DT-Web

DB00969 - Alosetron


Identification
Name Alosetron
Accession Number DB00969 (APRD00580)
Type small molecule
Description Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US market in November 2000 by the manufacturer due to numerous reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and death. In June 2002, the FDA approved a supplemental new drug application allowing the remarketing of the drug under restricted conditions of use.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 294.351
Groups approved
Monoisotopic Weight 294.148061218
Pharmacology
Indication Only for the treatment of symptoms of severe diarrhea-predominant irritable bowel syndrome (IBS) in women with chronic symptoms (generally lasting greater than 6 months) who does not present with anatomic or biochemical GI abnormalities and have not responded to conventional therapy.
Mechanism of action Alosetron is a potent and selective 5-HT3 receptor antagonist. 5-HT3 receptors are nonselective cation channels that are extensively distributed on enteric neurons in the human gastrointestinal tract, as well as other peripheral and central locations. Activation of these channels and the resulting neuronal depolarization affect the regulation of visceral pain, colonic transit and gastrointestinal secretions, processes that relate to the pathophysiology of irritable bowel syndrome (IBS). 5-HT3 receptor antagonists such as alosetron inhibit activation of non-selective cation channels which results in the modulation of serotonin-sensitive GI motor and sensory processes.
Absorption 50-60 %
Protein binding 82%
Biotransformation Hepatic, via microsomal cytochrome P450 (CYP)
Route of elimination Renal elimination of unchanged alosetron accounts for only 6% of the dose. Alosetron is extensively metabolized in humans.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Thiabendazole The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Alosetron by decreasing Alosetron metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Alosetron if Thiabendazole is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.
  • Absorption is decreased by about 25% when taken with meals.

Targets


5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action yes
Actions antagonist
References
  • Clayton NM, Sargent R, Butler A, Gale J, Maxwell MP, Hunt AA, Barrett VJ, Cambridge D, Bountra C, Humphrey PP: The pharmacological properties of the novel selective 5-HT3 receptor antagonist, alosetron, and its effects on normal and perturbed small intestinal transit in the fasted rat. Neurogastroenterol Motil. 1999 Jun;11(3):207-17. - Pubmed
  • Mayer EA, Bradesi S: Alosetron and irritable bowel syndrome. Expert Opin Pharmacother. 2003 Nov;4(11):2089-98. - Pubmed
  • Coldwell JR, Phillis BD, Sutherland K, Howarth GS, Blackshaw LA: Increased responsiveness of rat colonic splanchnic afferents to 5-HT after inflammation and recovery. J Physiol. 2007 Feb 15;579(Pt 1):203-13. Epub 2006 Nov 30. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Houghton LA, Foster JM, Whorwell PJ: Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers. Aliment Pharmacol Ther. 2000 Jun;14(6):775-82. - Pubmed
  • Gunput MD: Review article: clinical pharmacology of alosetron. Aliment Pharmacol Ther. 1999 May;13 Suppl 2:70-6. - Pubmed
  • Balfour JA, Goa KL, Perry CM: Alosetron. Drugs. 2000 Mar;59(3):511-8; discussion 519-20. - Pubmed
  • Camilleri M: Pharmacology and clinical experience with alosetron. Expert Opin Investig Drugs. 2000 Jan;9(1):147-59. - Pubmed
  • Rahimi R, Nikfar S, Abdollahi M: Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials. Clin Ther. 2008 May;30(5):884-901. - Pubmed
  • Lewis JH: Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective. Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29. - Pubmed
  • Andresen V, Hollerbach S: Reassessing the benefits and risks of alosetron: what is its place in the treatment of irritable bowel syndrome? Drug Saf. 2004;27(5):283-92. - Pubmed
DTHybrid score 0.1993

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3502
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4733
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3636
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2566

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2362
6016 Cytochrome P450 2C19 CYP2C19 0.2108
4924 Cytochrome P450 2C8 CYP2C8 0.1578
4118 Cytochrome P450 3A5 CYP3A5 0.1331
1588 Multidrug resistance protein 1 ABCB1 0.1313
6030 Cytochrome P450 2B6 CYP2B6 0.1193
6024 Cytochrome P450 1A1 CYP1A1 0.1026
6107 Cytochrome P450 3A7 CYP3A7 0.0934
5718 Cytochrome P450 2A6 CYP2A6 0.0883
20 Prostaglandin G/H synthase 1 PTGS1 0.0659
587 Serum albumin ALB 0.0574
492 Histamine H1 receptor HRH1 0.0515
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0467
502 5-hydroxytryptamine 2A receptor HTR2A 0.0449
6145 Solute carrier family 22 member 1 SLC22A1 0.0422
290 Prostaglandin G/H synthase 2 PTGS2 0.0406
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0389
318 Alpha-2A adrenergic receptor ADRA2A 0.0378
3811 Cytochrome P450 19A1 CYP19A1 0.0373
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0362
824 Sodium-dependent serotonin transporter SLC6A4 0.0354
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0354
6144 Solute carrier family 22 member 2 SLC22A2 0.0344
713 Sodium-dependent dopamine transporter SLC6A3 0.0344
