DT-Web

DB01410 - Ciclesonide


Identification
Name Ciclesonide
Accession Number DB01410
Type small molecule
Description Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 540.6876
Groups approved
Monoisotopic Weight 540.308703762
Pharmacology
Indication For the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older.
Mechanism of action Glucocorticoids such as ciclesonide can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Ciclesonide reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Ciclesonide is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.
Absorption Ciclesonide and des-ciclesonide have negligible oral bioavailability (both less than 1%) due to low gastrointestinal absorption and high first-pass metabolism. The intranasal administration of ciclesonide at recommended doses results in negligible serum concentrations of ciclesonide.
Protein binding The percentage of ciclesonide and des-ciclesonide bound to human plasma proteins averaged ≥ 99% each, with ≤ 1% of unbound drug detected in the systemic circulation.
Biotransformation Des-ciclesonide undergoes metabolism in the liver to additional metabolites mainly by the cytochrome P450 (CYP) 3A4 isozyme and to a lesser extent by CYP 2D6.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Itraconazole Increased effects/toxicity of ciclesonide
Ketoconazole Increased effects/toxicity of ciclesonide
Nelfinavir Increased effects/toxicity of ciclesonide
Ritonavir Increased effects/toxicity of ciclesonide
Telithromycin Telithromycin may reduce clearance of Ciclesonide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ciclesonide if Telithromycin is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of ciclesonide by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of ciclesonide if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Glucocorticoid receptor
Name Glucocorticoid receptor
Gene Name NR3C1
Pharmacological action yes
Actions agonist
References
  • Barnes NC: The properties of inhaled corticosteroids: similarities and differences. Prim Care Respir J. 2007 Jun;16(3):149-54. - Pubmed
DTHybrid score 1.1933

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4743
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions Not Available
References
  • -
  • Peet CF, Enos T, Nave R, Zech K, Hall M: Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomes. Eur J Drug Metab Pharmacokinet. 2005 Oct-Dec;30(4):275-86. - Pubmed
DTHybrid score 0.2916
Liver carboxylesterase 1
Name Liver carboxylesterase 1
Gene Name CES1
Actions substrate
References
  • Mutch E, Nave R, McCracken N, Zech K, Williams FM: The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. Biochem Pharmacol. 2007 May 15;73(10):1657-64. Epub 2007 Jan 28. - Pubmed
DTHybrid score 0.5383

Carriers


Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.1476
4118 Cytochrome P450 3A5 CYP3A5 0.1178
4757 Cytochrome P450 2C9 CYP2C9 0.1025
6016 Cytochrome P450 2C19 CYP2C19 0.0943
4200 Cytochrome P450 1A2 CYP1A2 0.094
4924 Cytochrome P450 2C8 CYP2C8 0.0838
6107 Cytochrome P450 3A7 CYP3A7 0.0728
6030 Cytochrome P450 2B6 CYP2B6 0.062
6013 Cytochrome P450 2E1 CYP2E1 0.0559
723 Cytosolic phospholipase A2 PLA2G4A 0.0545
5718 Cytochrome P450 2A6 CYP2A6 0.0438
6024 Cytochrome P450 1A1 CYP1A1 0.0436
469 Annexin A1 ANXA1 0.0395
587 Serum albumin ALB 0.0387
492 Histamine H1 receptor HRH1 0.0384
614 Progesterone receptor PGR 0.0383
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0365
6606 Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B3 0.0348
4175 Platelet-activating factor acetylhydrolase PLA2G7 0.0348
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0343
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0335
756 Sex hormone-binding globulin SHBG 0.0331
737 Mineralocorticoid receptor NR3C2 0.0328
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0321
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0321
824 Sodium-dependent serotonin transporter SLC6A4 0.0317
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0301
540 Sodium-dependent noradrenaline transporter SLC6A2 0.03
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0289
831 D(2) dopamine receptor DRD2 0.0264
3923 Cholinesterase BCHE 0.0264
556 Alpha-1A adrenergic receptor ADRA1A 0.0261
269 Adrenodoxin, mitochondrial FDX1 0.0258
502 5-hydroxytryptamine 2A receptor HTR2A 0.0256
3811 Cytochrome P450 19A1 CYP19A1 0.0255
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0248
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0243
