DT-Web

DB01086 - Benzocaine


Identification
Name Benzocaine
Accession Number DB01086 (APRD00539)
Type small molecule
Description A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 165.1891
Groups approved
Monoisotopic Weight 165.078978601
Pharmacology
Indication For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex.
Mechanism of action Benzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity LD50=3040 mg/kg (rat, oral)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sodium channel protein type 10 subunit alpha
Name Sodium channel protein type 10 subunit alpha
Gene Name SCN10A
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Ahern CA, Eastwood AL, Dougherty DA, Horn R: Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res. 2008 Jan 4;102(1):86-94. Epub 2007 Oct 25. - Pubmed
  • Hanck DA, Nikitina E, McNulty MM, Fozzard HA, Lipkind GM, Sheets MF: Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity. Circ Res. 2009 Aug 28;105(5):492-9. Epub 2009 Aug 6. - Pubmed
  • Lipkind GM, Fozzard HA: Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels. Mol Pharmacol. 2005 Dec;68(6):1611-22. Epub 2005 Sep 20. - Pubmed
DTHybrid score 0.6149

Enzymes


Liver carboxylesterase 1
Name Liver carboxylesterase 1
Gene Name CES1
Actions inhibitor
References
  • Bell FP: The effect of local anesthetics on arterial lipid metabolism. Inhibition of sterol esterification in vitro. Atherosclerosis. 1981 Jan-Feb;38(1-2):81-8. - Pubmed
DTHybrid score 0.5434

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
DTHybrid score 0.2384

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1193
3923 Cholinesterase BCHE 0.0692
4200 Cytochrome P450 1A2 CYP1A2 0.0626
4119 Cytochrome P450 2D6 CYP2D6 0.0624
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0613
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0499
4118 Cytochrome P450 3A5 CYP3A5 0.0494
6030 Cytochrome P450 2B6 CYP2B6 0.0417
4757 Cytochrome P450 2C9 CYP2C9 0.0416
6016 Cytochrome P450 2C19 CYP2C19 0.0404
4924 Cytochrome P450 2C8 CYP2C8 0.0399
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0379
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0365
6606 Platelet-activating factor acetylhydrolase IB subunit gamma PAFAH1B3 0.0348
4175 Platelet-activating factor acetylhydrolase PLA2G7 0.0348
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0341
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0339
6107 Cytochrome P450 3A7 CYP3A7 0.0327
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0319
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0305
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0305
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0289
587 Serum albumin ALB 0.0275
713 Sodium-dependent dopamine transporter SLC6A3 0.0272
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.027
341 5-hydroxytryptamine 3 receptor HTR3A 0.0235
6013 Cytochrome P450 2E1 CYP2E1 0.0233
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0225
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0211
465 Calmodulin CALM1 0.0209
862 Multidrug resistance-associated protein 1 ABCC1 0.0206
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0195
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0194
244 Angiotensin-converting enzyme ACE 0.0188
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0185
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0181
871 Glucocorticoid receptor NR3C1 0.018
6024 Cytochrome P450 1A1 CYP1A1 0.0167
6142 Solute carrier family 22 member 8 SLC22A8 0.0163
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0162
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0148
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0143
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.014
5718 Cytochrome P450 2A6 CYP2A6 0.0138
2178 Metabotropic glutamate receptor 5 GRM5 0.0136
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0134
492 Histamine H1 receptor HRH1 0.0131
2164 Multidrug resistance-associated protein 4 ABCC4 0.0131
824 Sodium-dependent serotonin transporter SLC6A4 0.013
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0126
6144 Solute carrier family 22 member 2 SLC22A2 0.0122
776 Bile salt export pump ABCB11 0.0121
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0121
1141 Sialidase-1 NEU1 0.012
64 Neuraminidase NA 0.012
641 Neuraminidase NA 0.012
2676 Neuraminidase NA 0.012
3026 Neuraminidase NA 0.012
3519 Neuraminidase NA 0.012
6007 Neuraminidase NA 0.012
118 Organic cation/carnitine transporter 2 SLC22A5 0.0116
3611 Cytidine deaminase cdd 0.0115
3707 Cytidine deaminase cdd 0.0115
4211 Cytidine deaminase CDA 0.0115
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0112
