DT-Web

DB01429 - Aprindine


Identification
Name Aprindine
Accession Number DB01429
Type small molecule
Description A cardiac depressant used in arrhythmias. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 322.487
Groups approved
Monoisotopic Weight 322.24089897
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Sato R, Hisatome I, Tanaka Y, Sasaki N, Kotake H, Mashiba H, Katori R: Aprindine blocks the sodium current in guinea-pig ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 1991 Sep;344(3):331-6. - Pubmed
  • Kamiya K, Kodama I, Toyama J: A combination of inactivated sodium channel blockers causes competitive interaction on dV/dtmax of single ventricular myocytes. Cardiovasc Res. 1991 Jun;25(6):516-22. - Pubmed
DTHybrid score 0.5023
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions inhibitor
References
  • Levine SN, Hollier B: Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):151-6. - Pubmed
DTHybrid score 0.4032

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3446

Carriers


Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1728
4200 Cytochrome P450 1A2 CYP1A2 0.111
4757 Cytochrome P450 2C9 CYP2C9 0.1082
1588 Multidrug resistance protein 1 ABCB1 0.105
6016 Cytochrome P450 2C19 CYP2C19 0.1038
587 Serum albumin ALB 0.0901
4924 Cytochrome P450 2C8 CYP2C8 0.0805
6030 Cytochrome P450 2B6 CYP2B6 0.0733
4118 Cytochrome P450 3A5 CYP3A5 0.0676
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0572
6107 Cytochrome P450 3A7 CYP3A7 0.0537
556 Alpha-1A adrenergic receptor ADRA1A 0.0482
6013 Cytochrome P450 2E1 CYP2E1 0.0477
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0475
6024 Cytochrome P450 1A1 CYP1A1 0.0425
831 D(2) dopamine receptor DRD2 0.042
492 Histamine H1 receptor HRH1 0.0412
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0387
824 Sodium-dependent serotonin transporter SLC6A4 0.0382
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0373
1507 Cytochrome c CYCS 0.0356
722 Troponin I, cardiac muscle TNNI3 0.0347
6145 Solute carrier family 22 member 1 SLC22A1 0.0325
6144 Solute carrier family 22 member 2 SLC22A2 0.0321
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0319
766 Beta-2 adrenergic receptor ADRB2 0.0315
3923 Cholinesterase BCHE 0.0289
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0277
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0277
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0276
502 5-hydroxytryptamine 2A receptor HTR2A 0.0272
193 Beta-1 adrenergic receptor ADRB1 0.0264
320 5-hydroxytryptamine 1A receptor HTR1A 0.026
5718 Cytochrome P450 2A6 CYP2A6 0.0256
713 Sodium-dependent dopamine transporter SLC6A3 0.0236
23 D(1A) dopamine receptor DRD1 0.0233
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0228
632 Alpha-1B adrenergic receptor ADRA1B 0.0221
6106 Cytochrome P450 2C18 CYP2C18 0.0219
318 Alpha-2A adrenergic receptor ADRA2A 0.0212
789 Alpha-1D adrenergic receptor ADRA1D 0.0211
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0206
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0203
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.02
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0199
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0197
118 Organic cation/carnitine transporter 2 SLC22A5 0.0195
847 Mu-type opioid receptor OPRM1 0.0191
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0181
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0179
172 Potassium channel subfamily K member 1 KCNK1 0.017
862 Multidrug resistance-associated protein 1 ABCC1 0.017
6147 Solute carrier family 22 member 3 SLC22A3 0.0169
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0163
6048 Troponin C, skeletal muscle TNNC2 0.0163
833 Organic cation/carnitine transporter 1 SLC22A4 0.0157
844 Epidermal growth factor receptor EGFR 0.0156
696 Kappa-type opioid receptor OPRK1 0.0156
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0151
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0149
590 5-hydroxytryptamine 2C receptor HTR2C 0.0148
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0144
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0141
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0137
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0137
467 Delta-type opioid receptor OPRD1 0.0136
3941 Amine oxidase [flavin-containing] A MAOA 0.0126
638 D(3) dopamine receptor DRD3 0.0125
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0125
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
629 Alpha-2B adrenergic receptor ADRA2B 0.0122
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.012
378 Alpha-2C adrenergic receptor ADRA2C 0.0118
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0118
2795 Methionine aminopeptidase 2 METAP2 0.0117
3939 Amine oxidase [flavin-containing] B MAOB 0.0108
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0107
20 Prostaglandin G/H synthase 1 PTGS1 0.0106
5682 Ribonuclease pancreatic RNASE1 0.0104
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0104
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0104
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.01
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0099
6220 Aryl hydrocarbon receptor AHR 0.0099
33 Cystine/glutamate transporter SLC7A11 0.0097
1898 Cytochrome P450 1B1 CYP1B1 0.0097
2132 Protein S100-B S100B 0.0096
6859 Protein S100-A4 S100A4 0.0094
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0093
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0092
