DT-Web

DB08911 - Trametinib


Identification
Name Trametinib
Accession Number DB08911
Type small molecule
Description Trametinib dimethyl sulfoxide is a kinase inhibitor. Each 1-mg tablet contains 1.127 mg trametinib dimethyl sulfoxide equivalent to 1 mg of trametinib non-solvated parent. FDA approved on May 29, 2013.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 615.3948
Groups approved
Monoisotopic Weight 615.077875874
Pharmacology
Indication Trametinib is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test.
Mechanism of action Trametinib is a reversible, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and of MEK1 and MEK2 kinase activity. MEK proteins are upstream regulators of the extracellular signal-related kinase (ERK) pathway, which promotes cellular proliferation. Trametinib helps with melanoma with the BRAF V600E or V600K as the mutation results in the constitutive activation of the BRAF pathway which includes MEK1 and MEK2.
Absorption Trametinib is rapidly absorbed. When an oral administration of trametinib was given to patients with BRAF V600 mutation-positive melanoma, peak plasma concentration occurred 1.5 hours post-dose (Tmax). A single 2 mg oral dose has a bioavailability of 72%. When a dose of 2mg/day is given, the peak plasma concentration (Cmax) is 22.2 ng/mL.
Protein binding 97.4% bound to human plasma proteins.
Biotransformation Trametinib is metabolized predominantly via deacetylation alone or with mono-oxygenation or in combination with glucuronidation biotransformation pathways in vitro. Deacetylation is likely mediated by hydrolytic enzymes, such as carboxyl-esterases or amidases. The cytochrome P450 enzyme system is not involved with the metabolism of trametinib. The predominant circulating component in the plasma is the parent compound.
Route of elimination 80% of the dose is excreted in the feces. <20% of the dose is excreted in the urine with <0.1% of the excreted dose in the form of the parent compound.
Toxicity Most common adverse reactions (>=20%) for trametinib include rash, diarrhea, and lymphedema.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • When taken with a high-fat, high-calorie meal, AUC and Cmax decreased. Tmax was also prolonged compared to fasted conditions.

Targets


Dual specificity mitogen-activated protein kinase kinase 1
Name Dual specificity mitogen-activated protein kinase kinase 1
Gene Name MAP2K1
Pharmacological action yes
Actions inhibitor
References
  • FDA label -
  • Salama AK, Kim KB: Trametinib (GSK1120212) in the treatment of melanoma. Expert Opin Pharmacother. 2013 Apr;14(5):619-27. doi: 10.1517/14656566.2013.770475. Epub 2013 Feb 23. - Pubmed
DTHybrid score 1.5494
Dual specificity mitogen-activated protein kinase kinase 2
Name Dual specificity mitogen-activated protein kinase kinase 2
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • FDA label -
  • Salama AK, Kim KB: Trametinib (GSK1120212) in the treatment of melanoma. Expert Opin Pharmacother. 2013 Apr;14(5):619-27. doi: 10.1517/14656566.2013.770475. Epub 2013 Feb 23. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • FDA label -
DTHybrid score 0.1976
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inducer
References
  • FDA label -
DTHybrid score 0.3325

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.1254
4119 Cytochrome P450 2D6 CYP2D6 0.0998
1588 Multidrug resistance protein 1 ABCB1 0.0958
1144 Hepatocyte growth factor receptor MET 0.0936
6016 Cytochrome P450 2C19 CYP2C19 0.0899
4118 Cytochrome P450 3A5 CYP3A5 0.0802
4200 Cytochrome P450 1A2 CYP1A2 0.0724
6030 Cytochrome P450 2B6 CYP2B6 0.0573
6107 Cytochrome P450 3A7 CYP3A7 0.0555
6013 Cytochrome P450 2E1 CYP2E1 0.0483
587 Serum albumin ALB 0.0343
6024 Cytochrome P450 1A1 CYP1A1 0.0321
20 Prostaglandin G/H synthase 1 PTGS1 0.0317
5718 Cytochrome P450 2A6 CYP2A6 0.0307
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0291
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.028
6824 Tyrosine-protein kinase Lyn LYN 0.0279
2599 Tyrosine-protein kinase HCK HCK 0.0261
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0246
6106 Cytochrome P450 2C18 CYP2C18 0.0221
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0214
871 Glucocorticoid receptor NR3C1 0.0213
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0197
3811 Cytochrome P450 19A1 CYP19A1 0.0194
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0194
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0186
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0173
492 Histamine H1 receptor HRH1 0.0171
862 Multidrug resistance-associated protein 1 ABCC1 0.0167
290 Prostaglandin G/H synthase 2 PTGS2 0.0166
1729 Solute carrier family 22 member 6 SLC22A6 0.0166
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0164
136 Estrogen receptor ESR1 0.0159
1898 Cytochrome P450 1B1 CYP1B1 0.0138
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0132
824 Sodium-dependent serotonin transporter SLC6A4 0.0129
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0129
847 Mu-type opioid receptor OPRM1 0.0127
2240 Cell division protein kinase 2 CDK2 0.0125
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0123
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0121
502 5-hydroxytryptamine 2A receptor HTR2A 0.0119
776 Bile salt export pump ABCB11 0.0118
467 Delta-type opioid receptor OPRD1 0.0118
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0117
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0115
731 HIV-1 protease HIV-1 protease 0.011
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0107
