DT-Web

DB03760 - Dihydrolipoic Acid


Identification
Name Dihydrolipoic Acid
Accession Number DB03760 (EXPT02769)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 208.341
Groups experimental
Monoisotopic Weight 208.059171136
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Aminomethyltransferase
Name Aminomethyltransferase
Gene Name gcvT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9331
Glycine cleavage system H protein, mitochondrial
Name Glycine cleavage system H protein, mitochondrial
Gene Name GCSH
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2056
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Name Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Gene Name DLAT
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8462
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
Name [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
Gene Name PDK3
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0386

Predictions


Id Partner name Gene Name Score
6840 Virulence sensor histidine kinase phoQ phoQ 0.3187
2091 Endoplasmin HSP90B1 0.2029
3193 Serine hydroxymethyltransferase glyA 0.1956
3342 Serine hydroxymethyltransferase glyA 0.1956
3456 Heat shock protein HSP 90-beta HSP90AB1 0.1917
3257 Bifunctional polymyxin resistance protein arnA arnA 0.1702
5072 N,N-dimethylglycine oxidase dmg 0.1702
914 Formimidoyltransferase-cyclodeaminase FTCD 0.1155
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0159
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0158
4057 Glycine N-acyltransferase GLYAT 0.0158
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0158
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0158
4061 Peroxisomal sarcosine oxidase PIPOX 0.0158
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0158
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0158
4056 N-arachidonyl glycine receptor GPR18 0.0158
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0158
1466 Glycyl-tRNA synthetase GARS 0.0158
383 Glycine amidinotransferase, mitochondrial GATM 0.0123
411 Glycine N-methyltransferase GNMT 0.0123
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0121
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0121
62 Glycine receptor subunit beta GLRB 0.0121
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0121
207 Glutathione synthetase GSS 0.0116
5269 Glutathione synthetase gshB 0.0116
593 Proton-coupled amino acid transporter 1 SLC36A1 0.011
349 Serine--pyruvate aminotransferase AGXT 0.0109
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0108
3879 Serine hydroxymethyltransferase 2 Not Available 0.0108
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0108
3884 SHMT2 protein SHMT2 0.0108
3901 SHMT2 protein SHMT2 0.0108
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0107
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0104
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0102
820 Glycine receptor subunit alpha-2 GLRA2 0.0098
461 Glycine receptor subunit alpha-3 GLRA3 0.0098
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0096
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0087
482 Glycine receptor subunit alpha-1 GLRA1 0.0085
6151 Monocarboxylate transporter 10 SLC16A10 0.0076
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0036
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0036
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0036
816 Biliverdin reductase A BLVRA 0.0036
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0035
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0035
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0035
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0035
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0035
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0035
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0035
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0035
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0035
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0035
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0035
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0035
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0035
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0035
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0035
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0035
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0035
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0035
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0035
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0035
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0035
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0035
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0035
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0035
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0035
644 Heme oxygenase 2 HMOX2 0.0035
4982 Heme oxygenase 2 pbsA2 0.0035
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0035
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0035
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0035
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0035
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0035
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0035
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0035
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0035
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0035
107 C-4 methylsterol oxidase SC4MOL 0.0035
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0035
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0035
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0035
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0035
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0035
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0035
167 L-lactate dehydrogenase C chain LDHC 0.0035
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0035
206 3-keto-steroid reductase HSD17B7 0.0035
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0035
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0035
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0035
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0035
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0035
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0035
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0035
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0035
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0035
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0035
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0035
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0035
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0035
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0035
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0035
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0035
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0035
34 7-dehydrocholesterol reductase DHCR7 0.0035
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0035
711 UDP-glucose 6-dehydrogenase UGDH 0.0035
3672 UDP-glucose 6-dehydrogenase hasB 0.0035
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0035
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0035
3726 D-3-phosphoglycerate dehydrogenase serA 0.0035
4291 D-3-phosphoglycerate dehydrogenase serA 0.0035
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0035
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0035
729 GDP-L-fucose synthetase TSTA3 0.0035
3463 GDP-L-fucose synthetase fcl 0.0035
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0035
643 Peroxisomal bifunctional enzyme EHHADH 0.0035
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0035
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0035
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0035
666 NADP-dependent malic enzyme ME1 0.0035
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0034
646 Malate dehydrogenase, cytoplasmic MDH1 0.0034
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0034
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0034
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0034
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0034
328 Sorbitol dehydrogenase SORD 0.0033
597 Dihydropteridine reductase QDPR 0.0033
857 Malate dehydrogenase, mitochondrial MDH2 0.0033
396 Alcohol dehydrogenase 4 ADH4 0.0033
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0033
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0033
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0032
77 L-lactate dehydrogenase B chain LDHB 0.0031
12 Alcohol dehydrogenase class 3 ADH5 0.0031
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0031
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0031
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0031
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.003
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.003
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0029
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0029
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0029
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0029
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0029
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0029
13 Aminomethyltransferase, mitochondrial AMT 0.0029
6026 Alcohol dehydrogenase 6 ADH6 0.0028
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0028
626 Cysteine dioxygenase type 1 CDO1 0.0028
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0028
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0028
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0028
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0028
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0028
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0028
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0028
627 11-cis retinol dehydrogenase RDH5 0.0028
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0028
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0027
654 Flavin reductase BLVRB 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
569 Retinal dehydrogenase 2 ALDH1A2 0.0027
611 Retinal dehydrogenase 1 ALDH1A1 0.0026
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0026
251 Alcohol dehydrogenase 1A ADH1A 0.0026
810 Heme oxygenase 1 HMOX1 0.0025
3391 Heme oxygenase 1 pbsA1 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0025
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0025
444 Alcohol dehydrogenase 1B ADH1B 0.0025
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0024
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0024
279 Tyrosinase TYR 0.0024
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0024
714 Glutathione reductase, mitochondrial GSR 0.0023
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0023
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0023
380 Cytochrome P450 17A1 CYP17A1 0.0023
517 Alcohol dehydrogenase 1C ADH1C 0.0022
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0022
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0021
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0021
822 Aldose reductase AKR1B1 0.0021
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
468 Cytochrome P450 4A11 CYP4A11 0.0019
6020 Aldehyde oxidase AOX1 0.0018
3947 Xanthine dehydrogenase/oxidase XDH 0.0017
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