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0108
556 Alpha-1A adrenergic receptor ADRA1A 0.0108
24 Thymidylate synthase TMP1 0.0107
359 Thymidylate synthase TYMS 0.0107
2626 Thymidylate synthase thyA 0.0107
2729 Thymidylate synthase thyA 0.0107
5352 Thymidylate synthase THYA 0.0107
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0106
6145 Solute carrier family 22 member 1 SLC22A1 0.0106
232 Corticosteroid-binding globulin SERPINA6 0.0106
844 Epidermal growth factor receptor EGFR 0.0103
5482 Sialidase-2 NEU2 0.0102
3639 Thymidine phosphorylase deoA 0.0101
3936 Thymidine phosphorylase TYMP 0.0101
122 P2Y purinoceptor 12 P2RY12 0.01
193 Beta-1 adrenergic receptor ADRB1 0.0093
1729 Solute carrier family 22 member 6 SLC22A6 0.0093
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0091
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.009
1353 DNA topoisomerase 1 TOP1 0.0089
3552 DNA topoisomerase 1 topA 0.0089
6106 Cytochrome P450 2C18 CYP2C18 0.0089
136 Estrogen receptor ESR1 0.0089
831 D(2) dopamine receptor DRD2 0.0087
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0086
6143 Solute carrier family 22 member 7 SLC22A7 0.0086
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0084
1192 Sulfotransferase 1A1 SULT1A1 0.0084
1898 Cytochrome P450 1B1 CYP1B1 0.0084
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0083
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0081
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.008
54 Prothrombin F2 0.0079
6141 Sodium/bile acid cotransporter SLC10A1 0.0077
3811 Cytochrome P450 19A1 CYP19A1 0.0075
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0075
20 Prostaglandin G/H synthase 1 PTGS1 0.0071
5414 Fiber protein L5 0.0071
5418 Fiber protein L5 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
1756 E-selectin SELE 0.0071
766 Beta-2 adrenergic receptor ADRB2 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0069
6147 Solute carrier family 22 member 3 SLC22A3 0.0065
502 5-hydroxytryptamine 2A receptor HTR2A 0.0065
817 DNA topoisomerase 2-alpha TOP2A 0.0065
6137 Multidrug resistance-associated protein 6 ABCC6 0.0064
833 Organic cation/carnitine transporter 1 SLC22A4 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
869 Estrogen receptor beta ESR2 0.0062
3629 Endo-N-acetylneuraminidase Not Available 0.0062
5416 Coat protein VP1 Not Available 0.0061
1130 Lithostathine 1 alpha REG1A 0.0061
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0059
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0059
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0059
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0059
632 Alpha-1B adrenergic receptor ADRA1B 0.0058
290 Prostaglandin G/H synthase 2 PTGS2 0.0057
2324 Botulinum neurotoxin type B botB 0.0057
3547 Enterotoxin type B entB 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
2058 P-selectin SELP 0.0056
551 Carnitine O-acetyltransferase CRAT 0.0056
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0056
6168 Solute carrier family 22 member 16 SLC22A16 0.0055
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0054
6182 Cytochrome P450 2J2 CYP2J2 0.0052
3947 Xanthine dehydrogenase/oxidase XDH 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0051
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0051
320 5-hydroxytryptamine 1A receptor HTR1A 0.005
789 Alpha-1D adrenergic receptor ADRA1D 0.005
731 HIV-1 protease HIV-1 protease 0.005
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0049
2570 Tetanus toxin tetX 0.0049
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0049
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0049
23 D(1A) dopamine receptor DRD1 0.0048
847 Mu-type opioid receptor OPRM1 0.0048
2616 Ganglioside GM2 activator GM2A 0.0047
1024 Solute carrier family 22 member 11 SLC22A11 0.0047
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0046
318 Alpha-2A adrenergic receptor ADRA2A 0.0045
124 Histamine H2 receptor HRH2 0.0044
952 Dipeptidyl peptidase 4 DPP4 0.0044
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0044
4120 NADPH--cytochrome P450 reductase POR 0.0043
467 Delta-type opioid receptor OPRD1 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0042
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
2723 Cholera enterotoxin subunit B ctxB 0.0042
614 Progesterone receptor PGR 0.0041
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
696 Kappa-type opioid receptor OPRK1 0.004
474 Acetylcholinesterase ACHE 0.004
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
885 5-hydroxytryptamine 1B receptor HTR1B 0.0038
725 5-hydroxytryptamine 1D receptor HTR1D 0.0038
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0038