556 Alpha-1A adrenergic receptor ADRA1A 0.0342
590 5-hydroxytryptamine 2C receptor HTR2C 0.0339
831 D(2) dopamine receptor DRD2 0.0339
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0335
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0328
320 5-hydroxytryptamine 1A receptor HTR1A 0.0316
540 Sodium-dependent noradrenaline transporter SLC6A2 0.031
6106 Cytochrome P450 2C18 CYP2C18 0.0307
1729 Solute carrier family 22 member 6 SLC22A6 0.0306
885 5-hydroxytryptamine 1B receptor HTR1B 0.0306
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0304
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0297
23 D(1A) dopamine receptor DRD1 0.0296
1898 Cytochrome P450 1B1 CYP1B1 0.0286
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0279
3923 Cholinesterase BCHE 0.0276
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0275
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0275
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0272
862 Multidrug resistance-associated protein 1 ABCC1 0.027
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0268
632 Alpha-1B adrenergic receptor ADRA1B 0.0259
36 Insulin receptor INSR 0.0258
136 Estrogen receptor ESR1 0.0255
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0248
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0242
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0233
847 Mu-type opioid receptor OPRM1 0.0231
725 5-hydroxytryptamine 1D receptor HTR1D 0.0231
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0226
638 D(3) dopamine receptor DRD3 0.0217
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0216
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0216
260 Cytochrome P450 51 ERG11 0.0216
761 Cytochrome P450 51 ERG11 0.0216
3163 Cytochrome P450 51 cyp51 0.0216
629 Alpha-2B adrenergic receptor ADRA2B 0.0215
94 5-hydroxytryptamine 4 receptor HTR4 0.0213
3941 Amine oxidase [flavin-containing] A MAOA 0.0213
696 Kappa-type opioid receptor OPRK1 0.0204
378 Alpha-2C adrenergic receptor ADRA2C 0.0199
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0199
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0198
871 Glucocorticoid receptor NR3C1 0.019
432 D(4) dopamine receptor DRD4 0.0188
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0185
776 Bile salt export pump ABCB11 0.0184
817 DNA topoisomerase 2-alpha TOP2A 0.0183
2164 Multidrug resistance-associated protein 4 ABCC4 0.0171
716 5-hydroxytryptamine 7 receptor HTR7 0.0171
118 Organic cation/carnitine transporter 2 SLC22A5 0.017
731 HIV-1 protease HIV-1 protease 0.0169
467 Delta-type opioid receptor OPRD1 0.0165
1256 5-hydroxytryptamine 6 receptor HTR6 0.0163
474 Acetylcholinesterase ACHE 0.016
789 Alpha-1D adrenergic receptor ADRA1D 0.0158
16 Adenosine A1 receptor ADORA1 0.0158
3939 Amine oxidase [flavin-containing] B MAOB 0.0158
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0156
528 5-hydroxytryptamine 1E receptor HTR1E 0.0156
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0155
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0152
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0152
6142 Solute carrier family 22 member 8 SLC22A8 0.0152
468 Cytochrome P450 4A11 CYP4A11 0.0149
465 Calmodulin CALM1 0.0147
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0146
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
122 P2Y purinoceptor 12 P2RY12 0.0143
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0142
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0142
891 Dihydropteroate synthase folP 0.0141
5359 Dihydropteroate synthase folP 0.0141
7175 Dihydropteroate synthase sulI 0.0141
6143 Solute carrier family 22 member 7 SLC22A7 0.0141
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0141
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0141
163 D(1B) dopamine receptor DRD5 0.014
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0137
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0137
766 Beta-2 adrenergic receptor ADRB2 0.0135
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0135
6031 Cytochrome P450 3A43 CYP3A43 0.0135
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0135
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0128
777 Tumor necrosis factor TNF 0.0126
1178 Adenosine A2a receptor ADORA2A 0.0122
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0122
6147 Solute carrier family 22 member 3 SLC22A3 0.012
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
193 Beta-1 adrenergic receptor ADRB1 0.0119
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0115
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0114
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0113
482 Glycine receptor subunit alpha-1 GLRA1 0.0113
6220 Aryl hydrocarbon receptor AHR 0.0112
833 Organic cation/carnitine transporter 1 SLC22A4 0.0111
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0111
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.011
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0109
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0109
811 Translocator protein TSPO 0.0108
613 Atrial natriuretic peptide receptor A NPR1 0.0106
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0106
4116 Dihydropteroate synthetase Not Available 0.0106
70 Type-1 angiotensin II receptor AGTR1 0.0104
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0103
6102 Arylamine N-acetyltransferase 2 NAT2 0.0102
