DT-Web

DB00394 - Beclometasone dipropionate


Identification
Name Beclometasone dipropionate
Accession Number DB00394 (APRD00564)
Type small molecule
Description Beclometasone dipropionate is a prodrug of the free form, beclometasone (beclomethasone-17-monopropionate). An anti-inflammatory, synthetic corticosteroid, it is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma and allergic rhinitis (seasonal and perennial). Beclometasone dipropionate is also being investigated for oral treatment in mild-to-moderate Crohn's disease of ileal or ileal-right colonic localisation and for "topical" use mild-to-moderate graft versus host disease. It is marketed under several brand names such as Qnasl (US) and Rivanase AQ (Canada).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 521.042
Groups approved
Monoisotopic Weight 520.222781245
Pharmacology
Indication Used in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older, and in treating symptoms for allergic rhinitis (seasonal or perennial) in patients 12 years of age and older. Also being investigated for oral treatment in mild-to-moderate Crohn's disease of ileal or ileal-right colonic localisation and for "topical" use mild-to-moderate graft versus host disease.
Mechanism of action Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. For the investigated use in the treatment of GvHD or Crohn's, beclometasone acts by binding to interleukin-13 to inhibit cytokines, which in turn inhibits inflammatory chemicals downstream.
Absorption Mean peak plasma concentration was 88pg/ml at 0.5 hour
Protein binding 87% to albumin and transcortin
Biotransformation Metabolism mediated via esterase enzymes that are found in most tissues. Undergoes rapid and extensive conversion to beclomenthasone-17-monopropionate (17-BMP) during absorption
Route of elimination Irrespective of the route of administration (injection, oral or inhalation), BDP and its metabolites are mainly excreted in the feces. Less than 10% of the drug and its metabolites are excreted in the urine.
Toxicity The acute toxicity of beclometasone dipropionate is low. The only harmful effect that follows inhalation of large amounts of the drug over a short period of time is suppression of hypothalamic-pituitary-adrenal (HPA) function. Chronic: The excessive use of beclometasone dipropionate over a long period could lead to adrenal suppression.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • No food effects were found when given with beclomethasone dipropionate.

Targets


Glucocorticoid receptor
Name Glucocorticoid receptor
Gene Name NR3C1
Pharmacological action yes
Actions agonist
References
  • Saklatvala J: Glucocorticoids: do we know how they work? Arthritis Res. 2002;4(3):146-50. Epub 2002 Jan 21. - Pubmed
  • Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. - Pubmed
  • Usmani OS, Ito K, Maneechotesuwan K, Ito M, Johnson M, Barnes PJ, Adcock IM: Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med. 2005 Sep 15;172(6):704-12. Epub 2005 Apr 28. - Pubmed
DTHybrid score 1.173

