DT-Web

DB04821 - Nomifensine


Identification
Name Nomifensine
Accession Number DB04821
Type small molecule
Description Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that Merital capsules were removed from the market for safety reasons (see the Federal Register of June 17, 1986 (51 FR 21981)). Approval of the NDA for Merital capsules was withdrawn on March 20, 1992 (see the Federal Register of March 20, 1992 (57 FR 9729)). Also withdrawn from the Canadian and UK markets.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 238.3275
Groups withdrawn
Monoisotopic Weight 238.146998586
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity A likely cause of nomifensine toxicity is the aromatic amine group, as compounds containing this chemical substructure are notorious for producing toxic metabolites.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action unknown
Actions Not Available
References
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.5112
Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Pharmacological action unknown
Actions Not Available
References
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.5283
Amine oxidase [flavin-containing] B
Name Amine oxidase [flavin-containing] B
Gene Name MAOB
Pharmacological action unknown
Actions Not Available
References
  • Egashira T, Takayama F, Yamanaka Y: The inhibition of monoamine oxidase activity by various antidepressants: differences found in various mammalian species. Jpn J Pharmacol. 1999 Sep;81(1):115-21. - Pubmed
DTHybrid score 1.0042
Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Pharmacological action unknown
Actions Not Available
References
  • Egashira T, Takayama F, Yamanaka Y: The inhibition of monoamine oxidase activity by various antidepressants: differences found in various mammalian species. Jpn J Pharmacol. 1999 Sep;81(1):115-21. - Pubmed
DTHybrid score 0.6042
Myeloperoxidase
Name Myeloperoxidase
Gene Name MPO
Pharmacological action unknown
Actions Not Available
References
  • Obach RS, Dalvie DK: Metabolism of nomifensine to a dihydroisoquinolinium ion metabolite by human myeloperoxidase, hemoglobin, monoamine oxidase A, and cytochrome P450 enzymes. Drug Metab Dispos. 2006 Aug;34(8):1310-6. Epub 2006 May 5. - Pubmed
DTHybrid score 0.3292

Carriers


Predictions


Id Partner name Gene Name Score
824 Sodium-dependent serotonin transporter SLC6A4 0.2791
4119 Cytochrome P450 2D6 CYP2D6 0.1944
4512 Cytochrome P450 3A4 CYP3A4 0.1361
4200 Cytochrome P450 1A2 CYP1A2 0.1197
556 Alpha-1A adrenergic receptor ADRA1A 0.1067
131 Synaptic vesicular amine transporter SLC18A2 0.1016
1588 Multidrug resistance protein 1 ABCB1 0.0951
6016 Cytochrome P450 2C19 CYP2C19 0.093
4757 Cytochrome P450 2C9 CYP2C9 0.0926
318 Alpha-2A adrenergic receptor ADRA2A 0.0666
632 Alpha-1B adrenergic receptor ADRA1B 0.0644
587 Serum albumin ALB 0.0604
492 Histamine H1 receptor HRH1 0.0547
6030 Cytochrome P450 2B6 CYP2B6 0.0524
502 5-hydroxytryptamine 2A receptor HTR2A 0.0484
4924 Cytochrome P450 2C8 CYP2C8 0.046
290 Prostaglandin G/H synthase 2 PTGS2 0.0418
6013 Cytochrome P450 2E1 CYP2E1 0.0415
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0413
193 Beta-1 adrenergic receptor ADRB1 0.0381
4118 Cytochrome P450 3A5 CYP3A5 0.0377
320 5-hydroxytryptamine 1A receptor HTR1A 0.0377
1636 Trace amine-associated receptor 1 TAAR1 0.0361
6144 Solute carrier family 22 member 2 SLC22A2 0.0342
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0329
511 5-hydroxytryptamine 1F receptor HTR1F 0.0325
118 Organic cation/carnitine transporter 2 SLC22A5 0.0323
766 Beta-2 adrenergic receptor ADRB2 0.0321
6147 Solute carrier family 22 member 3 SLC22A3 0.0317
1736 Somatostatin SST 0.0311
4186 Neuropeptide Y receptor type 2 NPY2R 0.0311
20 Prostaglandin G/H synthase 1 PTGS1 0.0311
153 Dopamine beta-hydroxylase DBH 0.0311
6107 Cytochrome P450 3A7 CYP3A7 0.0309
3810 Catechol O-methyltransferase COMT 0.0309
629 Alpha-2B adrenergic receptor ADRA2B 0.0307
789 Alpha-1D adrenergic receptor ADRA1D 0.0307
885 5-hydroxytryptamine 1B receptor HTR1B 0.0305
725 5-hydroxytryptamine 1D receptor HTR1D 0.029
6145 Solute carrier family 22 member 1 SLC22A1 0.0289
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0264
590 5-hydroxytryptamine 2C receptor HTR2C 0.0257
378 Alpha-2C adrenergic receptor ADRA2C 0.0256
6024 Cytochrome P450 1A1 CYP1A1 0.0255