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0236
290 Prostaglandin G/H synthase 2 PTGS2 0.0232
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0232
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.023
862 Multidrug resistance-associated protein 1 ABCC1 0.0228
766 Beta-2 adrenergic receptor ADRB2 0.0227
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0227
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0213
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0209
146 Androgen receptor AR 0.0208
193 Beta-1 adrenergic receptor ADRB1 0.0202
20 Prostaglandin G/H synthase 1 PTGS1 0.02
847 Mu-type opioid receptor OPRM1 0.0197
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0195
320 5-hydroxytryptamine 1A receptor HTR1A 0.0194
713 Sodium-dependent dopamine transporter SLC6A3 0.0186
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0183
318 Alpha-2A adrenergic receptor ADRA2A 0.0182
136 Estrogen receptor ESR1 0.0176
6145 Solute carrier family 22 member 1 SLC22A1 0.017
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0168
6142 Solute carrier family 22 member 8 SLC22A8 0.0167
118 Organic cation/carnitine transporter 2 SLC22A5 0.0167
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0166
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0162
590 5-hydroxytryptamine 2C receptor HTR2C 0.0161
23 D(1A) dopamine receptor DRD1 0.0158
467 Delta-type opioid receptor OPRD1 0.0157
632 Alpha-1B adrenergic receptor ADRA1B 0.0151
2178 Metabotropic glutamate receptor 5 GRM5 0.0147
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0142
381 Prolactin receptor PRLR 0.0142
1898 Cytochrome P450 1B1 CYP1B1 0.014
2164 Multidrug resistance-associated protein 4 ABCC4 0.0139
731 HIV-1 protease HIV-1 protease 0.0139
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0139
696 Kappa-type opioid receptor OPRK1 0.0139
244 Angiotensin-converting enzyme ACE 0.0138
6106 Cytochrome P450 2C18 CYP2C18 0.0138
6144 Solute carrier family 22 member 2 SLC22A2 0.0133
776 Bile salt export pump ABCB11 0.0131
1729 Solute carrier family 22 member 6 SLC22A6 0.013
341 5-hydroxytryptamine 3 receptor HTR3A 0.0128
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0125
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0123
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0121
1141 Sialidase-1 NEU1 0.012
64 Neuraminidase NA 0.012
641 Neuraminidase NA 0.012
2676 Neuraminidase NA 0.012
3026 Neuraminidase NA 0.012
3519 Neuraminidase NA 0.012
6007 Neuraminidase NA 0.012
638 D(3) dopamine receptor DRD3 0.0119
833 Organic cation/carnitine transporter 1 SLC22A4 0.0118
3611 Cytidine deaminase cdd 0.0112
3707 Cytidine deaminase cdd 0.0112
4211 Cytidine deaminase CDA 0.0112
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0109
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0108
122 P2Y purinoceptor 12 P2RY12 0.0107
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0105
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0105
629 Alpha-2B adrenergic receptor ADRA2B 0.0104
5482 Sialidase-2 NEU2 0.0102
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0102
3639 Thymidine phosphorylase deoA 0.0101
3936 Thymidine phosphorylase TYMP 0.0101
885 5-hydroxytryptamine 1B receptor HTR1B 0.01
378 Alpha-2C adrenergic receptor ADRA2C 0.0095
6147 Solute carrier family 22 member 3 SLC22A3 0.0094
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0093
4615 Chain A, Red Copper Protein Nitrosocyanin NE0143 0.0093
24 Thymidylate synthase TMP1 0.0093
359 Thymidylate synthase TYMS 0.0093
2626 Thymidylate synthase thyA 0.0093
2729 Thymidylate synthase thyA 0.0093
5352 Thymidylate synthase THYA 0.0093
432 D(4) dopamine receptor DRD4 0.0092
789 Alpha-1D adrenergic receptor ADRA1D 0.0091
6500 Phospholipase A2 PLA2G1B 0.0089
3941 Amine oxidase [flavin-containing] A MAOA 0.0087
474 Acetylcholinesterase ACHE 0.0086
465 Calmodulin CALM1 0.0085
6031 Cytochrome P450 3A43 CYP3A43 0.0085
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0084
725 5-hydroxytryptamine 1D receptor HTR1D 0.0082
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0082
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0082
436 5-hydroxytryptamine 2B receptor HTR2B 0.0081
54 Prothrombin F2 0.0081
260 Cytochrome P450 51 ERG11 0.0079
761 Cytochrome P450 51 ERG11 0.0079
3163 Cytochrome P450 51 cyp51 0.0079
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0079
6143 Solute carrier family 22 member 7 SLC22A7 0.0076
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0075
