DT-Web

DB08813 - Nadroparin


Identification
Name Nadroparin
Accession Number DB08813
Type small molecule
Description Nadroparin is a low molecular weight heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and factor Xa. Nadroparin halts the coagulation pathway by inhibiting the activation of thrombin (factor IIa) by factor Xa. The amplification of the fibrin clotting cascade is stopped once factors Xa and IIa are inactivated. It is derived from porcine sources and has a mean molecular size of 5000 daltons. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication Nadroparin is used for prophylaxis of thromboembolic disorders and general surgery in orthopedic surgery, treatment of deep vein thrombosis, prevention of clotting during hemodialysis and treatment of unstable angina and non-Q wave myocardial infarction
Mechanism of action The mechanism of action for nadroparin is similar to all other LMWHs. Like all LMWHs, nadroparin has a pentasaccharide sequence which binds to ATIII, which potentiates the action of ATIII. This complex greatly accelerates the inactivation of factor Xa and factor IIa. As a result, the coagulation cascade is inhibited.
Absorption Absorption is linear. The bioavailability of nadroparin after subcutaneous administration is about 89%.
Protein binding Much lower compared to heparin, which has over 90% protein bound.
Biotransformation Nadroparin is metabolized in the liver.
Route of elimination Nadroparin is eliminated via the kidneys through non-saturable mechanisms.
Toxicity Osteopenia with extended use, skin necrosis, thrombocytosis, severe immunologically-mediated thrombocytopenia, eosinophilia (rare), calcinosis rarely occurs at the injection site, severe bleeding, transient elevation of liver transaminases.
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Drotrecogin alfa The potential benefits of drotrecogin alfa should be weighed against an increased risk of bleeding in patients receiving therapeutic doses of low molecular weight heparins such as nadroparin. Monitor for bleeding during concomitant therapy, and immediately stop infusion of drotrecogin if clinically important bleeding occurs. In patients receiving prophylactic heparin doses, consider continuing this during drotrecogin.
Food Interactions
  • Danshen, dong quai, evening primrose oil, gingko, policosanol, willowbark

Targets


Antithrombin-III
Name Antithrombin-III
Gene Name SERPINC1
Pharmacological action yes
Actions potentiator
References
  • Davis R, Faulds D: Nadroparin calcium. A review of its pharmacology and clinical use in the prevention and treatment of thromboembolic disorders. Drugs Aging. 1997 Apr;10(4):299-322. - Pubmed
  • Frydman A: Low-molecular-weight heparins: an overview of their pharmacodynamics, pharmacokinetics and metabolism in humans. Haemostasis. 1996;26 Suppl 2:24-38. - Pubmed
DTHybrid score 1.1953
P-selectin
Name P-selectin
Gene Name SELP
Pharmacological action unknown
Actions inhibitor
References
  • Simonis D, Christ K, Alban S, Bendas G: Affinity and kinetics of different heparins binding to P- and L-selectin. Semin Thromb Hemost. 2007 Jul;33(5):534-9. - Pubmed
  • Ludwig RJ, Alban S, Bistrian R, Boehncke WH, Kaufmann R, Henschler R, Gille J: The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on bloodborne metastasis in vivo. Thromb Haemost. 2006 Mar;95(3):535-40. - Pubmed
DTHybrid score 0.99
Proto-oncogene protein c-fos
Name Proto-oncogene protein c-fos
Gene Name FOS
Pharmacological action unknown
Actions inhibitor
References
  • Nagy Z, Turcsik V, Blasko G: The effect of LMWH (Nadroparin) on tumor progression. Pathol Oncol Res. 2009 Dec;15(4):689-92. - Pubmed
  • Sustar V, Jansa R, Frank M, Hagerstrand H, Krzan M, Iglic A, Kralj-Iglic V: Suppression of membrane microvesiculation--a possible anticoagulant and anti-tumor progression effect of heparin. Blood Cells Mol Dis. 2009 May-Jun;42(3):223-7. Epub 2009 Mar 3. - Pubmed
DTHybrid score 0.9439
Myc proto-oncogene protein
Name Myc proto-oncogene protein
Gene Name Not Available
Pharmacological action unknown
Actions inhibitor
References
  • Nagy Z, Turcsik V, Blasko G: The effect of LMWH (Nadroparin) on tumor progression. Pathol Oncol Res. 2009 Dec;15(4):689-92. - Pubmed
