DT-Web: DB00763

Identification

Name

Methimazole

Accession Number

DB00763 (APRD00002)

Type

small molecule

Description

A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antithyroid Agents

Molecular Weight

114.169

Groups

approved

Monoisotopic Weight

114.025168892

Pharmacology

Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Mechanism of action

Methimazole binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. So methimazole effectively inhibits the production of new thyroid hormones.

Absorption

Rapid with an oral bioavailability of 93%.

Protein binding

None or minimal

Biotransformation

Primarily hepatic. Metabolized rapidly, requiring frequent administration.

Route of elimination

Methimazole is excreted in the urine.

Toxicity

Oral LD₅₀ in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	The antithyroid agent, methimazole, may decrease the anticoagulant effect of acenocoumarol.
Anisindione	The antithyroid agent, methimazole, may decrease the anticoagulant effect of anisindione.
Dicumarol	The antithyroid agent, methimazole, may decrease the anticoagulant effect of dicumarol.
Digoxin	The antithyroid agent increases the effect of digoxin
Tamoxifen	Methimazole may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Methimazole, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Methimazole is initiated, discontinued, or dose changed.
Warfarin	Methimazole may decrease the anticoagulant effect of warfarin. Monitor for changes in the therapeutic and adverse effects of warfarin if methimazole is initiated, discontinued or dose changed.

Food Interactions

Always take at the same moment in regard to meals, food may affect absorption unpredictably.

Thyroid peroxidase
Name	Thyroid peroxidase
Gene Name	TPO
Pharmacological action	yes
Actions	inhibitor
References	Sugawara M, Sugawara Y, Wen K: Methimazole and propylthiouracil increase cellular thyroid peroxidase activity and thyroid peroxidase mRNA in cultured porcine thyroid follicles. Thyroid. 1999 May;9(5):513-8. - Pubmed Manzon RG, Holmes JA, Youson JH: Variable effects of goitrogens in inducing precocious metamorphosis in sea lampreys (Petromyzon marinus). J Exp Zool. 2001 Apr 15;289(5):290-303. - Pubmed Ferreira AC, de Carvalho Cardoso L, Rosenthal D, de Carvalho DP: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole. Eur J Biochem. 2003 Jun;270(11):2363-8. - Pubmed Magnusson RP, Yu B, Brennan V: Effect of serum thyrotropin levels on the concentration of messenger RNA for thyroid peroxidase in the rat. Acta Endocrinol (Copenh). 1992 May;126(5):460-6. - Pubmed Chiovato L, Pinchera A: The microsomal/peroxidase antigen: modulation of its expression in thyroid cells. Autoimmunity. 1991;10(4):319-31. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.4362

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5159
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3724
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.388
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4976
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5545
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5586
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3753
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7122

