DT-Web

DB01549 - Rolicyclidine


Identification
Name Rolicyclidine
Accession Number DB01549
Type small molecule
Description Rolicyclidine (PCPy) is a dissociative anesthetic drug with hallucinogenic and sedative effects. Due to its similarity in effects to PCP, PCPy was placed into the Schedule I list of illegal drugs in the 1970s, although it has never been widely abused and is now little known.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 229.3605
Groups illicit
Monoisotopic Weight 229.183049741
Pharmacology
Indication Rolicyclidine has anesthetic properties and can induce a sedative effect.
Mechanism of action Rolicyclidine works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA Receptor.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glutamate [NMDA] receptor subunit 3A
Name Glutamate [NMDA] receptor subunit 3A
Gene Name GRIN3A
Pharmacological action yes
Actions Not Available
References
  • Leung K: 4-Acetoxy-7-chloro-3-(3-(-4-[11C]methoxybenzyl)phenyl)-2(1H)-quinolone - Pubmed
  • Yuede CM, Wozniak DF, Creeley CE, Taylor GT, Olney JW, Farber NB: Behavioral consequences of NMDA antagonist-induced neuroapoptosis in the infant mouse brain. PLoS One. 2010 Jun 29;5(6):e11374. - Pubmed
DTHybrid score 0.2291
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action unknown
Actions Not Available
References
  • Seeman P, Guan HC, Hirbec H: Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil. Synapse. 2009 Aug;63(8):698-704. - Pubmed
DTHybrid score 0.2515

