DT-Web

DB06637 - Dalfampridine


Identification
Name Dalfampridine
Accession Number DB06637
Type small molecule
Description Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 94.1145
Groups approved
Monoisotopic Weight 94.053098202
Pharmacology
Indication Dalfampridine is a neurofunctional modifier that helps improve walking speed in patients with multiple sclerosis (MS).
Mechanism of action In MS, axons are progressively demyelinated which exposes potassium channels. As a result, there is a leak of potassium ions which results in the repolarization of cells and a decrease in neuronal excitability. The overall impact is the impairment of neuromuscular transmission as it is harder to trigger an action potential. Dalfampridine inhibits voltage-gated potassium channels in the CNS to maintain the transmembrane potential and prolong action potential. In other words, dalfampridine works to make sure that the current available is high enough to stimulate conduction in demyelinated axons that are exposed in MS patients. Furthermore, it facilitates neuromuscular and synaptic transmission by relieving conduction blocks in demyelinated axons.
Absorption Orally-administered dalfampridine is rapidly and completely absorbed from the gastrointestinal tract. Tmax, immediate release form = 1 hour; Tmax, extended release form = 3.5 hours; Cmax, 10 mg extended release = 17.3 - 21.6 ng/mL; Relative bioavailability of 10 mg extended-release tablets compared to aqueous oral solution = 96%
Protein binding 10 mg extended release = 1-3% protein bound
Biotransformation Not extensively metabolized by the liver therefore drugs effecting the cytochrome P450 enzyme system that are concomitantly administered with dalfampridine are not expected to interact with each other. Metabolites include 3-hydroxy-4-aminopyridine and 3-hydroxy-4-aminopyridine sulfate and both are inactive. CYP2E1 is the enzyme responsible for 3-hydroxylation of dalfampridine.
Route of elimination Almost all of the dose and its metabolites are completely eliminated by the kidneys after 24 hours. Urine (96%; 90% of total dose as unchanged drug); Feces (0.5%)
Toxicity LD50, oral, mouse = 19 mg/kg LD50, oral, rat = 21 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • A high fat meal significantly increases Cmax but this effect is not clinically relevant. May take dalfampridine without regard to meals

Targets


Potassium voltage-gated channel subfamily A member 1
Name Potassium voltage-gated channel subfamily A member 1
Gene Name KCNA1
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score 0.2922
Potassium voltage-gated channel subfamily A member 2
Name Potassium voltage-gated channel subfamily A member 2
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily A member 3
Name Potassium voltage-gated channel subfamily A member 3
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily A member 4
Name Potassium voltage-gated channel subfamily A member 4
Gene Name KCNA4
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily A member 5
Name Potassium voltage-gated channel subfamily A member 5
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily A member 6
Name Potassium voltage-gated channel subfamily A member 6
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily A member 7
Name Potassium voltage-gated channel subfamily A member 7
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily A member 10
Name Potassium voltage-gated channel subfamily A member 10
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily B member 1
Name Potassium voltage-gated channel subfamily B member 1
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily B member 2
Name Potassium voltage-gated channel subfamily B member 2
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily C member 1
Name Potassium voltage-gated channel subfamily C member 1
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily C member 2
Name Potassium voltage-gated channel subfamily C member 2
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily C member 3
Name Potassium voltage-gated channel subfamily C member 3
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily D member 1
Name Potassium voltage-gated channel subfamily D member 1
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score Not Available
Potassium voltage-gated channel subfamily D member 2
Name Potassium voltage-gated channel subfamily D member 2
Gene Name KCND2
Pharmacological action yes
Actions antagonist
References
  • Goodman AD, Stone RT: Enhancing neural transmission in multiple sclerosis (4-aminopyridine therapy). Neurotherapeutics. 2013 Jan;10(1):106-10. doi: 10.1007/s13311-012-0156-3. - Pubmed
DTHybrid score 0.3638
Potassium voltage-gated channel subfamily D member 3