1517 Beta-3 adrenergic receptor ADRB3 0.0253
309 Antithrombin-III SERPINC1 0.0251
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0239
563 Thyroid peroxidase TPO 0.0238
2864 Penton protein PIII 0.0236
5718 Cytochrome P450 2A6 CYP2A6 0.023
831 D(2) dopamine receptor DRD2 0.0216
275 Arachidonate 5-lipoxygenase ALOX5 0.0215
503 Somatostatin receptor type 1 SSTR1 0.0214
23 D(1A) dopamine receptor DRD1 0.0212
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0211
723 Cytosolic phospholipase A2 PLA2G4A 0.021
6020 Aldehyde oxidase AOX1 0.0209
3866 Serum amyloid A protein SAA1 0.0209
1932 Apolipoprotein E APOE 0.0208
1200 AMBP protein AMBP 0.0208
54 Prothrombin F2 0.0207
1656 CYP2B protein CYP2B 0.0207
5841 Insulin-like growth factor IB IGF1 0.0206
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0206
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0203
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
3872 Somatostatin receptor type 5 SSTR5 0.02
6008 Somatostatin receptor type 2 SSTR2 0.02
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0199
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0198
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0192
856 Vitamin D3 receptor VDR 0.0189
3923 Cholinesterase BCHE 0.0185
3811 Cytochrome P450 19A1 CYP19A1 0.0185
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0175
274 Muscarinic acetylcholine receptor M5 CHRM5 0.017
146 Androgen receptor AR 0.0167
436 5-hydroxytryptamine 2B receptor HTR2B 0.0167
239 Coagulation factor X F10 0.0167
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0166
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0166
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0163
115 Penicillin-binding protein 2 mrdA 0.016
6069 Penicillin-binding protein 2 mrdA 0.016
6118 Penicillin-binding protein 2 penA 0.016
6187 Penicillin-binding protein 2 pbpA 0.016
6686 Penicillin-binding protein 2 pbp2 0.016
6939 Penicillin-binding protein 2 mrdA 0.016
7163 Penicillin-binding protein 2 pbpA 0.016
867 Penicillin-binding protein 3 pbpC 0.016
6119 Penicillin-binding protein 3 pbp3 0.016
7154 Penicillin-binding protein 3 pbp3 0.016
7157 Penicillin-binding protein 3 LMHCC_2184 0.016
7162 Penicillin-binding protein 3 pbpB 0.016
7172 Penicillin-binding protein 3 pbp3 0.016
6012 Tryptophan 2,3-dioxygenase TDO2 0.0155
341 5-hydroxytryptamine 3 receptor HTR3A 0.0154
273 Apoptosis regulator Bcl-2 BCL2 0.0149
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0143
6165 Copper-transporting ATPase 1 ATP7A 0.0132
6163 Copper-transporting ATPase 2 ATP7B 0.0132
633 Penicillin-binding proteins 1A/1B pbpA 0.0132
1729 Solute carrier family 22 member 6 SLC22A6 0.0129
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0128
6146 High affinity copper uptake protein 1 SLC31A1 0.0125
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0125
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0121
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0121
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0121
908 Glutathione S-transferase theta-1 GSTT1 0.0119
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0119
833 Organic cation/carnitine transporter 1 SLC22A4 0.0118
904 Glutathione S-transferase P GSTP1 0.0115
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0108
3947 Xanthine dehydrogenase/oxidase XDH 0.0107
465 Calmodulin CALM1 0.0107
844 Epidermal growth factor receptor EGFR 0.0106
896 Glutathione S-transferase Mu 1 GSTM1 0.0105
5698 Riboflavin synthase alpha chain ribE 0.0105
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0104
408 Riboflavin kinase RFK 0.0101
862 Multidrug resistance-associated protein 1 ABCC1 0.0101
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0101
6106 Cytochrome P450 2C18 CYP2C18 0.01
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0099
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0099
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0099
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0098
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0098
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0095
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0095
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0086
1898 Cytochrome P450 1B1 CYP1B1 0.0085
6432 Transporter snf 0.0083
696 Kappa-type opioid receptor OPRK1 0.0082
