DT-Web

DB04554 - 8-Bromoadenosine-5'-Diphosphate


Identification
Name 8-Bromoadenosine-5'-Diphosphate
Accession Number DB04554 (EXPT00401)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 506.097
Groups experimental
Monoisotopic Weight 504.939927364
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


S-adenosylmethionine synthetase
Name S-adenosylmethionine synthetase
Gene Name metK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8347

Predictions


Id Partner name Gene Name Score
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0261
2757 Inorganic pyrophosphatase ppa 0.0261
6238 Inorganic pyrophosphatase ppa 0.0261
6968 Inorganic pyrophosphatase PPA1 0.0261
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0228
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.0227
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0227
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0227
2647 RNA-directed RNA polymerase P2 0.0227
2149 Angiogenin ANG 0.021
3010 Regulatory protein blaR1 blaR1 0.021
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0198
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0198
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0198
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0198
4600 Malonamidase E2 Not Available 0.0198
6395 Myosin-14 MYH14 0.0197
2717 Folylpolyglutamate synthase fgs 0.0189
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0177
5294 Nucleoside diphosphate kinase A NME1 0.0167
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0148
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0128
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0128
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0128
5302 TrwB trwB 0.0128
5646 Galactokinase GALK1 0.0128
5265 FtsH ftsH 0.0127
5312 Kinesin-like protein KIF1A KIF1A 0.0117
2892 Acetylglutamate kinase argB 0.0111
3550 Acetylglutamate kinase argB 0.0111
2371 Pantothenate kinase coaA 0.0111
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0111
825 Arsenical pump-driving ATPase ASNA1 0.0111
3435 Arsenical pump-driving ATPase arsA 0.0111
1881 Hexokinase-1 HK1 0.0111
2615 Chemotaxis protein cheA cheA 0.0111
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0103
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0102
5641 Rod shape-determining protein MreB TM_0588 0.0102
5643 General secretion pathway protein E epsE 0.0102
5649 Potassium-transporting ATPase B chain kdpB 0.0102
3794 Osmolarity sensor protein envZ envZ 0.0102
5644 Sensor protein phoQ phoQ 0.0102
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0102
5645 DNA topoisomerase 4 subunit B parE 0.0102
6227 DNA topoisomerase 4 subunit B parE 0.0102
5642 Chaperone clpB clpB 0.0102
2251 Thymidylate kinase tmk 0.0092
2254 Thymidylate kinase DTYMK 0.0092
3522 Thymidylate kinase tmk 0.0092
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0089
2397 Dihydroxyacetone kinase dhaK 0.0089
4751 Mitogen-activated protein kinase 12 MAPK12 0.0089
740 Argininosuccinate synthase ASS1 0.0089
865 Argininosuccinate synthase ASS1 0.0089
2680 Argininosuccinate synthase argG 0.0089
3194 Argininosuccinate synthase argG 0.0089
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0089
2852 DNA mismatch repair protein mutL mutL 0.0089
3822 Actin, alpha skeletal muscle ACTA1 0.0086
207 Glutathione synthetase GSS 0.0086
5269 Glutathione synthetase gshB 0.0086
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0085
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0082
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0082
3231 Death-associated protein kinase 1 DAPK1 0.0082
1721 Glycogen synthase kinase-3 beta GSK3B 0.0079
887 DNA gyrase subunit B gyrB 0.0073
4150 DNA gyrase subunit B gyrB 0.0073
6225 DNA gyrase subunit B gyrB 0.0073
936 Ephrin type-A receptor 2 EPHA2 0.0073
958 Insulin-like growth factor 1 receptor IGF1R 0.0066
4192 DNA topoisomerase 2-beta TOP2B 0.006
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.006
1836 Mitogen-activated protein kinase 10 MAPK10 0.0058
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0055
2236 Casein kinase II subunit alpha CSNK2A1 0.0054
5287 Signaling protein Not Available 0.0044
3199 Phosphopantetheine adenylyltransferase coaD 0.0044
3543 Phosphopantetheine adenylyltransferase coaD 0.0044
3567 Phosphopantetheine adenylyltransferase coaD 0.0044
5289 Phosphopantetheine adenylyltransferase coaD 0.0044
5293 Shikimate kinase 2 aroL 0.0044
5288 Shikimate kinase aroK 0.0044
5304 UPF0166 protein TM_0021 TM_0021 0.0044
5266 Activator of hgdC 0.0044