2164 Multidrug resistance-associated protein 4 ABCC4 0.0107
831 D(2) dopamine receptor DRD2 0.0106
696 Kappa-type opioid receptor OPRK1 0.0106
6142 Solute carrier family 22 member 8 SLC22A8 0.0105
556 Alpha-1A adrenergic receptor ADRA1A 0.0105
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0103
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0102
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0097
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0093
260 Cytochrome P450 51 ERG11 0.0092
761 Cytochrome P450 51 ERG11 0.0092
3163 Cytochrome P450 51 cyp51 0.0092
6145 Solute carrier family 22 member 1 SLC22A1 0.0092
318 Alpha-2A adrenergic receptor ADRA2A 0.0091
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.009
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0089
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0089
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0087
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0086
6031 Cytochrome P450 3A43 CYP3A43 0.0085
6144 Solute carrier family 22 member 2 SLC22A2 0.0084
6143 Solute carrier family 22 member 7 SLC22A7 0.0084
6182 Cytochrome P450 2J2 CYP2J2 0.0083
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0083
614 Progesterone receptor PGR 0.0082
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0082
232 Corticosteroid-binding globulin SERPINA6 0.008
320 5-hydroxytryptamine 1A receptor HTR1A 0.008
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0079
23 D(1A) dopamine receptor DRD1 0.0073
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0072
146 Androgen receptor AR 0.0072
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0072
590 5-hydroxytryptamine 2C receptor HTR2C 0.0071
341 5-hydroxytryptamine 3 receptor HTR3A 0.0071
468 Cytochrome P450 4A11 CYP4A11 0.007
632 Alpha-1B adrenergic receptor ADRA1B 0.007
29 Tubulin beta-1 chain TUBB1 0.007
118 Organic cation/carnitine transporter 2 SLC22A5 0.0069
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0069
811 Translocator protein TSPO 0.0068
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0067
1024 Solute carrier family 22 member 11 SLC22A11 0.0067
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0066
952 Dipeptidyl peptidase 4 DPP4 0.0065
766 Beta-2 adrenergic receptor ADRB2 0.0064
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0064
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0062
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0062
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0062
2183 Fatty acid-binding protein, adipocyte FABP4 0.0061
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0061
450 Muscarinic acetylcholine receptor M4 CHRM4 0.006
713 Sodium-dependent dopamine transporter SLC6A3 0.006
70 Type-1 angiotensin II receptor AGTR1 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
122 P2Y purinoceptor 12 P2RY12 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
818 50S ribosomal protein L10 rplJ 0.0058
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0057
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0057
6102 Arylamine N-acetyltransferase 2 NAT2 0.0057
504 Mast/stem cell growth factor receptor KIT 0.0056
6141 Sodium/bile acid cotransporter SLC10A1 0.0056
844 Epidermal growth factor receptor EGFR 0.0055
885 5-hydroxytryptamine 1B receptor HTR1B 0.0054
789 Alpha-1D adrenergic receptor ADRA1D 0.0054
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0053
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0053
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0053
6147 Solute carrier family 22 member 3 SLC22A3 0.0052
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0052
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0052
638 D(3) dopamine receptor DRD3 0.0052
725 5-hydroxytryptamine 1D receptor HTR1D 0.0052
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0051
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0051
3923 Cholinesterase BCHE 0.0051
380 Cytochrome P450 17A1 CYP17A1 0.005
465 Calmodulin CALM1 0.005
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.005
869 Estrogen receptor beta ESR2 0.005
833 Organic cation/carnitine transporter 1 SLC22A4 0.005
606 Cytochrome P450 27, mitochondrial CYP27A1 0.005
1541 Metalloproteinase mmp20 0.0049
3941 Amine oxidase [flavin-containing] A MAOA 0.0049
6020 Aldehyde oxidase AOX1 0.0048
629 Alpha-2B adrenergic receptor ADRA2B 0.0048
737 Mineralocorticoid receptor NR3C2 0.0047
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0047
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0047
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0046
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0046
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0046
6148 Multidrug resistance-associated protein 7 ABCC10 0.0046
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0046
407 Vascular endothelial growth factor receptor 2 KDR 0.0045
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0045
365 Dihydrofolate reductase DHFR 0.0045
2381 Dihydrofolate reductase DFR1 0.0045
2833 Dihydrofolate reductase Not Available 0.0045
2931 Dihydrofolate reductase folA 0.0045
3544 Dihydrofolate reductase folA 0.0045
3682 Dihydrofolate reductase folA 0.0045
6642 Dihydrofolate reductase folA 0.0045
6756 Dihydrofolate reductase dfrA 0.0045
756 Sex hormone-binding globulin SHBG 0.0045
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0045
378 Alpha-2C adrenergic receptor ADRA2C 0.0044
161 Tubulin beta chain TUBB 0.0044
312 Tubulin beta chain TUB2 0.0044
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0044
6136 Multidrug resistance-associated protein 5 ABCC5 0.0044
