DT-Web

DB02262 - Orotic Acid


Identification
Name Orotic Acid
Accession Number DB02262 (EXPT02447)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 156.0963
Groups experimental
Monoisotopic Weight 156.017106626
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydroorotate dehydrogenase A
Name Dihydroorotate dehydrogenase A
Gene Name pyrDA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6155
Orotate phosphoribosyltransferase
Name Orotate phosphoribosyltransferase
Gene Name pyrE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6657
Dihydroorotate dehydrogenase, mitochondrial
Name Dihydroorotate dehydrogenase, mitochondrial
Gene Name DHODH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7031
Dihydroorotate dehydrogenase
Name Dihydroorotate dehydrogenase
Gene Name pyrD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5715
Dihydroorotase
Name Dihydroorotase
Gene Name pyrC
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.5188

Predictions


Id Partner name Gene Name Score
4271 Anthranilate phosphoribosyltransferase trpD 0.1556
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.1327
128 Adenine phosphoribosyltransferase APRT 0.1047
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0972
6532 Light-harvesting protein B-800/850 beta 1 chain B1 0.0419
3237 Beta-lactamase OXA-2 bla 0.0383
5201 FMN-binding protein DvMF_2023 0.0342
5178 Protein nrdI nrdI 0.0342
5198 Flavodoxin-1 fldA 0.0342
5181 Hypothetical protein yhdA azr 0.0342
5202 Nitroreductase family protein BC_1844 0.0342
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0342
5200 NADH dehydrogenase nox 0.0342
5175 Hypothetical protein SMU.260 SMU_260 0.0342
5131 PhzG phzG 0.0342
5179 Probable aromatic acid decarboxylase pad1 0.0342
3293 Flavodoxin Not Available 0.0342
4614 Flavodoxin DVU_2680 0.0342
5172 Flavodoxin isiB 0.0342
5173 Flavodoxin isiB 0.0342
5182 Flavodoxin fldA 0.0342
5193 Phenazine biosynthesis protein phzG phzG 0.0342
5170 Epidermin decarboxylase epiD 0.0342
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0342
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0342
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0342
5190 Rubredoxin-oxygen oxidoreductase roo 0.0342
4405 Nitric oxide reductase fprA 0.0342
5191 Morphinone reductase morB 0.0342
6765 3-ketoacyl-CoA thiolase fadA 0.0314
6530 Pancreatic lipase-related protein 2 PNLIPRP2 0.0313
6764 Fatty acid oxidation complex subunit alpha fadB 0.0313
4503 NADPH-flavin oxidoreductase frp 0.0298
4407 FMN-dependent NADH-azoreductase azoR 0.0298
5169 FMN-dependent NADH-azoreductase azoR 0.0298
5189 Trimethylamine dehydrogenase tmd 0.0298
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0298
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0298
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0298
3507 Chorismate synthase aroC 0.0298
5171 Chorismate synthase aroC 0.0298
5176 YtnJ moxC 0.0297
4819 Hydrolase Not Available 0.0296
5249 Hydrolase Not Available 0.0296
5436 Hydrolase Not Available 0.0296
3230 Non-ATP-dependent L-selective hydantoinase lhyD 0.0296
3168 Beta-lactamase OXA-1 bla 0.0296
3122 D-hydantoinase Not Available 0.0296
3145 D-hydantoinase hyuA 0.0296
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0274
2387 Ferripyoverdine receptor fpvA 0.0273
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0259
5180 L(+)-mandelate dehydrogenase mdlB 0.0259
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0259
3281 Isoaspartyl dipeptidase iadA 0.0258
3292 Alanine racemase, catabolic dadX 0.0257
4264 Alpha-L-fucosidase, putative TM_0306 0.0257
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0256
408 Riboflavin kinase RFK 0.0254
76 Nitric-oxide synthase, brain NOS1 0.0246
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0242