Name Potassium voltage-gated channel subfamily D member 3
Gene Name KCND3
Pharmacological action yes
Actions antagonist
References
  • Judge SI, Bever CT Jr: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment. Pharmacol Ther. 2006 Jul;111(1):224-59. Epub 2006 Feb 9. - Pubmed
DTHybrid score 0.3638

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Pikoulas TE, Fuller MA: Dalfampridine: a medication to improve walking in patients with multiple sclerosis. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1010-5. doi: 10.1345/aph.1Q714. Epub 2012 Jul 3. - Pubmed
DTHybrid score 0.3042

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1096
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0852
537 ATP synthase delta chain, mitochondrial ATP5D 0.0833
705 Glutamate receptor 1 GRIA1 0.0827
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0759
482 Glycine receptor subunit alpha-1 GLRA1 0.073
4200 Cytochrome P450 1A2 CYP1A2 0.072
6030 Cytochrome P450 2B6 CYP2B6 0.0709
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0664
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0644
4119 Cytochrome P450 2D6 CYP2D6 0.0642
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0627
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0611
6016 Cytochrome P450 2C19 CYP2C19 0.0598
4757 Cytochrome P450 2C9 CYP2C9 0.059
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0522
587 Serum albumin ALB 0.049
6144 Solute carrier family 22 member 2 SLC22A2 0.0476
6145 Solute carrier family 22 member 1 SLC22A1 0.0465
5718 Cytochrome P450 2A6 CYP2A6 0.0442
4924 Cytochrome P450 2C8 CYP2C8 0.0416
1588 Multidrug resistance protein 1 ABCB1 0.0406
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0401
824 Sodium-dependent serotonin transporter SLC6A4 0.0335
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0335
274 Muscarinic acetylcholine receptor M5 CHRM5 0.033
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0322
789 Alpha-1D adrenergic receptor ADRA1D 0.032
492 Histamine H1 receptor HRH1 0.0317
540 Sodium-dependent noradrenaline transporter SLC6A2 0.031
502 5-hydroxytryptamine 2A receptor HTR2A 0.0296
4118 Cytochrome P450 3A5 CYP3A5 0.0294
556 Alpha-1A adrenergic receptor ADRA1A 0.0293
6024 Cytochrome P450 1A1 CYP1A1 0.0282
6107 Cytochrome P450 3A7 CYP3A7 0.0265
1618 High affinity nerve growth factor receptor NTRK1 0.0251
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0245
6432 Transporter snf 0.0226
465 Calmodulin CALM1 0.0203
6106 Cytochrome P450 2C18 CYP2C18 0.0184
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0182
6147 Solute carrier family 22 member 3 SLC22A3 0.0169
320 5-hydroxytryptamine 1A receptor HTR1A 0.0167
833 Organic cation/carnitine transporter 1 SLC22A4 0.0165
318 Alpha-2A adrenergic receptor ADRA2A 0.0161
467 Delta-type opioid receptor OPRD1 0.0147
696 Kappa-type opioid receptor OPRK1 0.0147
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.01
3811 Cytochrome P450 19A1 CYP19A1 0.01
20 Prostaglandin G/H synthase 1 PTGS1 0.0098
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0095
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0091
260 Cytochrome P450 51 ERG11 0.0089
761 Cytochrome P450 51 ERG11 0.0089
3163 Cytochrome P450 51 cyp51 0.0089
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0088
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0085
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.008
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0079
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0074
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0074
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0074
16 Adenosine A1 receptor ADORA1 0.007
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0068
1898 Cytochrome P450 1B1 CYP1B1 0.0066
290 Prostaglandin G/H synthase 2 PTGS2 0.0066
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0065
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0059
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0057
613 Atrial natriuretic peptide receptor A NPR1 0.0056
468 Cytochrome P450 4A11 CYP4A11 0.0052
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0051
831 D(2) dopamine receptor DRD2 0.0051
1178 Adenosine A2a receptor ADORA2A 0.0048
1729 Solute carrier family 22 member 6 SLC22A6 0.0048
3941 Amine oxidase [flavin-containing] A MAOA 0.0047
776 Bile salt export pump ABCB11 0.0047
862 Multidrug resistance-associated protein 1 ABCC1 0.0047
23 D(1A) dopamine receptor DRD1 0.0045
6031 Cytochrome P450 3A43 CYP3A43 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
444 Alcohol dehydrogenase 1B ADH1B 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0042
6102 Arylamine N-acetyltransferase 2 NAT2 0.0042