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0044
5259 Transcriptional regulator ntrC1 0.0044
6699 Transcriptional regulator Cgl2612 0.0044
2874 Nitrogenase iron protein 1 nifH1 0.0044
5283 D-alanine--D-alanine ligase B ddlB 0.0044
5292 Putative partitioning protein TT_C1605 0.0044
5281 Plasmid segregation protein parM parM 0.0044
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0044
5299 D-alanine--D-alanine ligase ddl 0.0044
6598 D-alanine--D-alanine ligase ddl 0.0044
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0044
5276 Chromosomal replication initiator protein dnaA dnaA 0.0044
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0044
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0044
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0044
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0044
5291 Glycogen synthase 1 glgA1 0.0044
4346 Polynucleotide kinase pseT 0.0044
5264 DNA replication protein REP 0.0044
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0044
5308 Preprotein translocase secA 1 subunit secA1 0.0044
5285 Kinesin heavy chain KIF5B 0.0044
5315 Chaperone protein htpG htpG 0.0044
5284 Large T antigen Not Available 0.0044
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0044
5277 Preprotein translocase subunit secA secA 0.0044
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0044
5261 Phosphoribosylformylglycinamidine synthase purL 0.0044
4106 Guanylate kinase GUK1 0.0039
4516 Guanylate kinase gmk 0.0039
2270 Dephospho-CoA kinase coaE 0.0039
2284 Adenylate kinase adk 0.0039
2296 Adenylate kinase adk 0.0039
2311 Adenylate kinase adk 0.0039
2312 Adenylate kinase Not Available 0.0039
3470 Hypothetical protein MG245 homolog MPN_348 0.0039
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0039
4837 Cag-alfa cag-alfa 0.0039
4774 NTPase P4 Not Available 0.0039
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0039
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0039
6277 Heat shock cognate 71 kDa protein HSPA8 0.0039
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
3175 Glutamate--cysteine ligase gshA 0.0039
4838 PMS1 protein homolog 2 PMS2 0.0039
413 Amidophosphoribosyltransferase PPAT 0.0039
2515 Amidophosphoribosyltransferase purF 0.0039
3714 Amidophosphoribosyltransferase purF 0.0039
4839 DNA polymerase III subunit tau dnaX 0.0039
5189 Trimethylamine dehydrogenase tmd 0.0039
2390 Nonsecretory ribonuclease RNASE2 0.0036
2683 Mono-ADP-ribosyltransferase C3 C3 0.0036
2922 Glycerol kinase glpK 0.0036
5271 Focal adhesion kinase 1 PTK2 0.0036
340 Apoptotic protease-activating factor 1 APAF1 0.0035
2282 Protein recA recA 0.0034
2315 Protein recA recA 0.0034
2332 Protein recA recA 0.0034
5263 Protein recA recA 0.0034
3669 Ribokinase rbsK 0.0034
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0034
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0034
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0033
408 Riboflavin kinase RFK 0.0032
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0032
2334 Dethiobiotin synthetase bioD 0.0031
6555 Dethiobiotin synthetase bioD 0.0031
2697 Uridine-cytidine kinase 2 UCK2 0.0031
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0031
788 Creatine kinase M-type CKM 0.0031
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.003
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.003
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.003
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0029
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0029
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0029
2091 Endoplasmin HSP90B1 0.0028
48 Pyridoxal kinase PDXK 0.0028
702 UMP-CMP kinase CMPK1 0.0028
1422 Serine/threonine-protein kinase 6 AURKA 0.0027
3379 Kinesin-like protein KIF11 KIF11 0.0027
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0027
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0027
509 Thymidine kinase TK 0.0024
570 Thymidine kinase TK 0.0024
2559 Thymidine kinase TK 0.0024
3430 Thymidine kinase tdk 0.0024
3518 Thymidine kinase TK 0.0024
5301 Thymidine kinase tdk 0.0024
5771 Thymidine kinase ORF36 0.0024
7009 Thymidine kinase ORF36 0.0024
504 Mast/stem cell growth factor receptor KIT 0.0024
5682 Ribonuclease pancreatic RNASE1 0.0022
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0022
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0022
4773 Deoxycytidine kinase DCK 0.0021
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.002
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