3913 Glutamic acid decarboxylase GAD65 0.008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0079
847 Mu-type opioid receptor OPRM1 0.0079
1483 Membrane copper amine oxidase AOC3 0.0076
474 Acetylcholinesterase ACHE 0.0076
654 Flavin reductase BLVRB 0.0075
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0074
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0072
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0072
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0072
6142 Solute carrier family 22 member 8 SLC22A8 0.0071
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0071
6031 Cytochrome P450 3A43 CYP3A43 0.0067
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0067
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0067
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0067
4120 NADPH--cytochrome P450 reductase POR 0.0066
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0066
3917 Methylenetetrahydrofolate reductase MTHFR 0.0066
3601 Dihydropteroate synthase 1 folP1 0.0065
3807 Dihydropteroate synthase 1 folP1 0.0065
3808 Dihydropteroate synthase 2 folP2 0.0065
163 D(1B) dopamine receptor DRD5 0.0065
735 Alanine aminotransferase 1 GPT 0.0065
3904 Alanine aminotransferase 2 GPT2 0.0065
122 P2Y purinoceptor 12 P2RY12 0.0062
432 D(4) dopamine receptor DRD4 0.0062
638 D(3) dopamine receptor DRD3 0.006
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.006
694 Matrix protein 2 M 0.0059
6036 Eosinophil peroxidase EPX 0.0059
467 Delta-type opioid receptor OPRD1 0.0058
6168 Solute carrier family 22 member 16 SLC22A16 0.0058
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0058
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0058
3830 Calreticulin CALR 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
551 Carnitine O-acetyltransferase CRAT 0.0057
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0056
6034 Hydroxyindole O-methyltransferase ASMT 0.0055
6035 Nuclear receptor ROR-beta RORB 0.0055
6014 Cytochrome P450 2A13 CYP2A13 0.0052
1050 Bile salt sulfotransferase SULT2A1 0.0052
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0052
765 Indoleamine 2,3-dioxygenase IDO1 0.0047
5787 Angiopoietin-1 receptor TEK 0.0047
380 Cytochrome P450 17A1 CYP17A1 0.0046
2164 Multidrug resistance-associated protein 4 ABCC4 0.0046
1618 High affinity nerve growth factor receptor NTRK1 0.0046
6102 Arylamine N-acetyltransferase 2 NAT2 0.0045
362 Melatonin receptor type 1B MTNR1B 0.0045
571 Melatonin receptor type 1A MTNR1A 0.0045
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
183 Vascular endothelial growth factor A VEGFA 0.0044
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0044
828 Phenylalanine-4-hydroxylase PAH 0.0043
3109 Phenylalanine-4-hydroxylase phhA 0.0043
768 FK506-binding protein 1A FKBP1A 0.0043
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0042
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0042
6182 Cytochrome P450 2J2 CYP2J2 0.0041
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0041
482 Glycine receptor subunit alpha-1 GLRA1 0.004
6133 Sodium channel subunit beta-2 SCN2B 0.0038
6134 Sodium channel subunit beta-3 SCN3B 0.0038
6132 Sodium channel subunit beta-1 SCN1B 0.0038
6135 Sodium channel subunit beta-4 SCN4B 0.0038
6127 Carbonic anhydrase-related protein CA8 0.0038
6129 Carbonic anhydrase-related protein 11 CA11 0.0038
6128 Carbonic anhydrase-related protein 10 CA10 0.0038
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0038
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0038
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0038
4604 Liver carboxylesterase 1 CES1 0.0037
6141 Sodium/bile acid cotransporter SLC10A1 0.0037
1360 Sphingomyelin phosphodiesterase SMPD1 0.0037
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0036
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0036
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0036
6130 Carbonic anhydrase 13 CA13 0.0036
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0035
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0033
6131 Carbonic anhydrase 14 CA14 0.0032
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0032
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0032
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0031
6122 Carbonic anhydrase 3 CA3 0.0031
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0031
