DT-Web

DB07724 - 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid


Identification
Name 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
Accession Number DB07724
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 389.422
Groups experimental
Monoisotopic Weight 389.093308035
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nuclear receptor coactivator 1
Name Nuclear receptor coactivator 1
Gene Name NCOA1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1
Peroxisome proliferator-activated receptor alpha
Name Peroxisome proliferator-activated receptor alpha
Gene Name PPARA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6196
Peroxisome proliferator-activated receptor delta
Name Peroxisome proliferator-activated receptor delta
Gene Name PPARD
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9751
Peroxisome proliferator-activated receptor gamma
Name Peroxisome proliferator-activated receptor gamma
Gene Name PPARG
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1293

Predictions


Id Partner name Gene Name Score
869 Estrogen receptor beta ESR2 0.3028
5841 Insulin-like growth factor IB IGF1 0.1126
856 Vitamin D3 receptor VDR 0.0703
768 FK506-binding protein 1A FKBP1A 0.0646
4924 Cytochrome P450 2C8 CYP2C8 0.0588
3233 Bile acid receptor NR1H4 0.0588
4512 Cytochrome P450 3A4 CYP3A4 0.0585
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0549
4757 Cytochrome P450 2C9 CYP2C9 0.051
6241 Nuclear receptor coactivator 2 NCOA2 0.0481
1541 Metalloproteinase mmp20 0.0468
459 Retinoic acid receptor RXR-alpha RXRA 0.0465
6024 Cytochrome P450 1A1 CYP1A1 0.0449
20 Prostaglandin G/H synthase 1 PTGS1 0.0372
122 P2Y purinoceptor 12 P2RY12 0.0335
527 Prostacyclin receptor PTGIR 0.0331
290 Prostaglandin G/H synthase 2 PTGS2 0.0322
6350 Nuclear receptor subfamily 1 group I member 3 NR1I3 0.0318
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0264
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0262
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0235
136 Estrogen receptor ESR1 0.0229
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0226
759 Free fatty acid receptor 1 FFAR1 0.0216
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0215
737 Mineralocorticoid receptor NR3C2 0.0212
4200 Cytochrome P450 1A2 CYP1A2 0.0211
6016 Cytochrome P450 2C19 CYP2C19 0.0206
1053 BC269730_2 FADS1 0.0186
1395 Sodium/calcium exchanger 1 SLC8A1 0.0186
2907 Oxysterols receptor LXR-beta NR1H2 0.0185
6283 Oxysterols receptor LXR-alpha NR1H3 0.0185
6043 Putative G-protein coupled receptor 44 GPR44 0.0177
3932 Glutathione S-transferase A2 GSTA2 0.0176
3312 Fatty acid-binding protein, brain FABP7 0.0175
587 Serum albumin ALB 0.0174
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0172
275 Arachidonate 5-lipoxygenase ALOX5 0.0171
468 Cytochrome P450 4A11 CYP4A11 0.0163
1714 Mitogen-activated protein kinase 3 MAPK3 0.0151
5718 Cytochrome P450 2A6 CYP2A6 0.0138
703 NADPH azoreductase azr 0.0122
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0117
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0117
88 Retinoic acid receptor RXR-beta RXRB 0.0117
822 Aldose reductase AKR1B1 0.0116
6030 Cytochrome P450 2B6 CYP2B6 0.0113
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0113
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0112
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0107
6013 Cytochrome P450 2E1 CYP2E1 0.0102
1729 Solute carrier family 22 member 6 SLC22A6 0.0102
992 Protein tyrosine kinase 2 beta PTK2B 0.0084
1588 Multidrug resistance protein 1 ABCB1 0.0079
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0076
862 Multidrug resistance-associated protein 1 ABCC1 0.0064
70 Type-1 angiotensin II receptor AGTR1 0.0063
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.006
373 Transthyretin TTR 0.0058
1757 Myeloperoxidase MPO 0.0058
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0055
4119 Cytochrome P450 2D6 CYP2D6 0.0052
817 DNA topoisomerase 2-alpha TOP2A 0.0048
1650 Heme carrier protein 1 SLC46A1 0.0044
4118 Cytochrome P450 3A5 CYP3A5 0.0043
2164 Multidrug resistance-associated protein 4 ABCC4 0.0041
33 Cystine/glutamate transporter SLC7A11 0.004
6085 Fatty acid-binding protein, intestinal FABP2 0.0038
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0037
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0036
6753 Apolipoprotein M APOM 0.0032
2528 Fatty acid metabolism regulator protein fadR 0.0032
6740 Fatty acid metabolism regulator protein fadR 0.0032