1757 Myeloperoxidase MPO 0.0037
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0036
504 Mast/stem cell growth factor receptor KIT 0.0036
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
2391 Ferrochelatase hemH 0.0035
6502 Ferrochelatase DKFZp686P18130 0.0035
1591 Ferrochelatase, mitochondrial FECH 0.0035
6042 Prostaglandin reductase 2 PTGR2 0.0035
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0034
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0034
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0033
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0033
3941 Amine oxidase [flavin-containing] A MAOA 0.0033
3939 Amine oxidase [flavin-containing] B MAOB 0.0032
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0032
3587 Gastrotropin FABP6 0.0032
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
6500 Phospholipase A2 PLA2G1B 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0031
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0031
638 D(3) dopamine receptor DRD3 0.0031
6043 Putative G-protein coupled receptor 44 GPR44 0.0031
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.003
6493 Cytochrome c oxidase subunit 6C COX6C 0.003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.003
756 Sex hormone-binding globulin SHBG 0.003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.003
6559 Cytochrome c oxidase subunit 2 ctaC 0.003
6669 Cytochrome c oxidase subunit 2 ctaC 0.003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.003
6558 Cytochrome c oxidase subunit 1 ctaD 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
590 5-hydroxytryptamine 2C receptor HTR2C 0.003
26 Vascular endothelial growth factor receptor 3 FLT4 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
6136 Multidrug resistance-associated protein 5 ABCC5 0.0029
380 Cytochrome P450 17A1 CYP17A1 0.0029
3809 Estrogen-related receptor gamma ESRRG 0.0029
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0029
683 Potassium transporter GK0582 0.0029
70 Type-1 angiotensin II receptor AGTR1 0.0029
629 Alpha-2B adrenergic receptor ADRA2B 0.0029
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
32 Vascular endothelial growth factor receptor 1 FLT1 0.0028
2540 Choloylglycine hydrolase cbh 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
1313 Lactoylglutathione lyase GLO1 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
777 Tumor necrosis factor TNF 0.0027
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0026
6501 Fatty acid-binding protein, liver FABP1 0.0026
228 Beta platelet-derived growth factor receptor PDGFRB 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
146 Androgen receptor AR 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
373 Transthyretin TTR 0.0023
738 Monocarboxylate transporter 1 SLC16A1 0.0023
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
468 Cytochrome P450 4A11 CYP4A11 0.0021
378 Alpha-2C adrenergic receptor ADRA2C 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
4878 Glycoprotein hormones alpha chain CGA 0.002
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.002
1072 Granzyme B GZMB 0.002
4877 Beta-mannanase man 0.002
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.002
4850 Beta-2-glycoprotein 1 APOH 0.002
4856 CD209 antigen CD209 0.002
4889 Ig epsilon chain C region IGHE 0.002
4869 Major capsid protein A430L 0.002
4852 Reticulon-4 receptor RTN4R 0.002
4880 Membrane cofactor protein CD46 0.002
757 Fusion glycoprotein F0 F 0.002
4875 Fusion glycoprotein F0 F 0.002
4721 Beta-1,4-mannanase manA 0.002
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.002
1354 Beta-glucuronidase GUSB 0.002
442 Envelope glycoprotein gp41 0.002
4859 Envelope glycoprotein env 0.002
4189 Alpha-galactosidase A GLA 0.002
4845 ADAM 33 ADAM33 0.002
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.002
3352 Structural polyprotein Not Available 0.002
3628 Structural polyprotein Not Available 0.002
4892 Structural polyprotein Not Available 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
517 Alcohol dehydrogenase 1C ADH1C 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0018
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0018
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0018
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0018
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0018
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0017
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0017
6858 Inactive carboxylesterase 4 CES1P1 0.0017
793 T-cell surface antigen CD2 CD2 0.0017
4861 Interleukin-6 receptor alpha chain IL6R 0.0017
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0017
3837 Cytokine receptor common beta chain CSF2RB 0.0017