  • Sustar V, Jansa R, Frank M, Hagerstrand H, Krzan M, Iglic A, Kralj-Iglic V: Suppression of membrane microvesiculation--a possible anticoagulant and anti-tumor progression effect of heparin. Blood Cells Mol Dis. 2009 May-Jun;42(3):223-7. Epub 2009 Mar 3. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
1719 Heparanase HPSE 0.3118
852 Heparin cofactor 2 SERPIND1 0.2155
239 Coagulation factor X F10 0.1817
1334 Tissue factor pathway inhibitor TFPI 0.1448
183 Vascular endothelial growth factor A VEGFA 0.0951
2020 Stromal cell-derived factor 1 CXCL12 0.0902
647 Integrin alpha-4 ITGA4 0.0783
1757 Myeloperoxidase MPO 0.0403
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0344
1756 E-selectin SELE 0.0342
5414 Fiber protein L5 0.034
5418 Fiber protein L5 0.034
5416 Coat protein VP1 Not Available 0.0296
3629 Endo-N-acetylneuraminidase Not Available 0.0296
1130 Lithostathine 1 alpha REG1A 0.0295
3547 Enterotoxin type B entB 0.0275
2324 Botulinum neurotoxin type B botB 0.0272
2570 Tetanus toxin tetX 0.0238
2723 Cholera enterotoxin subunit B ctxB 0.02
4604 Liver carboxylesterase 1 CES1 0.0187
6589 Delta-hemolysin hld 0.0056
6424 Light-harvesting protein B-800/820 beta chain Not Available 0.0056
6591 ATP synthase C chain atpH 0.0056
6587 Rubredoxin rub 0.0056
6423 Light-harvesting protein B-800/820 alpha chain Not Available 0.0056
6586 Protein S100-G S100G 0.0056
6588 Methionyl-tRNA formyltransferase fmt 0.0056
4718 Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP 0.0056
6592 Probable L-ascorbate-6-phosphate lactonase ulaG ulaG 0.0056
6585 HLA class I histocompatibility antigen, B-27 alpha chain HLA-B 0.0056
6593 Immunoglobulin G-binding protein G spg 0.0056
3175 Glutamate--cysteine ligase gshA 0.0053
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0049
6493 Cytochrome c oxidase subunit 6C COX6C 0.0048
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0048
6279 Beta-2-microglobulin B2M 0.0048
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0048
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0048
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0048
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0048
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0048
6559 Cytochrome c oxidase subunit 2 ctaC 0.0048
6669 Cytochrome c oxidase subunit 2 ctaC 0.0048
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0048
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0048
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0048
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0048
6558 Cytochrome c oxidase subunit 1 ctaD 0.0048
6319 Respiratory nitrate reductase 1 gamma chain narI 0.0048
6318 Respiratory nitrate reductase 1 beta chain narH 0.0048
6317 Respiratory nitrate reductase 1 alpha chain narG 0.0048
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0045
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0045
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0045
6576 Geranylgeranyl transferase type-2 subunit beta RABGGTB 0.0042
6575 Geranylgeranyl transferase type-2 subunit alpha RABGGTA 0.0042
2132 Protein S100-B S100B 0.0041
4878 Glycoprotein hormones alpha chain CGA 0.0041
4856 CD209 antigen CD209 0.0041
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0041
1072 Granzyme B GZMB 0.0041
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0041
4850 Beta-2-glycoprotein 1 APOH 0.0041
4880 Membrane cofactor protein CD46 0.0041
4889 Ig epsilon chain C region IGHE 0.0041
4189 Alpha-galactosidase A GLA 0.0041
4869 Major capsid protein A430L 0.0041
4852 Reticulon-4 receptor RTN4R 0.0041
4877 Beta-mannanase man 0.0041
442 Envelope glycoprotein gp41 0.0041
4859 Envelope glycoprotein env 0.0041
4845 ADAM 33 ADAM33 0.0041
757 Fusion glycoprotein F0 F 0.0041
4875 Fusion glycoprotein F0 F 0.0041
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0041
1354 Beta-glucuronidase GUSB 0.0041
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0041
4721 Beta-1,4-mannanase manA 0.0041
3352 Structural polyprotein Not Available 0.0041
3628 Structural polyprotein Not Available 0.0041
