DT-Web

DB08847 - Hydroxyproline


Identification
Name Hydroxyproline
Accession Number DB08847
Type small molecule
Description Hydroxyproline is a neutral heterocyclic protein amino acid. It is found in collagen and as such it is common in many gelatin products. Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline is being studied as an an experimental medicine but is approved in France as a combination topical gel product called Cicactive for small, superficial wounds.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 131.1299
Groups approved
Monoisotopic Weight 131.058243159
Pharmacology
Indication Used in France as a combination product for the treatment of small, superficial wounds.
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Transporters


Proton-coupled amino acid transporter 1
Name Proton-coupled amino acid transporter 1
Gene Name SLC36A1
Actions Not Available
References
  • Metzner L, Kalbitz J, Brandsch M: Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1. J Pharmacol Exp Ther. 2004 Apr;309(1):28-35. Epub 2004 Jan 12. - Pubmed
DTHybrid score 0.8414

Predictions


Id Partner name Gene Name Score
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0683
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0655
4096 Metabotropic glutamate receptor 3 GRM3 0.0401
1362 Metabotropic glutamate receptor 2 GRM2 0.04
2178 Metabotropic glutamate receptor 5 GRM5 0.0375
916 Metabotropic glutamate receptor 1 GRM1 0.0359
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0208
532 Neutral amino acid transporter A SLC1A4 0.0203
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0203
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0203
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0192
349 Serine--pyruvate aminotransferase AGXT 0.0186
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0154
435 Kynureninase KYNU 0.0151
4654 Kynureninase kynU 0.0151
169 Cysteine desulfurase, mitochondrial NFS1 0.0147
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0139
6151 Monocarboxylate transporter 10 SLC16A10 0.0134
735 Alanine aminotransferase 1 GPT 0.0133
3904 Alanine aminotransferase 2 GPT2 0.0133
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0079
4056 N-arachidonyl glycine receptor GPR18 0.0079
4061 Peroxisomal sarcosine oxidase PIPOX 0.0079
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0079
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0079
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0079
4057 Glycine N-acyltransferase GLYAT 0.0079
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0079
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0079
1466 Glycyl-tRNA synthetase GARS 0.0079
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0079
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0066
62 Glycine receptor subunit beta GLRB 0.0061
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0061
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0061
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0061
383 Glycine amidinotransferase, mitochondrial GATM 0.006
411 Glycine N-methyltransferase GNMT 0.0059
207 Glutathione synthetase GSS 0.0057
5269 Glutathione synthetase gshB 0.0057
3884 SHMT2 protein SHMT2 0.0055
3901 SHMT2 protein SHMT2 0.0055
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0055
3879 Serine hydroxymethyltransferase 2 Not Available 0.0055
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0055
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0053
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.005
461 Glycine receptor subunit alpha-3 GLRA3 0.005
820 Glycine receptor subunit alpha-2 GLRA2 0.0049
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0049
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0045
482 Glycine receptor subunit alpha-1 GLRA1 0.0042
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