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.003
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.003
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0029
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0029
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0029
4205 Carbonic anhydrase 9 CA9 0.0028
3007 Carbonic anhydrase 12 CA12 0.0028
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
468 Cytochrome P450 4A11 CYP4A11 0.0026
6137 Multidrug resistance-associated protein 6 ABCC6 0.0026
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0025
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0025
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0025
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0025
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0024
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0024
136 Estrogen receptor ESR1 0.0024
6136 Multidrug resistance-associated protein 5 ABCC5 0.0024
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0023
124 Histamine H2 receptor HRH2 0.0023
1864 RET proto-oncogene RET 0.0023
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0023
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0023
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0023
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0022
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0022
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0022
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0021
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0021
592 Carbonic anhydrase 4 CA4 0.0021
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.002
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.002
295 Carbonic anhydrase 1 CA1 0.002
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.002
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.002
731 HIV-1 protease HIV-1 protease 0.0019
738 Monocarboxylate transporter 1 SLC16A1 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0018
6151 Monocarboxylate transporter 10 SLC16A10 0.0018
4486 Phenol 2-hydroxylase component B pheA2 0.0018
4477 Dihydrolipoyl dehydrogenase lpdV 0.0018
5077 Dihydrolipoyl dehydrogenase Not Available 0.0018
5117 Dihydrolipoyl dehydrogenase lpd 0.0018
4439 Ferredoxin reductase bphA4 0.0018
5078 Amine oxidase, flavin-containing PSPTO1126 0.0018
526 Thioredoxin reductase trxB 0.0018
3767 Thioredoxin reductase trxB 0.0018
5122 Mersacidin decarboxylase mrsD 0.0017
5095 Putidaredoxin reductase camA 0.0017
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0017
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0017
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0017
5109 Outer membrane protein p64k or PM-6 m-6 0.0017
5115 FkbI fkbI 0.0017
3133 UDP-galactopyranose mutase glf 0.0017
5099 UDP-galactopyranose mutase glf 0.0017
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0017
3763 5,10-methylenetetrahydrofolate reductase metF 0.0017
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0017
5094 5,10-methylenetetrahydrofolate reductase metF 0.0017
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0017
5111 Phenylacetone monooxygenase pamO 0.0017
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0017
5083 Cryptochrome DASH cry 0.0017
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0017
5081 L-aspartate oxidase nadB 0.0017
1410 Oxidoreductase HSD17B6 0.0017
4725 Oxidoreductase Not Available 0.0017
5124 Oxidoreductase Not Available 0.0017
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0017
228 Beta platelet-derived growth factor receptor PDGFRB 0.0017
357 Carbonic anhydrase 2 CA2 0.0017
504 Mast/stem cell growth factor receptor KIT 0.0016
4440 NADH peroxidase npr 0.0015
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0015
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0015
3102 Flavohemoprotein hmp 0.0015
4969 Flavohemoprotein hmp 0.0015
3594 Deoxyribodipyrimidine photo-lyase phr 0.0015
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0015
5080 Deoxyribodipyrimidine photo-lyase phr 0.0015
5072 N,N-dimethylglycine oxidase dmg 0.0015
2470 Pyruvate oxidase pox5 0.0015
5073 Ferredoxin--NADP reductase petH 0.0015
5076 Ferredoxin--NADP reductase fpr 0.0015
5119 Ferredoxin--NADP reductase petH 0.0015
5121 Ferredoxin--NADP reductase fpr 0.0015
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0015
