DT-Web

DB02031 - (6s)-5,6,7,8-Tetrahydrofolate


Identification
Name (6s)-5,6,7,8-Tetrahydrofolate
Accession Number DB02031 (EXPT03050)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 445.4292
Groups experimental
Monoisotopic Weight 445.170981503
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nitric oxide synthase oxygenase
Name Nitric oxide synthase oxygenase
Gene Name nos
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5302
Thymidylate synthase
Name Thymidylate synthase
Gene Name thyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0254

Predictions


Id Partner name Gene Name Score
2701 Nitric oxide synthase oxygenase nos 0.5302
315 Arginase-1 ARG1 0.0905
76 Nitric-oxide synthase, brain NOS1 0.0757
7 Nitric oxide synthase, inducible NOS2 0.0687
291 Nitric-oxide synthase, endothelial NOS3 0.0682
3596 Deoxynucleotide monophosphate kinase 1 0.0625
2257 Uridine phosphorylase udp 0.0447
5132 Uridine phosphorylase udp 0.0447
2567 Thymidylate synthase thyX thyX 0.0409
3586 Thymidylate synthase A thyA1 0.036
2717 Folylpolyglutamate synthase fgs 0.0347
24 Thymidylate synthase TMP1 0.0254
359 Thymidylate synthase TYMS 0.0254
2729 Thymidylate synthase thyA 0.0254
5352 Thymidylate synthase THYA 0.0254
4680 Amicyanin mauC 0.0251
3747 Cellulase B precursor celB 0.0231
4681 Aminopeptidase Not Available 0.0231
6513 Urease subunit gamma ureA 0.0206
6512 Urease subunit beta ureB 0.0205
6511 Urease subunit alpha ureC 0.0205
6514 Probable rRNA methylase TTHA1387 0.0205
4272 POSSIBLE CELLULASE CELA1 celA1 0.0192
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0166
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0165
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0165
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0153
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0136
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0136
2555 Pol polyprotein pol 0.0125
3242 Pol polyprotein gag-pol 0.0125
3471 Pol polyprotein gag-pro-pol 0.0125
5256 Pol polyprotein pol 0.0125
6469 Pol polyprotein gag-pol 0.0125
6565 Pol polyprotein Not Available 0.0125
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0096
5694 Transcription antiterminator licT licT 0.0096
3361 Serpin B5 SERPINB5 0.0096
56 Delta-aminolevulinic acid dehydratase ALAD 0.0077
2356 Delta-aminolevulinic acid dehydratase hemB 0.0077
3613 Delta-aminolevulinic acid dehydratase hemB 0.0077
3674 Delta-aminolevulinic acid dehydratase hemB 0.0077
2286 Isocitrate dehydrogenase [NADP] icd 0.0073
2302 Isocitrate dehydrogenase [NADP] icd 0.0073
2771 Isocitrate dehydrogenase [NADP] icd 0.0073
4534 Cytohesin-2 CYTH2 0.0069
3668 Maltose-binding periplasmic protein precursor malE 0.0067
5669 50S ribosomal protein L27 rpmA 0.0065
5670 Organic hydroperoxide resistance protein ohr 0.0065
5675 Chaperone protein torD torD 0.0065
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0065
5410 Unsaturated glucuronyl hydrolase ugl 0.0065
5676 Axin-1 AXIN1 0.0065
5673 C protein alpha-antigen bca 0.0065
4984 Neuroglobin NGB 0.0062
4936 Cytochrome c2 iso-2 Not Available 0.0062
4925 Cytochrome c-type protein SHP shp 0.0062
5000 HemO hemO 0.0062
4975 Cytochrome c-556 RPA3973 0.0062
4943 Cytochrome c6 petJ 0.0062
3116 Bacterioferritin bfr 0.0062
4906 Bacterioferritin bfr 0.0062