251 Alcohol dehydrogenase 1A ADH1A 0.0041
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0041
777 Tumor necrosis factor TNF 0.0041
341 5-hydroxytryptamine 3 receptor HTR3A 0.004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.004
3823 Cytokine receptor common gamma chain IL2RG 0.0039
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0038
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0038
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0037
1010 Cytochrome P450 51A1 CYP51A1 0.0036
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
3939 Amine oxidase [flavin-containing] B MAOB 0.0035
2164 Multidrug resistance-associated protein 4 ABCC4 0.0035
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
590 5-hydroxytryptamine 2C receptor HTR2C 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0034
811 Translocator protein TSPO 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0033
4116 Dihydropteroate synthetase Not Available 0.0033
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
517 Alcohol dehydrogenase 1C ADH1C 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
94 5-hydroxytryptamine 4 receptor HTR4 0.0031
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0031
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0031
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0031
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0031
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0031
136 Estrogen receptor ESR1 0.0031
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0031
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0031
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0031
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0029
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0029
3947 Xanthine dehydrogenase/oxidase XDH 0.0029
632 Alpha-1B adrenergic receptor ADRA1B 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
390 Adenosine A3 receptor ADORA3 0.0028
1757 Myeloperoxidase MPO 0.0028
3810 Catechol O-methyltransferase COMT 0.0028
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0027
3404 Exotoxin A eta 0.0027
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0027
4604 Liver carboxylesterase 1 CES1 0.0026
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0026
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0026
638 D(3) dopamine receptor DRD3 0.0026
6220 Aryl hydrocarbon receptor AHR 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
885 5-hydroxytryptamine 1B receptor HTR1B 0.0025
817 DNA topoisomerase 2-alpha TOP2A 0.0024
6126 Carbonic anhydrase 7 CA7 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0024
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
358 Cystathionine beta-synthase CBS 0.0023
6014 Cytochrome P450 2A13 CYP2A13 0.0023
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
118 Organic cation/carnitine transporter 2 SLC22A5 0.0021
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0021
3937 Fatty-acid amide hydrolase FAAH 0.0021
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0021
2298 Cytochrome P450-cam camC 0.002
518 Peroxidase/catalase T katG 0.002
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.002
80 Peroxisome proliferator-activated receptor alpha PPARA 0.002
592 Carbonic anhydrase 4 CA4 0.002
3917 Methylenetetrahydrofolate reductase MTHFR 0.002
921 Glutamate receptor 2 GRIA2 0.0019
904 Glutathione S-transferase P GSTP1 0.0019
3932 Glutathione S-transferase A2 GSTA2 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
563 Thyroid peroxidase TPO 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0019
713 Sodium-dependent dopamine transporter SLC6A3 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
295 Carbonic anhydrase 1 CA1 0.0019
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0019
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0018
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
908 Glutathione S-transferase theta-1 GSTT1 0.0017
1192 Sulfotransferase 1A1 SULT1A1 0.0017
823 Fibroblast growth factor receptor 2 FGFR2 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6141 Sodium/bile acid cotransporter SLC10A1 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
6148 Multidrug resistance-associated protein 7 ABCC10 0.0016
432 D(4) dopamine receptor DRD4 0.0016
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
3923 Cholinesterase BCHE 0.0016
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0016
378 Alpha-2C adrenergic receptor ADRA2C 0.0015
365 Dihydrofolate reductase DHFR 0.0015
2381 Dihydrofolate reductase DFR1 0.0015
2833 Dihydrofolate reductase Not Available 0.0015
2931 Dihydrofolate reductase folA 0.0015
3544 Dihydrofolate reductase folA 0.0015
