DT-Web

DB04392 - Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]


Identification
Name Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]
Accession Number DB04392 (EXPT01281)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 336.295
Groups experimental
Monoisotopic Weight 336.063388116
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Oxygen-insensitive NAD(P)H nitroreductase
Name Oxygen-insensitive NAD(P)H nitroreductase
Gene Name nfnB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2331
NAD(P)H dehydrogenase [quinone] 1
Name NAD(P)H dehydrogenase [quinone] 1
Gene Name NQO1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9523
FMN-dependent NADH-azoreductase
Name FMN-dependent NADH-azoreductase
Gene Name azoR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5219

Predictions


Id Partner name Gene Name Score
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 1.2331
5169 FMN-dependent NADH-azoreductase azoR 0.5219
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.1136
904 Glutathione S-transferase P GSTP1 0.0544
2159 Quinone oxidoreductase CRYZ 0.0297
5201 FMN-binding protein DvMF_2023 0.0262
5178 Protein nrdI nrdI 0.0262
3293 Flavodoxin Not Available 0.0262
4614 Flavodoxin DVU_2680 0.0262
5172 Flavodoxin isiB 0.0262
5173 Flavodoxin isiB 0.0262
5182 Flavodoxin fldA 0.0262
5179 Probable aromatic acid decarboxylase pad1 0.0262
5200 NADH dehydrogenase nox 0.0262
5202 Nitroreductase family protein BC_1844 0.0262
5193 Phenazine biosynthesis protein phzG phzG 0.0262
5131 PhzG phzG 0.0262
5198 Flavodoxin-1 fldA 0.0262
5170 Epidermin decarboxylase epiD 0.0262
4405 Nitric oxide reductase fprA 0.0261
5181 Hypothetical protein yhdA azr 0.0261
4037 Hypothetical protein GPX1 0.0261
4297 Hypothetical protein SP_1951 0.0261
4521 Hypothetical protein BC_2969 0.0261
4540 Hypothetical protein TM_1070 0.0261
4555 Hypothetical protein MT1739 0.0261
4569 Hypothetical protein mshD 0.0261
4578 Hypothetical protein PA3270 0.0261
4747 Hypothetical protein PA3967 0.0261
5177 Hypothetical protein TM_0096 0.0261
5194 Hypothetical protein PA1204 0.0261
5240 Hypothetical protein Rv2991 0.0261
5370 Hypothetical protein TM_1158 0.0261
5710 Hypothetical protein Tb927.5.1360 0.0261
5175 Hypothetical protein SMU.260 SMU_260 0.0261
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0261
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0261
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0261
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0261
5191 Morphinone reductase morB 0.0261
5190 Rubredoxin-oxygen oxidoreductase roo 0.0261
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0252
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0246
4503 NADPH-flavin oxidoreductase frp 0.0228
3680 Dihydroorotate dehydrogenase A pyrDA 0.0228
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0228
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0228
3507 Chorismate synthase aroC 0.0227
5171 Chorismate synthase aroC 0.0227
5176 YtnJ moxC 0.0227
5189 Trimethylamine dehydrogenase tmd 0.0227
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0227
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0212
2775 Dihydroorotate dehydrogenase pyrD 0.021
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.021
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0206
5180 L(+)-mandelate dehydrogenase mdlB 0.0198
408 Riboflavin kinase RFK 0.0193
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0186
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0184
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0184
203 Pyridoxine-5'-phosphate oxidase PNPO 0.018
4284 Pentaerythritol tetranitrate reductase onr 0.0177
76 Nitric-oxide synthase, brain NOS1 0.0172
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0166
6268 Hydroxyacid oxidase 1 HAO1 0.0165
6163 Copper-transporting ATPase 2 ATP7B 0.0164
6165 Copper-transporting ATPase 1 ATP7A 0.0164
654 Flavin reductase BLVRB 0.0162
4120 NADPH--cytochrome P450 reductase POR 0.0157
6146 High affinity copper uptake protein 1 SLC31A1 0.0154
3947 Xanthine dehydrogenase/oxidase XDH 0.0147
908 Glutathione S-transferase theta-1 GSTT1 0.0146
896 Glutathione S-transferase Mu 1 GSTM1 0.0144
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0133
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0121
1757 Myeloperoxidase MPO 0.012
4757 Cytochrome P450 2C9 CYP2C9 0.0115
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0109
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0108
400 Coagulation factor IX F9 0.0068
5461 Coagulation factor IX F9 0.0068
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0064
604 Vitamin K-dependent protein Z PROZ 0.0064
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0064
5591 Complement component C8 gamma chain C8G 0.0064
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0064
5582 Regulator of transcription; stringent starvation protein A sspA 0.0064
2838 Ribose-5-phosphate isomerase A rpiA 0.0064
2952 Ribose-5-phosphate isomerase A rpiA 0.0064
5595 Ribose-5-phosphate isomerase A rpiA 0.0064
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0064