4965 Bacterioferritin bfr 0.0062
4954 Soluble cytochrome b558 Not Available 0.0062
4934 Cytochrome c-551 nirM 0.0062
5218 Cytochrome c-551 nirM 0.0062
4905 Cytochrome c2 Not Available 0.0062
4939 Cytochrome c2 cycA 0.0062
4964 Cytochrome c2 cycA 0.0062
4979 Cytochrome c2 cycA 0.0062
6673 Cytochrome c2 cycA 0.0062
4910 Cytoglobin CYGB 0.0062
4916 Cyanoglobin glbN 0.0062
4994 Hemoglobin-like protein HbO glbO 0.0062
4915 Cytochrome c-550 psbV 0.0062
4959 Cytochrome c-550 psbV 0.0062
5216 Cytochrome c-550 psbV 0.0062
4998 Hemoglobin-like protein yjbI yjbI 0.0062
644 Heme oxygenase 2 HMOX2 0.0062
4982 Heme oxygenase 2 pbsA2 0.0062
4981 Iron-starvation protein PigA pigA 0.0062
4947 Bacterial hemoglobin vhb 0.0062
4942 Diheme cytochrome c napB napB 0.0062
4931 Cytochrome P450 167A1 CYP167A1 0.0062
4971 Nonaheme cytochrome c hmcA 0.0062
4989 Cytochrome c551 peroxidase ccp 0.0062
5222 Cytochrome c551 peroxidase ccpA 0.0062
4961 Hemophore HasA hasA 0.0062
4976 Apocytochrome f petA 0.0062
6407 Apocytochrome f petA 0.0062
4904 Cytochrome c family protein GSU1996 0.0062
4907 Cytochrome c-L moxG 0.0062
6865 Cytochrome c-L moxG 0.0062
4909 CooA protein cooA 0.0062
4999 Cytochrome P450 165B3 CYP165B3 0.0062
4972 P450cin cinA 0.0062
4764 Cytochrome P450 165C4 CYP165C4 0.0062
4960 Putative cytochrome P450-family protein SCO7417 0.0062
4935 Cytochrome c-554 cycA1 0.0061
4926 Heme-based aerotactic transducer hemAT hemAT 0.0061
4952 Catalase/peroxidase katA 0.0061
3093 Catalase HPII katE 0.0061
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0061
4937 Cytochrome oxidase subunit II rcoxA 0.0061
4993 Hydroxylamine oxidoreductase hao1 0.0061
4903 Methyl-accepting chemotaxis protein Tar4 0.0061
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0061
4922 Cytochrome c, putative SO_4144 0.0061
2592 Beta-galactosidase lacZ 0.0059
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0057
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0057
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0057
2636 Shikimate dehydrogenase aroE 0.0057
3515 Shikimate dehydrogenase aroE 0.0057
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0057
4948 Cytochrome c-553 Not Available 0.0054
2119 Cytochrome b5 CYB5A 0.0054
4990 PpcA ppcA 0.0054
4385 Cytochrome c' Not Available 0.0054
4967 Cytochrome c' cycA 0.0054
5038 Cytochrome c' Not Available 0.0054
5223 Cytochrome c' cycP 0.0054
3375 Acidic cytochrome c3 Not Available 0.0054
4923 Cytochrome c3 DvMF_2499 0.0054
4945 Cytochrome c3 Not Available 0.0054
4949 Cytochrome c3 DVU_3171 0.0054
4968 Cytochrome c3 cytc3 0.0054
4997 Cytochrome c3 SO_2727 0.0054
5219 Cytochrome c3 cyd 0.0054
4037 Hypothetical protein GPX1 0.0054
4297 Hypothetical protein SP_1951 0.0054
4521 Hypothetical protein BC_2969 0.0054
4540 Hypothetical protein TM_1070 0.0054
4555 Hypothetical protein MT1739 0.0054
4569 Hypothetical protein mshD 0.0054
4578 Hypothetical protein PA3270 0.0054
4747 Hypothetical protein PA3967 0.0054
5177 Hypothetical protein TM_0096 0.0054
5194 Hypothetical protein PA1204 0.0054
5240 Hypothetical protein Rv2991 0.0054
5370 Hypothetical protein TM_1158 0.0054
5710 Hypothetical protein Tb927.5.1360 0.0054
4902 Nine-heme cytochrome c Ddes_2038 0.0054
4988 Sulfite oxidase, mitochondrial SUOX 0.0054
