DT-Web

DB00923 - Ceforanide


Identification
Name Ceforanide
Accession Number DB00923 (APRD00853)
Type small molecule
Description Ceforanide is a second-generation parenteral cephalosporin antibiotic. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, a second-generation cephalosporin, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 519.554
Groups approved
Monoisotopic Weight 519.099472819
Pharmacology
Indication For the treatment of infections caused by susceptible organisms.
Mechanism of action The bactericidal activity of ceforanide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Absorption Rapidly absorbed following intramuscular injection.
Protein binding 80.6%
Biotransformation The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine.
Route of elimination Not Available
Toxicity Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased risk of nephrotoxicity
Gentamicin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Tobramycin Increased risk of nephrotoxicity
Food Interactions Not Available

Targets


Penicillin-binding protein 2
Name Penicillin-binding protein 2
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Barriere SL, Mills J: Ceforanide: antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy. 1982 Nov-Dec;2(6):322-7. - Pubmed
  • Yotsuji A, Mitsuyama J, Hori R, Yasuda T, Saikawa I, Inoue M, Mitsuhashi S: Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis. Antimicrob Agents Chemother. 1988 Dec;32(12):1848-53. - Pubmed
DTHybrid score 1.1647

Predictions


Id Partner name Gene Name Score
115 Penicillin-binding protein 2 mrdA 1.1647
6069 Penicillin-binding protein 2 mrdA 1.1647
6118 Penicillin-binding protein 2 penA 1.1647
6686 Penicillin-binding protein 2 pbp2 1.1647
6939 Penicillin-binding protein 2 mrdA 1.1647
7163 Penicillin-binding protein 2 pbpA 1.1647
1024 Solute carrier family 22 member 11 SLC22A11 0.0638
6143 Solute carrier family 22 member 7 SLC22A7 0.061
6142 Solute carrier family 22 member 8 SLC22A8 0.054
1729 Solute carrier family 22 member 6 SLC22A6 0.0498
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