3947 Xanthine dehydrogenase/oxidase XDH 0.0074
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0072
5414 Fiber protein L5 0.0071
5418 Fiber protein L5 0.0071
1756 E-selectin SELE 0.0071
817 DNA topoisomerase 2-alpha TOP2A 0.007
6182 Cytochrome P450 2J2 CYP2J2 0.0069
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0069
1758 GTPase HRas HRAS 0.0068
952 Dipeptidyl peptidase 4 DPP4 0.0068
163 D(1B) dopamine receptor DRD5 0.0068
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0067
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0066
380 Cytochrome P450 17A1 CYP17A1 0.0065
3939 Amine oxidase [flavin-containing] B MAOB 0.0064
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0064
468 Cytochrome P450 4A11 CYP4A11 0.0062
3629 Endo-N-acetylneuraminidase Not Available 0.0062
5416 Coat protein VP1 Not Available 0.0061
1130 Lithostathine 1 alpha REG1A 0.0061
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.006
238 Peroxisome proliferator-activated receptor gamma PPARG 0.006
131 Synaptic vesicular amine transporter SLC18A2 0.0059
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0059
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0059
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0059
716 5-hydroxytryptamine 7 receptor HTR7 0.0059
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0058
161 Tubulin beta chain TUBB 0.0058
312 Tubulin beta chain TUB2 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
2300 Lysozyme E 0.0058
3633 Lysozyme R 0.0058
5597 Lysozyme 17 0.0058
6168 Solute carrier family 22 member 16 SLC22A16 0.0057
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0057
6043 Putative G-protein coupled receptor 44 GPR44 0.0057
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0057
2324 Botulinum neurotoxin type B botB 0.0057
3547 Enterotoxin type B entB 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
2058 P-selectin SELP 0.0056
551 Carnitine O-acetyltransferase CRAT 0.0056
6506 Stathmin-4 STMN4 0.0055
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0054
6141 Sodium/bile acid cotransporter SLC10A1 0.0054
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0054
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0054
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0054
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0053
1353 DNA topoisomerase 1 TOP1 0.0053
3552 DNA topoisomerase 1 topA 0.0053
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0052
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0051
2112 Toll-like receptor 9 TLR9 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0049
2570 Tetanus toxin tetX 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6137 Multidrug resistance-associated protein 6 ABCC6 0.0048
124 Histamine H2 receptor HRH2 0.0047
1757 Myeloperoxidase MPO 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
869 Estrogen receptor beta ESR2 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
1024 Solute carrier family 22 member 11 SLC22A11 0.0045
504 Mast/stem cell growth factor receptor KIT 0.0044
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0044
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0044
1256 5-hydroxytryptamine 6 receptor HTR6 0.0044
1192 Sulfotransferase 1A1 SULT1A1 0.0042
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0042
2723 Cholera enterotoxin subunit B ctxB 0.0042
94 5-hydroxytryptamine 4 receptor HTR4 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
844 Epidermal growth factor receptor EGFR 0.0041
1656 CYP2B protein CYP2B 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
856 Vitamin D3 receptor VDR 0.004
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.004
29 Tubulin beta-1 chain TUBB1 0.004
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.004
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0039
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0039
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0039
814 Ryanodine receptor 1 RYR1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0039
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0038
592 Carbonic anhydrase 4 CA4 0.0038
6220 Aryl hydrocarbon receptor AHR 0.0038
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0038
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0038
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0037
6148 Multidrug resistance-associated protein 7 ABCC10 0.0037
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
