DT-Web

DB04551 - Fructose-1,6-Diphosphate


Identification
Name Fructose-1,6-Diphosphate
Accession Number DB04551 (EXPT01395)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 340.1157
Groups experimental
Monoisotopic Weight 339.996048936
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glycerol kinase
Name Glycerol kinase
Gene Name glpK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7842
Pyruvate kinase isozymes R/L
Name Pyruvate kinase isozymes R/L
Gene Name PKLR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5023

Transporters


Solute carrier organic anion transporter family member 2A1
Name Solute carrier organic anion transporter family member 2A1
Gene Name SLCO2A1
Actions inhibitor
References
  • Chan BS, Endo S, Kanai N, Schuster VL: Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT. Am J Physiol Renal Physiol. 2002 Jun;282(6):F1097-102. - Pubmed
DTHybrid score 0.4722

Predictions


Id Partner name Gene Name Score
2434 NH(3)-dependent NAD(+) synthetase nadE 0.268
2910 NH(3)-dependent NAD(+) synthetase nadE 0.268
3217 NH(3)-dependent NAD(+) synthetase nadE 0.268
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0759
3676 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive aroG 0.0712
2904 Phosphatase yniC yniC 0.0571
3192 Glucosamine-6-phosphate deaminase 1 nagB 0.0494
3309 6-phosphofructokinase pfkA 0.049
3467 Methylglyoxal synthase mgsA 0.0463
500 Monocarboxylate transporter 4 SLC16A3 0.0428
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0425
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
489 Monocarboxylate transporter 2 SLC16A7 0.0425
429 Monocarboxylate transporter 6 SLC16A5 0.042
218 Monocarboxylate transporter 5 SLC16A4 0.042
195 Monocarboxylate transporter 7 SLC16A6 0.042
397 Monocarboxylate transporter 3 SLC16A8 0.042
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0403
2314 Triosephosphate isomerase TPI 0.0401
3417 Triosephosphate isomerase tpiA 0.0401
3443 Triosephosphate isomerase tpiA 0.0401
6346 Triosephosphate isomerase TPI1 0.0401
2206 Glucose-6-phosphate isomerase GPI 0.0381
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0376
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0375
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0373
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0342
771 Pyruvate carboxylase, mitochondrial PC 0.0342
738 Monocarboxylate transporter 1 SLC16A1 0.0331
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0307
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0295
6151 Monocarboxylate transporter 10 SLC16A10 0.0293
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0288
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.026
199 Monocarboxylate transporter 8 SLC16A2 0.0259
527 Prostacyclin receptor PTGIR 0.0233
2853 14 kDa fatty acid-binding protein Not Available 0.0219
5650 NimA-related protein DR_0842 0.0218
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0218
3134 Phospho-2-dehydro-3-deoxyheptonate aldolase aroF 0.0215
4384 Capsule biosynthesis protein synC 0.0199
1116 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] PCK1 0.0188
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0175
1024 Solute carrier family 22 member 11 SLC22A11 0.0173
2310 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.0163
2542 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.0163
6085 Fatty acid-binding protein, intestinal FABP2 0.0156
6142 Solute carrier family 22 member 8 SLC22A8 0.0152
2183 Fatty acid-binding protein, adipocyte FABP4 0.015
6136 Multidrug resistance-associated protein 5 ABCC5 0.0147
1729 Solute carrier family 22 member 6 SLC22A6 0.0137
587 Serum albumin ALB 0.0132
2164 Multidrug resistance-associated protein 4 ABCC4 0.0123
672 Prostaglandin F2-alpha receptor PTGFR 0.0123
1792 Tissue-type plasminogen activator PLAT 0.0116
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0104
6143 Solute carrier family 22 member 7 SLC22A7 0.0103
6144 Solute carrier family 22 member 2 SLC22A2 0.0093
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0092
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.009
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0087
