629 Transcription factor AP-1 JUN 0.003
1517 Beta-3 adrenergic receptor ADRB3 0.003
4103 Proteasome subunit beta type 2 PSMB2 0.003
4102 Proteasome subunit beta type 5 PSMB5 0.003
4101 Proteasome subunit beta type 1 PSMB1 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
4203 Histamine N-methyltransferase HNMT 0.0029
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0029
683 Potassium transporter GK0582 0.0029
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0027
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
174 Sigma 1-type opioid receptor SIGMAR1 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
1010 Cytochrome P450 51A1 CYP51A1 0.0025
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0025
6432 Transporter snf 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
165 FL cytokine receptor FLT3 0.0023
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0022
76 Nitric-oxide synthase, brain NOS1 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0022
511 5-hydroxytryptamine 1F receptor HTR1F 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0021
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0021
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
144 Hemoglobin subunit alpha HBA1 0.002
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.002
6220 Aryl hydrocarbon receptor AHR 0.002
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.002
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
4773 Deoxycytidine kinase DCK 0.0019
1050 Bile salt sulfotransferase SULT2A1 0.0019
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1618 High affinity nerve growth factor receptor NTRK1 0.0017
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
3932 Glutathione S-transferase A2 GSTA2 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0017
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
6102 Arylamine N-acetyltransferase 2 NAT2 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0015
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0015
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0015
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0015
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0015
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
4311 tRNA TRDMT1 0.0014
4325 tRNA trmD 0.0014
4328 tRNA trmD 0.0014
6014 Cytochrome P450 2A13 CYP2A13 0.0014
469 Annexin A1 ANXA1 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
16 Adenosine A1 receptor ADORA1 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
273 Apoptosis regulator Bcl-2 BCL2 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
3404 Exotoxin A eta 0.0013
164 Histamine H4 receptor HRH4 0.0013
3957 Adenosine deaminase ADA 0.0013
1630 Integrin beta-2 ITGB2 0.0013
976 Platelet glycoprotein IX GP9 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
5787 Angiopoietin-1 receptor TEK 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
823 Fibroblast growth factor receptor 2 FGFR2 0.0012
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
694 Matrix protein 2 M 0.0012
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0012
295 Carbonic anhydrase 1 CA1 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0012
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6859 Protein S100-A4 S100A4 0.0012
3810 Catechol O-methyltransferase COMT 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
6459 Glycodelin PAEP 0.0011
427 Substance-P receptor TACR1 0.0011
6044 Serum paraoxonase/lactonase 3 PON3 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
811 Translocator protein TSPO 0.001
572 Integrin alpha-L ITGAL 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
518 Peroxidase/catalase T katG 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
1864 RET proto-oncogene RET 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
563 Thyroid peroxidase TPO 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
1275 Estrogen sulfotransferase SULT1E1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
760 Fibroblast growth factor 1 FGF1 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
54 Prothrombin F2 0.0009
1757 Myeloperoxidase MPO 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
1341 Histamine H3 receptor HRH3 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
2207 Rhodopsin RHO 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
1360 Sphingomyelin phosphodiesterase SMPD1 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
84 Nuclear receptor 0B1 NR0B1 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1992 Vitamin D-binding protein GC 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0006
592 Carbonic anhydrase 4 CA4 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
2021 Thrombomodulin THBD 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
856 Vitamin D3 receptor VDR 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
153 Dopamine beta-hydroxylase DBH 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
6218 Pannexin-1 PANX1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6020 Aldehyde oxidase AOX1 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
517 Alcohol dehydrogenase 1C ADH1C 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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