4238 50S ribosomal protein L4 rplD 0.0064
5578 50S ribosomal protein L4 rplD 0.0064
6173 50S ribosomal protein L4 rplD 0.0064
6219 50S ribosomal protein L4 rplD 0.0064
4695 UPF0124 protein yfiH yfiH 0.0064
5590 N utilization substance protein B homolog nusB 0.0064
5588 Cell division protein FtsY TM_0570 0.0064
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0064
2300 Lysozyme E 0.0064
3633 Lysozyme R 0.0064
5597 Lysozyme 17 0.0064
5587 Iron(III)-binding periplasmic protein fbpA 0.0064
5593 Transferase Not Available 0.0064
5581 Beta-fructosidase bfrA 0.0063
5060 Intron-associated endonuclease 1 ITEVIR 0.0063
5575 Short tail fiber protein 12 0.0063
5600 Pyruvate decarboxylase pdc 0.0063
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0063
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0063
4375 Glutamine synthetase 1 glnA1 0.0063
5580 Hexon protein PII 0.0063
5574 Invasin YPTB1668 0.0063
4076 Diacylglycerol kinase alpha DGKA 0.0063
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0063
375 SEC14-like protein 3 SEC14L3 0.0063
86 SEC14-like protein 4 SEC14L4 0.0063
708 Alpha-tocopherol transfer protein TTPA 0.0063
283 SEC14-like protein 2 SEC14L2 0.0062
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.006
997 Protein kinase C beta type PRKCB 0.006
6137 Multidrug resistance-associated protein 6 ABCC6 0.0059
1245 Vitamin K-dependent protein S PROS1 0.0057
422 Vitamin K-dependent protein C PROC 0.0057
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0055
5006 RNASE4 protein RNASE4 0.0055
4533 Glyoxalase family protein BC_1747 0.0055
3132 Tryptophan synthase alpha chain trpA 0.0055
6568 Tryptophan synthase alpha chain trpA 0.0055
4992 Cytochrome c peroxidase Not Available 0.0055
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0055
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0055
3729 Citrate synthase gltA 0.0055
4575 Citrate synthase cit 0.0055
4580 Citrate synthase gltA 0.0055
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0055
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0055
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0055
5328 Prostaglandin F synthase Tb11.02.2310 0.0055
2555 Pol polyprotein pol 0.0055
3242 Pol polyprotein gag-pol 0.0055
3471 Pol polyprotein gag-pro-pol 0.0055
5256 Pol polyprotein pol 0.0055
6469 Pol polyprotein gag-pol 0.0055
6565 Pol polyprotein Not Available 0.0055
1898 Cytochrome P450 1B1 CYP1B1 0.0055
1970 Protein kinase C alpha type PRKCA 0.0054
905 Glutathione transferase omega-1 GSTO1 0.0053
899 Glutathione S-transferase Mu 3 GSTM3 0.0053
798 Osteocalcin BGLAP 0.0052
6144 Solute carrier family 22 member 2 SLC22A2 0.0052
2603 Beta-lactamase II blm 0.0051
2149 Angiogenin ANG 0.0051
3583 6-phosphogluconolactonase pgl 0.0051
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0051
6024 Cytochrome P450 1A1 CYP1A1 0.0051
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0051
2521 Cell division protein ftsZ ftsZ 0.0051
3301 Cell division protein ftsZ ftsZ 0.0051
448 Vitamin K-dependent gamma-carboxylase GGCX 0.005
810 Heme oxygenase 1 HMOX1 0.005
3391 Heme oxygenase 1 pbsA1 0.005
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.005
6013 Cytochrome P450 2E1 CYP2E1 0.0049
3486 Fumarate hydratase class II fumC 0.0048
2942 Sialidase nanH 0.0048
3546 Sialidase nedA 0.0048
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0048
2286 Isocitrate dehydrogenase [NADP] icd 0.0048
2302 Isocitrate dehydrogenase [NADP] icd 0.0048
2771 Isocitrate dehydrogenase [NADP] icd 0.0048
369 Coagulation factor VII F7 0.0048
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0048
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0046
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0045
857 Malate dehydrogenase, mitochondrial MDH2 0.0045
1123 Eosinophil cationic protein RNASE3 0.0045
332 Beta-lactamase blaZ 0.0044
2478 Beta-lactamase ampC 0.0044
2613 Beta-lactamase ampC 0.0044
2635 Beta-lactamase ampC 0.0044
2700 Beta-lactamase penP 0.0044
5445 Beta-lactamase blaB 0.0044
6019 Beta-lactamase SHV-7 0.0044
6701 Beta-lactamase cphA 0.0044
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0044
2697 Uridine-cytidine kinase 2 UCK2 0.0044
2452 Tryptophanyl-tRNA synthetase trpS 0.0044
4200 Cytochrome P450 1A2 CYP1A2 0.0043
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0042
5579 Carboxypeptidase B CPB1 0.0042
3384 Macrophage migration inhibitory factor MIF 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.0041
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0041
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0041
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0039
411 Glycine N-methyltransferase GNMT 0.0039
275 Arachidonate 5-lipoxygenase ALOX5 0.0038
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0038
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0038
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0038
6030 Cytochrome P450 2B6 CYP2B6 0.0038
6168 Solute carrier family 22 member 16 SLC22A16 0.0037
3917 Methylenetetrahydrofolate reductase MTHFR 0.0037
239 Coagulation factor X F10 0.0037