3682 Dihydrofolate reductase folA 0.0015
6642 Dihydrofolate reductase folA 0.0015
6756 Dihydrofolate reductase dfrA 0.0015
725 5-hydroxytryptamine 1D receptor HTR1D 0.0015
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0015
122 P2Y purinoceptor 12 P2RY12 0.0015
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0015
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
6143 Solute carrier family 22 member 7 SLC22A7 0.0015
869 Estrogen receptor beta ESR2 0.0014
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0014
29 Tubulin beta-1 chain TUBB1 0.0014
6136 Multidrug resistance-associated protein 5 ABCC5 0.0014
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0014
161 Tubulin beta chain TUBB 0.0014
312 Tubulin beta chain TUB2 0.0014
1024 Solute carrier family 22 member 11 SLC22A11 0.0014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0013
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0013
976 Platelet glycoprotein IX GP9 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0013
373 Transthyretin TTR 0.0013
1256 5-hydroxytryptamine 6 receptor HTR6 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
3809 Estrogen-related receptor gamma ESRRG 0.0013
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
716 5-hydroxytryptamine 7 receptor HTR7 0.0012
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0012
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
6142 Solute carrier family 22 member 8 SLC22A8 0.0011
268 Adenosine A2b receptor ADORA2B 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
820 Glycine receptor subunit alpha-2 GLRA2 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.001
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
193 Beta-1 adrenergic receptor ADRB1 0.001
6131 Carbonic anhydrase 14 CA14 0.001
183 Vascular endothelial growth factor A VEGFA 0.001
766 Beta-2 adrenergic receptor ADRB2 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
997 Protein kinase C beta type PRKCB 0.0009
6122 Carbonic anhydrase 3 CA3 0.0009
847 Mu-type opioid receptor OPRM1 0.0009
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
1275 Estrogen sulfotransferase SULT1E1 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
7 Nitric oxide synthase, inducible NOS2 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
798 Osteocalcin BGLAP 0.0009
4192 DNA topoisomerase 2-beta TOP2B 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
3221 Cytochrome c4 cc4 0.0009
1050 Bile salt sulfotransferase SULT2A1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
3007 Carbonic anhydrase 12 CA12 0.0009
4205 Carbonic anhydrase 9 CA9 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0008
629 Alpha-2B adrenergic receptor ADRA2B 0.0008
4311 tRNA TRDMT1 0.0008
4325 tRNA trmD 0.0008
4328 tRNA trmD 0.0008
6459 Glycodelin PAEP 0.0008
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
1360 Sphingomyelin phosphodiesterase SMPD1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
369 Coagulation factor VII F7 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
896 Glutathione S-transferase Mu 1 GSTM1 0.0008
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0008
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0007
84 Nuclear receptor 0B1 NR0B1 0.0007
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0007
3957 Adenosine deaminase ADA 0.0007
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0007
2802 Endoglucanase G celCCG 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0007
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0007
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
6020 Aldehyde oxidase AOX1 0.0007
469 Annexin A1 ANXA1 0.0007
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0007
284 DNA-directed RNA polymerase beta chain rpoB 0.0007
5773 DNA-directed RNA polymerase beta chain rpoB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0007
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0006
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0006
2207 Rhodopsin RHO 0.0006
239 Coagulation factor X F10 0.0006
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0006
163 D(1B) dopamine receptor DRD5 0.0006
380 Cytochrome P450 17A1 CYP17A1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
124 Histamine H2 receptor HRH2 0.0006
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0005
2981 Phospholipase A2, membrane associated PLA2G2A 0.0005
164 Histamine H4 receptor HRH4 0.0005
275 Arachidonate 5-lipoxygenase ALOX5 0.0005
54 Prothrombin F2 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0005
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0004
528 5-hydroxytryptamine 1E receptor HTR1E 0.0004
871 Glucocorticoid receptor NR3C1 0.0004
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