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0015
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0015
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0015
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0015
2268 Cholesterol oxidase choB 0.0015
2822 Cholesterol oxidase choA 0.0015
2526 NADPH-ferredoxin reductase fprA fprA 0.0015
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0015
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0015
6689 TraN protein traN 0.0015
6672 Destrin DSTN 0.0015
6680 Cofilin-1 CFL1 0.0015
6670 Ig kappa chain V-I region Bi Not Available 0.0015
6671 Ig heavy chain V-III region VH26 Not Available 0.0015
4905 Cytochrome c2 Not Available 0.0015
4939 Cytochrome c2 cycA 0.0015
4964 Cytochrome c2 cycA 0.0015
4979 Cytochrome c2 cycA 0.0015
6673 Cytochrome c2 cycA 0.0015
6688 TraF protein traF 0.0015
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0015
6404 Rhomboid protease glpG glpG 0.0015
6797 Rhomboid protease glpG glpG 0.0015
3710 Acyl-CoA thioesterase 2 tesB 0.0015
6685 Outer membrane protein II porB 0.0015
6690 BenF-like porin PFL_1329 0.0015
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0015
6687 TraO protein traO 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0015
6679 Colicin-Ia cia 0.0015
6676 Fe(3+)-pyochelin receptor fptA 0.0015
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0015
327 Glutathione reductase gor 0.0015
5110 Glutathione reductase GR2 0.0015
756 Sex hormone-binding globulin SHBG 0.0015
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0015
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0015
126 D-lactate dehydrogenase dld 0.0014
3545 D-lactate dehydrogenase Not Available 0.0014
4510 D-lactate dehydrogenase ldhA 0.0014
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0014
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0014
2893 Glycine oxidase thiO 0.0014
605 Fumarate reductase flavoprotein subunit frdA 0.0014
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0014
3673 Fumarate reductase flavoprotein subunit fccA 0.0014
4912 Fumarate reductase flavoprotein subunit ifcA 0.0014
6549 Fumarate reductase flavoprotein subunit frdA 0.0014
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0013
2567 Thymidylate synthase thyX thyX 0.0013
2823 Trypanothione reductase TPR 0.0013
2769 P-hydroxybenzoate hydroxylase pobA 0.0013
2809 P-hydroxybenzoate hydroxylase pobA 0.0013
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0013
4760 Mll3241 protein mll3241 0.0013
3395 Iron(III) dicitrate transport protein fecA fecA 0.0013
6385 H subunit of photosynthetic reaction center complex puhA 0.0013
6474 Outer membrane protein W ompW 0.0013
6678 Colicin I receptor cirA 0.0013
3578 Protein crcA crcA 0.0013
6675 Colicin-E3 ceaC 0.0013
2925 Long-chain fatty acid transport protein fadL 0.0013
6480 Outer membrane usher protein papC papC 0.0013
6438 Outer membrane protein G ompG 0.0013
2447 Ammonia channel amtB 0.0013
2380 Monomeric sarcosine oxidase soxA 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6645 D-amino-acid oxidase DAO 0.0012
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0012
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0012
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0012
6524 Protein tonB tonB 0.0012
2679 Vitamin B12 transporter btuB btuB 0.0012
6143 Solute carrier family 22 member 7 SLC22A7 0.0011
528 5-hydroxytryptamine 1E receptor HTR1E 0.0011
776 Bile salt export pump ABCB11 0.0011
6677 Myelin P2 protein PMP2 0.0011
1256 5-hydroxytryptamine 6 receptor HTR6 0.0011
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0011
714 Glutathione reductase, mitochondrial GSR 0.001
716 5-hydroxytryptamine 7 receptor HTR7 0.001
6352 Reaction center protein H chain puhA 0.001
6456 Reaction center protein H chain puhA 0.001
6682 Reaction center protein H chain puhA 0.001
6353 Reaction center protein L chain pufL 0.001
6454 Reaction center protein L chain pufL 0.001
6683 Reaction center protein L chain pufL 0.001
6354 Reaction center protein M chain pufM 0.001
6455 Reaction center protein M chain pufM 0.001
6684 Reaction center protein M chain pufM 0.001
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.001
2828 Squalene--hopene cyclase shc 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
2207 Rhodopsin RHO 0.0009
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0008
↑