DB00429 - Carboprost Tromethamine
| Identification | |
|---|---|
| Name | Carboprost Tromethamine |
| Accession Number | DB00429 (APRD00847) |
| Type | small molecule |
| Description | A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy. [PubChem] |
| Structure |
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| Categories (*) | |
| Molecular Weight | 489.6426 |
| Groups | approved |
| Monoisotopic Weight | 489.330167485 |
| Pharmacology | |
| Indication | For aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method; 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity; 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus; 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management. |
| Mechanism of action | Carboprost is a synthetic prostaglandin. It binds the prostaglandin E2 receptor, causing myometrial contractions, casuing the induction of labour or the expulsion of the placenta. Prostaglandins occur naturally in the body and act at several sites in the body including the womb (uterus). They act on the muscles of the womb, causing them to contract. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Metabolized in the lungs and liver. Metabolites are excreted in urine. |
| Route of elimination | Not Available |
| Toxicity | Symptoms of overdose include irritation, nausea, vomiting, diarrhea, coughing, dyspnea, asthma, hypertension, flushing, and pyrexia. |
| Affected organisms |
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| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Prostaglandin E2 receptor, EP1 subtype | |
|---|---|
| Name | Prostaglandin E2 receptor, EP1 subtype |
| Gene Name | PTGER1 |
| Pharmacological action | yes |
| Actions | agonist |
| References |
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| DTHybrid score | 0.4488 |