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.024
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.024
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0239
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0239
3259 Autolysin lytA 0.0238
2801 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase murE 0.0237
2983 Methylmalonyl-CoA carboxyltransferase 5S subunit Not Available 0.0237
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0236
4284 Pentaerythritol tetranitrate reductase onr 0.0232
4549 Endonuclease III HP_0602 0.0224
6268 Hydroxyacid oxidase 1 HAO1 0.0216
2717 Folylpolyglutamate synthase fgs 0.0214
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0214
1227 Cytochrome b MT-CYB 0.0214
6386 Cytochrome b petB 0.0214
6937 Cytochrome b MT-CYB 0.0214
654 Flavin reductase BLVRB 0.0213
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0205
2340 Beta-lactamase PSE-2 bla 0.0202
2796 Parathion hydrolase opd 0.02
6539 Parathion hydrolase opd 0.02
894 Alanine racemase alr 0.0195
2453 Alanine racemase alr 0.0195
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0191
2427 Ferrichrome-iron receptor fhuA 0.0176
4120 NADPH--cytochrome P450 reductase POR 0.0152
4514 Citrate lyase beta subunit-like protein citE 0.0144
4781 Citrate lyase beta subunit-like protein DR_1240 0.0144
4037 Hypothetical protein GPX1 0.0144
4297 Hypothetical protein SP_1951 0.0144
4521 Hypothetical protein BC_2969 0.0144
4540 Hypothetical protein TM_1070 0.0144
4555 Hypothetical protein MT1739 0.0144
4569 Hypothetical protein mshD 0.0144
4578 Hypothetical protein PA3270 0.0144
4747 Hypothetical protein PA3967 0.0144
5177 Hypothetical protein TM_0096 0.0144
5194 Hypothetical protein PA1204 0.0144
5240 Hypothetical protein Rv2991 0.0144
5370 Hypothetical protein TM_1158 0.0144
5710 Hypothetical protein Tb927.5.1360 0.0144
4106 Guanylate kinase GUK1 0.0144
4516 Guanylate kinase gmk 0.0144
4527 Putative hydrolase ycdX ycdX 0.0144
2501 Protein ygbM ygbM 0.0144
4545 Molybdopterin-converting factor subunit 2 moaE 0.0144
4524 Mannose-6-phosphate isomerase yvyI 0.0144
4522 Arginine N-succinyltransferase subunit alpha astA 0.0144
4538 Hypothetical protein VC1899 VC_1899 0.0144
4529 Oxalate decarboxylase oxdC oxdC 0.0144
4546 Aminotransferase, putative TM_1131 0.0144
4536 Transcriptional regulator, IclR family TM_0065 0.0144
658 Para-aminobenzoate synthase component 1 pabB 0.0144
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0144
4547 Iron binding protein FbpA fbpA 0.0144
4548 Gyrase B gyrB 0.0144
4515 Peripheral plasma membrane protein CASK CASK 0.0144
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0144
992 Protein tyrosine kinase 2 beta PTK2B 0.0135
3759 Glutathione S-transferase gst 0.0126
4541 Glutathione S-transferase GST 0.0126
4528 Phenazine biosynthesis protein PhzD phzD1 0.0126
4517 Probable butyrate kinase 2 buk2 0.0126
4533 Glyoxalase family protein BC_1747 0.0126
4542 Glutaminase 1 glsA1 0.0126
4544 Glutaminase 1 glsA1 0.0126
56 Delta-aminolevulinic acid dehydratase ALAD 0.0126
2356 Delta-aminolevulinic acid dehydratase hemB 0.0126
3613 Delta-aminolevulinic acid dehydratase hemB 0.0126
3674 Delta-aminolevulinic acid dehydratase hemB 0.0126
3261 Signal recognition particle protein ffh 0.0126
4496 C-terminal-binding protein 1 CTBP1 0.0126
2929 (S)-2-haloacid dehalogenase dhlB 0.0126
2995 (S)-2-haloacid dehalogenase Not Available 0.0126
4532 Gephyrin GPHN 0.0126
4757 Cytochrome P450 2C9 CYP2C9 0.0121
3583 6-phosphogluconolactonase pgl 0.0116
4531 Putative ketoacyl reductase actIII 0.0116
3467 Methylglyoxal synthase mgsA 0.0116
2230 Catalase CAT 0.0116
3249 Catalase katA 0.0116
3625 Catalase katA 0.0116
4539 Catalase katA 0.0116
4941 Catalase katB 0.0116
2240 Cell division protein kinase 2 CDK2 0.0111