394 Calcineurin subunit B isoform 1 PPP3R1 0.0032
6742 Recoverin RCVRN 0.0032
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0032
6743 Non-fluorescent flavoprotein luxF 0.0032
6747 Chalcone/stilbene synthase family protein MT1417 0.0032
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0032
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0032
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0032
6751 Gag polyprotein gag 0.0032
6749 Polyprotein Not Available 0.0032
5961 Insulin INS 0.0028
6527 Lymphocyte antigen 96 LY96 0.0028
6755 Poliovirus receptor PVR 0.0028
2021 Thrombomodulin THBD 0.0027
6750 ADP-ribosylation factor 6 ARF6 0.0026
6221 Steroid hormone receptor ERR1 ESRRA 0.0026
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0025
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0025
6524 Protein tonB tonB 0.0025
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
2616 Ganglioside GM2 activator GM2A 0.0024
6107 Cytochrome P450 3A7 CYP3A7 0.0024
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0023
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0023
1024 Solute carrier family 22 member 11 SLC22A11 0.0023
738 Monocarboxylate transporter 1 SLC16A1 0.0023
6042 Prostaglandin reductase 2 PTGR2 0.0023
4210 Toll-like receptor 4 TLR4 0.0023
2297 Genome polyprotein Not Available 0.0022
2322 Genome polyprotein Not Available 0.0022
2694 Genome polyprotein Not Available 0.0022
2719 Genome polyprotein Not Available 0.0022
2860 Genome polyprotein Not Available 0.0022
2928 Genome polyprotein Not Available 0.0022
3160 Genome polyprotein Not Available 0.0022
3260 Genome polyprotein Not Available 0.0022
4783 Genome polyprotein Not Available 0.0022
5726 Genome polyprotein Not Available 0.0022
5779 Genome polyprotein Not Available 0.0022
5867 Genome polyprotein Not Available 0.0022
6253 Genome polyprotein Not Available 0.0022
6301 Genome polyprotein Not Available 0.0022
6380 Genome polyprotein Not Available 0.0022
6381 Genome polyprotein Not Available 0.0022
6437 Genome polyprotein Not Available 0.0022
6520 Genome polyprotein Not Available 0.0022
6521 Genome polyprotein Not Available 0.0022
6652 Genome polyprotein Not Available 0.0022
6734 Genome polyprotein Not Available 0.0022
6735 Genome polyprotein Not Available 0.0022
6736 Genome polyprotein Not Available 0.0022
6737 Genome polyprotein Not Available 0.0022
6738 Genome polyprotein Not Available 0.0022
6739 Genome polyprotein Not Available 0.0022
6744 Genome polyprotein Not Available 0.0022
6748 Genome polyprotein Not Available 0.0022
6894 Genome polyprotein Not Available 0.0022
6898 Genome polyprotein Not Available 0.0022
6316 ADP-ribosylation factor 1 ARF1 0.0022
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0021
3809 Estrogen-related receptor gamma ESRRG 0.0021
864 Gag-Pol polyprotein gag-pol 0.002
2237 Gag-Pol polyprotein gag-pol 0.002
2326 Gag-Pol polyprotein gag-pol 0.002
2451 Gag-Pol polyprotein gag-pol 0.002
2901 Gag-Pol polyprotein gag-pol 0.002
3165 Gag-Pol polyprotein gag-pol 0.002
3722 Gag-Pol polyprotein gag-pol 0.002
6306 Gag-Pol polyprotein gag-pol 0.002
6624 Gag-Pol polyprotein gag-pol 0.002
6142 Solute carrier family 22 member 8 SLC22A8 0.002
1792 Tissue-type plasminogen activator PLAT 0.002
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.002
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0019
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0019
1313 Lactoylglutathione lyase GLO1 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
2427 Ferrichrome-iron receptor fhuA 0.0018
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0018
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0017
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0017
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0017
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0017
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0016
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0016
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0015
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
4604 Liver carboxylesterase 1 CES1 0.0014
6137 Multidrug resistance-associated protein 6 ABCC6 0.0013
465 Calmodulin CALM1 0.0013
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0013
776 Bile salt export pump ABCB11 0.0013
3811 Cytochrome P450 19A1 CYP19A1 0.0012
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0012
6143 Solute carrier family 22 member 7 SLC22A7 0.0011
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