295 Carbonic anhydrase 1 CA1 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
407 Vascular endothelial growth factor receptor 2 KDR 0.0036
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0035
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0035
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0035
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0035
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0035
939 50S ribosomal protein L3 rplC 0.0035
811 Translocator protein TSPO 0.0035
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0034
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0034
6020 Aldehyde oxidase AOX1 0.0033
373 Transthyretin TTR 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0033
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0033
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0032
4120 NADPH--cytochrome P450 reductase POR 0.0032
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0032
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
777 Tumor necrosis factor TNF 0.0032
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0032
84 Nuclear receptor 0B1 NR0B1 0.0032
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
1050 Bile salt sulfotransferase SULT2A1 0.0031
6014 Cytochrome P450 2A13 CYP2A13 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
2391 Ferrochelatase hemH 0.0031
6502 Ferrochelatase DKFZp686P18130 0.0031
1591 Ferrochelatase, mitochondrial FECH 0.0031
365 Dihydrofolate reductase DHFR 0.0031
2381 Dihydrofolate reductase DFR1 0.0031
2833 Dihydrofolate reductase Not Available 0.0031
2931 Dihydrofolate reductase folA 0.0031
3544 Dihydrofolate reductase folA 0.0031
3682 Dihydrofolate reductase folA 0.0031
6642 Dihydrofolate reductase folA 0.0031
6756 Dihydrofolate reductase dfrA 0.0031
6042 Prostaglandin reductase 2 PTGR2 0.0031
1629 Transcription factor AP-1 JUN 0.0031
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0031
70 Type-1 angiotensin II receptor AGTR1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
705 Glutamate receptor 1 GRIA1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6102 Arylamine N-acetyltransferase 2 NAT2 0.003
4203 Histamine N-methyltransferase HNMT 0.003
1178 Adenosine A2a receptor ADORA2A 0.0029
528 5-hydroxytryptamine 1E receptor HTR1E 0.0029
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
228 Beta platelet-derived growth factor receptor PDGFRB 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0027
26 Vascular endothelial growth factor receptor 3 FLT4 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0027
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0027
6493 Cytochrome c oxidase subunit 6C COX6C 0.0027
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0027
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0027
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0027
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0027
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0027
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0027
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0027
6559 Cytochrome c oxidase subunit 2 ctaC 0.0027
6669 Cytochrome c oxidase subunit 2 ctaC 0.0027
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0027
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0027
6558 Cytochrome c oxidase subunit 1 ctaD 0.0027
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0027
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0026
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0026
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0026
1010 Cytochrome P450 51A1 CYP51A1 0.0026
3809 Estrogen-related receptor gamma ESRRG 0.0026
32 Vascular endothelial growth factor receptor 1 FLT1 0.0026
49 Endothelin B receptor EDNRB 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
3587 Gastrotropin FABP6 0.0025
2540 Choloylglycine hydrolase cbh 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
2981 Phospholipase A2, membrane associated PLA2G2A 0.0025
1313 Lactoylglutathione lyase GLO1 0.0025
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0024
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0024
174 Sigma 1-type opioid receptor SIGMAR1 0.0024
6501 Fatty acid-binding protein, liver FABP1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0022
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
4122 Histone deacetylase 2 HDAC2 0.0022
581 Cytochrome P450 2R1 CYP2R1 0.0022
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