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.01
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0099
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0098
1757 Myeloperoxidase MPO 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0096
1024 Solute carrier family 22 member 11 SLC22A11 0.0095
3947 Xanthine dehydrogenase/oxidase XDH 0.0094
705 Glutamate receptor 1 GRIA1 0.0093
6014 Cytochrome P450 2A13 CYP2A13 0.0092
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0092
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0092
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.009
571 Melatonin receptor type 1A MTNR1A 0.009
362 Melatonin receptor type 1B MTNR1B 0.009
818 50S ribosomal protein L10 rplJ 0.0089
4122 Histone deacetylase 2 HDAC2 0.0089
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0089
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0087
592 Carbonic anhydrase 4 CA4 0.0086
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0086
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0086
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0086
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0086
3810 Catechol O-methyltransferase COMT 0.0085
295 Carbonic anhydrase 1 CA1 0.0085
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0085
4604 Liver carboxylesterase 1 CES1 0.0084
537 ATP synthase delta chain, mitochondrial ATP5D 0.0084
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0083
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0082
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0082
436 5-hydroxytryptamine 2B receptor HTR2B 0.0082
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0082
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0082
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0081
6148 Multidrug resistance-associated protein 7 ABCC10 0.0081
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
1010 Cytochrome P450 51A1 CYP51A1 0.008
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.008
614 Progesterone receptor PGR 0.0079
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0079
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0079
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0077
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0077
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0076
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0076
869 Estrogen receptor beta ESR2 0.0076
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0074
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0073
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0073
146 Androgen receptor AR 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.007
49 Endothelin B receptor EDNRB 0.0069
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0069
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0068
6182 Cytochrome P450 2J2 CYP2J2 0.0068
365 Dihydrofolate reductase DHFR 0.0068
2381 Dihydrofolate reductase DFR1 0.0068
2833 Dihydrofolate reductase Not Available 0.0068
2931 Dihydrofolate reductase folA 0.0068
3544 Dihydrofolate reductase folA 0.0068
3682 Dihydrofolate reductase folA 0.0068
6642 Dihydrofolate reductase folA 0.0068
6756 Dihydrofolate reductase dfrA 0.0068
6136 Multidrug resistance-associated protein 5 ABCC5 0.0067
29 Tubulin beta-1 chain TUBB1 0.0066
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
357 Carbonic anhydrase 2 CA2 0.0065
6137 Multidrug resistance-associated protein 6 ABCC6 0.0064
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
407 Vascular endothelial growth factor receptor 2 KDR 0.0063
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0063
133 Dihydropterate synthase sulI 0.0063
153 Dopamine beta-hydroxylase DBH 0.0062
6126 Carbonic anhydrase 7 CA7 0.0062
275 Arachidonate 5-lipoxygenase ALOX5 0.0062
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0062
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0061
6020 Aldehyde oxidase AOX1 0.006
921 Glutamate receptor 2 GRIA2 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
814 Ryanodine receptor 1 RYR1 0.0059
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0059
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0059
504 Mast/stem cell growth factor receptor KIT 0.0059
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
444 Alcohol dehydrogenase 1B ADH1B 0.0058
284 DNA-directed RNA polymerase beta chain rpoB 0.0058
5773 DNA-directed RNA polymerase beta chain rpoB 0.0058
251 Alcohol dehydrogenase 1A ADH1A 0.0057
6141 Sodium/bile acid cotransporter SLC10A1 0.0056
427 Substance-P receptor TACR1 0.0056
756 Sex hormone-binding globulin SHBG 0.0056
161 Tubulin beta chain TUBB 0.0056
312 Tubulin beta chain TUB2 0.0056
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0055
373 Transthyretin TTR 0.0055
124 Histamine H2 receptor HRH2 0.0055
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0054
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0053
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0053
1656 CYP2B protein CYP2B 0.0053
1275 Estrogen sulfotransferase SULT1E1 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
164 Histamine H4 receptor HRH4 0.005
518 Peroxidase/catalase T katG 0.005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.005
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.005
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