Predictions


Id Partner name Gene Name Score
23 D(1A) dopamine receptor DRD1 0.079
502 5-hydroxytryptamine 2A receptor HTR2A 0.0764
4119 Cytochrome P450 2D6 CYP2D6 0.0553
4512 Cytochrome P450 3A4 CYP3A4 0.0474
6030 Cytochrome P450 2B6 CYP2B6 0.047
638 D(3) dopamine receptor DRD3 0.046
556 Alpha-1A adrenergic receptor ADRA1A 0.0384
174 Sigma 1-type opioid receptor SIGMAR1 0.0379
3923 Cholinesterase BCHE 0.0366
320 5-hydroxytryptamine 1A receptor HTR1A 0.0363
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0356
432 D(4) dopamine receptor DRD4 0.0353
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0352
103 Muscarinic acetylcholine receptor M1 CHRM1 0.034
590 5-hydroxytryptamine 2C receptor HTR2C 0.0337
1588 Multidrug resistance protein 1 ABCB1 0.0337
341 5-hydroxytryptamine 3 receptor HTR3A 0.0303
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0287
163 D(1B) dopamine receptor DRD5 0.0285
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0276
6016 Cytochrome P450 2C19 CYP2C19 0.0269
4200 Cytochrome P450 1A2 CYP1A2 0.0265
6013 Cytochrome P450 2E1 CYP2E1 0.0254
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0243
318 Alpha-2A adrenergic receptor ADRA2A 0.0233
617 Muscarinic acetylcholine receptor M2 CHRM2 0.023
632 Alpha-1B adrenergic receptor ADRA1B 0.0223
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0219
629 Alpha-2B adrenergic receptor ADRA2B 0.0217
4757 Cytochrome P450 2C9 CYP2C9 0.0215
378 Alpha-2C adrenergic receptor ADRA2C 0.0214
713 Sodium-dependent dopamine transporter SLC6A3 0.0206
492 Histamine H1 receptor HRH1 0.0194
6145 Solute carrier family 22 member 1 SLC22A1 0.0185
3876 Aromatic-L-amino-acid decarboxylase DDC 0.018
716 5-hydroxytryptamine 7 receptor HTR7 0.0175
436 5-hydroxytryptamine 2B receptor HTR2B 0.0174
4096 Metabotropic glutamate receptor 3 GRM3 0.0174
1362 Metabotropic glutamate receptor 2 GRM2 0.0174
725 5-hydroxytryptamine 1D receptor HTR1D 0.0171
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.017
694 Matrix protein 2 M 0.016
916 Metabotropic glutamate receptor 1 GRM1 0.0157
2178 Metabotropic glutamate receptor 5 GRM5 0.0157
885 5-hydroxytryptamine 1B receptor HTR1B 0.0154
6144 Solute carrier family 22 member 2 SLC22A2 0.0153
4924 Cytochrome P450 2C8 CYP2C8 0.0147
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0143
4118 Cytochrome P450 3A5 CYP3A5 0.014
6107 Cytochrome P450 3A7 CYP3A7 0.0139
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0136
427 Substance-P receptor TACR1 0.0132
824 Sodium-dependent serotonin transporter SLC6A4 0.0131
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.013
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0128
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0118
789 Alpha-1D adrenergic receptor ADRA1D 0.0105
465 Calmodulin CALM1 0.0102
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0101
587 Serum albumin ALB 0.0101
3939 Amine oxidase [flavin-containing] B MAOB 0.0101
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0098
1256 5-hydroxytryptamine 6 receptor HTR6 0.009
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0087
923 Glutamate receptor 3 GRIA3 0.0086
5718 Cytochrome P450 2A6 CYP2A6 0.0085
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0083
467 Delta-type opioid receptor OPRD1 0.0082
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0081
847 Mu-type opioid receptor OPRM1 0.0078
482 Glycine receptor subunit alpha-1 GLRA1 0.0072
319 Opioid receptor, sigma 1 OPRS1 0.0066
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0066
20 Prostaglandin G/H synthase 1 PTGS1 0.0066
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0061
131 Synaptic vesicular amine transporter SLC18A2 0.006
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0055
251 Alcohol dehydrogenase 1A ADH1A 0.0054
6106 Cytochrome P450 2C18 CYP2C18 0.0053
6024 Cytochrome P450 1A1 CYP1A1 0.0053
921 Glutamate receptor 2 GRIA2 0.0053
820 Glycine receptor subunit alpha-2 GLRA2 0.0051
444 Alcohol dehydrogenase 1B ADH1B 0.0047
696 Kappa-type opioid receptor OPRK1 0.0046
468 Cytochrome P450 4A11 CYP4A11 0.0045
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0043
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0043
1268 Neuropeptide S receptor NPSR1 0.0043
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0043
528 5-hydroxytryptamine 1E receptor HTR1E 0.0042
6859 Protein S100-A4 S100A4 0.0041
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0041
517 Alcohol dehydrogenase 1C ADH1C 0.0041
94 5-hydroxytryptamine 4 receptor HTR4 0.004
6073 Potassium channel subfamily K member 9 KCNK9 0.0039
6072 Potassium channel subfamily K member 3 KCNK3 0.0039
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
380 Cytochrome P450 17A1 CYP17A1 0.0035
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0034
3811 Cytochrome P450 19A1 CYP19A1 0.0033
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0031
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0031
1181 Alpha-1-acid glycoprotein 1 ORM1 0.003
537 ATP synthase delta chain, mitochondrial ATP5D 0.003
3941 Amine oxidase [flavin-containing] A MAOA 0.0029
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0028
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0028
2207 Rhodopsin RHO 0.0028
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0027
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0024
6151 Monocarboxylate transporter 10 SLC16A10 0.0024
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0023
3947 Xanthine dehydrogenase/oxidase XDH 0.002
124 Histamine H2 receptor HRH2 0.0018
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0018
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0018
474 Acetylcholinesterase ACHE 0.0018
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0018
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0017
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0016
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0015
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0015
922 Glutamate receptor 4 GRIA4 0.0015
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0015
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0015
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0015
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0015
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0015
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0015
4018 Glutamate receptor delta-2 subunit GRID2 0.0015
4027 Glutamate receptor delta-1 subunit GRID1 0.0015
1912 Excitatory amino acid transporter 1 SLC1A3 0.0015
4019 Excitatory amino acid transporter 4 SLC1A6 0.0015
4016 Excitatory amino acid transporter 5 SLC1A7 0.0015
4026 Aspartyl aminopeptidase DNPEP 0.0015
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0015
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0015
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0015
1047 Excitatory amino acid transporter 2 SLC1A2 0.0015
664 Glutamate decarboxylase 2 GAD2 0.0015
3890 Glutamate decarboxylase 2 GAD2 0.0015
4017 5-oxoprolinase OPLAH 0.0015
927 Metabotropic glutamate receptor 8 GRM8 0.0015
925 Metabotropic glutamate receptor 4 GRM4 0.0015
926 Metabotropic glutamate receptor 7 GRM7 0.0015
4020 Glutamyl aminopeptidase ENPEP 0.0015
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0015
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0014
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0013
625 Glutamate carboxypeptidase 2 FOLH1 0.0013
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0013
665 Phosphoserine aminotransferase PSAT1 0.0013
4652 Phosphoserine aminotransferase serC 0.0013
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0013
420 Glutamate decarboxylase 1 GAD1 0.0013
3900 Glutamate decarboxylase 1 GAD1 0.0013
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0013
917 Glutaminase kidney isoform, mitochondrial GLS 0.0013
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0013
5 Glutaminase liver isoform, mitochondrial GLS2 0.0013
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0013
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0013
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0013
5261 Phosphoribosylformylglycinamidine synthase purL 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0013
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0013
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0013
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0012
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0012
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0012
3877 Growth-inhibiting protein 18 GIG18 0.0012
3810 Catechol O-methyltransferase COMT 0.0012
763 Tyrosine aminotransferase TAT 0.0012
5493 Tyrosine aminotransferase Not Available 0.0012
1671 Excitatory amino acid transporter 3 SLC1A1 0.0012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0011
776 Bile salt export pump ABCB11 0.0011
735 Alanine aminotransferase 1 GPT 0.0011
3904 Alanine aminotransferase 2 GPT2 0.0011
426 Aspartate aminotransferase, mitochondrial GOT2 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0011
705 Glutamate receptor 1 GRIA1 0.0011
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0011
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.001
3426 Glutamine synthetase glnA 0.001
3987 Glutamine synthetase GLUL 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.001
6147 Solute carrier family 22 member 3 SLC22A3 0.001
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.001
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.001
118 Organic cation/carnitine transporter 2 SLC22A5 0.0009
164 Histamine H4 receptor HRH4 0.0008
738 Monocarboxylate transporter 1 SLC16A1 0.0008
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0008
193 Beta-1 adrenergic receptor ADRB1 0.0008
766 Beta-2 adrenergic receptor ADRB2 0.0008
1898 Cytochrome P450 1B1 CYP1B1 0.0005
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