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.1809

Carriers


Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.237
6107 Cytochrome P450 3A7 CYP3A7 0.0951
1588 Multidrug resistance protein 1 ABCB1 0.0887
4119 Cytochrome P450 2D6 CYP2D6 0.0548
723 Cytosolic phospholipase A2 PLA2G4A 0.0547
4924 Cytochrome P450 2C8 CYP2C8 0.0449
6016 Cytochrome P450 2C19 CYP2C19 0.0418
469 Annexin A1 ANXA1 0.0403
4200 Cytochrome P450 1A2 CYP1A2 0.037
4757 Cytochrome P450 2C9 CYP2C9 0.0362
737 Mineralocorticoid receptor NR3C2 0.0355
614 Progesterone receptor PGR 0.0354
756 Sex hormone-binding globulin SHBG 0.0333
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0283
6024 Cytochrome P450 1A1 CYP1A1 0.0262
269 Adrenodoxin, mitochondrial FDX1 0.0258
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0235
5718 Cytochrome P450 2A6 CYP2A6 0.0218
6030 Cytochrome P450 2B6 CYP2B6 0.0216
4604 Liver carboxylesterase 1 CES1 0.0202
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0186
146 Androgen receptor AR 0.0184
290 Prostaglandin G/H synthase 2 PTGS2 0.0162
3923 Cholinesterase BCHE 0.0147
587 Serum albumin ALB 0.0145
6013 Cytochrome P450 2E1 CYP2E1 0.0142
381 Prolactin receptor PRLR 0.0142
862 Multidrug resistance-associated protein 1 ABCC1 0.0141
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0136
6031 Cytochrome P450 3A43 CYP3A43 0.0122
3811 Cytochrome P450 19A1 CYP19A1 0.012
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0111
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0105
4615 Chain A, Red Copper Protein Nitrosocyanin NE0143 0.0093
776 Bile salt export pump ABCB11 0.009
1898 Cytochrome P450 1B1 CYP1B1 0.0088
6145 Solute carrier family 22 member 1 SLC22A1 0.0082
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0078
847 Mu-type opioid receptor OPRM1 0.0078
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0077
6106 Cytochrome P450 2C18 CYP2C18 0.0075
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0071
1758 GTPase HRas HRAS 0.0068
136 Estrogen receptor ESR1 0.0067
320 5-hydroxytryptamine 1A receptor HTR1A 0.0067
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
6182 Cytochrome P450 2J2 CYP2J2 0.0065
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0063
6144 Solute carrier family 22 member 2 SLC22A2 0.0063
492 Histamine H1 receptor HRH1 0.0063
20 Prostaglandin G/H synthase 1 PTGS1 0.0061
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0061
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.006
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.006
6500 Phospholipase A2 PLA2G1B 0.006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0058
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0058
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0056
824 Sodium-dependent serotonin transporter SLC6A4 0.0056
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0054
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0053
831 D(2) dopamine receptor DRD2 0.0052
6143 Solute carrier family 22 member 7 SLC22A7 0.0052
468 Cytochrome P450 4A11 CYP4A11 0.0052
467 Delta-type opioid receptor OPRD1 0.0051
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.005
6148 Multidrug resistance-associated protein 7 ABCC10 0.005
502 5-hydroxytryptamine 2A receptor HTR2A 0.005
638 D(3) dopamine receptor DRD3 0.0049
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0048
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0047
2300 Lysozyme E 0.0047
3633 Lysozyme R 0.0047
5597 Lysozyme 17 0.0047
341 5-hydroxytryptamine 3 receptor HTR3A 0.0047
817 DNA topoisomerase 2-alpha TOP2A 0.0046
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0046
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0046
844 Epidermal growth factor receptor EGFR 0.0045
696 Kappa-type opioid receptor OPRK1 0.0044
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0044
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0043
705 Glutamate receptor 1 GRIA1 0.0042
731 HIV-1 protease HIV-1 protease 0.0041
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0041
1729 Solute carrier family 22 member 6 SLC22A6 0.0041
556 Alpha-1A adrenergic receptor ADRA1A 0.0041
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.004
632 Alpha-1B adrenergic receptor ADRA1B 0.0039
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0038
318 Alpha-2A adrenergic receptor ADRA2A 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0037
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0037
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0037
6142 Solute carrier family 22 member 8 SLC22A8 0.0037
84 Nuclear receptor 0B1 NR0B1 0.0037
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0036
6220 Aryl hydrocarbon receptor AHR 0.0035
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0035
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0035
6147 Solute carrier family 22 member 3 SLC22A3 0.0034
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0033
713 Sodium-dependent dopamine transporter SLC6A3 0.0033
2164 Multidrug resistance-associated protein 4 ABCC4 0.0033
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0032
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0032
378 Alpha-2C adrenergic receptor ADRA2C 0.0032