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0109
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0109
6220 Aryl hydrocarbon receptor AHR 0.0109
2688 Peptide deformylase def 0.0105
2708 Peptide deformylase def 0.0105
3004 Peptide deformylase def 0.0105
4337 Peptide deformylase def 0.0105
4338 Peptide deformylase def 0.0105
5368 Peptide deformylase def 0.0105
5371 Peptide deformylase def 0.0105
6375 Peptide deformylase def 0.0105
6378 Peptide deformylase def 0.0105
6379 Peptide deformylase def 0.0105
6776 Peptide deformylase def 0.0105
6900 Peptide deformylase def 0.0105
4534 Cytohesin-2 CYTH2 0.0105
2548 Subtilisin Carlsberg apr 0.0101
760 Fibroblast growth factor 1 FGF1 0.0085
810 Heme oxygenase 1 HMOX1 0.0084
3391 Heme oxygenase 1 pbsA1 0.0084
3027 Streptavidin Not Available 0.0084
500 Monocarboxylate transporter 4 SLC16A3 0.0081
5682 Ribonuclease pancreatic RNASE1 0.0072
357 Carbonic anhydrase 2 CA2 0.0053
4200 Cytochrome P450 1A2 CYP1A2 0.005
6689 TraN protein traN 0.0026
6671 Ig heavy chain V-III region VH26 Not Available 0.0026
6680 Cofilin-1 CFL1 0.0026
6404 Rhomboid protease glpG glpG 0.0026
6797 Rhomboid protease glpG glpG 0.0026
6670 Ig kappa chain V-I region Bi Not Available 0.0026
4905 Cytochrome c2 Not Available 0.0026
4939 Cytochrome c2 cycA 0.0026
4964 Cytochrome c2 cycA 0.0026
4979 Cytochrome c2 cycA 0.0026
6673 Cytochrome c2 cycA 0.0026
6690 BenF-like porin PFL_1329 0.0026
3710 Acyl-CoA thioesterase 2 tesB 0.0026
6672 Destrin DSTN 0.0026
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0026
6559 Cytochrome c oxidase subunit 2 ctaC 0.0026
6669 Cytochrome c oxidase subunit 2 ctaC 0.0026
6688 TraF protein traF 0.0026
6679 Colicin-Ia cia 0.0026
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0026
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0026
6687 TraO protein traO 0.0026
6685 Outer membrane protein II porB 0.0026
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0026
6676 Fe(3+)-pyochelin receptor fptA 0.0026
115 Penicillin-binding protein 2 mrdA 0.0026
6069 Penicillin-binding protein 2 mrdA 0.0026
6118 Penicillin-binding protein 2 penA 0.0026
6187 Penicillin-binding protein 2 pbpA 0.0026
6686 Penicillin-binding protein 2 pbp2 0.0026
6939 Penicillin-binding protein 2 mrdA 0.0026
7163 Penicillin-binding protein 2 pbpA 0.0026
4760 Mll3241 protein mll3241 0.0023
3578 Protein crcA crcA 0.0023
6438 Outer membrane protein G ompG 0.0023
6474 Outer membrane protein W ompW 0.0023
2447 Ammonia channel amtB 0.0023
6675 Colicin-E3 ceaC 0.0023
2925 Long-chain fatty acid transport protein fadL 0.0023
6385 H subunit of photosynthetic reaction center complex puhA 0.0023
6480 Outer membrane usher protein papC papC 0.0023
3395 Iron(III) dicitrate transport protein fecA fecA 0.0023
6678 Colicin I receptor cirA 0.0023
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0021
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0021
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0021
6524 Protein tonB tonB 0.0021
2679 Vitamin B12 transporter btuB btuB 0.0021
6677 Myelin P2 protein PMP2 0.002
6354 Reaction center protein M chain pufM 0.0017
6455 Reaction center protein M chain pufM 0.0017
6684 Reaction center protein M chain pufM 0.0017
6352 Reaction center protein H chain puhA 0.0017
6456 Reaction center protein H chain puhA 0.0017
6682 Reaction center protein H chain puhA 0.0017
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0017
6353 Reaction center protein L chain pufL 0.0017
6454 Reaction center protein L chain pufL 0.0017
6683 Reaction center protein L chain pufL 0.0017
2828 Squalene--hopene cyclase shc 0.0016
2207 Rhodopsin RHO 0.0015
3939 Amine oxidase [flavin-containing] B MAOB 0.0011
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