Id	Partner name	Gene Name	Score
4924	Cytochrome P450 2C8	CYP2C8	0.2888
1588	Multidrug resistance protein 1	ABCB1	0.2501
4118	Cytochrome P450 3A5	CYP3A5	0.2182
6024	Cytochrome P450 1A1	CYP1A1	0.1677
6107	Cytochrome P450 3A7	CYP3A7	0.1608
3811	Cytochrome P450 19A1	CYP19A1	0.152
20	Prostaglandin G/H synthase 1	PTGS1	0.1081
153	Dopamine beta-hydroxylase	DBH	0.1
587	Serum albumin	ALB	0.098
492	Histamine H1 receptor	HRH1	0.0909
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0837
1757	Myeloperoxidase	MPO	0.0801
6106	Cytochrome P450 2C18	CYP2C18	0.0792
824	Sodium-dependent serotonin transporter	SLC6A4	0.0771
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0726
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0636
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0597
1181	Alpha-1-acid glycoprotein 1	ORM1	0.057
831	D(2) dopamine receptor	DRD2	0.056
556	Alpha-1A adrenergic receptor	ADRA1A	0.0554
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0546
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0539
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.053
290	Prostaglandin G/H synthase 2	PTGS2	0.0523
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0499
1729	Solute carrier family 22 member 6	SLC22A6	0.0499
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0475
713	Sodium-dependent dopamine transporter	SLC6A3	0.0474
1898	Cytochrome P450 1B1	CYP1B1	0.0467
6145	Solute carrier family 22 member 1	SLC22A1	0.0467
862	Multidrug resistance-associated protein 1	ABCC1	0.0464
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0456
766	Beta-2 adrenergic receptor	ADRB2	0.0452
6144	Solute carrier family 22 member 2	SLC22A2	0.0443
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0432
318	Alpha-2A adrenergic receptor	ADRA2A	0.0431
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0419
3941	Amine oxidase [flavin-containing] A	MAOA	0.0409
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0404
260	Cytochrome P450 51	ERG11	0.0393
761	Cytochrome P450 51	ERG11	0.0393
3163	Cytochrome P450 51	cyp51	0.0393
118	Organic cation/carnitine transporter 2	SLC22A5	0.0389
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0382
136	Estrogen receptor	ESR1	0.0376
23	D(1A) dopamine receptor	DRD1	0.0375
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0375
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0368
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0354
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0353
758	Thyroid hormone receptor alpha	THRA	0.0352
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0348
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0348
731	HIV-1 protease	HIV-1 protease	0.0342
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0342
468	Cytochrome P450 4A11	CYP4A11	0.034
632	Alpha-1B adrenergic receptor	ADRA1B	0.0338
776	Bile salt export pump	ABCB11	0.0335
193	Beta-1 adrenergic receptor	ADRB1	0.0334
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0333
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.033
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0329
465	Calmodulin	CALM1	0.0328
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0326
847	Mu-type opioid receptor	OPRM1	0.0325
3939	Amine oxidase [flavin-containing] B	MAOB	0.032
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0317
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0317
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0311
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0308
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0308
346	Thyroid hormone receptor beta-1	THRB	0.0291
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0282
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0281
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0277
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0274
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0272
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0271
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0266
2164	Multidrug resistance-associated protein 4	ABCC4	0.0266
817	DNA topoisomerase 2-alpha	TOP2A	0.0266
467	Delta-type opioid receptor	OPRD1	0.0264
6147	Solute carrier family 22 member 3	SLC22A3	0.0264
871	Glucocorticoid receptor	NR3C1	0.0259
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0259
36	Insulin receptor	INSR	0.0258
6142	Solute carrier family 22 member 8	SLC22A8	0.0257
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0257
6031	Cytochrome P450 3A43	CYP3A43	0.0255
696	Kappa-type opioid receptor	OPRK1	0.0253
122	P2Y purinoceptor 12	P2RY12	0.0248
638	D(3) dopamine receptor	DRD3	0.0247
891	Dihydropteroate synthase	folP	0.0246
5359	Dihydropteroate synthase	folP	0.0246
7175	Dihydropteroate synthase	sulI	0.0246
6014	Cytochrome P450 2A13	CYP2A13	0.0245
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0242
6143	Solute carrier family 22 member 7	SLC22A7	0.0238
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0231
789	Alpha-1D adrenergic receptor	ADRA1D	0.0228
833	Organic cation/carnitine transporter 1	SLC22A4	0.0227
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0221
482	Glycine receptor subunit alpha-1	GLRA1	0.0221
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.022
3923	Cholinesterase	BCHE	0.0219
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0217
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0216
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.021
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0208
629	Alpha-2B adrenergic receptor	ADRA2B	0.0207
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.02
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0199
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0196
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0196
6102	Arylamine N-acetyltransferase 2	NAT2	0.0192
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0192
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0182
6220	Aryl hydrocarbon receptor	AHR	0.0181
378	Alpha-2C adrenergic receptor	ADRA2C	0.018
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.018