558 Solute carrier family 12 member 1 SLC12A1 0.0084
20 Prostaglandin G/H synthase 1 PTGS1 0.0083
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.008
4757 Cytochrome P450 2C9 CYP2C9 0.008
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0079
5304 UPF0166 protein TM_0021 TM_0021 0.0067
5287 Signaling protein Not Available 0.0067
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0067
5283 D-alanine--D-alanine ligase B ddlB 0.0067
5292 Putative partitioning protein TT_C1605 0.0067
3199 Phosphopantetheine adenylyltransferase coaD 0.0067
3543 Phosphopantetheine adenylyltransferase coaD 0.0067
3567 Phosphopantetheine adenylyltransferase coaD 0.0067
5289 Phosphopantetheine adenylyltransferase coaD 0.0067
5266 Activator of hgdC 0.0067
5288 Shikimate kinase aroK 0.0067
2874 Nitrogenase iron protein 1 nifH1 0.0067
4346 Polynucleotide kinase pseT 0.0067
5291 Glycogen synthase 1 glgA1 0.0067
5293 Shikimate kinase 2 aroL 0.0067
5281 Plasmid segregation protein parM parM 0.0067
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0067
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0067
5299 D-alanine--D-alanine ligase ddl 0.0067
6598 D-alanine--D-alanine ligase ddl 0.0067
5276 Chromosomal replication initiator protein dnaA dnaA 0.0067
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0067
5259 Transcriptional regulator ntrC1 0.0067
6699 Transcriptional regulator Cgl2612 0.0067
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0067
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0067
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0067
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0067
5264 DNA replication protein REP 0.0067
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0067
5308 Preprotein translocase secA 1 subunit secA1 0.0067
5315 Chaperone protein htpG htpG 0.0067
5277 Preprotein translocase subunit secA secA 0.0067
5284 Large T antigen Not Available 0.0067
5285 Kinesin heavy chain KIF5B 0.0067
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0067
5261 Phosphoribosylformylglycinamidine synthase purL 0.0067
357 Carbonic anhydrase 2 CA2 0.0067
118 Organic cation/carnitine transporter 2 SLC22A5 0.0063
2270 Dephospho-CoA kinase coaE 0.0058
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0058
2284 Adenylate kinase adk 0.0058
2296 Adenylate kinase adk 0.0058
2311 Adenylate kinase adk 0.0058
2312 Adenylate kinase Not Available 0.0058
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0058
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0058
3470 Hypothetical protein MG245 homolog MPN_348 0.0058
413 Amidophosphoribosyltransferase PPAT 0.0058
2515 Amidophosphoribosyltransferase purF 0.0058
3714 Amidophosphoribosyltransferase purF 0.0058
5302 TrwB trwB 0.0058
4837 Cag-alfa cag-alfa 0.0058
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0058
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0058
4106 Guanylate kinase GUK1 0.0058
4516 Guanylate kinase gmk 0.0058
5646 Galactokinase GALK1 0.0058
3426 Glutamine synthetase glnA 0.0058
3987 Glutamine synthetase GLUL 0.0058
3175 Glutamate--cysteine ligase gshA 0.0058
4774 NTPase P4 Not Available 0.0058
5265 FtsH ftsH 0.0058
4839 DNA polymerase III subunit tau dnaX 0.0058
6277 Heat shock cognate 71 kDa protein HSPA8 0.0058
4838 PMS1 protein homolog 2 PMS2 0.0058
5189 Trimethylamine dehydrogenase tmd 0.0058
340 Apoptotic protease-activating factor 1 APAF1 0.0054
2390 Nonsecretory ribonuclease RNASE2 0.0054
2683 Mono-ADP-ribosyltransferase C3 C3 0.0054
5271 Focal adhesion kinase 1 PTK2 0.0054
5312 Kinesin-like protein KIF1A KIF1A 0.0054
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0053
2282 Protein recA recA 0.0051
2315 Protein recA recA 0.0051
2332 Protein recA recA 0.0051
5263 Protein recA recA 0.0051
2892 Acetylglutamate kinase argB 0.0051
3550 Acetylglutamate kinase argB 0.0051
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0051
3669 Ribokinase rbsK 0.0051
2371 Pantothenate kinase coaA 0.0051
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0051
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0051
825 Arsenical pump-driving ATPase ASNA1 0.0051
3435 Arsenical pump-driving ATPase arsA 0.0051