590 5-hydroxytryptamine 2C receptor HTR2C 0.0032
118 Organic cation/carnitine transporter 2 SLC22A5 0.0032
260 Cytochrome P450 51 ERG11 0.0032
761 Cytochrome P450 51 ERG11 0.0032
3163 Cytochrome P450 51 cyp51 0.0032
504 Mast/stem cell growth factor receptor KIT 0.0031
811 Translocator protein TSPO 0.0031
26 Vascular endothelial growth factor receptor 3 FLT4 0.0031
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.003
32 Vascular endothelial growth factor receptor 1 FLT1 0.0029
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0029
6137 Multidrug resistance-associated protein 6 ABCC6 0.0029
407 Vascular endothelial growth factor receptor 2 KDR 0.0029
23 D(1A) dopamine receptor DRD1 0.0028
239 Coagulation factor X F10 0.0028
29 Tubulin beta-1 chain TUBB1 0.0028
777 Tumor necrosis factor TNF 0.0028
228 Beta platelet-derived growth factor receptor PDGFRB 0.0027
380 Cytochrome P450 17A1 CYP17A1 0.0027
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0027
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0027
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0027
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0027
629 Alpha-2B adrenergic receptor ADRA2B 0.0026
432 D(4) dopamine receptor DRD4 0.0026
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0026
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0026
54 Prothrombin F2 0.0026
768 FK506-binding protein 1A FKBP1A 0.0025
5300 Antigen peptide transporter 1 TAP1 0.0025
2539 Tubulin alpha-1 chain TUBA4A 0.0025
477 DNA topoisomerase 4 subunit A parC 0.0024
886 DNA topoisomerase 4 subunit A parC 0.0024
6226 DNA topoisomerase 4 subunit A parC 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
404 DNA gyrase subunit A gyrA 0.0024
6224 DNA gyrase subunit A gyrA 0.0024
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0023
766 Beta-2 adrenergic receptor ADRB2 0.0023
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0023
1770 Phospholipase C PLCL1 0.0023
2841 Phospholipase C plc 0.0023
165 FL cytokine receptor FLT3 0.0023
3086 Plasmepsin-2 Not Available 0.0023
153 Dopamine beta-hydroxylase DBH 0.0022
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
833 Organic cation/carnitine transporter 1 SLC22A4 0.0022
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0022
465 Calmodulin CALM1 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0022
427 Substance-P receptor TACR1 0.0021
94 5-hydroxytryptamine 4 receptor HTR4 0.0021
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0021
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0021
274 Muscarinic acetylcholine receptor M5 CHRM5 0.002
725 5-hydroxytryptamine 1D receptor HTR1D 0.002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
1656 CYP2B protein CYP2B 0.002
1010 Cytochrome P450 51A1 CYP51A1 0.002
450 Muscarinic acetylcholine receptor M4 CHRM4 0.002
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.002
823 Fibroblast growth factor receptor 2 FGFR2 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.002
33 Cystine/glutamate transporter SLC7A11 0.0019
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0019
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0019
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0019
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0019
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0019
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0019
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0019
1256 5-hydroxytryptamine 6 receptor HTR6 0.0019
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0019
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0019
952 Dipeptidyl peptidase 4 DPP4 0.0018
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0018
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0018
6020 Aldehyde oxidase AOX1 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0018
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0018
5924 Microtubule-associated protein 4 MAP4 0.0018
5923 Microtubule-associated protein tau MAPT 0.0018
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0018
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0017
716 5-hydroxytryptamine 7 receptor HTR7 0.0017
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0017
124 Histamine H2 receptor HRH2 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0016
818 50S ribosomal protein L10 rplJ 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0016
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0016
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0016
6136 Multidrug resistance-associated protein 5 ABCC5 0.0016
273 Apoptosis regulator Bcl-2 BCL2 0.0016
4203 Histamine N-methyltransferase HNMT 0.0016
4238 50S ribosomal protein L4 rplD 0.0015
5578 50S ribosomal protein L4 rplD 0.0015
6173 50S ribosomal protein L4 rplD 0.0015
6219 50S ribosomal protein L4 rplD 0.0015
1196 Complement decay-accelerating factor CD55 0.0015
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0015
738 Monocarboxylate transporter 1 SLC16A1 0.0015
4192 DNA topoisomerase 2-beta TOP2B 0.0015
789 Alpha-1D adrenergic receptor ADRA1D 0.0014
4237 50S ribosomal protein L22 rplV 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