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
6824 Tyrosine-protein kinase Lyn LYN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
4890 Hemagglutinin HA 0.0016
6566 Hemagglutinin Not Available 0.0016
1379 Interleukin-12 subunit beta IL12B 0.0016
1184 Interferon beta IFNB1 0.0015
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
6755 Poliovirus receptor PVR 0.0015
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0015
702 UMP-CMP kinase CMPK1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0015
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0015
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0015
165 FL cytokine receptor FLT3 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
2207 Rhodopsin RHO 0.0014
1178 Adenosine A2a receptor ADORA2A 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1629 Transcription factor AP-1 JUN 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
1859 Prostatic acid phosphatase ACPP 0.0014
3140 Hemagglutinin-neuraminidase HN 0.0014
3609 Hemagglutinin-neuraminidase HN 0.0014
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0014
3444 Cyanovirin-N Not Available 0.0014
554 Low-density lipoprotein receptor LDLR 0.0014
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0014
852 Heparin cofactor 2 SERPIND1 0.0014
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0014
4787 Envelope glycoprotein gp160 env 0.0013
4820 Envelope glycoprotein gp160 env 0.0013
5727 Envelope glycoprotein gp160 env 0.0013
273 Apoptosis regulator Bcl-2 BCL2 0.0013
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0013
595 Fibrinogen alpha chain FGA 0.0013
4666 Fucose-binding lectin PA-IIL lecB 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
2372 Bifunctional tail protein 9 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
6432 Transporter snf 0.0013
365 Dihydrofolate reductase DHFR 0.0013
2381 Dihydrofolate reductase DFR1 0.0013
2833 Dihydrofolate reductase Not Available 0.0013
2931 Dihydrofolate reductase folA 0.0013
3544 Dihydrofolate reductase folA 0.0013
3682 Dihydrofolate reductase folA 0.0013
6642 Dihydrofolate reductase folA 0.0013
6756 Dihydrofolate reductase dfrA 0.0013
4773 Deoxycytidine kinase DCK 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
694 Matrix protein 2 M 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
3480 Mannan endo-1,4-beta-mannosidase manA 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
958 Insulin-like growth factor 1 receptor IGF1R 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
432 D(4) dopamine receptor DRD4 0.0012
1243 Cathepsin D CTSD 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
1439 Lactotransferrin LTF 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0011
3814 Complement C1r subcomponent C1R 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
76 Nitric-oxide synthase, brain NOS1 0.0011
1618 High affinity nerve growth factor receptor NTRK1 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
427 Substance-P receptor TACR1 0.0011
2430 Chondroitinase B cslB 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
6307 Ig gamma-2 chain C region IGHG2 0.001
2581 Chondroitinase AC cslA 0.001
309 Antithrombin-III SERPINC1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
6847 Lactase-phlorizin hydrolase LCT 0.001
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
3957 Adenosine deaminase ADA 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
4785 Ig gamma-1 chain C region IGHG1 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
823 Fibroblast growth factor receptor 2 FGFR2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
908 Glutathione S-transferase theta-1 GSTT1 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
163 D(1B) dopamine receptor DRD5 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0006
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2021 Thrombomodulin THBD 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
572 Integrin alpha-L ITGAL 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
4122 Histone deacetylase 2 HDAC2 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6218 Pannexin-1 PANX1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
6220 Aryl hydrocarbon receptor AHR 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
6014 Cytochrome P450 2A13 CYP2A13 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
295 Carbonic anhydrase 1 CA1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
164 Histamine H4 receptor HRH4 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
6020 Aldehyde oxidase AOX1 0.0002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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