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0051
2615 Chemotaxis protein cheA cheA 0.0051
1881 Hexokinase-1 HK1 0.0051
5300 Antigen peptide transporter 1 TAP1 0.005
408 Riboflavin kinase RFK 0.005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0049
2727 S-adenosylmethionine synthetase metK 0.0048
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0048
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0048
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0047
788 Creatine kinase M-type CKM 0.0047
6167 Organic solute transporter subunit beta OSTB 0.0047
2334 Dethiobiotin synthetase bioD 0.0047
6555 Dethiobiotin synthetase bioD 0.0047
2697 Uridine-cytidine kinase 2 UCK2 0.0047
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0047
6166 Organic solute transporter subunit alpha OSTA 0.0047
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0045
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0045
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0045
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0044
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0044
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0043
6395 Myosin-14 MYH14 0.0043
48 Pyridoxal kinase PDXK 0.0043
702 UMP-CMP kinase CMPK1 0.0043
2091 Endoplasmin HSP90B1 0.0043
2251 Thymidylate kinase tmk 0.0042
2254 Thymidylate kinase DTYMK 0.0042
3522 Thymidylate kinase tmk 0.0042
1422 Serine/threonine-protein kinase 6 AURKA 0.0041
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0041
3379 Kinesin-like protein KIF11 KIF11 0.0041
207 Glutathione synthetase GSS 0.004
5269 Glutathione synthetase gshB 0.004
3456 Heat shock protein HSP 90-beta HSP90AB1 0.004
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.004
3822 Actin, alpha skeletal muscle ACTA1 0.0039
504 Mast/stem cell growth factor receptor KIT 0.0038
509 Thymidine kinase TK 0.0037
570 Thymidine kinase TK 0.0037
2559 Thymidine kinase TK 0.0037
3430 Thymidine kinase tdk 0.0037
3518 Thymidine kinase TK 0.0037
5301 Thymidine kinase tdk 0.0037
5771 Thymidine kinase ORF36 0.0037
7009 Thymidine kinase ORF36 0.0037
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0037
5294 Nucleoside diphosphate kinase A NME1 0.0037
1721 Glycogen synthase kinase-3 beta GSK3B 0.0036
4200 Cytochrome P450 1A2 CYP1A2 0.0035
5682 Ribonuclease pancreatic RNASE1 0.0034
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0034
4773 Deoxycytidine kinase DCK 0.0033
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0033
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0033
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0033
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0031
468 Cytochrome P450 4A11 CYP4A11 0.0028
3811 Cytochrome P450 19A1 CYP19A1 0.0028
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0027
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0026
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0026
921 Glutamate receptor 2 GRIA2 0.0025
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0025
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0025
6145 Solute carrier family 22 member 1 SLC22A1 0.0025
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0024
6106 Cytochrome P450 2C18 CYP2C18 0.0024
776 Bile salt export pump ABCB11 0.0023
1898 Cytochrome P450 1B1 CYP1B1 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0022
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0022
862 Multidrug resistance-associated protein 1 ABCC1 0.0021
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0021
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0021
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0021
5718 Cytochrome P450 2A6 CYP2A6 0.002
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.002
6024 Cytochrome P450 1A1 CYP1A1 0.0019
6030 Cytochrome P450 2B6 CYP2B6 0.0018
6013 Cytochrome P450 2E1 CYP2E1 0.0018
6107 Cytochrome P450 3A7 CYP3A7 0.0017
4118 Cytochrome P450 3A5 CYP3A5 0.0017
4924 Cytochrome P450 2C8 CYP2C8 0.0016
6016 Cytochrome P450 2C19 CYP2C19 0.0016
1588 Multidrug resistance protein 1 ABCB1 0.0015
4512 Cytochrome P450 3A4 CYP3A4 0.0013
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