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0044
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0044
4604 Liver carboxylesterase 1 CES1 0.0043
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0043
856 Vitamin D3 receptor VDR 0.0043
891 Dihydropteroate synthase folP 0.0043
5359 Dihydropteroate synthase folP 0.0043
7175 Dihydropteroate synthase sulI 0.0043
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0043
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0043
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0042
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0042
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0042
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0042
817 DNA topoisomerase 2-alpha TOP2A 0.0042
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0042
814 Ryanodine receptor 1 RYR1 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
193 Beta-1 adrenergic receptor ADRB1 0.004
6137 Multidrug resistance-associated protein 6 ABCC6 0.004
158 Sodium channel protein type 1 subunit alpha SCN1A 0.004
4120 NADPH--cytochrome P450 reductase POR 0.004
373 Transthyretin TTR 0.0039
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0039
1050 Bile salt sulfotransferase SULT2A1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
88 Retinoic acid receptor RXR-beta RXRB 0.0038
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0038
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0038
26 Vascular endothelial growth factor receptor 3 FLT4 0.0038
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0037
777 Tumor necrosis factor TNF 0.0037
436 5-hydroxytryptamine 2B receptor HTR2B 0.0037
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0037
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0036
32 Vascular endothelial growth factor receptor 1 FLT1 0.0036
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0035
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0035
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0035
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0034
1010 Cytochrome P450 51A1 CYP51A1 0.0034
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0034
228 Beta platelet-derived growth factor receptor PDGFRB 0.0034
284 DNA-directed RNA polymerase beta chain rpoB 0.0034
5773 DNA-directed RNA polymerase beta chain rpoB 0.0034
432 D(4) dopamine receptor DRD4 0.0034
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0034
6085 Fatty acid-binding protein, intestinal FABP2 0.0033
474 Acetylcholinesterase ACHE 0.0033
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0033
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0033
275 Arachidonate 5-lipoxygenase ALOX5 0.0033
5880 Thrombopoietin receptor MPL 0.0033
716 5-hydroxytryptamine 7 receptor HTR7 0.0032
3932 Glutathione S-transferase A2 GSTA2 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
3939 Amine oxidase [flavin-containing] B MAOB 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
295 Carbonic anhydrase 1 CA1 0.0031
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1648 Elastin ELN 0.0031
427 Substance-P receptor TACR1 0.0031
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6014 Cytochrome P450 2A13 CYP2A13 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
4203 Histamine N-methyltransferase HNMT 0.003
94 5-hydroxytryptamine 4 receptor HTR4 0.003
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.003
1629 Transcription factor AP-1 JUN 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
208 DNA-directed RNA polymerase beta' chain rpoC 0.003
5774 DNA-directed RNA polymerase beta' chain rpoC 0.003
6138 Multidrug resistance protein 3 ABCB4 0.0029
162 Retinoic acid receptor gamma-1 RARG 0.0029
24 Thymidylate synthase TMP1 0.0028
359 Thymidylate synthase TYMS 0.0028
2626 Thymidylate synthase thyA 0.0028
2729 Thymidylate synthase thyA 0.0028
5352 Thymidylate synthase THYA 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0028
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0028
6220 Aryl hydrocarbon receptor AHR 0.0027
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4122 Histone deacetylase 2 HDAC2 0.0027
16 Adenosine A1 receptor ADORA1 0.0026
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0026
921 Glutamate receptor 2 GRIA2 0.0026
581 Cytochrome P450 2R1 CYP2R1 0.0026
49 Endothelin B receptor EDNRB 0.0026
3856 Fibroblast growth factor receptor 3 FGFR3 0.0026
1178 Adenosine A2a receptor ADORA2A 0.0025
3947 Xanthine dehydrogenase/oxidase XDH 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0025
705 Glutamate receptor 1 GRIA1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
738 Monocarboxylate transporter 1 SLC16A1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
229 Retinoic acid receptor beta RARB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
518 Peroxidase/catalase T katG 0.0023
469 Annexin A1 ANXA1 0.0023
5787 Angiopoietin-1 receptor TEK 0.0023
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
1852 Microtubule-associated protein 2 MAP2 0.0023
124 Histamine H2 receptor HRH2 0.0022
4311 tRNA TRDMT1 0.0022
4325 tRNA trmD 0.0022
4328 tRNA trmD 0.0022
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
1757 Myeloperoxidase MPO 0.0022
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
165 FL cytokine receptor FLT3 0.0021
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0021
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0021
6174 50S ribosomal protein L32 rpmF 0.0021
1656 CYP2B protein CYP2B 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
163 D(1B) dopamine receptor DRD5 0.0021