7 Nitric oxide synthase, inducible NOS2 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
3404 Exotoxin A eta 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
298 Renin REN 0.0021
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0021
16 Adenosine A1 receptor ADORA1 0.0021
738 Monocarboxylate transporter 1 SLC16A1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6136 Multidrug resistance-associated protein 5 ABCC5 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.002
6432 Transporter snf 0.002
6126 Carbonic anhydrase 7 CA7 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
4878 Glycoprotein hormones alpha chain CGA 0.002
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.002
1072 Granzyme B GZMB 0.002
4877 Beta-mannanase man 0.002
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.002
4850 Beta-2-glycoprotein 1 APOH 0.002
4856 CD209 antigen CD209 0.002
4889 Ig epsilon chain C region IGHE 0.002
4869 Major capsid protein A430L 0.002
4852 Reticulon-4 receptor RTN4R 0.002
4880 Membrane cofactor protein CD46 0.002
757 Fusion glycoprotein F0 F 0.002
4875 Fusion glycoprotein F0 F 0.002
4721 Beta-1,4-mannanase manA 0.002
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.002
1354 Beta-glucuronidase GUSB 0.002
442 Envelope glycoprotein gp41 0.002
4859 Envelope glycoprotein env 0.002
4189 Alpha-galactosidase A GLA 0.002
4845 ADAM 33 ADAM33 0.002
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.002
3352 Structural polyprotein Not Available 0.002
3628 Structural polyprotein Not Available 0.002
4892 Structural polyprotein Not Available 0.002
482 Glycine receptor subunit alpha-1 GLRA1 0.002
517 Alcohol dehydrogenase 1C ADH1C 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
164 Histamine H4 receptor HRH4 0.0017
6858 Inactive carboxylesterase 4 CES1P1 0.0017
793 T-cell surface antigen CD2 CD2 0.0017
4861 Interleukin-6 receptor alpha chain IL6R 0.0017
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0017
3837 Cytokine receptor common beta chain CSF2RB 0.0017
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
165 FL cytokine receptor FLT3 0.0017
4311 tRNA TRDMT1 0.0017
4325 tRNA trmD 0.0017
4328 tRNA trmD 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
904 Glutathione S-transferase P GSTP1 0.0017
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0017
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0017
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0017
518 Peroxidase/catalase T katG 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
4890 Hemagglutinin HA 0.0016
6566 Hemagglutinin Not Available 0.0016
1379 Interleukin-12 subunit beta IL12B 0.0016
1184 Interferon beta IFNB1 0.0015
3233 Bile acid receptor NR1H4 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
5787 Angiopoietin-1 receptor TEK 0.0015
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0015
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0015
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
563 Thyroid peroxidase TPO 0.0015
427 Substance-P receptor TACR1 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
275 Arachidonate 5-lipoxygenase ALOX5 0.0015
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0015
2297 Genome polyprotein Not Available 0.0015
2322 Genome polyprotein Not Available 0.0015
2694 Genome polyprotein Not Available 0.0015
2719 Genome polyprotein Not Available 0.0015
2860 Genome polyprotein Not Available 0.0015
2928 Genome polyprotein Not Available 0.0015
3160 Genome polyprotein Not Available 0.0015
3260 Genome polyprotein Not Available 0.0015
4783 Genome polyprotein Not Available 0.0015
5726 Genome polyprotein Not Available 0.0015
5779 Genome polyprotein Not Available 0.0015
5867 Genome polyprotein Not Available 0.0015
6253 Genome polyprotein Not Available 0.0015
6301 Genome polyprotein Not Available 0.0015
6380 Genome polyprotein Not Available 0.0015
6381 Genome polyprotein Not Available 0.0015
6437 Genome polyprotein Not Available 0.0015
6520 Genome polyprotein Not Available 0.0015
6521 Genome polyprotein Not Available 0.0015
6652 Genome polyprotein Not Available 0.0015
6734 Genome polyprotein Not Available 0.0015
6735 Genome polyprotein Not Available 0.0015
6736 Genome polyprotein Not Available 0.0015
6737 Genome polyprotein Not Available 0.0015
6738 Genome polyprotein Not Available 0.0015
6739 Genome polyprotein Not Available 0.0015
6744 Genome polyprotein Not Available 0.0015
6748 Genome polyprotein Not Available 0.0015
6894 Genome polyprotein Not Available 0.0015
6898 Genome polyprotein Not Available 0.0015