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0089
1517 Beta-3 adrenergic receptor ADRB3 0.0088
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0086
885 5-hydroxytryptamine 1B receptor HTR1B 0.0086
1757 Myeloperoxidase MPO 0.0085
341 5-hydroxytryptamine 3 receptor HTR3A 0.0085
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0083
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0083
380 Cytochrome P450 17A1 CYP17A1 0.008
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.008
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0079
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0076
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0076
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0075
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0074
2164 Multidrug resistance-associated protein 4 ABCC4 0.0074
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0073
1262 Corticotropin-lipotropin POMC 0.0073
731 HIV-1 protease HIV-1 protease 0.0071
921 Glutamate receptor 2 GRIA2 0.007
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.007
432 D(4) dopamine receptor DRD4 0.0069
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0068
776 Bile salt export pump ABCB11 0.0068
1050 Bile salt sulfotransferase SULT2A1 0.0067
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0066
436 5-hydroxytryptamine 2B receptor HTR2B 0.0066
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0065
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0065
3947 Xanthine dehydrogenase/oxidase XDH 0.0064
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0064
705 Glutamate receptor 1 GRIA1 0.0061
537 ATP synthase delta chain, mitochondrial ATP5D 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0059
6142 Solute carrier family 22 member 8 SLC22A8 0.0059
482 Glycine receptor subunit alpha-1 GLRA1 0.0058
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0058
163 D(1B) dopamine receptor DRD5 0.0056
768 FK506-binding protein 1A FKBP1A 0.0056
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0054
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0054
1729 Solute carrier family 22 member 6 SLC22A6 0.0054
1656 CYP2B protein CYP2B 0.0054
3830 Calreticulin CALR 0.0053
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0053
474 Acetylcholinesterase ACHE 0.0053
131 Synaptic vesicular amine transporter SLC18A2 0.0053
751 Potassium channel subfamily K member 6 KCNK6 0.0052
5787 Angiopoietin-1 receptor TEK 0.0052
725 5-hydroxytryptamine 1D receptor HTR1D 0.005
6035 Nuclear receptor ROR-beta RORB 0.005
6034 Hydroxyindole O-methyltransferase ASMT 0.005
6036 Eosinophil peroxidase EPX 0.005
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.005
3811 Cytochrome P450 19A1 CYP19A1 0.0049
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0049
183 Vascular endothelial growth factor A VEGFA 0.0048
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0048
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0048
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0047
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0047
290 Prostaglandin G/H synthase 2 PTGS2 0.0046
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0046
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
765 Indoleamine 2,3-dioxygenase IDO1 0.0044
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0043
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0043
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0043
362 Melatonin receptor type 1B MTNR1B 0.0042
571 Melatonin receptor type 1A MTNR1A 0.0042
6432 Transporter snf 0.0042
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0042
124 Histamine H2 receptor HRH2 0.0041
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0041
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0041
1618 High affinity nerve growth factor receptor NTRK1 0.004
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0039
716 5-hydroxytryptamine 7 receptor HTR7 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
504 Mast/stem cell growth factor receptor KIT 0.0038
1256 5-hydroxytryptamine 6 receptor HTR6 0.0038
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0036
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
737 Mineralocorticoid receptor NR3C2 0.0033
6506 Stathmin-4 STMN4 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
6182 Cytochrome P450 2J2 CYP2J2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0033
817 DNA topoisomerase 2-alpha TOP2A 0.0033
738 Monocarboxylate transporter 1 SLC16A1 0.0033
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0032
1636 Trace amine-associated receptor 1 TAAR1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
528 5-hydroxytryptamine 1E receptor HTR1E 0.0029
228 Beta platelet-derived growth factor receptor PDGFRB 0.0029
6141 Sodium/bile acid cotransporter SLC10A1 0.0029
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
6031 Cytochrome P450 3A43 CYP3A43 0.0028
1864 RET proto-oncogene RET 0.0028
136 Estrogen receptor ESR1 0.0028
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0028
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0028
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0028
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0025
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0025
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0025
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
1360 Sphingomyelin phosphodiesterase SMPD1 0.0024
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0024