432	D(4) dopamine receptor	DRD4	0.0179
705	Glutamate receptor 1	GRIA1	0.0176
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0174
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0171
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0171
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0171
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0169
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0168
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0168
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0168
16	Adenosine A1 receptor	ADORA1	0.0167
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0166
146	Androgen receptor	AR	0.0166
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0166
477	DNA topoisomerase 4 subunit A	parC	0.0165
886	DNA topoisomerase 4 subunit A	parC	0.0165
6226	DNA topoisomerase 4 subunit A	parC	0.0165
404	DNA gyrase subunit A	gyrA	0.0163
6224	DNA gyrase subunit A	gyrA	0.0163
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0162
777	Tumor necrosis factor	TNF	0.0162
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.016
94	5-hydroxytryptamine 4 receptor	HTR4	0.016
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0156
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0155
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0153
6136	Multidrug resistance-associated protein 5	ABCC5	0.0152
811	Translocator protein	TSPO	0.0152
1010	Cytochrome P450 51A1	CYP51A1	0.0149
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0149
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0149
716	5-hydroxytryptamine 7 receptor	HTR7	0.0148
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0148
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0148
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0148
4604	Liver carboxylesterase 1	CES1	0.0146
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0146
6182	Cytochrome P450 2J2	CYP2J2	0.0145
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0145
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0145
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0145
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0145
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0145
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0143
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0143
1178	Adenosine A2a receptor	ADORA2A	0.014
124	Histamine H2 receptor	HRH2	0.0137
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0137
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0135
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0135
1024	Solute carrier family 22 member 11	SLC22A11	0.0134
818	50S ribosomal protein L10	rplJ	0.0134
70	Type-1 angiotensin II receptor	AGTR1	0.0133
3947	Xanthine dehydrogenase/oxidase	XDH	0.013
869	Estrogen receptor beta	ESR2	0.0129
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0129
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0126
380	Cytochrome P450 17A1	CYP17A1	0.0126
921	Glutamate receptor 2	GRIA2	0.0126
1656	CYP2B protein	CYP2B	0.0125
232	Corticosteroid-binding globulin	SERPINA6	0.0125
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0124
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0124
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0123
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0122
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0122
504	Mast/stem cell growth factor receptor	KIT	0.0122
251	Alcohol dehydrogenase 1A	ADH1A	0.0121
4120	NADPH--cytochrome P450 reductase	POR	0.0121
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0121
295	Carbonic anhydrase 1	CA1	0.0121
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.012
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.012
174	Sigma 1-type opioid receptor	SIGMAR1	0.0119
163	D(1B) dopamine receptor	DRD5	0.0118
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0117
592	Carbonic anhydrase 4	CA4	0.0116
844	Epidermal growth factor receptor	EGFR	0.0116
6148	Multidrug resistance-associated protein 7	ABCC10	0.0116
6137	Multidrug resistance-associated protein 6	ABCC6	0.0116
444	Alcohol dehydrogenase 1B	ADH1B	0.0115
161	Tubulin beta chain	TUBB	0.0115
312	Tubulin beta chain	TUB2	0.0115
474	Acetylcholinesterase	ACHE	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
614	Progesterone receptor	PGR	0.0113
2230	Catalase	CAT	0.0112
3249	Catalase	katA	0.0112
3625	Catalase	katA	0.0112
4539	Catalase	katA	0.0112
4941	Catalase	katB	0.0112
3810	Catechol O-methyltransferase	COMT	0.011
131	Synaptic vesicular amine transporter	SLC18A2	0.0109
373	Transthyretin	TTR	0.0108
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0106
613	Atrial natriuretic peptide receptor A	NPR1	0.0106
4116	Dihydropteroate synthetase	Not Available	0.0106
518	Peroxidase/catalase T	katG	0.0106
4122	Histone deacetylase 2	HDAC2	0.0103
407	Vascular endothelial growth factor receptor 2	KDR	0.0102
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0102
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0102
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
4237	50S ribosomal protein L22	rplV	0.01
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0099
275	Arachidonate 5-lipoxygenase	ALOX5	0.0099
365	Dihydrofolate reductase	DHFR	0.0097
2381	Dihydrofolate reductase	DFR1	0.0097
2833	Dihydrofolate reductase	Not Available	0.0097
2931	Dihydrofolate reductase	folA	0.0097
3544	Dihydrofolate reductase	folA	0.0097
3682	Dihydrofolate reductase	folA	0.0097
6642	Dihydrofolate reductase	folA	0.0097
6756	Dihydrofolate reductase	dfrA	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
756	Sex hormone-binding globulin	SHBG	0.0097
49	Endothelin B receptor	EDNRB	0.0096
3932	Glutathione S-transferase A2	GSTA2	0.0095
427	Substance-P receptor	TACR1	0.0095
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0095
26	Vascular endothelial growth factor receptor 3	FLT4	0.0094
6141	Sodium/bile acid cotransporter	SLC10A1	0.0094
517	Alcohol dehydrogenase 1C	ADH1C	0.0094
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0093
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0093