844 Epidermal growth factor receptor EGFR 0.0049
183 Vascular endothelial growth factor A VEGFA 0.0049
273 Apoptosis regulator Bcl-2 BCL2 0.0049
380 Cytochrome P450 17A1 CYP17A1 0.0049
26 Vascular endothelial growth factor receptor 3 FLT4 0.0048
904 Glutathione S-transferase P GSTP1 0.0048
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0048
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
511 5-hydroxytryptamine 1F receptor HTR1F 0.0047
228 Beta platelet-derived growth factor receptor PDGFRB 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
563 Thyroid peroxidase TPO 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
32 Vascular endothelial growth factor receptor 1 FLT1 0.0046
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0046
173 Toll-like receptor 7 TLR7 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
54 Prothrombin F2 0.0045
2230 Catalase CAT 0.0044
3249 Catalase katA 0.0044
3625 Catalase katA 0.0044
4539 Catalase katA 0.0044
4941 Catalase katB 0.0044
6043 Putative G-protein coupled receptor 44 GPR44 0.0044
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0044
517 Alcohol dehydrogenase 1C ADH1C 0.0044
823 Fibroblast growth factor receptor 2 FGFR2 0.0044
6138 Multidrug resistance protein 3 ABCB4 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0043
780 Retinoic acid receptor RXR-gamma RXRG 0.0043
952 Dipeptidyl peptidase 4 DPP4 0.0043
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1648 Elastin ELN 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
1192 Sulfotransferase 1A1 SULT1A1 0.0041
856 Vitamin D3 receptor VDR 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1541 Metalloproteinase mmp20 0.0039
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0039
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0039
88 Retinoic acid receptor RXR-beta RXRB 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
3932 Glutathione S-transferase A2 GSTA2 0.0039
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0038
4120 NADPH--cytochrome P450 reductase POR 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
1483 Membrane copper amine oxidase AOC3 0.0038
1629 Transcription factor AP-1 JUN 0.0037
6044 Serum paraoxonase/lactonase 3 PON3 0.0037
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0036
3957 Adenosine deaminase ADA 0.0036
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0036
3937 Fatty-acid amide hydrolase FAAH 0.0036
6146 High affinity copper uptake protein 1 SLC31A1 0.0036
3404 Exotoxin A eta 0.0036
1050 Bile salt sulfotransferase SULT2A1 0.0035
6085 Fatty acid-binding protein, intestinal FABP2 0.0035
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
634 Squalene monooxygenase SQLE 0.0034
7196 Squalene monooxygenase ERG1 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
6432 Transporter snf 0.0034
239 Coagulation factor X F10 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
908 Glutathione S-transferase theta-1 GSTT1 0.0034
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
737 Mineralocorticoid receptor NR3C2 0.0033
3917 Methylenetetrahydrofolate reductase MTHFR 0.0033
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0033
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0033
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0033
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0033
976 Platelet glycoprotein IX GP9 0.0032
1618 High affinity nerve growth factor receptor NTRK1 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
4203 Histamine N-methyltransferase HNMT 0.0031
1374 Natriuretic peptides B NPPB 0.0031
1827 Gap junction alpha-1 protein GJA1 0.0031
1908 Vascular cell adhesion protein 1 VCAM1 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0029
3809 Estrogen-related receptor gamma ESRRG 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0029
3808 Dihydropteroate synthase 2 folP2 0.0029
3601 Dihydropteroate synthase 1 folP1 0.0029
3807 Dihydropteroate synthase 1 folP1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2298 Cytochrome P450-cam camC 0.0028
738 Monocarboxylate transporter 1 SLC16A1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4311 tRNA TRDMT1 0.0027
4325 tRNA trmD 0.0027
4328 tRNA trmD 0.0027
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0027
33 Cystine/glutamate transporter SLC7A11 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
2981 Phospholipase A2, membrane associated PLA2G2A 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0027
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
268 Adenosine A2b receptor ADORA2B 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0025
5880 Thrombopoietin receptor MPL 0.0025
319 Opioid receptor, sigma 1 OPRS1 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0025
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0025
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0025
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0025
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
358 Cystathionine beta-synthase CBS 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0024
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0024
208 DNA-directed RNA polymerase beta' chain rpoC 0.0023
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0023
896 Glutathione S-transferase Mu 1 GSTM1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
581 Cytochrome P450 2R1 CYP2R1 0.0023