2915 Sensor protein fixL fixL 0.0054
4944 Sensor protein fixL fixL 0.0054
4813 Heme oxygenase hmuO 0.0054
5769 Heme oxygenase Not Available 0.0054
4289 Cytochrome P450 TT_P0059 0.0054
6262 Cytochrome P450 staP 0.0054
4992 Cytochrome c peroxidase Not Available 0.0054
3189 High-molecular-weight cytochrome c hmcA 0.0054
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0054
3570 Cytochrome P450 152A1 cypC 0.0054
4920 Peroxidase/catalase katG 0.0054
2280 Listeriolysin regulatory protein prfA 0.0052
4811 Amylosucrase ams 0.0052
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0052
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0052
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0051
3191 Histidinol dehydrogenase hisD 0.0049
4386 Hemoglobin-like protein HbN glbN 0.0049
3670 Soluble cytochrome b562 precursor cybC 0.0049
3291 Cytochrome c-552 cycA 0.0049
4927 Cytochrome c-552 nrfA 0.0049
4938 Cytochrome c-552 cycA 0.0049
4953 Cytochrome c-552 nrfA 0.0049
5217 Cytochrome c-552 cycM 0.0049
3102 Flavohemoprotein hmp 0.0049
4969 Flavohemoprotein hmp 0.0049
3411 Cytochrome P450 121 cyp121 0.0049
191 Peptide methionine sulfoxide reductase MSRA 0.0047
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0047
3221 Cytochrome c4 cc4 0.0047
3127 Nitrite reductase nirS 0.0047
3284 Nitrite reductase nirS 0.0047
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0047
2230 Catalase CAT 0.0046
3249 Catalase katA 0.0046
3625 Catalase katA 0.0046
4539 Catalase katA 0.0046
4941 Catalase katB 0.0046
909 Maleylacetoacetate isomerase GSTZ1 0.0046
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0045
4608 Putative cytochrome P450 SCO1207 0.0045
4963 Putative cytochrome P450 SCO2884 0.0045
6254 Putative cytochrome P450 SCO6998 0.0045
605 Fumarate reductase flavoprotein subunit frdA 0.0044
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0044
3673 Fumarate reductase flavoprotein subunit fccA 0.0044
4912 Fumarate reductase flavoprotein subunit ifcA 0.0044
6549 Fumarate reductase flavoprotein subunit frdA 0.0044
2972 6-deoxyerythronolide B hydroxylase eryF 0.0043
260 Cytochrome P450 51 ERG11 0.0042
761 Cytochrome P450 51 ERG11 0.0042
3163 Cytochrome P450 51 cyp51 0.0042
518 Peroxidase/catalase T katG 0.0041
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0041
1507 Cytochrome c CYCS 0.004
2314 Triosephosphate isomerase TPI 0.004
3417 Triosephosphate isomerase tpiA 0.004
3443 Triosephosphate isomerase tpiA 0.004
6346 Triosephosphate isomerase TPI1 0.004
693 Hemoglobin subunit beta HBB 0.0039
6268 Hydroxyacid oxidase 1 HAO1 0.0039
810 Heme oxygenase 1 HMOX1 0.0037
3391 Heme oxygenase 1 pbsA1 0.0037
358 Cystathionine beta-synthase CBS 0.0037
611 Retinal dehydrogenase 1 ALDH1A1 0.0036
2298 Cytochrome P450-cam camC 0.0034
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.003
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.003
275 Arachidonate 5-lipoxygenase ALOX5 0.0028
6106 Cytochrome P450 2C18 CYP2C18 0.0024
290 Prostaglandin G/H synthase 2 PTGS2 0.0021
20 Prostaglandin G/H synthase 1 PTGS1 0.002
587 Serum albumin ALB 0.0019
6030 Cytochrome P450 2B6 CYP2B6 0.0018
4924 Cytochrome P450 2C8 CYP2C8 0.0017
4757 Cytochrome P450 2C9 CYP2C9 0.0016
4512 Cytochrome P450 3A4 CYP3A4 0.0014
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