DT-Web

DB02530 - Gamma(Amino)-Butyric Acid


Identification
Name Gamma(Amino)-Butyric Acid
Accession Number DB02530 (EXPT00402)
Type small molecule
Description The most common inhibitory neurotransmitter in the central nervous system. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 103.1198
Groups experimental
Monoisotopic Weight 103.063328537
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glycine amidinotransferase, mitochondrial
Name Glycine amidinotransferase, mitochondrial
Gene Name GATM
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7248

Predictions


Id Partner name Gene Name Score
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.152
56 Delta-aminolevulinic acid dehydratase ALAD 0.1186
2356 Delta-aminolevulinic acid dehydratase hemB 0.1186
3613 Delta-aminolevulinic acid dehydratase hemB 0.1186
3674 Delta-aminolevulinic acid dehydratase hemB 0.1186
4551 Lantibiotic mersacidin mrsA 0.0738
1278 Pro-epidermal growth factor EGF 0.0682
864 Gag-Pol polyprotein gag-pol 0.059
2237 Gag-Pol polyprotein gag-pol 0.059
2326 Gag-Pol polyprotein gag-pol 0.059
2451 Gag-Pol polyprotein gag-pol 0.059
2901 Gag-Pol polyprotein gag-pol 0.059
3165 Gag-Pol polyprotein gag-pol 0.059
3722 Gag-Pol polyprotein gag-pol 0.059
6306 Gag-Pol polyprotein gag-pol 0.059
6624 Gag-Pol polyprotein gag-pol 0.059
3981 Ornithine decarboxylase antizyme 3 OAZ3 0.0254
410 Ornithine decarboxylase antizyme OAZ1 0.0254
224 Mitochondrial ornithine transporter 1 SLC25A15 0.0254
285 Mitochondrial ornithine transporter 2 SLC25A2 0.0254
3980 Ornithine decarboxylase antizyme 2 OAZ2 0.0254
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0211
834 Arginase-2, mitochondrial ARG2 0.0201
150 Cationic amino acid transporter 3 SLC7A3 0.0193
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0193
58 Cationic amino acid transporter 4 SLC7A4 0.0193
472 Ornithine aminotransferase, mitochondrial OAT 0.018
315 Arginase-1 ARG1 0.0159
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0096
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0096
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0096
4061 Peroxisomal sarcosine oxidase PIPOX 0.0096
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0096
1466 Glycyl-tRNA synthetase GARS 0.0096
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0096
4057 Glycine N-acyltransferase GLYAT 0.0096
4056 N-arachidonyl glycine receptor GPR18 0.0096
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0096
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0096
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0081
411 Glycine N-methyltransferase GNMT 0.0072
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0072
62 Glycine receptor subunit beta GLRB 0.0071
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0071
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0071
207 Glutathione synthetase GSS 0.0069
5269 Glutathione synthetase gshB 0.0069
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0065
349 Serine--pyruvate aminotransferase AGXT 0.0065
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0065
3884 SHMT2 protein SHMT2 0.0064
3901 SHMT2 protein SHMT2 0.0064
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0064
3879 Serine hydroxymethyltransferase 2 Not Available 0.0064
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0064
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0062
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0061
820 Glycine receptor subunit alpha-2 GLRA2 0.0057
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0057
461 Glycine receptor subunit alpha-3 GLRA3 0.0057
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0052
482 Glycine receptor subunit alpha-1 GLRA1 0.0049
6151 Monocarboxylate transporter 10 SLC16A10 0.0047
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