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0022
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0022
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0022
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0022
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0022
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0022
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
84 Nuclear receptor 0B1 NR0B1 0.0022
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
7 Nitric oxide synthase, inducible NOS2 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
2232 Interleukin-5 IL5 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0021
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0021
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0021
174 Sigma 1-type opioid receptor SIGMAR1 0.0021
2091 Endoplasmin HSP90B1 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
1820 Beta-nerve growth factor NGF 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.002
6164 POU domain, class 5, transcription factor 1 POU5F1 0.002
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0019
6165 Copper-transporting ATPase 1 ATP7A 0.0019
3913 Glutamic acid decarboxylase GAD65 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
4103 Proteasome subunit beta type 2 PSMB2 0.0018
4102 Proteasome subunit beta type 5 PSMB5 0.0018
4101 Proteasome subunit beta type 1 PSMB1 0.0018
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0018
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0018
683 Potassium transporter GK0582 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0017
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0017
165 FL cytokine receptor FLT3 0.0017
469 Annexin A1 ANXA1 0.0017
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
106 Cannabinoid receptor 2 CNR2 0.0017
4773 Deoxycytidine kinase DCK 0.0017
6174 50S ribosomal protein L32 rpmF 0.0017
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
1268 Neuropeptide S receptor NPSR1 0.0017
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0017
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0017
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0017
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0017
1196 Complement decay-accelerating factor CD55 0.0017
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0017
735 Alanine aminotransferase 1 GPT 0.0016
3904 Alanine aminotransferase 2 GPT2 0.0016
1243 Cathepsin D CTSD 0.0016
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
936 Ephrin type-A receptor 2 EPHA2 0.0016
3830 Calreticulin CALR 0.0016
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0016
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0016
3233 Bile acid receptor NR1H4 0.0015
1360 Sphingomyelin phosphodiesterase SMPD1 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
3856 Fibroblast growth factor receptor 3 FGFR3 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
558 Solute carrier family 12 member 1 SLC12A1 0.0015
3221 Cytochrome c4 cc4 0.0015
5787 Angiopoietin-1 receptor TEK 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
6036 Eosinophil peroxidase EPX 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
1341 Histamine H3 receptor HRH3 0.0014
2808 Chloramphenicol acetyltransferase 3 cat3 0.0014
162 Retinoic acid receptor gamma-1 RARG 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
798 Osteocalcin BGLAP 0.0014
6859 Protein S100-A4 S100A4 0.0014
1864 RET proto-oncogene RET 0.0014
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0014
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0014
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
2417 Chloramphenicol acetyltransferase cat 0.0013
3278 Chloramphenicol acetyltransferase cat 0.0013
2810 Dr hemagglutinin structural subunit draA 0.0013
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
291 Nitric-oxide synthase, endothelial NOS3 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
369 Coagulation factor VII F7 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
1039 Histone deacetylase 9 HDAC9 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
1992 Vitamin D-binding protein GC 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
2207 Rhodopsin RHO 0.0011
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0011
1630 Integrin beta-2 ITGB2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
4217 Telomerase reverse transcriptase TERT 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.001
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.001
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
997 Protein kinase C beta type PRKCB 0.0009
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
229 Retinoic acid receptor beta RARB 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
572 Integrin alpha-L ITGAL 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6459 Glycodelin PAEP 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
267 Plasminogen activator inhibitor 1 SERPINE1 0.0008
760 Fibroblast growth factor 1 FGF1 0.0008
1867 Major prion protein PRNP 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
6218 Pannexin-1 PANX1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
2021 Thrombomodulin THBD 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
1507 Cytochrome c CYCS 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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