6020	Aldehyde oxidase	AOX1	0.0093
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0093
578	Endothelin-1 receptor	EDNRA	0.009
32	Vascular endothelial growth factor receptor 1	FLT1	0.009
4238	50S ribosomal protein L4	rplD	0.0088
5578	50S ribosomal protein L4	rplD	0.0088
6173	50S ribosomal protein L4	rplD	0.0088
6219	50S ribosomal protein L4	rplD	0.0088
1192	Sulfotransferase 1A1	SULT1A1	0.0088
68	Cannabinoid receptor 1	CNR1	0.0087
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0087
357	Carbonic anhydrase 2	CA2	0.0087
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0085
6432	Transporter	snf	0.0084
6126	Carbonic anhydrase 7	CA7	0.0084
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0082
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0082
29	Tubulin beta-1 chain	TUBB1	0.0081
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.008
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.008
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0079
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0079
284	DNA-directed RNA polymerase beta chain	rpoB	0.0079
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0079
173	Toll-like receptor 7	TLR7	0.0079
183	Vascular endothelial growth factor A	VEGFA	0.0077
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0076
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0076
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0076
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0076
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0073
84	Nuclear receptor 0B1	NR0B1	0.0073
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
952	Dipeptidyl peptidase 4	DPP4	0.0072
1275	Estrogen sulfotransferase	SULT1E1	0.0071
823	Fibroblast growth factor receptor 2	FGFR2	0.0071
790	DNA polymerase subunit alpha B	POLA2	0.0071
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.007
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0069
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0069
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0069
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0069
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0069
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0069
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0069
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0069
1636	Trace amine-associated receptor 1	TAAR1	0.0067
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0066
1618	High affinity nerve growth factor receptor	NTRK1	0.0066
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0065
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0065
3937	Fatty-acid amide hydrolase	FAAH	0.0065
814	Ryanodine receptor 1	RYR1	0.0065
904	Glutathione S-transferase P	GSTP1	0.0065
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0063
1050	Bile salt sulfotransferase	SULT2A1	0.0063
856	Vitamin D3 receptor	VDR	0.0063
6138	Multidrug resistance protein 3	ABCB4	0.0063
780	Retinoic acid receptor RXR-gamma	RXRG	0.0063
133	Dihydropterate synthase	sulI	0.0063
7	Nitric oxide synthase, inducible	NOS2	0.0063
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0063
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0062
106	Cannabinoid receptor 2	CNR2	0.0062
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0061
6174	50S ribosomal protein L32	rpmF	0.0061
2298	Cytochrome P450-cam	camC	0.006
3809	Estrogen-related receptor gamma	ESRRG	0.006
738	Monocarboxylate transporter 1	SLC16A1	0.006
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0059
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0058
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0058
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0058
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0057
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0057
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
88	Retinoic acid receptor RXR-beta	RXRB	0.0057
6085	Fatty acid-binding protein, intestinal	FABP2	0.0057
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0057
6146	High affinity copper uptake protein 1	SLC31A1	0.0057
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0056
1517	Beta-3 adrenergic receptor	ADRB3	0.0055
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0055
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0055
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0055
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0055
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0055
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0055
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0055
6506	Stathmin-4	STMN4	0.0055
319	Opioid receptor, sigma 1	OPRS1	0.0055
634	Squalene monooxygenase	SQLE	0.0055
7196	Squalene monooxygenase	ERG1	0.0055
581	Cytochrome P450 2R1	CYP2R1	0.0054
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0054
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0054
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0054
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0054
737	Mineralocorticoid receptor	NR3C2	0.0054
273	Apoptosis regulator Bcl-2	BCL2	0.0053
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0053
1629	Transcription factor AP-1	JUN	0.0053
390	Adenosine A3 receptor	ADORA3	0.0053
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
54	Prothrombin	F2	0.0052
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0052
712	Tubulin alpha chain	TUB1	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0052
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0052
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0051
239	Coagulation factor X	F10	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
4311	tRNA	TRDMT1	0.0051
4325	tRNA	trmD	0.0051
4328	tRNA	trmD	0.0051
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.005
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.005
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.005
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.005
6766	O-GlcNAcase BT_4395	BT_4395	0.0049
6043	Putative G-protein coupled receptor 44	GPR44	0.0049
