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DB02746 - Phthalic Acid


Identification
Name Phthalic Acid
Accession Number DB02746 (EXPT02595)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 166.1308
Groups experimental
Monoisotopic Weight 166.02660868
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Name Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Gene Name nadC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0078

Transporters


Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions inhibitor
References
  • Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. - Pubmed
DTHybrid score 0.2825

Predictions


Id Partner name Gene Name Score
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.1465
738 Monocarboxylate transporter 1 SLC16A1 0.0395
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0265
6142 Solute carrier family 22 member 8 SLC22A8 0.0254
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0246
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0236
1588 Multidrug resistance protein 1 ABCB1 0.0224
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0205
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.019
4757 Cytochrome P450 2C9 CYP2C9 0.018
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0179
862 Multidrug resistance-associated protein 1 ABCC1 0.0175
672 Prostaglandin F2-alpha receptor PTGFR 0.0171
4512 Cytochrome P450 3A4 CYP3A4 0.0164
6599 HTH-type transcriptional regulator ttgR ttgR 0.0163
4924 Cytochrome P450 2C8 CYP2C8 0.0148
1729 Solute carrier family 22 member 6 SLC22A6 0.0138
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0136
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0136
2164 Multidrug resistance-associated protein 4 ABCC4 0.0135
6145 Solute carrier family 22 member 1 SLC22A1 0.0131
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.013
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0128
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0128
1024 Solute carrier family 22 member 11 SLC22A11 0.0127
500 Monocarboxylate transporter 4 SLC16A3 0.0111
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.011
587 Serum albumin ALB 0.0105
6136 Multidrug resistance-associated protein 5 ABCC5 0.0103
776 Bile salt export pump ABCB11 0.0103
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0101
6167 Organic solute transporter subunit beta OSTB 0.0101
6166 Organic solute transporter subunit alpha OSTA 0.0101
5650 NimA-related protein DR_0842 0.0098
6016 Cytochrome P450 2C19 CYP2C19 0.0098
4119 Cytochrome P450 2D6 CYP2D6 0.009
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0088
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0088
4118 Cytochrome P450 3A5 CYP3A5 0.0088
489 Monocarboxylate transporter 2 SLC16A7 0.0085
6143 Solute carrier family 22 member 7 SLC22A7 0.0083
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0081
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0079
860 Nicotinamide N-methyltransferase NNMT 0.0078
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0078
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
699 Nicotinic acid receptor 1 GPR109A 0.0078
928 Nicotinic acid receptor 2 GPR109B 0.0078
1792 Tissue-type plasminogen activator PLAT 0.0077
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0076
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0073
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0073
20 Prostaglandin G/H synthase 1 PTGS1 0.0069
6149 Solute carrier family 22 member 10 SLC22A10 0.0066
320 5-hydroxytryptamine 1A receptor HTR1A 0.0064
4200 Cytochrome P450 1A2 CYP1A2 0.0063
118 Organic cation/carnitine transporter 2 SLC22A5 0.0063
318 Alpha-2A adrenergic receptor ADRA2A 0.0062
6141 Sodium/bile acid cotransporter SLC10A1 0.0062
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0061
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.006
556 Alpha-1A adrenergic receptor ADRA1A 0.0058
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0056
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0056
6030 Cytochrome P450 2B6 CYP2B6 0.0054
275 Arachidonate 5-lipoxygenase ALOX5 0.0053
527 Prostacyclin receptor PTGIR 0.0052
33 Cystine/glutamate transporter SLC7A11 0.0051
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.005
5718 Cytochrome P450 2A6 CYP2A6 0.0048
3014 Ribonuclease UK114 HRSP12 0.0046
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0046
5428 Replication protein repA 0.0046
3617 Non-heme chloroperoxidase cpo 0.0046
5426 Non-heme chloroperoxidase cpo 0.0046
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0046
3018 HTH-type transcriptional regulator malT malT 0.0046
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0045