4892 Structural polyprotein Not Available 0.0041
6352 Reaction center protein H chain puhA 0.0036
6456 Reaction center protein H chain puhA 0.0036
6682 Reaction center protein H chain puhA 0.0036
6353 Reaction center protein L chain pufL 0.0036
6454 Reaction center protein L chain pufL 0.0036
6683 Reaction center protein L chain pufL 0.0036
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0036
6354 Reaction center protein M chain pufM 0.0036
6455 Reaction center protein M chain pufM 0.0036
6684 Reaction center protein M chain pufM 0.0036
793 T-cell surface antigen CD2 CD2 0.0036
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0036
4861 Interleukin-6 receptor alpha chain IL6R 0.0036
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0036
3837 Cytokine receptor common beta chain CSF2RB 0.0036
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0035
1184 Interferon beta IFNB1 0.0033
1379 Interleukin-12 subunit beta IL12B 0.0033
6858 Inactive carboxylesterase 4 CES1P1 0.0033
4890 Hemagglutinin HA 0.0033
6566 Hemagglutinin Not Available 0.0033
3027 Streptavidin Not Available 0.0032
554 Low-density lipoprotein receptor LDLR 0.0032
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0031
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0031
2297 Genome polyprotein Not Available 0.0031
2322 Genome polyprotein Not Available 0.0031
2694 Genome polyprotein Not Available 0.0031
2719 Genome polyprotein Not Available 0.0031
2860 Genome polyprotein Not Available 0.0031
2928 Genome polyprotein Not Available 0.0031
3160 Genome polyprotein Not Available 0.0031
3260 Genome polyprotein Not Available 0.0031
4783 Genome polyprotein Not Available 0.0031
5726 Genome polyprotein Not Available 0.0031
5779 Genome polyprotein Not Available 0.0031
5867 Genome polyprotein Not Available 0.0031
6253 Genome polyprotein Not Available 0.0031
6301 Genome polyprotein Not Available 0.0031
6380 Genome polyprotein Not Available 0.0031
6381 Genome polyprotein Not Available 0.0031
6437 Genome polyprotein Not Available 0.0031
6520 Genome polyprotein Not Available 0.0031
6521 Genome polyprotein Not Available 0.0031
6652 Genome polyprotein Not Available 0.0031
6734 Genome polyprotein Not Available 0.0031
6735 Genome polyprotein Not Available 0.0031
6736 Genome polyprotein Not Available 0.0031
6737 Genome polyprotein Not Available 0.0031
6738 Genome polyprotein Not Available 0.0031
6739 Genome polyprotein Not Available 0.0031
6744 Genome polyprotein Not Available 0.0031
6748 Genome polyprotein Not Available 0.0031
6894 Genome polyprotein Not Available 0.0031
6898 Genome polyprotein Not Available 0.0031
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0031
3444 Cyanovirin-N Not Available 0.003
3140 Hemagglutinin-neuraminidase HN 0.003
3609 Hemagglutinin-neuraminidase HN 0.003
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.003
1859 Prostatic acid phosphatase ACPP 0.0029
4787 Envelope glycoprotein gp160 env 0.0029
4820 Envelope glycoprotein gp160 env 0.0029
5727 Envelope glycoprotein gp160 env 0.0029
5682 Ribonuclease pancreatic RNASE1 0.0029
4666 Fucose-binding lectin PA-IIL lecB 0.0028
595 Fibrinogen alpha chain FGA 0.0028
2372 Bifunctional tail protein 9 0.0028
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0026
3480 Mannan endo-1,4-beta-mannosidase manA 0.0026
958 Insulin-like growth factor 1 receptor IGF1R 0.0025
64 Neuraminidase NA 0.0025
641 Neuraminidase NA 0.0025
2676 Neuraminidase NA 0.0025
3026 Neuraminidase NA 0.0025
3519 Neuraminidase NA 0.0025
6007 Neuraminidase NA 0.0025
1243 Cathepsin D CTSD 0.0024
1439 Lactotransferrin LTF 0.0024
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0024
2430 Chondroitinase B cslB 0.0023
3814 Complement C1r subcomponent C1R 0.0023
2581 Chondroitinase AC cslA 0.0022
6847 Lactase-phlorizin hydrolase LCT 0.0022
6307 Ig gamma-2 chain C region IGHG2 0.0022
6500 Phospholipase A2 PLA2G1B 0.0021
2207 Rhodopsin RHO 0.0021
4785 Ig gamma-1 chain C region IGHG1 0.0018
76 Nitric-oxide synthase, brain NOS1 0.0018
952 Dipeptidyl peptidase 4 DPP4 0.0016
3923 Cholinesterase BCHE 0.0014
20 Prostaglandin G/H synthase 1 PTGS1 0.0013
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