3809 Estrogen-related receptor gamma ESRRG 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
239 Coagulation factor X F10 0.002
1256 5-hydroxytryptamine 6 receptor HTR6 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
780 Retinoic acid receptor RXR-gamma RXRG 0.0018
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
2808 Chloramphenicol acetyltransferase 3 cat3 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
84 Nuclear receptor 0B1 NR0B1 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
712 Tubulin alpha chain TUB1 0.0018
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
1192 Sulfotransferase 1A1 SULT1A1 0.0018
683 Potassium transporter GK0582 0.0018
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0017
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0017
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0017
823 Fibroblast growth factor receptor 2 FGFR2 0.0017
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
904 Glutathione S-transferase P GSTP1 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
1618 High affinity nerve growth factor receptor NTRK1 0.0017
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0016
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0016
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0016
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0016
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
1992 Vitamin D-binding protein GC 0.0015
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0015
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
319 Opioid receptor, sigma 1 OPRS1 0.0015
528 5-hydroxytryptamine 1E receptor HTR1E 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
5923 Microtubule-associated protein tau MAPT 0.0014
5924 Microtubule-associated protein 4 MAP4 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1630 Integrin beta-2 ITGB2 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
976 Platelet glycoprotein IX GP9 0.0014
4103 Proteasome subunit beta type 2 PSMB2 0.0014
4102 Proteasome subunit beta type 5 PSMB5 0.0014
4101 Proteasome subunit beta type 1 PSMB1 0.0014
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0013
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0013
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
4217 Telomerase reverse transcriptase TERT 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
3810 Catechol O-methyltransferase COMT 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0013
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
4192 DNA topoisomerase 2-beta TOP2B 0.0012
3937 Fatty-acid amide hydrolase FAAH 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6048 Troponin C, skeletal muscle TNNC2 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
719 Retinoic acid receptor responder protein 1 RARRES1 0.0012
770 Retinoic acid-induced protein 3 GPRC5A 0.0012
489 Monocarboxylate transporter 2 SLC16A7 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
936 Ephrin type-A receptor 2 EPHA2 0.0011
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0011
6044 Serum paraoxonase/lactonase 3 PON3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
572 Integrin alpha-L ITGAL 0.0011
164 Histamine H4 receptor HRH4 0.001
54 Prothrombin F2 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
5798 Mitogen-activated protein kinase 11 MAPK11 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2320 Thymidine kinase, cytosolic TK1 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
267 Plasminogen activator inhibitor 1 SERPINE1 0.001
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
6149 Solute carrier family 22 member 10 SLC22A10 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.001
760 Fibroblast growth factor 1 FGF1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
4226 Uridine phosphorylase 2 UPP2 0.0009
4773 Deoxycytidine kinase DCK 0.0009
2207 Rhodopsin RHO 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
6221 Steroid hormone receptor ERR1 ESRRA 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6218 Pannexin-1 PANX1 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6677 Myelin P2 protein PMP2 0.0009
908 Glutathione S-transferase theta-1 GSTT1 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
183 Vascular endothelial growth factor A VEGFA 0.0009
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0009
7 Nitric oxide synthase, inducible NOS2 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
4225 Uridine phosphorylase 1 UPP1 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
413 Amidophosphoribosyltransferase PPAT 0.0008
2515 Amidophosphoribosyltransferase purF 0.0008
3714 Amidophosphoribosyltransferase purF 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
2021 Thrombomodulin THBD 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
6432 Transporter snf 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2298 Cytochrome P450-cam camC 0.0008
3957 Adenosine deaminase ADA 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0008
2091 Endoplasmin HSP90B1 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
125 DNA polymerase beta POLB 0.0007
3639 Thymidine phosphorylase deoA 0.0007
3936 Thymidine phosphorylase TYMP 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0006
3917 Methylenetetrahydrofolate reductase MTHFR 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
563 Thyroid peroxidase TPO 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
1864 RET proto-oncogene RET 0.0003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
3221 Cytochrome c4 cc4 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
↑