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0015
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0015
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0015
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
2207 Rhodopsin RHO 0.0014
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0014
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1859 Prostatic acid phosphatase ACPP 0.0014
3140 Hemagglutinin-neuraminidase HN 0.0014
3609 Hemagglutinin-neuraminidase HN 0.0014
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0014
3444 Cyanovirin-N Not Available 0.0014
554 Low-density lipoprotein receptor LDLR 0.0014
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0014
1341 Histamine H3 receptor HRH3 0.0014
852 Heparin cofactor 2 SERPIND1 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
183 Vascular endothelial growth factor A VEGFA 0.0014
4787 Envelope glycoprotein gp160 env 0.0013
4820 Envelope glycoprotein gp160 env 0.0013
5727 Envelope glycoprotein gp160 env 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0013
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0013
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
153 Dopamine beta-hydroxylase DBH 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
595 Fibrinogen alpha chain FGA 0.0013
4666 Fucose-binding lectin PA-IIL lecB 0.0013
2372 Bifunctional tail protein 9 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
3480 Mannan endo-1,4-beta-mannosidase manA 0.0012
1295 Fatty acid synthase FASN 0.0012
958 Insulin-like growth factor 1 receptor IGF1R 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
1243 Cathepsin D CTSD 0.0011
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
239 Coagulation factor X F10 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
1439 Lactotransferrin LTF 0.0011
921 Glutamate receptor 2 GRIA2 0.0011
1992 Vitamin D-binding protein GC 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
319 Opioid receptor, sigma 1 OPRS1 0.0011
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
3814 Complement C1r subcomponent C1R 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
2430 Chondroitinase B cslB 0.0011
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
4103 Proteasome subunit beta type 2 PSMB2 0.001
4102 Proteasome subunit beta type 5 PSMB5 0.001
4101 Proteasome subunit beta type 1 PSMB1 0.001
976 Platelet glycoprotein IX GP9 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
1630 Integrin beta-2 ITGB2 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
6307 Ig gamma-2 chain C region IGHG2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
2581 Chondroitinase AC cslA 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1374 Natriuretic peptides B NPPB 0.001
309 Antithrombin-III SERPINC1 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
6847 Lactase-phlorizin hydrolase LCT 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
511 5-hydroxytryptamine 1F receptor HTR1F 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
6146 High affinity copper uptake protein 1 SLC31A1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
823 Fibroblast growth factor receptor 2 FGFR2 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
4785 Ig gamma-1 chain C region IGHG1 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
6044 Serum paraoxonase/lactonase 3 PON3 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
1867 Major prion protein PRNP 0.0008
572 Integrin alpha-L ITGAL 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1864 RET proto-oncogene RET 0.0008
1025 Aquaporin-1 AQP1 0.0008
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
1275 Estrogen sulfotransferase SULT1E1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
2298 Cytochrome P450-cam camC 0.0007
751 Potassium channel subfamily K member 6 KCNK6 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
1360 Sphingomyelin phosphodiesterase SMPD1 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
172 Potassium channel subfamily K member 1 KCNK1 0.0006
273 Apoptosis regulator Bcl-2 BCL2 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
6085 Fatty acid-binding protein, intestinal FABP2 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
3957 Adenosine deaminase ADA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
908 Glutathione S-transferase theta-1 GSTT1 0.0003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0001
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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