24	Thymidylate synthase	TMP1	0.0049
359	Thymidylate synthase	TYMS	0.0049
2626	Thymidylate synthase	thyA	0.0049
2729	Thymidylate synthase	thyA	0.0049
5352	Thymidylate synthase	THYA	0.0049
6044	Serum paraoxonase/lactonase 3	PON3	0.0049
3404	Exotoxin A	eta	0.0049
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0049
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0048
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0048
164	Histamine H4 receptor	HRH4	0.0048
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
976	Platelet glycoprotein IX	GP9	0.0047
723	Cytosolic phospholipase A2	PLA2G4A	0.0047
1483	Membrane copper amine oxidase	AOC3	0.0046
1253	Interferon gamma	IFNG	0.0046
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0046
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
820	Glycine receptor subunit alpha-2	GLRA2	0.0045
65	Matrix metalloproteinase-9	Not Available	0.0044
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0044
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0044
5934	Cytochrome P450 26A1	CYP26A1	0.0044
1268	Neuropeptide S receptor	NPSR1	0.0044
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0044
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0044
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
2539	Tubulin alpha-1 chain	TUBA4A	0.0043
469	Annexin A1	ANXA1	0.0043
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0042
473	L-lactate dehydrogenase A chain	LDHA	0.0042
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
1992	Vitamin D-binding protein	GC	0.0042
1648	Elastin	ELN	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
459	Retinoic acid receptor RXR-alpha	RXRA	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
908	Glutathione S-transferase theta-1	GSTT1	0.0041
400	Coagulation factor IX	F9	0.004
5461	Coagulation factor IX	F9	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6073	Potassium channel subfamily K member 9	KCNK9	0.004
6072	Potassium channel subfamily K member 3	KCNK3	0.004
3957	Adenosine deaminase	ADA	0.004
564	Cellular retinoic acid-binding protein 1	CRABP1	0.004
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.004
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.004
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0039
1541	Metalloproteinase	mmp20	0.0039
3808	Dihydropteroate synthase 2	folP2	0.0039
3601	Dihydropteroate synthase 1	folP1	0.0039
3807	Dihydropteroate synthase 1	folP1	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
1039	Histone deacetylase 9	HDAC9	0.0039
1630	Integrin beta-2	ITGB2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0038
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
165	FL cytokine receptor	FLT3	0.0038
4217	Telomerase reverse transcriptase	TERT	0.0038
85	Growth hormone receptor	GHR	0.0038
1374	Natriuretic peptides B	NPPB	0.0038
3639	Thymidine phosphorylase	deoA	0.0037
3936	Thymidine phosphorylase	TYMP	0.0037
1827	Gap junction alpha-1 protein	GJA1	0.0037
1908	Vascular cell adhesion protein 1	VCAM1	0.0037
719	Retinoic acid receptor responder protein 1	RARRES1	0.0037
770	Retinoic acid-induced protein 3	GPRC5A	0.0037
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0037
604	Vitamin K-dependent protein Z	PROZ	0.0037
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0037
291	Nitric-oxide synthase, endothelial	NOS3	0.0037
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0036
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
1245	Vitamin K-dependent protein S	PROS1	0.0034
422	Vitamin K-dependent protein C	PROC	0.0034
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0034
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0034
33	Cystine/glutamate transporter	SLC7A11	0.0033
4226	Uridine phosphorylase 2	UPP2	0.0033
558	Solute carrier family 12 member 1	SLC12A1	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
751	Potassium channel subfamily K member 6	KCNK6	0.0033
4103	Proteasome subunit beta type 2	PSMB2	0.0033
4102	Proteasome subunit beta type 5	PSMB5	0.0033
4101	Proteasome subunit beta type 1	PSMB1	0.0033
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0033
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0033
569	Retinal dehydrogenase 2	ALDH1A2	0.0033
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0032
162	Retinoic acid receptor gamma-1	RARG	0.0032
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0032
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0032
268	Adenosine A2b receptor	ADORA2B	0.0032
5787	Angiopoietin-1 receptor	TEK	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
1262	Corticotropin-lipotropin	POMC	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
5300	Antigen peptide transporter 1	TAP1	0.0031
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0031
611	Retinal dehydrogenase 1	ALDH1A1	0.0031
4225	Uridine phosphorylase 1	UPP1	0.0031
172	Potassium channel subfamily K member 1	KCNK1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
2207	Rhodopsin	RHO	0.003
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
896	Glutathione S-transferase Mu 1	GSTM1	0.0029
2320	Thymidine kinase, cytosolic	TK1	0.0029
1196	Complement decay-accelerating factor	CD55	0.0029
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0029
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0029
3913	Glutamic acid decarboxylase	GAD65	0.0029
413	Amidophosphoribosyltransferase	PPAT	0.0029
2515	Amidophosphoribosyltransferase	purF	0.0029
3714	Amidophosphoribosyltransferase	purF	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
936	Ephrin type-A receptor 2	EPHA2	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0028
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
798	Osteocalcin	BGLAP	0.0028
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3856	Fibroblast growth factor receptor 3	FGFR3	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6163	Copper-transporting ATPase 2	ATP7B	0.0027
6165	Copper-transporting ATPase 1	ATP7A	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0026
358	Cystathionine beta-synthase	CBS	0.0026
2808	Chloramphenicol acetyltransferase 3	cat3	0.0026
