DT-Web

DB04419 - Norleucine


Identification
Name Norleucine
Accession Number DB04419 (EXPT02355)
Type small molecule
Description An unnatural amino acid that is used experimentally to study protein structure and function. It is structurally similar to METHIONINE, however it does not contain SULFUR. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 131.1729
Groups experimental
Monoisotopic Weight 131.094628665
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Parathyroid hormone
Name Parathyroid hormone
Gene Name PTH
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.1158
Hepatocyte nuclear factor 1-alpha
Name Hepatocyte nuclear factor 1-alpha
Gene Name HNF1A
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Phenylalanine-4-hydroxylase
Name Phenylalanine-4-hydroxylase
Gene Name PAH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.05

Predictions


Id Partner name Gene Name Score
3109 Phenylalanine-4-hydroxylase phhA 1.05
676 Tyrosine 3-monooxygenase TH 0.0797
7 Nitric oxide synthase, inducible NOS2 0.0487
291 Nitric-oxide synthase, endothelial NOS3 0.0481
2675 Pteridine reductase 1 PTR1 0.035
134 Tryptophan 5-hydroxylase 1 TPH1 0.0336
76 Nitric-oxide synthase, brain NOS1 0.0299
2360 Dihydroneopterin aldolase folB 0.0293
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0251
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0251
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0251
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0251
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0251
789 Alpha-1D adrenergic receptor ADRA1D 0.0203
6151 Monocarboxylate transporter 10 SLC16A10 0.0196
629 Alpha-2B adrenergic receptor ADRA2B 0.0191
193 Beta-1 adrenergic receptor ADRB1 0.0188
766 Beta-2 adrenergic receptor ADRB2 0.0183
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.018
1517 Beta-3 adrenergic receptor ADRB3 0.018
632 Alpha-1B adrenergic receptor ADRA1B 0.0179
763 Tyrosine aminotransferase TAT 0.0178
5493 Tyrosine aminotransferase Not Available 0.0178
318 Alpha-2A adrenergic receptor ADRA2A 0.017
290 Prostaglandin G/H synthase 2 PTGS2 0.0159
556 Alpha-1A adrenergic receptor ADRA1A 0.0159
378 Alpha-2C adrenergic receptor ADRA2C 0.0129
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0119
118 Organic cation/carnitine transporter 2 SLC22A5 0.0106
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0103
6144 Solute carrier family 22 member 2 SLC22A2 0.0102
6145 Solute carrier family 22 member 1 SLC22A1 0.01
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0096
4200 Cytochrome P450 1A2 CYP1A2 0.0078
6147 Solute carrier family 22 member 3 SLC22A3 0.0053
4757 Cytochrome P450 2C9 CYP2C9 0.0042
4512 Cytochrome P450 3A4 CYP3A4 0.0037
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