| Name |
Virulence sensor histidine kinase phoQ |
| Synonyms |
9087 |
| Gene name |
phoQ |
| General function |
Signal transduction mechanisms |
| Specific function |
Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence, adaptation to low Mg(2+) environments and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to phoP, which results in the expression of phoP-activated genes (PAG) and repression of phoP-repressed genes (PRG). In presence of high periplasmic Mg(2+) concentrations, acts as a protein phosphatase that dephosphorylates phospho-phoP, which results in the repression of phoP-activated genes and may lead to expression of some phoP- repressed genes. Promotes intramacrophage survival of S.typhimurium. Is essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system ssrB/spiR at transcriptional and post- transcriptional levels respectively. Promotes expression of the two-component regulatory system pmrA/pmrB via activation of pmrD gene. Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells. Also, negatively regulates prgH, which is required for invasion of epithelial cells |
| Gene sequence |
+ ...
ATGATGCGCGTACTGGTTGTAGAGGATAATGCATTATTACGCCACCACCTGAAGGTTCAGCTCCAGGATTCAGGTCACCAGGTCGATGCCGCAGAAGATGCCAGGGAAGCTGATTACTACCTTAATGAACACCTTCCGGATATCGCTATTGTCGATTTAGGTCTGCCGGATGAAGACGGCCTTTCCTTAATACGCCGCTGGCGCAGCAGTGATGTTTCACTGCCGGTTCTGGTGTTAACCGCGCGCGAAGGCTGGCAGGATAAAGTCGAGGTTCTCAGCTCCGGGGCCGATGACTACGTGACGAAGCCATTCCACATCGAAGAGGTAATGGCGCGTATGCAGGCGTTAATGCGCCGTAATAGCGGTCTGGCCTCCCAGGTGATCAACATCCCGCCGTTCCAGGTGGATCTCTCACGCCGGGAATTATCCGTCAATGAAGAGGTCATCAAACTCACGGCGTTCGAATACACCATTATGGAAACGCTTATCCGTAACAACGGTAAAGTGGTCAGCAAAGATTCGCTGATGCTTCAGCTGTATCCGGATGCGGAACTGCGGGAAAGTCATACCATTGATGTTCTCATGGGGCGTCTGCGGAAAAAAATACAGGCCCAGTATCCGCACGATGTCATTACCACCGTACGCGGACAAGGATATCTTTTTGAATTGCGCTAA
|
| Protein sequence |
+ ...
MNKFARHFLPLSLRVRFLLATAGVVLVLSLAYGIVALVGYSVSFDKTTFRLLRGESNLFYTLAKWENNKISVELPENLDMQSPTMTLIYDETGKLLWTQRNIPWLIKSIQPEWLKTNGFHEIETNVDATSTLLSEDHSAQEKLKEVREDDDDAEMTHSVAVNIYPATARMPQLTIVVVDTIPIELKRSYMVWSWFVYVLAANLLLVIPLLWIAAWWSLRPIEALAREVRELEDHHREMLNPETTRELTSLVRNLNQLLKSERERYNKYRTTLTDLTHSLKTPLAVLQSTLRSLRNEKMSVSKAEPVMLEQISRISQQIGYYLHRASMRGSGVLLSRELHPVAPLLDNLISALNKVYQRKGVNISMDISPEISFVGEQNDFVEVMGNVLDNACKYCLEFVEISARQTDDHLHIFVEDDGPGIPHSKRSLVFDRGQRADTLRPGQGVGLAVAREITEQYAGQIIASDSLLGGARMEVVFGRQHPTQKEE
|
| GO Classification |
| component |
| cell |
| membrane |
| function |
| protein kinase activity |
| purine nucleotide binding |
| adenyl nucleotide binding |
| protein histidine kinase activity |
| transferase activity |
| two-component sensor molecule activity |
| binding |
| nucleotide binding |
| signal transducer activity |
| catalytic activity |
| ATP binding |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| process |
| protein modification |
| protein amino acid phosphorylation |
| phosphorus metabolism |
| physiological process |
| phosphate metabolism |
| phosphorylation |
| cellular process |
| metabolism |
| cell communication |
| cellular metabolism |
| signal transduction |
| macromolecule metabolism |
| biopolymer metabolism |
| biopolymer modification |
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