4192	DNA topoisomerase 2-beta	TOP2B	0.0025
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
6149	Solute carrier family 22 member 10	SLC22A10	0.0025
3830	Calreticulin	CALR	0.0025
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0025
369	Coagulation factor VII	F7	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
5798	Mitogen-activated protein kinase 11	MAPK11	0.0025
1864	RET proto-oncogene	RET	0.0025
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0024
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0024
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0024
735	Alanine aminotransferase 1	GPT	0.0024
3904	Alanine aminotransferase 2	GPT2	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
267	Plasminogen activator inhibitor 1	SERPINE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0024
6070	Nischarin	NISCH	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4773	Deoxycytidine kinase	DCK	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
3086	Plasmepsin-2	Not Available	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
2417	Chloramphenicol acetyltransferase	cat	0.0023
3278	Chloramphenicol acetyltransferase	cat	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
2810	Dr hemagglutinin structural subunit	draA	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0023
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0023
1353	DNA topoisomerase 1	TOP1	0.0023
3552	DNA topoisomerase 1	topA	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
6131	Carbonic anhydrase 14	CA14	0.0023
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
6221	Steroid hormone receptor ERR1	ESRRA	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
6122	Carbonic anhydrase 3	CA3	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1852	Microtubule-associated protein 2	MAP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
1820	Beta-nerve growth factor	NGF	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
572	Integrin alpha-L	ITGAL	0.002
3868	Calcineurin subunit B isoform 2	PPP3R2	0.002
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.002
2236	Casein kinase II subunit alpha	CSNK2A1	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
3221	Cytochrome c4	cc4	0.0017
293	Gamma-glutamyl hydrolase	GGH	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
1243	Cathepsin D	CTSD	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0015
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
1714	Mitogen-activated protein kinase 3	MAPK3	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1650	Heme carrier protein 1	SLC46A1	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0014
6167	Organic solute transporter subunit beta	OSTB	0.0014
6166	Organic solute transporter subunit alpha	OSTA	0.0014
6859	Protein S100-A4	S100A4	0.0014
3007	Carbonic anhydrase 12	CA12	0.0014
4205	Carbonic anhydrase 9	CA9	0.0014
244	Angiotensin-converting enzyme	ACE	0.0013
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0013
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0013
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0013
6218	Pannexin-1	PANX1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6168	Solute carrier family 22 member 16	SLC22A16	0.0013
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0013
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
2021	Thrombomodulin	THBD	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
1295	Fatty acid synthase	FASN	0.0012
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0012
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0011
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
76	Nitric-oxide synthase, brain	NOS1	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3238	Multidrug resistance protein mexA	mexA	0.001
3709	Glycerol uptake facilitator protein	glpF	0.001
3116	Bacterioferritin	bfr	0.001
4906	Bacterioferritin	bfr	0.001
4965	Bacterioferritin	bfr	0.001
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.001
3173	Enolase	eno	0.001
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.001
3393	TGF-beta receptor type-2	TGFBR2	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
997	Protein kinase C beta type	PRKCB	0.0009
484	Tyrosine-protein kinase ABL2	ABL2	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2852	DNA mismatch repair protein mutL	mutL	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6042	Prostaglandin reductase 2	PTGR2	0.0009
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0009
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3191	Histidinol dehydrogenase	hisD	0.0009
1970	Protein kinase C alpha type	PRKCA	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
740	Argininosuccinate synthase	ASS1	0.0009
865	Argininosuccinate synthase	ASS1	0.0009
2680	Argininosuccinate synthase	argG	0.0009
3194	Argininosuccinate synthase	argG	0.0009
1792	Tissue-type plasminogen activator	PLAT	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
6459	Glycodelin	PAEP	0.0008
4692	A/G-specific adenine glycosylase	mutY	0.0008
489	Monocarboxylate transporter 2	SLC16A7	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
2802	Endoglucanase G	celCCG	0.0007
822	Aldose reductase	AKR1B1	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
1313	Lactoylglutathione lyase	GLO1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1507	Cytochrome c	CYCS	0.0007
125	DNA polymerase beta	POLB	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4916	Cyanoglobin	glbN	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4984	Neuroglobin	NGB	0.0006
4943	Cytochrome c6	petJ	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
5000	HemO	hemO	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4909	CooA protein	cooA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4961	Hemophore HasA	hasA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4972	P450cin	cinA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
3093	Catalase HPII	katE	0.0006
4952	Catalase/peroxidase	katA	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00763 - Methimazole

Targets

Enzymes

Predictions