6134 Sodium channel subunit beta-3 SCN3B 0.0024
6132 Sodium channel subunit beta-1 SCN1B 0.0024
6135 Sodium channel subunit beta-4 SCN4B 0.0024
6127 Carbonic anhydrase-related protein CA8 0.0024
6133 Sodium channel subunit beta-2 SCN2B 0.0024
6128 Carbonic anhydrase-related protein 10 CA10 0.0024
6129 Carbonic anhydrase-related protein 11 CA11 0.0024
6126 Carbonic anhydrase 7 CA7 0.0024
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
6148 Multidrug resistance-associated protein 7 ABCC10 0.0022
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0022
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0021
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0021
295 Carbonic anhydrase 1 CA1 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6130 Carbonic anhydrase 13 CA13 0.002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.002
174 Sigma 1-type opioid receptor SIGMAR1 0.002
5961 Insulin INS 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
6131 Carbonic anhydrase 14 CA14 0.0019
4203 Histamine N-methyltransferase HNMT 0.0019
6755 Poliovirus receptor PVR 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
592 Carbonic anhydrase 4 CA4 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0017
4210 Toll-like receptor 4 TLR4 0.0017
2616 Ganglioside GM2 activator GM2A 0.0017
3007 Carbonic anhydrase 12 CA12 0.0017
4205 Carbonic anhydrase 9 CA9 0.0017
146 Androgen receptor AR 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0016
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
468 Cytochrome P450 4A11 CYP4A11 0.0016
1629 Transcription factor AP-1 JUN 0.0016
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2297 Genome polyprotein Not Available 0.0015
2322 Genome polyprotein Not Available 0.0015
2694 Genome polyprotein Not Available 0.0015
2719 Genome polyprotein Not Available 0.0015
2860 Genome polyprotein Not Available 0.0015
2928 Genome polyprotein Not Available 0.0015
3160 Genome polyprotein Not Available 0.0015
3260 Genome polyprotein Not Available 0.0015
4783 Genome polyprotein Not Available 0.0015
5726 Genome polyprotein Not Available 0.0015
5779 Genome polyprotein Not Available 0.0015
5867 Genome polyprotein Not Available 0.0015
6253 Genome polyprotein Not Available 0.0015
6301 Genome polyprotein Not Available 0.0015
6380 Genome polyprotein Not Available 0.0015
6381 Genome polyprotein Not Available 0.0015
6437 Genome polyprotein Not Available 0.0015
6520 Genome polyprotein Not Available 0.0015
6521 Genome polyprotein Not Available 0.0015
6652 Genome polyprotein Not Available 0.0015
6734 Genome polyprotein Not Available 0.0015
6735 Genome polyprotein Not Available 0.0015
6736 Genome polyprotein Not Available 0.0015
6737 Genome polyprotein Not Available 0.0015
6738 Genome polyprotein Not Available 0.0015
6739 Genome polyprotein Not Available 0.0015
6744 Genome polyprotein Not Available 0.0015
6748 Genome polyprotein Not Available 0.0015
6894 Genome polyprotein Not Available 0.0015
6898 Genome polyprotein Not Available 0.0015
6316 ADP-ribosylation factor 1 ARF1 0.0015
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0015
4604 Liver carboxylesterase 1 CES1 0.0015
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0015
6085 Fatty acid-binding protein, intestinal FABP2 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
4120 NADPH--cytochrome P450 reductase POR 0.0014
3086 Plasmepsin-2 Not Available 0.0014
373 Transthyretin TTR 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
6143 Solute carrier family 22 member 7 SLC22A7 0.0013
3404 Exotoxin A eta 0.0013
6020 Aldehyde oxidase AOX1 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0012
1010 Cytochrome P450 51A1 CYP51A1 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
6228 Nuclear receptor coactivator 1 NCOA1 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
473 L-lactate dehydrogenase A chain LDHA 0.0011
6014 Cytochrome P450 2A13 CYP2A13 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0011
164 Histamine H4 receptor HRH4 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
614 Progesterone receptor PGR 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
144 Hemoglobin subunit alpha HBA1 0.001
518 Peroxidase/catalase T katG 0.001
777 Tumor necrosis factor TNF 0.0009
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
563 Thyroid peroxidase TPO 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
1341 Histamine H3 receptor HRH3 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
6136 Multidrug resistance-associated protein 5 ABCC5 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
4773 Deoxycytidine kinase DCK 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
976 Platelet glycoprotein IX GP9 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
6146 High affinity copper uptake protein 1 SLC31A1 0.0006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
1024 Solute carrier family 22 member 11 SLC22A11 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
572 Integrin alpha-L ITGAL 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
153 Dopamine beta-hydroxylase DBH 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3810 Catechol O-methyltransferase COMT 0.0004
3957 Adenosine deaminase ADA 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
469 Annexin A1 ANXA1 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
2207 Rhodopsin RHO 0.0003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
869 Estrogen receptor beta ESR2 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
↑