136 Estrogen receptor ESR1 0.0045
6151 Monocarboxylate transporter 10 SLC16A10 0.0044
6024 Cytochrome P450 1A1 CYP1A1 0.0043
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0043
468 Cytochrome P450 4A11 CYP4A11 0.0042
6837 Serine/threonine-protein kinase 17B STK17B 0.0042
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0042
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0042
492 Histamine H1 receptor HRH1 0.0041
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0041
2958 Probable tautomerase ydcE pptA 0.004
2573 Cocaine esterase cocE 0.004
7263 Cocaine esterase Not Available 0.004
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0039
3115 Ras-related protein Rab-9 RAB9A 0.0039
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0039
6085 Fatty acid-binding protein, intestinal FABP2 0.0038
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0038
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0038
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0037
290 Prostaglandin G/H synthase 2 PTGS2 0.0036
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0034
1898 Cytochrome P450 1B1 CYP1B1 0.0033
6106 Cytochrome P450 2C18 CYP2C18 0.0032
833 Organic cation/carnitine transporter 1 SLC22A4 0.0032
2599 Tyrosine-protein kinase HCK HCK 0.0032
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0031
2021 Thrombomodulin THBD 0.0031
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.003
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.003
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.003
2693 Heat-labile enterotoxin B chain eltB 0.003
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.003
6107 Cytochrome P450 3A7 CYP3A7 0.003
6645 D-amino-acid oxidase DAO 0.0029
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0029
6148 Multidrug resistance-associated protein 7 ABCC10 0.0028
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0027
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0027
6013 Cytochrome P450 2E1 CYP2E1 0.0026
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0025
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0025
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0025
3587 Gastrotropin FABP6 0.0025
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0024
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0023
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0023
6144 Solute carrier family 22 member 2 SLC22A2 0.0023
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0023
6220 Aryl hydrocarbon receptor AHR 0.0023
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0021
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0021
273 Apoptosis regulator Bcl-2 BCL2 0.0021
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.002
284 DNA-directed RNA polymerase beta chain rpoB 0.002
5773 DNA-directed RNA polymerase beta chain rpoB 0.002
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0018
3810 Catechol O-methyltransferase COMT 0.0017
952 Dipeptidyl peptidase 4 DPP4 0.0016
6031 Cytochrome P450 3A43 CYP3A43 0.0016
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0014
756 Sex hormone-binding globulin SHBG 0.0014
3811 Cytochrome P450 19A1 CYP19A1 0.0014
869 Estrogen receptor beta ESR2 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
2300 Lysozyme E 0.0012
3633 Lysozyme R 0.0012
5597 Lysozyme 17 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
4238 50S ribosomal protein L4 rplD 0.0012
5578 50S ribosomal protein L4 rplD 0.0012
6173 50S ribosomal protein L4 rplD 0.0012
6219 50S ribosomal protein L4 rplD 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
6147 Solute carrier family 22 member 3 SLC22A3 0.0012
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5006 RNASE4 protein RNASE4 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
2149 Angiogenin ANG 0.001
3583 6-phosphogluconolactonase pgl 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
1123 Eosinophil cationic protein RNASE3 0.0009
332 Beta-lactamase blaZ 0.0009
2478 Beta-lactamase ampC 0.0009
2613 Beta-lactamase ampC 0.0009
2635 Beta-lactamase ampC 0.0009
2700 Beta-lactamase penP 0.0009
5445 Beta-lactamase blaB 0.0009
6019 Beta-lactamase SHV-7 0.0009
6701 Beta-lactamase cphA 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
2286 Isocitrate dehydrogenase [NADP] icd 0.0009
2302 Isocitrate dehydrogenase [NADP] icd 0.0009
2771 Isocitrate dehydrogenase [NADP] icd 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
5579 Carboxypeptidase B CPB1 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0008
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0007
5682 Ribonuclease pancreatic RNASE1 0.0006
822 Aldose reductase AKR1B1 0.0006
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