1525 Heparin-binding growth factor 2 FGF2 0.0014
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0014
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
3932 Glutathione S-transferase A2 GSTA2 0.0014
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0014
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
2808 Chloramphenicol acetyltransferase 3 cat3 0.0013
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0013
122 P2Y purinoceptor 12 P2RY12 0.0013
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
2417 Chloramphenicol acetyltransferase cat 0.0012
3278 Chloramphenicol acetyltransferase cat 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
3601 Dihydropteroate synthase 1 folP1 0.0012
3807 Dihydropteroate synthase 1 folP1 0.0012
3808 Dihydropteroate synthase 2 folP2 0.0012
193 Beta-1 adrenergic receptor ADRB1 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
2810 Dr hemagglutinin structural subunit draA 0.0012
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0012
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0012
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0012
3913 Glutamic acid decarboxylase GAD65 0.0011
4773 Deoxycytidine kinase DCK 0.0011
1024 Solute carrier family 22 member 11 SLC22A11 0.0011
319 Opioid receptor, sigma 1 OPRS1 0.0011
1618 High affinity nerve growth factor receptor NTRK1 0.0011
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0011
1483 Membrane copper amine oxidase AOC3 0.0011
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0011
1630 Integrin beta-2 ITGB2 0.001
976 Platelet glycoprotein IX GP9 0.001
163 D(1B) dopamine receptor DRD5 0.001
275 Arachidonate 5-lipoxygenase ALOX5 0.001
3941 Amine oxidase [flavin-containing] A MAOA 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.001
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
814 Ryanodine receptor 1 RYR1 0.001
3904 Alanine aminotransferase 2 GPT2 0.001
735 Alanine aminotransferase 1 GPT 0.001
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.001
161 Tubulin beta chain TUBB 0.0009
312 Tubulin beta chain TUB2 0.0009
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
6044 Serum paraoxonase/lactonase 3 PON3 0.0009
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
936 Ephrin type-A receptor 2 EPHA2 0.0008
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0008
1517 Beta-3 adrenergic receptor ADRB3 0.0008
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0008
16 Adenosine A1 receptor ADORA1 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0008
1178 Adenosine A2a receptor ADORA2A 0.0008
572 Integrin alpha-L ITGAL 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
267 Plasminogen activator inhibitor 1 SERPINE1 0.0008
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
1864 RET proto-oncogene RET 0.0008
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0008
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0008
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0007
1353 DNA topoisomerase 1 TOP1 0.0007
3552 DNA topoisomerase 1 topA 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
4122 Histone deacetylase 2 HDAC2 0.0007
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
869 Estrogen receptor beta ESR2 0.0007
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
5787 Angiopoietin-1 receptor TEK 0.0007
1757 Myeloperoxidase MPO 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
1039 Histone deacetylase 9 HDAC9 0.0007
908 Glutathione S-transferase theta-1 GSTT1 0.0007
4120 NADPH--cytochrome P450 reductase POR 0.0007
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0007
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0006
3939 Amine oxidase [flavin-containing] B MAOB 0.0006
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0006
780 Retinoic acid receptor RXR-gamma RXRG 0.0006
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0006
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0006
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0006
3947 Xanthine dehydrogenase/oxidase XDH 0.0006
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0006
1192 Sulfotransferase 1A1 SULT1A1 0.0006
88 Retinoic acid receptor RXR-beta RXRB 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
162 Retinoic acid receptor gamma-1 RARG 0.0006
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0005
6014 Cytochrome P450 2A13 CYP2A13 0.0005
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0005
3809 Estrogen-related receptor gamma ESRRG 0.0005
284 DNA-directed RNA polymerase beta chain rpoB 0.0005
5773 DNA-directed RNA polymerase beta chain rpoB 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0005
295 Carbonic anhydrase 1 CA1 0.0005
6085 Fatty acid-binding protein, intestinal FABP2 0.0004
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0004
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0004
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0004
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0004
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0003
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0003
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0003
921 Glutamate receptor 2 GRIA2 0.0003
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