Identification | |
---|---|
Name | Velaglucerase alfa |
Accession Number | DB06720 |
Type | biotech |
Description | Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease. |
Structure |
|
Categories (*) | |
Molecular Weight | ~63 kDa |
Groups | approved |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | Velaglucerase alfa is a hydrolytic lysosomal glucocerebroside-specific enzyme indicated for long-term enzyme replacement therapy for pediatric and adult patients with type 1 Gaucher disease. |
Mechanism of action | Velaglucerase alfa catalyzes the hydrolysis of glucocerebroside, reducing the amount of accumulated glucocerebroside. |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms | Not Available |
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
Glucosylceramidase | |
---|---|
Name | Glucosylceramidase |
Gene Name | GBA |
Pharmacological action | unknown |
Actions | Not Available |
References |
|
DTHybrid score | 1.1806 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
3942 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | CDIPT | 0.1405 |
3562 | 1-phosphatidylinositol phosphodiesterase | Not Available | 0.1222 |
5040 | 1-phosphatidylinositol phosphodiesterase | plcA | 0.1222 |
3626 | Probable polysaccharide deacetylase pdaA | pdaA | 0.0624 |
2998 | Sialic acid-binding Ig-like lectin 7 | SIGLEC7 | 0.0501 |
4666 | Fucose-binding lectin PA-IIL | lecB | 0.0474 |
3140 | Hemagglutinin-neuraminidase | HN | 0.0473 |
3609 | Hemagglutinin-neuraminidase | HN | 0.0473 |
4787 | Envelope glycoprotein gp160 | env | 0.0473 |
4820 | Envelope glycoprotein gp160 | env | 0.0473 |
5727 | Envelope glycoprotein gp160 | env | 0.0473 |
4785 | Ig gamma-1 chain C region | IGHG1 | 0.0324 |
244 | Angiotensin-converting enzyme | ACE | 0.0272 |
474 | Acetylcholinesterase | ACHE | 0.0254 |