128 Adenine phosphoribosyltransferase APRT 0.0036
6020 Aldehyde oxidase AOX1 0.0035
6147 Solute carrier family 22 member 3 SLC22A3 0.0034
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0033
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0033
1588 Multidrug resistance protein 1 ABCB1 0.0032
468 Cytochrome P450 4A11 CYP4A11 0.0032
5682 Ribonuclease pancreatic RNASE1 0.0032
822 Aldose reductase AKR1B1 0.0032
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0031
54 Prothrombin F2 0.0031
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.003
6136 Multidrug resistance-associated protein 5 ABCC5 0.0029
6145 Solute carrier family 22 member 1 SLC22A1 0.0028
7 Nitric oxide synthase, inducible NOS2 0.0027
291 Nitric-oxide synthase, endothelial NOS3 0.0026
5718 Cytochrome P450 2A6 CYP2A6 0.0026
6148 Multidrug resistance-associated protein 7 ABCC10 0.0025
3923 Cholinesterase BCHE 0.0024
817 DNA topoisomerase 2-alpha TOP2A 0.0024
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0024
290 Prostaglandin G/H synthase 2 PTGS2 0.0023
776 Bile salt export pump ABCB11 0.0022
862 Multidrug resistance-associated protein 1 ABCC1 0.002
5122 Mersacidin decarboxylase mrsD 0.0019
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0019
5095 Putidaredoxin reductase camA 0.0019
3763 5,10-methylenetetrahydrofolate reductase metF 0.0019
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0019
5094 5,10-methylenetetrahydrofolate reductase metF 0.0019
526 Thioredoxin reductase trxB 0.0019
3767 Thioredoxin reductase trxB 0.0019
5078 Amine oxidase, flavin-containing PSPTO1126 0.0019
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0019
5109 Outer membrane protein p64k or PM-6 m-6 0.0019
5115 FkbI fkbI 0.0019
5083 Cryptochrome DASH cry 0.0019
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0019
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0019
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0019
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0019
5081 L-aspartate oxidase nadB 0.0019
1410 Oxidoreductase HSD17B6 0.0019
4725 Oxidoreductase Not Available 0.0019
5124 Oxidoreductase Not Available 0.0019
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0019
3133 UDP-galactopyranose mutase glf 0.0019
5099 UDP-galactopyranose mutase glf 0.0019
5111 Phenylacetone monooxygenase pamO 0.0019
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0019
4486 Phenol 2-hydroxylase component B pheA2 0.0018
4477 Dihydrolipoyl dehydrogenase lpdV 0.0018
5077 Dihydrolipoyl dehydrogenase Not Available 0.0018
5117 Dihydrolipoyl dehydrogenase lpd 0.0018
4439 Ferredoxin reductase bphA4 0.0018
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0017
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0017
2268 Cholesterol oxidase choB 0.0017
2822 Cholesterol oxidase choA 0.0017
5072 N,N-dimethylglycine oxidase dmg 0.0017
5073 Ferredoxin--NADP reductase petH 0.0017
5076 Ferredoxin--NADP reductase fpr 0.0017
5119 Ferredoxin--NADP reductase petH 0.0017
5121 Ferredoxin--NADP reductase fpr 0.0017
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0017
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0017
3594 Deoxyribodipyrimidine photo-lyase phr 0.0017
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0017
5080 Deoxyribodipyrimidine photo-lyase phr 0.0017
2526 NADPH-ferredoxin reductase fprA fprA 0.0017
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0017
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0017
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0017
2470 Pyruvate oxidase pox5 0.0017
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0017
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0017
3102 Flavohemoprotein hmp 0.0016
4969 Flavohemoprotein hmp 0.0016
4440 NADH peroxidase npr 0.0016
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0015
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0015
2893 Glycine oxidase thiO 0.0015
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0015
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0015
327 Glutathione reductase gor 0.0015
5110 Glutathione reductase GR2 0.0015
126 D-lactate dehydrogenase dld 0.0015
3545 D-lactate dehydrogenase Not Available 0.0015
4510 D-lactate dehydrogenase ldhA 0.0015
2567 Thymidylate synthase thyX thyX 0.0015
2823 Trypanothione reductase TPR 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0014
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0014
3673 Fumarate reductase flavoprotein subunit fccA 0.0014
4912 Fumarate reductase flavoprotein subunit ifcA 0.0014
6549 Fumarate reductase flavoprotein subunit frdA 0.0014
4119 Cytochrome P450 2D6 CYP2D6 0.0014
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0014
2769 P-hydroxybenzoate hydroxylase pobA 0.0014
2809 P-hydroxybenzoate hydroxylase pobA 0.0014
2380 Monomeric sarcosine oxidase soxA 0.0013
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0013
4512 Cytochrome P450 3A4 CYP3A4 0.0013
6645 D-amino-acid oxidase DAO 0.0013
714 Glutathione reductase, mitochondrial GSR 0.0011
3939 Amine oxidase [flavin-containing] B MAOB 0.0008
3941 Amine oxidase [flavin-containing] A MAOA 0.0008
↑